Imaging Microglial Activation in Untreated First-Episode Psychosis: A PET Study With [(18)F]FEPPA.
CONCLUSIONS: The lack of significant differences in [(18)F]FEPPA VT between groups suggests that microglial activation is not present in first-episode psychosis. PMID: 27609240 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 9, 2016 Category: Psychiatry Authors: Hafizi S, Tseng HH, Rao N, Selvanathan T, Kenk M, Bazinet RP, Suridjan I, Wilson AA, Meyer JH, Remington G, Houle S, Rusjan PM, Mizrahi R Tags: Am J Psychiatry Source Type: research

Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis.
CONCLUSIONS: The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful. PMID: 27609241 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 9, 2016 Category: Psychiatry Authors: Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Tags: Am J Psychiatry Source Type: research

Patient Expectancy as a Mediator of Placebo Effects in Antidepressant Clinical Trials.
CONCLUSIONS: Patient expectancy is a significant mediator of placebo effects in antidepressant trials. Expectancy-related interventions should be investigated as a means of controlling placebo responses in antidepressant clinical trials and improving patient outcome in clinical treatment. PMID: 27609242 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 9, 2016 Category: Psychiatry Authors: Rutherford BR, Wall MM, Brown PJ, Choo TH, Wager TD, Peterson BS, Chung S, Kirsch I, Roose SP Tags: Am J Psychiatry Source Type: research

Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA.
CONCLUSIONS: The review findings indicate that hypnotic medications are associated with suicidal ideation. Future studies should be designed to assess whether increases in suicidality result from CNS impairments from a given hypnotic medication or whether such medication decreases suicidality because of improvements in insomnia. PMID: 27609243 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 9, 2016 Category: Psychiatry Authors: McCall WV, Benca RM, Rosenquist PB, Riley MA, McCloud L, Newman JC, Case D, Rumble M, Krystal AD Tags: Am J Psychiatry Source Type: research

Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework.
Abstract Tremendous progress has been made in basic neuroscience in recent decades. One area that has been especially successful is research on how the brain detects and responds to threats. Such studies have demonstrated comparable patterns of brain-behavior relationships underlying threat processing across a range of mammalian species, including humans. This would seem to be an ideal body of information for advancing our understanding of disorders in which altered threat processing is a key factor, namely, fear and anxiety disorders. But research on threat processing has not led to significant improvements in cl...
Source: The American Journal of Psychiatry - September 9, 2016 Category: Psychiatry Authors: LeDoux JE, Pine DS Tags: Am J Psychiatry Source Type: research

Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood.
CONCLUSIONS: Postpartum psychosis offers an intriguing model to explore etiologic contributions to the neurobiology of affective psychosis. PMID: 27609245 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 9, 2016 Category: Psychiatry Authors: Bergink V, Rasgon N, Wisner KL Tags: Am J Psychiatry Source Type: research

Relapse Prevention and the Need for Ongoing Pharmacological Treatment in Body Dysmorphic Disorder.
PMID: 27581691 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Hollander E, Hong K Tags: Am J Psychiatry Source Type: research

Risk Management and Unintended Consequences: The Perils of the Precautionary Principle.
PMID: 27581692 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Rosenheck R Tags: Am J Psychiatry Source Type: research

Can Positive Parental Reinforcement Counter Genetic Risk for Callous-Unemotional Behavior?
PMID: 27581693 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Viding E, Pingault JB Tags: Am J Psychiatry Source Type: research

Seeking the Best Bereavement-Related Diagnostic Criteria.
PMID: 27581694 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Friedman MJ Tags: Am J Psychiatry Source Type: research

To Kick a Patient.
PMID: 27581695 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Steele TE Tags: Am J Psychiatry Source Type: research

Trichotillomania.
PMID: 27581696 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Grant JE, Chamberlain SR Tags: Am J Psychiatry Source Type: research

Psychiatrists as Cartoon Characters: How The New Yorker Has Traced Psychiatry Over the Decades.
PMID: 27581697 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Parker G Tags: Am J Psychiatry Source Type: research

Antipsychotic Treatment of Young Chinese Individuals From 2004 to 2015: A Population-Based Study in Hong Kong.
PMID: 27581698 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Lee EH, Hui CL, Lin J, Chang WC, Chan SK, Chen EY Tags: Am J Psychiatry Source Type: research

Can Botulinum Toxin Help Patients With Borderline Personality Disorder?
PMID: 27581699 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Kruger TH, Magid M, Wollmer MA Tags: Am J Psychiatry Source Type: research

Ibuprofen May Increase Pharmacological Action of Valproate by Displacing It From Plasma Proteins: A Case Report.
eon J PMID: 27581700 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Lana F, Martí-Bonany J, de Leon J Tags: Am J Psychiatry Source Type: research

Culture and PTSD: Trauma in Global and Historical Perspectiveedited by Devon E. Hinton and Byron J. Good. Philadelphia, University of Pennsylvania Press, 2015, 440 pp., $75.00 (hardcover).
PMID: 27581701 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - September 1, 2016 Category: Psychiatry Authors: Legha RK Tags: Am J Psychiatry Source Type: research

