How Long Does Antidepressant Withdrawal Typically Last?
PMID: 31154817 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Hengartner MP, Davies J, Read J Tags: Am J Psychiatry Source Type: research

Correction to Attia et al.
Authors: PMID: 31154818 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Developing Novel Psychopharmacological Strategies and Therapeutics.
PMID: 31154819 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Correction to Kwako et al.
Authors: PMID: 31154820 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Addressing Clinical Challenges of Antidepressant Discontinuation.
PMID: 31154821 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Fava GA, Cosci F Tags: Am J Psychiatry Source Type: research

When Discontinuing SSRI Antidepressants Is a Challenge: A Response to Letters to the Editor.
PMID: 31154822 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - June 1, 2019 Category: Psychiatry Authors: Jha MK, Trivedi MH Tags: Am J Psychiatry Source Type: research

A Word to the Wise About Intranasal Esketamine.
PMID: 31109197 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Schatzberg AF Tags: Am J Psychiatry Source Type: research

Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial.
CONCLUSIONS: CBD's potential to reduce cue-induced craving and anxiety provides a strong basis for further investigation of this phytocannabinoid as a treatment option for opioid use disorder. PMID: 31109198 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Hurd YL, Spriggs S, Alishayev J, Winkel G, Gurgov K, Kudrich C, Oprescu AM, Salsitz E Tags: Am J Psychiatry Source Type: research

Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Prospective Multicenter Randomized Double-Blind Placebo-Controlled Trial.
CONCLUSIONS: High-frequency dTMS over the medial prefrontal cortex and anterior cingulate cortex significantly improved OCD symptoms and may be considered as a potential intervention for patients who do not respond adequately to pharmacological and psychological interventions. PMID: 31109199 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Carmi L, Tendler A, Bystritsky A, Hollander E, Blumberger DM, Daskalakis J, Ward H, Lapidus K, Goodman W, Casuto L, Feifel D, Barnea-Ygael N, Roth Y, Zangen A, Zohar J Tags: Am J Psychiatry Source Type: research

Continued Benefits of Methylphenidate in ADHD After 2 Years in Clinical Practice: A Randomized Placebo-Controlled Discontinuation Study.
CONCLUSIONS: Continued treatment with methylphenidate remains effective after long-term use. Some individual patients may, however, be withdrawn from methylphenidate without deterioration. This finding supports guideline recommendations that patients be assessed periodically to determine whether there is a continued need for methylphenidate treatment. PMID: 31109200 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Matthijssen AM, Dietrich A, Bierens M, Kleine Deters R, van de Loo-Neus GHH, van den Hoofdakker BJ, Buitelaar JK, Hoekstra PJ Tags: Am J Psychiatry Source Type: research

Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study.
CONCLUSIONS: Current treatment options for treatment-resistant depression have considerable limitations in terms of efficacy and patient acceptability. Esketamine is expected to address an unmet medical need in this population through its novel mechanism of action and rapid onset of antidepressant efficacy. The study supports the efficacy and safety of esketamine nasal spray as a rapidly acting antidepressant for patients with treatment-resistant depression. PMID: 31109201 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 21, 2019 Category: Psychiatry Authors: Popova V, Daly EJ, Trivedi M, Cooper K, Lane R, Lim P, Mazzucco C, Hough D, Thase ME, Shelton RC, Molero P, Vieta E, Bajbouj M, Manji H, Drevets WC, Singh JB Tags: Am J Psychiatry Source Type: research

Prediction of Onset of Substance-Induced Psychotic Disorder and Its Progression to Schizophrenia in a Swedish National Sample.
CONCLUSIONS: Substance-induced psychotic disorder appears to result from substantial drug exposure in individuals at high familial risk for substance abuse and moderately elevated familial risk for psychosis. Familial risk for psychosis, but not substance abuse, predicts progression from substance-induced psychosis to schizophrenia. Schizophrenia following substance-induced psychosis is likely a drug-precipitated disorder in highly vulnerable individuals, not a syndrome predominantly caused by drug exposure. PMID: 31055966 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 6, 2019 Category: Psychiatry Authors: Kendler KS, Ohlsson H, Sundquist J, Sundquist K Tags: Am J Psychiatry Source Type: research

