Cerebellar Stimulation: Lighting the Way
(Source: The Cerebellum)
Source: The Cerebellum - February 1, 2024 Category: Neurology Source Type: research
Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping
(Source: The Cerebellum)
Source: The Cerebellum - February 1, 2024 Category: Neurology Source Type: research
Correction to: The Role of the Cerebellum in Visual-Spatial Memory in Pediatric Posterior Fossa Tumor Survivors
(Source: The Cerebellum)
Source: The Cerebellum - February 1, 2024 Category: Neurology Source Type: research
Correction to: A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals
(Source: The Cerebellum)
Source: The Cerebellum - February 1, 2024 Category: Neurology Source Type: research
Correction to: Catch-Up Saccades in Vestibular Hypofunction: A Contribution of the Cerebellum?
(Source: The Cerebellum)
Source: The Cerebellum - February 1, 2024 Category: Neurology Source Type: research
Correction to: Autoimmune Cerebellar Ataxia Associated with Anti-Glutamate Receptor δ2 Antibodies: a Rare but Treatable Entity
(Source: The Cerebellum)
Source: The Cerebellum - February 1, 2024 Category: Neurology Source Type: research
New Horizon of Multiple System Atrophy Research
(Source: The Cerebellum)
Source: The Cerebellum - February 1, 2024 Category: Neurology Source Type: research
The Use of the Voice Trainer App for Vocal Control in People with a Degenerative Ataxia: A Pilot Intervention Study
AbstractDysarthria is disabling in persons with degenerative ataxia. There is limited evidence for speech therapy interventions. In this pilot study, we used the Voice trainer app, which was originally developed for patients with Parkinson ’s disease, as a feedback tool for vocal control. We hypothesized that patients with ataxic dysarthria would benefit from the Voice trainer app to better control their loudness and pitch, resulting in a lower speaking rate and better intelligibility. This intervention study consisted of five thera py sessions of 30 min within 3 weeks using the principles of the Pitch Limiting Voice T...
Source: The Cerebellum - January 29, 2024 Category: Neurology Source Type: research
Factors Influencing Health-Related Quality of Life of Patients with Spinocerebellar Ataxia
This study is to assess HRQoL progression and identify factors affecting SCA patients ’ HRQoL.MethodsLongitudinal data (three-year follow-up) of 310 SCA patients of the European SCA3/Machado-Joseph-Disease Initiative (ESMI) (2016-2022) and 525 SCA patients (SCA1, SCA2, SCA3 or SCA6) of the EUROSCA natural history study cohort (2006 –2015) were assessed. Both large cohort studies share standardized assessments of clinical measures, SARA, INAS, PHQ-9, and HRQoL (EQ-5D-3L). The association between HRQoL and clinical measures was assessed by Spearman Correlation (rs). Multivariable panel regression models were performed to...
Source: The Cerebellum - January 27, 2024 Category: Neurology Source Type: research
Local Dynamic Stability of Trunk During Gait is Responsive to Rehabilitation in Subjects with Primary Degenerative Cerebellar Ataxia
This study aimed to assess the responsiveness to the rehabilitation of three trunk acceleration-derived gait indexes, namely the harmonic ratio (HR), the short-term longest Lyapunov ’s exponent (sLLE), and the step-to-step coefficient of variation (CV), in a sample of subjects with primary degenerative cerebellar ataxia (swCA), and investigate the correlations between their improvements (∆), clinical characteristics, and spatio-temporal and kinematic gait features. The trun k acceleration patterns in the antero-posterior (AP), medio-lateral (ML), and vertical (V) directions during gait of 21 swCA were recorded using a ...
Source: The Cerebellum - January 27, 2024 Category: Neurology Source Type: research
Efficacy of Cerebellar Transcranial Magnetic Stimulation for Post-stroke Balance and Limb Motor Function Impairments: Meta-analyses of Random Controlled Trials and Resting-State fMRI Studies
This study aimed to investigate the potential therapeutic effects of cerebellar transcranial magnetic stimulation (TMS) on balance and limb motor impairments in stroke patients. A meta-analysis of randomized controlled trials was conducted to assess the effects of cerebellar TMS on balance and motor impairments in stroke patients. Additionally, an activation likelihood estimation (ALE) meta-analysis was performed on resting-state functional magnetic resonance imaging (fMRI) studies to compare spontaneous neural activity differences between stroke patients and healthy controls using measures including the amplitude of low f...
Source: The Cerebellum - January 27, 2024 Category: Neurology Source Type: research
Cerebellar Neurostimulation for Boosting Social and Affective Functions: Implications for the Rehabilitation of Hereditary Ataxia Patients
AbstractBeyond motor deficits, spinocerebellar ataxia (SCA) patients also suffer cognitive decline and show socio-affective difficulties, negatively impacting on their social functioning. The possibility to modulate cerebello-cerebral networks involved in social cognition through cerebellar neurostimulation has opened up potential therapeutic applications for ameliorating social and affective difficulties. The present review offers an overview of the research on cerebellar neurostimulation for the modulation of socio-affective functions in both healthy individuals and different clinical populations, published in the time p...
Source: The Cerebellum - January 25, 2024 Category: Neurology Source Type: research
Cerebellar-Induced Aphasia After Stroke: Evidence for the “Linguistic Cerebellum”
AbstractThe cerebellum is traditionally known to subserve motor functions. However, for several decades, the concept of the “cerebellar cognitive affective syndrome” has evolved. Studies in healthy participants and patients have confirmed the cerebellar role in language. The exact involvement of the cerebellum regardingcerebellar aphasia remains uncertain. We included 43 cerebellar stroke patients who were tested at 3 months post-onset with the Boston Naming Test (BNT), the Token Test (TT), and the Diagnostic Instrument for Mild Aphasia (DIMA). Lesion side (left/right) and volume (cm3) were investigated. Patients signi...
Source: The Cerebellum - January 20, 2024 Category: Neurology Source Type: research
A Systematic Review of the Spectrum and Prevalence of Non-motor Symptoms in Multiple System Atrophy
ConclusionIn routine clinical practice, NMS in MSA are under-recognised by clinicians. These impact hugely on patient quality of life and contribute to their overall morbidity. A methodical ascertainment of these complaints will address an unmet need, and lead to a more holistic approach of care for individuals with MSA. (Source: The Cerebellum)
Source: The Cerebellum - January 16, 2024 Category: Neurology Source Type: research
Early-Life Social Determinants of SCA6 Age at Onset, Severity, and Progression
AbstractSCA6 patients with the same size CAG repeat allele can vary significantly in age at onset (AAO) and clinical progression. The specific external factors affecting SCA6 have yet to be investigated. We assessed the effect of early life events on AAO, severity, and progression in SCA6 patients using a social determinant of health approach. We performed a survey of biological and social factors in SCA6 patients enrolled in the SCA6 Network at the University of Chicago. AAO of ataxia symptoms and patient-reported outcome measure (PROM) of ataxia were used as primary outcome measures. Least absolute shrinkage and selectio...
Source: The Cerebellum - January 13, 2024 Category: Neurology Source Type: research
