Cannabis, Psychosis, and Mortality: A Cohort Study of 50,373 Swedish Men.
CONCLUSIONS: The results suggest that individuals with an early history of heavy use of cannabis are at a higher risk of death than those with a history of no use of cannabis. Although the authors adjusted for several confounders at baseline, the results should be interpreted with caution because of a lack of information on confounders in the period after conscription. PMID: 27102239 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 22, 2016 Category: Psychiatry Authors: Manrique-Garcia E, Ponce de Leon A, Dalman C, Andréasson S, Allebeck P Tags: Am J Psychiatry Source Type: research

Hyperresponsiveness of the Neural Fear Network During Fear Conditioning and Extinction Learning in Male Cocaine Users.
CONCLUSIONS: Increased sensitivity to aversive conditioned cues in cocaine users might be a risk factor for stress-relief craving in cocaine use disorder. These results support the postulated role of altered aversive conditioning in cocaine use disorder and may be an important step in understanding the role of aversive learning in the pathology of cocaine use disorder. PMID: 27079132 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 15, 2016 Category: Psychiatry Authors: Kaag AM, Levar N, Woutersen K, Homberg J, van den Brink W, Reneman L, van Wingen G Tags: Am J Psychiatry Source Type: research

Mixed Depression in Bipolar Disorder: Prevalence Rate and Clinical Correlates During Naturalistic Follow-Up in the Stanley Bipolar Network.
Abstract OBJECTIVE: DSM-5 introduced the "with mixed features" specifier for major depressive episodes. The authors assessed the prevalence and phenomenology of mixed depression among bipolar disorder patients and qualitatively compared a range of diagnostic thresholds for mixed depression. METHOD: In a naturalistic study, 907 adult outpatients with bipolar disorder participating in the Stanley Foundation Bipolar Network were followed longitudinally across 14,310 visits from 1995 to 2002. The Inventory of Depressive Symptomatology-Clinician-Rated Version (IDS-C) and the Young Mania Rating Scale (YMR...
Source: The American Journal of Psychiatry - April 15, 2016 Category: Psychiatry Authors: Miller S, Suppes T, Mintz J, Hellemann G, Frye MA, McElroy SL, Nolen WA, Kupka R, Leverich GS, Grunze H, Altshuler LL, Keck PE, Post RM Tags: Am J Psychiatry Source Type: research

Pharmacotherapy Relapse Prevention in Body Dysmorphic Disorder: A Double-Blind, Placebo-Controlled Trial.
CONCLUSIONS: Continuation-phase escitalopram delayed time to relapse, and fewer escitalopram-treated subjects relapsed than did placebo-treated subjects. Body dysmorphic disorder severity significantly improved during 6 additional months of escitalopram treatment following acute response; more than one-third of escitalopram-treated subjects experienced further improvement. PMID: 27056606 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 8, 2016 Category: Psychiatry Authors: Phillips KA, Keshaviah A, Dougherty DD, Stout RL, Menard W, Wilhelm S Tags: Am J Psychiatry Source Type: research

Heritable and Nonheritable Pathways to Early Callous-Unemotional Behaviors.
CONCLUSIONS: The findings elucidate heritable and nonheritable pathways to early callous-unemotional behaviors. The results provide a specific heritable pathway to callous-unemotional behaviors and compelling evidence that parenting is an important nonheritable factor in the development of callous-unemotional behaviors. The finding that positive reinforcement buffered heritable risk for callous-unemotional behaviors has important translational implications for the prevention of trajectories to serious antisocial behavior. PMID: 27056607 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 8, 2016 Category: Psychiatry Authors: Hyde LW, Waller R, Trentacosta CJ, Shaw DS, Neiderhiser JM, Ganiban JM, Reiss D, Leve LD Tags: Am J Psychiatry Source Type: research

A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression.
CONCLUSIONS: Twice-weekly and thrice-weekly administration of ketamine at 0.5 mg/kg similarly maintained antidepressant efficacy over 15 days. PMID: 27056608 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 8, 2016 Category: Psychiatry Authors: Singh JB, Fedgchin M, Daly EJ, De Boer P, Cooper K, Lim P, Pinter C, Murrough JW, Sanacora G, Shelton RC, Kurian B, Winokur A, Fava M, Manji H, Drevets WC, Van Nueten L Tags: Am J Psychiatry Source Type: research

