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New Challenges and rising expectations for the Brazilian Journal of Infectious Diseases, 2019
Publication date: January–February 2019Source: The Brazilian Journal of Infectious Diseases, Volume 23, Issue 1Author(s): Luciano Z. Goldani (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 17, 2019 Category: Infectious Diseases Source Type: research

Long term neurologic sequelae in a Mexican rocky mountain spotted fever case
We present the case of a Mexican pediatric patient with neurologic sequelae 10 years after an acute infection by R. rickettsii. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 17, 2019 Category: Infectious Diseases Source Type: research

Molecular characteristics of methicillin-resistant Staphylococcus aureus isolates from hospital and community environments in northeastern Brazil
This study characterized 30 MRSA isolates from intensive care unit (ICU) environment and equipment surfaces and healthy children. The SCCmec types I, IVa and V were detected in HA-MRSA isolates while CA-MRSA showed the SCCmec type IVa and V. Most isolates were classified as agr group II. All isolates presented the sei gene, and only HA-MRSA were positive for etb e tst genes. Three genotypes were related to Pediatric (ST5/SCCmecIV) and Berlin (ST45/SCCmecIV) clones. The present study showed molecular similarity between CA- and HA-MRSA isolates in hospital and community settings in a Brazilian region. (Source: The Brazilian ...
Source: The Brazilian Journal of Infectious Diseases - May 17, 2019 Category: Infectious Diseases Source Type: research

Early switch/early discharge opportunities for hospitalized patients with methicillin-resistant Staphylococcus aureus complicated skin and soft tissue infections in Brazil
ConclusionsOnly 2% of patients were switched from IV to oral antibiotics in our study while almost one-third were ES eligible. Additionally, one-third of hospitalized patients with MRSA cSSTI were ED eligible indicating opportunity for reducing IV therapy and days of hospital stay. These results provide insight into possible benefits of implementation of ES/ED protocols in Brazil. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 11, 2019 Category: Infectious Diseases Source Type: research

Editorial 2019
Publication date: January–February 2019Source: The Brazilian Journal of Infectious Diseases, Volume 23, Issue 1Author(s): Luciano Z. Goldani (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 9, 2019 Category: Infectious Diseases Source Type: research

Revisiting Keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1): prevalence, clinical aspects and proviral load
ConclusionBurning and/or pain and itching and low corrected visual acuity were the most common alterations of HTLV-1/KCS. High PVL was found to be associated with the presence of KCS. It is strongly recommended that HTLV-1 patients undergo periodic ophthalmologic examination to promote the early diagnosis of KCS and prevent the consequences associated with Dry Eye Disease. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 5, 2019 Category: Infectious Diseases Source Type: research

Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis – a review
Publication date: Available online 1 May 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Gilberto Silva Nunes Bezerra, Walter Lins Barbosa, Elis Dionísio da Silva, Nilma Cintra Leal, Zulma Maria de MedeirosAbstractVisceral leishmaniasis (VL) is a serious and debilitating infection with high fatality rate in tropical and subtropical countries. As clinical symptoms of VL are not so specific, confirmatory diagnostic methods with high sensitivity and specificity are needed. Noninvasive methods have been developed using urine as a clinical sample for VL diagnosis. In fact, there is a clear correlation betwee...
Source: The Brazilian Journal of Infectious Diseases - May 2, 2019 Category: Infectious Diseases Source Type: research

Daptomycin and vancomycin non-susceptible methicillin-resistant Staphylococcus aureus clonal lineages from bloodstream infection in a Brazilian teaching hospital
ConclusionsDaptomycin and vancomycin non-susceptible MRSA clonal lineages were found in BSI over five years, highlighting the importance of continuous surveillance of multiresistant bacteria in hospitals. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - April 26, 2019 Category: Infectious Diseases Source Type: research

High prevalence of CTX-M-1 group in ESBL-producing enterobacteriaceae infection in intensive care units in southern Chile
Publication date: Available online 24 April 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Monica Pavez, Claudia Troncoso, Irma Osses, Rodrigo Salazar, Vijna Illesca, Patricia Reydet, Claudio Rodriguez, Carolina Chain, Carla Concha, Leticia BarrientosAbstractEnterobacteria-producing extended-spectrum β-lactamases (ESBL) play an important role in healthcare infections, increasing hospitalization time, morbidity and mortality rates. Among several ESBLs that emerge from these pathogens, CTX-M-type enzymes had the most successful global spread in different epidemiological settings. Latin America presents h...
Source: The Brazilian Journal of Infectious Diseases - April 24, 2019 Category: Infectious Diseases Source Type: research

Editorial
Publication date: January–February 2019Source: The Brazilian Journal of Infectious Diseases, Volume 23, Issue 1Author(s): Luciano Z. Goldani (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - April 18, 2019 Category: Infectious Diseases Source Type: research

Epidemiology and clinical characteristics of herpes zoster in a tertiary care hospital in Brazil
ConclusionThe results of this study demonstrate a high burden of HZ disease in a Brazilian tertiary care hospital in the HZ vaccination era. Awareness of the incidence and comorbidity factors associated with HZ in Latin American countries such as Brazil contribute for adoption and implementation of strategies for immunization in this area. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - March 31, 2019 Category: Infectious Diseases Source Type: research

A systematic review on the influence of hla-b polymorphisms on hiv-1 mother-to-child-transmission
ConclusionHLA-B*57 group allele can be protective against MTCT while HLA-B*35 groups alleles are consistently associated with HIV-1 MTCT. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - March 27, 2019 Category: Infectious Diseases Source Type: research

Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women
ConclusionsHTLV-1 infection induces immune activation in cervicovaginal environment, characterized by elevated concentrations of Th1, Th2, and IL17 in the cervicovaginal fluid. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - March 19, 2019 Category: Infectious Diseases Source Type: research

The first outbreak of measles virus caused by imported genotype D8 in Jiangsu province of China
Publication date: Available online 12 March 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Xiuying Deng, Ying Hu, Peishan Lu, Ming-hao Zhou, Hongxiong GuoAbstractHere we reported the outbreak of measles cases caused by the genotype D8 measles virus (MeV) for the first time in Jiangsu province in China, which was possibly imported by a foreign student from Laos. Throat swab specimens were collected, and used to isolate virus. 634-bp fragment of the N gene and 1854-bp fragment of H gene were amplified by reverse transcription-PCR and sequenced, respectively. Phylogenetic results indicated that they belong...
Source: The Brazilian Journal of Infectious Diseases - March 13, 2019 Category: Infectious Diseases Source Type: research

How are HCV-infected patients being identified in Brazil: a multicenter study
ConclusionsThis multicenter Brazilian study showed that the mean time to reach a referral center for treatment was almost two years. Primary care physicians diagnoses most hepatitis C cases in the country. Population campaigns and medical education should be encouraged to intensify screening of asymptomatic individuals, considering the efficiency of check-ups in identifying new patients. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - March 7, 2019 Category: Infectious Diseases Source Type: research