Exposure to Maternal Depressive Symptoms in Fetal Life or Childhood and Offspring Brain Development: A Population-Based Imaging Study.
CONCLUSIONS: Perinatal maternal depressive symptoms were consistently associated with child brain development assessed 10 years later. These results suggest that the postnatal period is a window of vulnerability for adversities such as maternal depressive symptoms. PMID: 31055967 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 6, 2019 Category: Psychiatry Authors: Zou R, Tiemeier H, van der Ende J, Verhulst FC, Muetzel RL, White T, Hillegers M, El Marroun H Tags: Am J Psychiatry Source Type: research

Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [11C]NOP-1A.
CONCLUSIONS: Increased NOP in cocaine use disorder suggests an adaptive response to decreased N/OFQ, or increased CRF transmission, or both. Future studies should examine the interactions between CRF and NOP to elucidate their role in negative reinforcement and relapse. NOP agonist medications to enhance N/OFQ should be explored as a therapeutic to treat cocaine use disorder. PMID: 31055968 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 6, 2019 Category: Psychiatry Authors: Narendran R, Tollefson S, Himes ML, Paris J, Lopresti B, Ciccocioppo R, Mason NS Tags: Am J Psychiatry Source Type: research

Increased Protein Insolubility in Brains From a Subset of Patients With Schizophrenia.
CONCLUSIONS: This study suggests a pathological process related to protein insolubility for a subset of patients with schizophrenia. Determining the molecular mechanism of this subtype of schizophrenia could lead to a better understanding of the pathways underlying the clinical phenotype in some patients with major mental illness as well as to improved nosology and identification of novel therapeutic targets. PMID: 31055969 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 6, 2019 Category: Psychiatry Authors: Nucifora LG, MacDonald ML, Lee BJ, Peters ME, Norris AL, Orsburn BC, Yang K, Gleason K, Margolis RL, Pevsner J, Tamminga CA, Sweet RA, Ross CA, Sawa A, Nucifora FC Tags: Am J Psychiatry Source Type: research

Rigorous Translational Models Are Key to Studying Ketamine's Antidepressant Mechanism: Response to Wang and Kaplin.
PMID: 31039633 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Heifets BD, Williams NR, Blasey C, Sudheimer K, Rodriguez CI, Schatzberg AF Tags: Am J Psychiatry Source Type: research

Heterogeneity in Major Depressive Disorder: Lessons From Developmental Research on Irritability.
PMID: 31039634 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Pine DS Tags: Am J Psychiatry Source Type: research

Consumer Warning for Genetic Tests Claiming to Predict Response to Medications: Implications for Psychiatry.
PMID: 31039635 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Rosenblat JD, Goldberg JF, McIntyre RS Tags: Am J Psychiatry Source Type: research

New Insights Into the Mechanisms of Ketamine's Antidepressant Effects: Understanding the Role of VEGF in Mediating Plasticity Processes.
PMID: 31039637 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Kenwood MM, Roseboom PH, Oler JA, Kalin NH Tags: Am J Psychiatry Source Type: research

Opportunities for Improving Access to Evidence-Based Treatments of Depression.
PMID: 31039638 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Weissman MM, Wainberg ML, Olfson M Tags: Am J Psychiatry Source Type: research

Explaining Naltrexone's Interference With Ketamine's Antidepressant Effect.
PMID: 31039639 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Wang M, Kaplin A Tags: Am J Psychiatry Source Type: research

The Concept of Mania in Traditional Andean Culture.
PMID: 31039640 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Uscamayta Ayvar MJ, Sanchez Garrafa R, Escobar JI, de Erausquin GA Tags: Am J Psychiatry Source Type: research

Improving the Lives of Patients With Major Depression by Focusing on New Treatment Approaches.
PMID: 31039641 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Vladimir Horowitz (1903-1989).
PMID: 31039642 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Hart AR, Kellner CH Tags: Am J Psychiatry Source Type: research