Interpersonal Psychotherapy for Mental Health Problems: A Comprehensive Meta-Analysis.
CONCLUSIONS: IPT is effective in the acute treatment of depression and may be effective in the prevention of new depressive disorders and in preventing relapse. IPT may also be effective in the treatment of eating disorders and anxiety disorders and has shown promising effects in some other mental health disorders. PMID: 27032627 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Cuijpers P, Donker T, Weissman MM, Ravitz P, Cristea IA Tags: Am J Psychiatry Source Type: research

Effects of Citalopram on Neuropsychiatric Symptoms in Alzheimer's Dementia: Evidence From the CitAD Study.
CONCLUSIONS: While dosage constraints must be considered because of citalopram's adverse effect profile, this agent's overall therapeutic effects in patients with Alzheimer's disease and agitation, in addition to efficacy for agitation/aggression, included reductions in the frequency of irritability, anxiety, and delusions; among patients who had these symptoms at week 9, they included a reduction in the severity of hallucinations but an increase in the severity of sleep/nighttime behavior disorders. PMID: 27032628 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Leonpacher AK, Peters ME, Drye LT, Makino KM, Newell JA, Devanand DP, Frangakis C, Munro CA, Mintzer JE, Pollock BG, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG, Porsteinsson AP, CitAD Research Group Tags: Am J Psychiatry Source Type: research

Biotypes in Psychosis: Has the RDoC Era Arrived?
PMID: 27035527 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Javitt DC Tags: Am J Psychiatry Source Type: research

A Medication for Depression With Mixed Features.
PMID: 27035528 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Coryell W Tags: Am J Psychiatry Source Type: research

Appetite Changes in Depression.
PMID: 27035529 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Baxter LC Tags: Am J Psychiatry Source Type: research

Hope, Faith, Love, and Treating Serious Mental Health Conditions.
PMID: 27035530 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Bauer MS Tags: Am J Psychiatry Source Type: research

A Case of Attenuated Psychosis Syndrome: A Broad Differential Diagnosis Requires Broad-Spectrum Treatment.
PMID: 27035531 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Cadenhead KS, Mirzakhanian H Tags: Am J Psychiatry Source Type: research

Trauma and Depression in Ethiopian Women Returning From Middle Eastern Countries.
PMID: 27035532 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Getnet B, Fekadu A, Getnet A, Wondie Y Tags: Am J Psychiatry Source Type: research

Personalized Human Cortical Spheroids.
PMID: 27035533 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Paşca SP Tags: Am J Psychiatry Source Type: research

Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs.
PMID: 27035534 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Sheng Y, Filichia E, Shick E, Preston KL, Phillips KA, Cooperman L, Lin Z, Tesar P, Hoffer BJ, Luo Y Tags: Am J Psychiatry Source Type: research

Critical Appraisal of Existing Ketamine Trials: Existing Limitations and Limited Applicability for Treatment.
PMID: 27035535 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Zhang MW, Ho R Tags: Am J Psychiatry Source Type: research

Response to Zhang and Ho: Addressing Ketamine's Use in Depression.
PMID: 27035536 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Newport DJ, Nemeroff CB Tags: Am J Psychiatry Source Type: research

Disclosure of Editors' Financial Relationships.
Authors: PMID: 27035537 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Marijuana: The Unbiased Truth About the World's Most Popular Weedby Kevin P. Hill, M.D. Center City, Minn., Hazelden Publishing Group, 2015, 240 pp., $14.95 (paperback).
PMID: 27035538 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Fong T Tags: Am J Psychiatry Source Type: research

Sleep Paralysis: Historical, Psychological, and Medical Perspectivesby Brian Sharpless, Ph.D., and Karl Doghramji, M.D. New York, Oxford University Press, 2015, 304 pp., $55.00 (paperback).
PMID: 27035539 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Authors: Peterson MJ Tags: Am J Psychiatry Source Type: research

Books Received.
Authors: PMID: 27035540 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2016 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior.
CONCLUSIONS: This is the first study to link the effects of pregnant women's distress on the fetus and epigenetic changes in placental genes. Since increased DNA methylation in HSD11B2 and FKBP5 are seen in a minority of bisulfite sequencing clones, these epigenetic changes, and functional consequences, may affect subpopulations of placental cells. PMID: 27013342 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 25, 2016 Category: Psychiatry Authors: Monk C, Feng T, Lee S, Krupska I, Champagne FA, Tycko B Tags: Am J Psychiatry Source Type: research

