Characteristics associated with anti-HCV serological markers in prisoners in the state of Paraná, Brazil: a case-control study
ConclusionsThis study provides evidence that HCV infection is associated with drug use by this population. This information is pivotal for tailoring prevention programs and guiding specific socioeducational measures that aim to reduce or prevent HCV transmission within the prison setting. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - June 20, 2019 Category: Infectious Diseases Source Type: research

Daptomycin to bone and joint infections and prosthesis joint infections: a systematic review
ConclusionAlthough a randomized clinical trial is needed, this systematic review tends to support daptomycin usage for bone and joint infections. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - June 16, 2019 Category: Infectious Diseases Source Type: research

Genomic features of a clinical ESBL-producing and colistin-resistant hypermucoviscous K. quasipneumoniae subsp. similipneumoniae from Brazil
Publication date: Available online 28 May 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Melina Lorraine Ferreira, Bruna Fuga Araújo, Louise Teixeira Cerdeira, César Toshio, Rosineide Marques Ribas (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - June 14, 2019 Category: Infectious Diseases Source Type: research

Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry and real-time PCR in a combined protocol for diagnosis of bloodstream infections: a turnaround time approach
Publication date: Available online 5 June 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Milene Gonçalves Quiles, Bruno Cruz Boettger, Fernanda Matsiko Inoue, Jussimara Monteiro, Daniel Wagner Santos, Vinicius Ponzio, Fabianne Carlesse, Paola Cappellano, Cecilia Godoy Carvalhaes, Antonio Carlos Campos PignatariAbstractBloodstream infections (BSIs) are serious infections associated with high rates of morbidity and mortality. Every hour delay in initiation of an effective antibiotic increases mortality due to sepsis by 7%. Turnaround time (TAT) for conventional blood cultures takes 48 h, forcing phy...
Source: The Brazilian Journal of Infectious Diseases - June 7, 2019 Category: Infectious Diseases Source Type: research

Brazil is so far free from Candida auris. Are we missing something?
Publication date: Available online 29 May 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Alessandro C. Pasqualotto, Teresa C.T. Sukiennik, Jacques F. Meis (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - June 5, 2019 Category: Infectious Diseases Source Type: research

Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load
ConclusionBurning and/or pain and itching and low corrected visual acuity were the most common alterations of HTLV-1/KCS. High Proviral load was found to be associated with the presence of KCS. It is strongly recommended that HTLV-1 patients undergo periodic ophthalmologic examination to promote the early diagnosis of KCS and prevent the consequences associated with dry eye disease. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - June 1, 2019 Category: Infectious Diseases Source Type: research

Brazil is so far free from Candida auris. Are you sure?
Publication date: Available online 29 May 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Alessandro C. Pasqualotto, Teresa C.T. Sukiennik, Jacques F. Meis (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 30, 2019 Category: Infectious Diseases Source Type: research

Genomic features of clinical ESBL-producing and colistin-resistant hypermucoviscous highly virulent Klebsiella quasipneumoniae subsp. similipneumoniae from Brazil
Publication date: Available online 28 May 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Melina Lorraine Ferreira, Bruna Fuga Araújo, Louise Teixeira Cerdeira, César Toshio, Rosineide Marques Ribas (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 29, 2019 Category: Infectious Diseases Source Type: research

Hepatitis C disease burden and strategies for elimination by 2030 in Brazil. A mathematical modeling approach
ConclusionAchieving the WHO targets is technically feasible in Brazil with a scale-up of treatment and diagnosis over time, beginning in 2018. However, elimination of hepatitis C requires policy changes to substantially scale-up prevention, screening and treatment of HCV, together with public health advocacy to raise awareness among affected populations and healthcare providers. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 29, 2019 Category: Infectious Diseases Source Type: research

Fusarium solani keratitis: role of antifungal susceptibility testing and identification to the species level for proper management
Publication date: Available online 23 May 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Priscila Dallé Rosa, Karla Sheid, Claudete Locatelli, Diane Marinho, Luciano GoldaniAbstractA case report of fungal keratitis caused by a multiresistant Fusarium solani in a tertiary care hospital located in southern Brazil. A 55-year-old man with a history of ocular trauma presented with keratitis in left eye. The patient has a complicated clinical course and failed to respond to local and systemic antifungal treatment, and required eye enucleation. Despite multiple topical, intraocular and systemic antifungal tre...
Source: The Brazilian Journal of Infectious Diseases - May 24, 2019 Category: Infectious Diseases Source Type: research

Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis
Publication date: Available online 22 May 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Breno Kristoffer Beleza Uchoa, Carlos Augusto Abreu Albério, Ana Carla Godinho Pinto, Stefania Lucena de Medeiros, José Luiz Fernandes VieiraAbstractRifampicin is used in both phases of treatment for tuberculosis. In chronic use, the short half-life and the self-induction of metabolism can decrease the levels of the drug below the minimal inhibitory concentration. The aim of the study was to investigate whether plasma concentrations of rifampicin are sustained above 0.5 μg/mL in patients with tuberculosis us...
Source: The Brazilian Journal of Infectious Diseases - May 23, 2019 Category: Infectious Diseases Source Type: research

Epidemiological aspects of the first human autochthonous visceral leishmaniosis cases in Porto Alegre, Brazil
This article aims to portray the current epidemiological situation of the HVL arrival in Porto Alegre city, located in the southern region of Brazil. It is a descriptive study, a case series and a critical review. Six human cases with HVL were notified by the date of conclusion of the study, all HVL cases were diagnosed at late stage, leading to four deaths. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 22, 2019 Category: Infectious Diseases Source Type: research

T helper type cytokines in sepsis: time-shared variance and correlation with organ dysfunction and hospital mortality
ConclusionInflammatory and anti-inflammatory cytokines shared co-variance in septic patients and were related to organ dysfunctions and hospital mortality. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 19, 2019 Category: Infectious Diseases Source Type: research

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil
ConclusionsExpression of HLA-B*14 allele in children exposed to HIV-1 is predictive of vertical transmission and reinforces the important role of genetics in mother-to-child transmission. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 19, 2019 Category: Infectious Diseases Source Type: research

Occurrence of hemoplasmas in free-ranging and captive wild felines
This study contributes to the understanding of their epidemiology. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - May 18, 2019 Category: Infectious Diseases Source Type: research