Scientific Issues Relevant to Improving the Diagnosis, Risk Assessment, and Treatment of Major Depression.
Abstract Over the past two decades, research in the biology and treatment of major depression has led to advances in our understanding of the biology of the disorder and to the development of novel treatments. While progress has been made, a number of key issues have emerged regarding diagnosis of the disorder and how we develop and test new therapies. Among these are the potential need to include new dimensions in the diagnostic criteria, the limited utility of clinical predictors of response, the moving away from traditional blinded trials in major depression, and whether preclinical models tell us much about no...
Source: The American Journal of Psychiatry - May 1, 2019 Category: Psychiatry Authors: Schatzberg AF Tags: Am J Psychiatry Source Type: research

Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.
CONCLUSIONS: Subtle differences in cortical surface area are widespread in children but not adolescents and adults with ADHD, confirming involvement of the frontal cortex and highlighting regions deserving further attention. Notably, the alterations behave like endophenotypes in families and are linked to ADHD symptoms in the population, extending evidence that ADHD behaves as a continuous trait in the population. Future longitudinal studies should clarify individual lifespan trajectories that lead to nonsignificant findings in adolescent and adult groups despite the presence of an ADHD diagnosis. PMID: 31014101 [PubM...
Source: The American Journal of Psychiatry - April 24, 2019 Category: Psychiatry Authors: Hoogman M, Muetzel R, Guimaraes JP, Shumskaya E, Mennes M, Zwiers MP, Jahanshad N, Sudre G, Wolfers T, Earl EA, Soliva Vila JC, Vives-Gilabert Y, Khadka S, Novotny SE, Hartman CA, Heslenfeld DJ, Schweren LJS, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avanc Tags: Am J Psychiatry Source Type: research

Correlates of Future Violence in People Being Treated for Schizophrenia.
CONCLUSIONS: This is the first longitudinal multivariable analysis of predictors of injurious violence in a large cohort of patients with schizophrenia followed over 18 months. The results revealed simultaneous strong effects of baseline injurious violence and recent violent victimization on future injurious violent behavior. Among clinical variables, poor medication adherence, but not baseline symptoms of psychosis or depression, significantly predicted injurious violence. Treatment strategies to reduce risk should emphasize medication adherence. PMID: 31014102 [PubMed - as supplied by publisher] (Source: The America...
Source: The American Journal of Psychiatry - April 24, 2019 Category: Psychiatry Authors: Buchanan A, Sint K, Swanson J, Rosenheck R Tags: Am J Psychiatry Source Type: research

General Predictors and Moderators of Depression Remission: A VAST-D Report.
CONCLUSIONS:: If replicated, these preliminary findings could help clinicians determine which patients with depression requiring next-step treatment will benefit most from a specific augmentation, combination, or switching strategy. PMID: 30947531 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 5, 2019 Category: Psychiatry Authors: Zisook S, Johnson GR, Tal I, Hicks P, Chen P, Davis L, Thase M, Zhao Y, Vertrees J, Mohamed S Tags: Am J Psychiatry Source Type: research

Polygenic Risk: Predicting Depression Outcomes in Clinical and Epidemiological Cohorts of Youths.
CONCLUSIONS:: Depression PRSs derived from adults generalize to depression outcomes in youths and may serve as an early indicator of clinically significant levels of depression. PMID: 30947532 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 5, 2019 Category: Psychiatry Authors: Halldorsdottir T, Piechaczek C, Soares de Matos AP, Czamara D, Pehl V, Wagenbuechler P, Feldmann L, Quickenstedt-Reinhardt P, Allgaier AK, Freisleder FJ, Greimel E, Kvist T, Lahti J, Räikkönen K, Rex-Haffner M, Arnarson EÖ, Craighead WE, Schulte-Körne Tags: Am J Psychiatry Source Type: research

Neurobiology of Self-Regulation: Longitudinal Influence of FKBP5 and Intimate Partner Violence on Emotional and Cognitive Development in Childhood.
CONCLUSIONS:: The interaction of FKBP5 and IPV affects the physiological response to stress early in life, with consequences for emotional and cognitive self-regulation. Targeting self-regulation may present an early intervention strategy for children facing genetic and environmental risk. PMID: 30947533 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 5, 2019 Category: Psychiatry Authors: Halldorsdottir T, Kurtoic D, Müller-Myhsok B, Binder EB, Blair C Tags: Am J Psychiatry Source Type: research