The Bidirectional Associations Between Psychotic Experiences and DSM-IV Mental Disorders.
CONCLUSIONS: While temporally primary psychotic experiences are associated with an elevated risk of several subsequent mental disorders, these data show that most mental disorders are associated with an elevated risk of subsequent psychotic experiences. Further investigation of the underlying factors accounting for these time-order relationships may shed light on the etiology of psychotic experiences. PMID: 26988628 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 17, 2016 Category: Psychiatry Authors: McGrath JJ, Saha S, Al-Hamzawi A, Andrade L, Benjet C, Bromet EJ, Browne MO, Caldas de Almeida JM, Chiu WT, Demyttenaere K, Fayyad J, Florescu S, de Girolamo G, Gureje O, Haro JM, Ten Have M, Hu C, Kovess-Masfety V, Lim CC, Navarro-Mateu F, Sampson N, Pos Tags: Am J Psychiatry Source Type: research

Messages for Clinicians: Moderators and Mediators of Treatment Outcome in Randomized Clinical Trials.
Abstract Many problems in randomized clinical trial design, execution, analysis, presentation and interpretation stem in part from an inadequate understanding of the roles of moderators and mediators of treatment outcome. As a result, 1) the results of clinical research are slow to have an impact on clinical decision making and thus to benefit patients; 2) it is difficult for clinicians or patients to apply randomized clinical trial results comparing two treatments (treatment versus control); 3) when such trials are conducted at various sites, the results often do not replicate; 4) when the results influence clini...
Source: The American Journal of Psychiatry - March 17, 2016 Category: Psychiatry Authors: Kraemer HC Tags: Am J Psychiatry Source Type: research

All-Cause Mortality in Women With Severe Postpartum Psychiatric Disorders.
CONCLUSIONS: Women with severe postpartum psychiatric disorders had increased MRRs compared with mothers without psychiatric diagnoses, and the first year after diagnosis represents a time of particularly high relative risk for suicide in this vulnerable group. PMID: 26940804 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 4, 2016 Category: Psychiatry Authors: Johannsen BM, Larsen JT, Laursen TM, Bergink V, Meltzer-Brody S, Munk-Olsen T Tags: Am J Psychiatry Source Type: research

A Randomized Trial to Assess the Efficacy and Safety of ABT-126, a Selective α7 Nicotinic Acetylcholine Receptor Agonist, in the Treatment of Cognitive Impairment in Schizophrenia.
A Randomized Trial to Assess the Efficacy and Safety of ABT-126, a Selective α7 Nicotinic Acetylcholine Receptor Agonist, in the Treatment of Cognitive Impairment in Schizophrenia. Am J Psychiatry. 2016 Mar 4;:appiajp201515010093 Authors: Haig GM, Bain EE, Robieson WZ, Baker JD, Othman AA Abstract OBJECTIVE: The authors sought to evaluate the efficacy and safety of ABT-126, a selective α7 nicotinic receptor partial agonist, in stable patients with schizophrenia. METHOD: A 12-week, double-blind, placebo-controlled, parallel-group phase 2 study was conducted in 22 centers in the United ...
Source: The American Journal of Psychiatry - March 4, 2016 Category: Psychiatry Authors: Haig GM, Bain EE, Robieson WZ, Baker JD, Othman AA Tags: Am J Psychiatry Source Type: research

Depressive and Anxiety Disorders Showing Robust, but Non-Dynamic, 6-Year Longitudinal Association With Short Leukocyte Telomere Length.
CONCLUSIONS: This study confirmed robust associations of depressive and anxiety disorders with shorter telomeres, but interestingly, it did not demonstrate that depressive and anxiety disorders and LTL change together over time, suggesting the absence of a direct within-person relationship. Short LTL is suggested to be either a long-term consequence or an underlying vulnerability factor for depressive or anxiety disorders. PMID: 26940806 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 4, 2016 Category: Psychiatry Authors: Verhoeven JE, van Oppen P, Révész D, Wolkowitz OM, Penninx BW Tags: Am J Psychiatry Source Type: research

Prevalence and Correlates of DSM-5 Cannabis Use Disorder, 2012-2013: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III.
CONCLUSIONS: DSM-5 cannabis use disorder is prevalent, associated with comorbidity and disability, and largely untreated. Findings suggest the need to improve prevention and educate the public, professionals, and policy makers about possible harms associated with cannabis use disorders and available interventions. PMID: 26940807 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 4, 2016 Category: Psychiatry Authors: Hasin DS, Kerridge BT, Saha TD, Huang B, Pickering R, Smith SM, Jung J, Zhang H, Grant BF Tags: Am J Psychiatry Source Type: research

Isn't Your Staff Trained To Manage My Mother?
PMID: 26926122 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Steinberg M Tags: Am J Psychiatry Source Type: research

Evidence-Based Pregnancy Registries: Good for Babies and Their Mothers.
PMID: 26926123 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Burt VK Tags: Am J Psychiatry Source Type: research

A New Option for Treating Bipolar I Depression.
PMID: 26926124 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Swartz HA, Tasosa JT Tags: Am J Psychiatry Source Type: research

Dissecting the Brain Mechanisms of Violence.
PMID: 26926125 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Freedman R, Michels R Tags: Am J Psychiatry Source Type: research

Editor's Note.
Authors: PMID: 26926126 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Potential Risks of Poorly Monitored Ketamine Use in Depression Treatment.
PMID: 26926127 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Schak KM, Vande Voort JL, Johnson EK, Kung S, Leung JG, Rasmussen KG, Palmer BA, Frye MA Tags: Am J Psychiatry Source Type: research

"Jinn Possession" and Delirious Mania in a Pakistani Woman.
"Jinn Possession" and Delirious Mania in a Pakistani Woman. Am J Psychiatry. 2016 Mar 1;173(3):219-20 Authors: Khan QU, Sanober A PMID: 26926128 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Khan QU, Sanober A Tags: Am J Psychiatry Source Type: research

Gene-Environment Interaction in Youth Depression: Differential Susceptibility?
PMID: 26926129 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Plakun EM Tags: Am J Psychiatry Source Type: research

Response to Plakun: Addressing Differential Susceptibility With Regard to Gene-Environment Interaction in Youth Depression.
PMID: 26926130 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Rocha TB, Rohde LA, Kieling C Tags: Am J Psychiatry Source Type: research

Reflections on "Emil Kraepelin: Icon and Reality".
Reflections on "Emil Kraepelin: Icon and Reality". Am J Psychiatry. 2016 Mar 1;173(3):300-1 Authors: Strous RD, Opler AA, Opler LA PMID: 26926131 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Strous RD, Opler AA, Opler LA Tags: Am J Psychiatry Source Type: research

Response to Strous et al.: A Focus on Kraepelin's Clinical Research Methodology.
PMID: 26926132 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Kendler KS, Engstrom EJ Tags: Am J Psychiatry Source Type: research

Going Beyond Finding the "Lesion": A Path for Maturation of Neuroimaging.
Going Beyond Finding the "Lesion": A Path for Maturation of Neuroimaging. Am J Psychiatry. 2016 Mar 1;173(3):302-3 Authors: Eickhoff SB, Etkin A PMID: 26926133 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Eickhoff SB, Etkin A Tags: Am J Psychiatry Source Type: research

Psychiatric Polarities: Methodology and Practiceby Phillip R. Slavney, M.D., and Paul R. McHugh, M.D. Baltimore, Johns Hopkins University Press, 2015, 144 pp., $35.00 (paperback).
PMID: 26926134 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Authors: Lyketsos CG Tags: Am J Psychiatry Source Type: research

Books Received.
Authors: PMID: 26926135 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - March 1, 2016 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Association of Resting Metabolism in the Fear Neural Network With Extinction Recall Activations and Clinical Measures in Trauma-Exposed Individuals.
CONCLUSIONS: Resting metabolism in the fear circuitry correlated with functioning, PTSD symptoms, and extinction recall activations, further supporting the relevance of this network to the pathophysiology of PTSD. The study findings also highlight the fact that chronic dysfunction in the amygdala and hippocampus is demonstrable in PTSD and other trauma-exposed individuals, even without exposure to an evocative stimulus. PMID: 26917165 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - February 26, 2016 Category: Psychiatry Authors: Marin MF, Song H, VanElzakker MB, Staples-Bradley LK, Linnman C, Pace-Schott EF, Lasko NB, Shin LM, Milad MR Tags: Am J Psychiatry Source Type: research

Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study.
CONCLUSIONS: The progressive brain loss in schizophrenia appears to reflect two different processes: one relatively homogeneous, reflecting accelerated aging of the brain and related to various measures of outcome, and a more variable one, possibly reflecting individual variation and medication use. Differentiating between these two processes may not only elucidate the various factors influencing brain loss in schizophrenia, but also assist in individualizing treatment. PMID: 26917166 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - February 26, 2016 Category: Psychiatry Authors: Schnack HG, van Haren NE, Nieuwenhuis M, Hulshoff Pol HE, Cahn W, Kahn RS Tags: Am J Psychiatry Source Type: research

Bitemporal Versus High-Dose Unilateral Twice-Weekly Electroconvulsive Therapy for Depression (EFFECT-Dep): A Pragmatic, Randomized, Non-Inferiority Trial.
CONCLUSIONS: Twice-weekly high-dose unilateral ECT is not inferior to bitemporal ECT for depression and may be preferable because of its better cognitive side-effect profile. PMID: 26892939 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - February 19, 2016 Category: Psychiatry Authors: Semkovska M, Landau S, Dunne R, Kolshus E, Kavanagh A, Jelovac A, Noone M, Carton M, Lambe S, McHugh C, McLoughlin DM Tags: Am J Psychiatry Source Type: research

Toward the Definition of a Bipolar Prodrome: Dimensional Predictors of Bipolar Spectrum Disorders in At-Risk Youths.
Abstract OBJECTIVE: The authors sought to assess dimensional symptomatic predictors of new-onset bipolar spectrum disorders in youths at familial risk of bipolar disorder ("at-risk" youths). METHOD: Offspring 6-18 years old of parents with bipolar I or II disorder (N=359) and community comparison offspring (N=220) were recruited. At baseline, 8.4% of the offspring of bipolar parents had a bipolar spectrum disorder. Over 8 years, 14.7% of offspring for whom follow-up data were available (44/299) developed a new-onset bipolar spectrum disorder (15 with bipolar I or II disorder). Measures collected at ...
Source: The American Journal of Psychiatry - February 19, 2016 Category: Psychiatry Authors: Hafeman DM, Merranko J, Axelson D, Goldstein BI, Goldstein T, Monk K, Hickey MB, Sakolsky D, Diler R, Iyengar S, Brent D, Kupfer D, Birmaher B Tags: Am J Psychiatry Source Type: research

Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107.
CONCLUSIONS: Patients with schizophrenia have normal availability of PDE10A in brain regions thought to be involved in the pathophysiology of this disorder. The findings do not support the proposal of an altered PDE10A availability in schizophrenia. The implication of this finding for future drug development is discussed. PMID: 26892941 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - February 19, 2016 Category: Psychiatry Authors: Marques TR, Natesan S, Niccolini F, Politis M, Gunn RN, Searle GE, Howes O, Rabiner EA, Kapur S Tags: Am J Psychiatry Source Type: research

Neural Correlates of Irritability in Disruptive Mood Dysregulation and Bipolar Disorders.
CONCLUSIONS: These results suggest diagnostic specificity in the neural correlates of irritability, a symptom of both DMDD and bipolar disorder. Such evidence of distinct neural correlates suggests the need to evaluate different approaches to treating irritability in the two disorders. PMID: 26892942 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - February 19, 2016 Category: Psychiatry Authors: Wiggins JL, Brotman MA, Adleman NE, Kim P, Oakes AH, Reynolds RC, Chen G, Pine DS, Leibenluft E Tags: Am J Psychiatry Source Type: research

Divergent Outcomes in Cognitive-Behavioral Therapy and Pharmacotherapy for Adult Depression.
CONCLUSIONS: Deterioration and extreme nonresponse and, similarly, superior improvement and superior response, both occur infrequently in randomized clinical trials comparing CBT and pharmacotherapy for depression. Pretreatment symptom levels help forecast negative and unusually positive outcomes but do not guide selection of CBT versus pharmacotherapy. Pharmacotherapy may produce clinician-rated superior improvement and attrition more frequently than does CBT. PMID: 26869246 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - February 12, 2016 Category: Psychiatry Authors: Vittengl JR, Jarrett RB, Weitz E, Hollon SD, Twisk J, Cristea I, David D, DeRubeis RJ, Dimidjian S, Dunlop BW, Faramarzi M, Hegerl U, Kennedy SH, Kheirkhah F, Mergl R, Miranda J, Mohr DC, Rush AJ, Segal ZV, Siddique J, Simons AD, Cuijpers P Tags: Am J Psychiatry Source Type: research