Using Insomnia as a Model for Optimizing Internet-Delivered Psychotherapy.
PMID: 30929498 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Authors: Rumble ME, Plante DT Tags: Am J Psychiatry Source Type: research

Correction.
CORRECTION. Am J Psychiatry. 2019 Apr 01;176(4):324 Authors: PMID: 30929499 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Psychiatric Comorbidity in Moyamoya Disease and Preliminary Guidelines For Treatment.
PMID: 30929500 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Authors: Richards M, Grzenda A, Nelson E, Gitlin M Tags: Am J Psychiatry Source Type: research

Cognitive Remediation and Social Skills Training for Schizotypal Personality Disorder: Greater Gains With Guanfacine?
PMID: 30929501 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Authors: McGurk SR Tags: Am J Psychiatry Source Type: research

Has the Time Come for Cognitive Remediation in Schizophrenia …Again?
Has the Time Come for Cognitive Remediation in Schizophrenia…Again? Am J Psychiatry. 2019 Apr 01;176(4):262-264 Authors: Vinogradov S PMID: 30929502 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Authors: Vinogradov S Tags: Am J Psychiatry Source Type: research

Correction.
CORRECTION. Am J Psychiatry. 2019 Apr 01;176(4):324 Authors: PMID: 30929503 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Optimizing the Efficacy of Psychotherapy, Cognitive Training, and Internet Interventions.
PMID: 30929504 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

Treatment of Depression Versus Treatment of PTSD.
PMID: 30929505 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Authors: Hollon SD Tags: Am J Psychiatry Source Type: research

Disclosure of Editors' Financial Relationships.
Authors: PMID: 30929506 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2019 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Irritability and Its Clinical Utility in Major Depressive Disorder: Prediction of Individual-Level Acute-Phase Outcomes Using Early Changes in Irritability and Depression Severity.
Abstract OBJECTIVE:: The authors evaluated improvement in irritability with antidepressant treatment and its prognostic utility in treatment-seeking adult outpatients with major depressive disorder. METHODS:: Mixed-model analyses were used to assess changes in irritability (as measured with the five-item irritability domain of the Concise Associated Symptom Tracking [CAST-IRR] scale) from baseline to week 4 after controlling for depression severity (as measured with the 16-item Quick Inventory of Depressive Symptomatology-Clinician Rated [QIDS-C]) in the Combining Medications to Enhance Depression Outcomes (C...
Source: The American Journal of Psychiatry - March 29, 2019 Category: Psychiatry Authors: Jha MK, Minhajuddin A, South C, Rush AJ, Trivedi MH Tags: Am J Psychiatry Source Type: research

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial.
CONCLUSIONS:: Repeated ketamine infusions have cumulative and sustained antidepressant effects. Reductions in depressive symptoms were maintained among responders through once-weekly infusions. These findings provide novel data on efficacious administration strategies for ketamine in patients with treatment-resistant depression. Future studies should further expand on optimizing administration to better translate the use of ketamine into clinical settings. PMID: 30922101 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 29, 2019 Category: Psychiatry Authors: Phillips JL, Norris S, Talbot J, Birmingham M, Hatchard T, Ortiz A, Owoeye O, Batten LA, Blier P Tags: Am J Psychiatry Source Type: research

Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism.
CONCLUSIONS:: Common genetic variants with large effects on clozapine metabolism exist and can be found via genome-wide approaches. Their identification opens the way for clinical studies assessing the use of pharmacogenomics in the clinical management of patients with treatment-resistant schizophrenia. PMID: 30922102 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 29, 2019 Category: Psychiatry Authors: Pardiñas AF, Nalmpanti M, Pocklington AJ, Legge SE, Medway C, King A, Jansen J, Helthuis M, Zammit S, MacCabe J, Owen MJ, O'Donovan MC, Walters JTR Tags: Am J Psychiatry Source Type: research

Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study.
CONCLUSIONS:: Cariprazine, at both 1.5 mg/day and 3.0 mg/day, was effective, generally well tolerated, and relatively safe in reducing depressive symptoms in adults with bipolar I depression. PMID: 30845817 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 8, 2019 Category: Psychiatry Authors: Earley W, Victoria Burgess M, Rekeda L, Dickinson R, Szatmári B, Németh G, McIntyre RS, Sachs GS, Yatham LN Tags: Am J Psychiatry Source Type: research

Mitigation of Olanzapine-Induced Weight Gain With Samidorphan, an Opioid Antagonist: A Randomized Double-Blind Phase 2 Study in Patients With Schizophrenia.
CONCLUSIONS:: The antipsychotic efficacy of olanzapine plus samidorphan was equivalent to that of olanzapine plus placebo, and olanzapine plus samidorphan was associated with clinically meaningful and statistically significant mitigation of weight gain compared with olanzapine plus placebo. Olanzapine plus samidorphan was generally well tolerated, with a safety profile similar to olanzapine plus placebo. PMID: 30845818 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 8, 2019 Category: Psychiatry Authors: Martin WF, Correll CU, Weiden PJ, Jiang Y, Pathak S, DiPetrillo L, Silverman BL, Ehrich EW Tags: Am J Psychiatry Source Type: research

A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning.
CONCLUSIONS:: Both perceptual training and executive training improved neurophysiological mechanisms specific to their domains of intervention, although only executive training resulted in improvement in neurocognition and functioning. Improvements in favor of executive training did not appear immediately after treatment but emerged 12 weeks after the end of active treatment. Thus, short-term intervention targeting higher-order cognitive functions may prime further cognitive and functional improvement. PMID: 30845819 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 8, 2019 Category: Psychiatry Authors: Best MW, Milanovic M, Iftene F, Bowie CR Tags: Am J Psychiatry Source Type: research

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples.
CONCLUSIONS:: The study results do not support previous depression candidate gene findings, in which large genetic effects are frequently reported in samples orders of magnitude smaller than those examined here. Instead, the results suggest that early hypotheses about depression candidate genes were incorrect and that the large number of associations reported in the depression candidate gene literature are likely to be false positives. PMID: 30845820 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 8, 2019 Category: Psychiatry Authors: Border R, Johnson EC, Evans LM, Smolen A, Berley N, Sullivan PF, Keller MC Tags: Am J Psychiatry Source Type: research

New Insights Highlighting Neurodevelopmental Issues That Predispose to Childhood and Adolescent Psychopathology.
PMID: 30818983 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2019 Category: Psychiatry Authors: Kalin NH Tags: Am J Psychiatry Source Type: research

A Contagion Model for Within-Family Transmission of Drug Abuse.
CONCLUSIONS:: These results suggest that drug abuse can be transmitted within families by an environmentally mediated temporally defined model of contagion. The most important methodological limitation is that drug abuse registration is an inaccurate measure of the onset of drug abuse. Indeed, as predicted, drug abuse risk increased among potential secondary case subjects in the year before drug abuse registration of the index case subject. PMID: 30818984 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2019 Category: Psychiatry Authors: Kendler KS, Ohlsson H, Sundquist J, Sundquist K Tags: Am J Psychiatry Source Type: research

Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.
Abstract The transition from childhood to adulthood represents the developmental time frame in which the majority of psychiatric disorders emerge. Recent efforts to identify risk factors mediating the susceptibility to psychopathology have led to a heightened focus on both typical and atypical trajectories of neural circuit maturation. Mounting evidence has highlighted the immense neural plasticity apparent in the developing brain. Although in many cases adaptive, the capacity for neural circuit alteration also induces a state of vulnerability to environmental perturbations, such that early-life experiences have l...
Source: The American Journal of Psychiatry - March 1, 2019 Category: Psychiatry Authors: Meyer HC, Lee FS Tags: Am J Psychiatry Source Type: research

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism: Is It a Ketamine-Specific Effect?
PMID: 30818986 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2019 Category: Psychiatry Authors: Amiaz R Tags: Am J Psychiatry Source Type: research