Neural Predictors of Initiating Alcohol Use During Adolescence.
CONCLUSIONS: The results provide evidence that multimodal neuroimaging data, as well as neuropsychological testing, can be used to generate predictions of future behaviors such as adolescent alcohol use with significantly better accuracy than demographic information alone. PMID: 27539487 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 19, 2016 Category: Psychiatry Authors: Squeglia LM, Ball TM, Jacobus J, Brumback T, McKenna BS, Nguyen-Louie TT, Sorg SF, Paulus MP, Tapert SF Tags: Am J Psychiatry Source Type: research

No Association of Lower Hippocampal Volume With Alzheimer's Disease Pathology in Late-Life Depression.
CONCLUSIONS: Lower hippocampal volume was not related to amyloid pathology in this sample of patients with late-life depression. These data counter the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer's disease. PMID: 27539488 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 19, 2016 Category: Psychiatry Authors: De Winter FL, Emsell L, Bouckaert F, Claes L, Jain S, Farrar G, Billiet T, Evers S, Van den Stock J, Sienaert P, Obbels J, Sunaert S, Adamczuk K, Vandenberghe R, Van Laere K, Vandenbulcke M Tags: Am J Psychiatry Source Type: research

Suicide Attempt as a Risk Factor for Completed Suicide: Even More Lethal Than We Knew.
CONCLUSIONS: At 5.4%, completed suicide prevalence in this community cohort of suicide attempters was almost 59% higher than previously reported. An innovative aspect of this study explains the discrepancy: by including index attempt deaths-approximately 60% of total suicides-suicide prevalence more than doubled. We contend that counting both index and subsequent attempt deaths more accurately reflects prevalence. Our findings support suicide attempt as an even more lethal risk factor for completed suicide than previously thought. Research should focus on identifying risk factors for populations vulnerable to making first ...
Source: The American Journal of Psychiatry - August 13, 2016 Category: Psychiatry Authors: Bostwick JM, Pabbati C, Geske JR, McKean AJ Tags: Am J Psychiatry Source Type: research

Meta-Analysis of fMRI Studies of Disruptive Behavior Disorders.
CONCLUSIONS: The findings show that the most consistent dysfunction in youths with disruptive behavior disorder is in the rostro-dorsomedial, fronto-cingulate, and ventral-striatal regions that mediate reward-based decision making, which is typically compromised in the disorder. Youths with psychopathic traits, on the other hand, have dysfunctions associated with the ventromedial prefrontal cortex and limbic system, together with dorsal and fronto-striatal hyperfunctioning, which may reflect poor affect reactivity and empathy in the presence of hyperactive executive control. These findings provide potential targets for neu...
Source: The American Journal of Psychiatry - August 13, 2016 Category: Psychiatry Authors: Alegria AA, Radua J, Rubia K Tags: Am J Psychiatry Source Type: research

Increased Activity or Energy as a Primary Criterion for the Diagnosis of Bipolar Mania in DSM-5: Findings From the STEP-BD Study.
CONCLUSIONS: The findings confirm that including increased activity or energy as part of DSM-5 criterion A decreases the prevalence of manic and hypomanic episodes but does not affect longitudinal clinical outcomes. PMID: 27523498 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 13, 2016 Category: Psychiatry Authors: Machado-Vieira R, Luckenbaugh DA, Ballard ED, Henter ID, Tohen M, Suppes T, Zarate CA Tags: Am J Psychiatry Source Type: research

Neurometabolic Disorders: Potentially Treatable Abnormalities in Patients With Treatment-Refractory Depression and Suicidal Behavior.
CONCLUSIONS: Examination of metabolic disorders in treatment-refractory depression identified an unexpectedly large proportion of patients with potentially treatable abnormalities. The etiology of these abnormalities remains to be determined. PMID: 27523499 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 13, 2016 Category: Psychiatry Authors: Pan LA, Martin P, Zimmer T, Segreti AM, Kassiff S, McKain BW, Baca CA, Rengasamy M, Hyland K, Walano N, Steinfeld R, Hughes M, Dobrowolski SK, Pasquino M, Diler R, Perel J, Finegold DN, Peters DG, Naviaux RK, Brent DA, Vockley J Tags: Am J Psychiatry Source Type: research

Toward the Reliable Diagnosis of DSM-5 Premenstrual Dysphoric Disorder: The Carolina Premenstrual Assessment Scoring System (C-PASS).
CONCLUSIONS: The C-PASS is a reliable and valid companion protocol to the DRSP that standardizes and streamlines the complex, multilevel diagnosis of DSM-5 PMDD. Consistent use of this robust diagnostic method would result in more clearly defined, homogeneous samples of women with PMDD, thereby improving the clarity of studies seeking to characterize and treat the underlying pathophysiology of the disorder. PMID: 27523500 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 13, 2016 Category: Psychiatry Authors: Eisenlohr-Moul TA, Girdler SS, Schmalenberger KM, Dawson DN, Surana P, Johnson JL, Rubinow DR Tags: Am J Psychiatry Source Type: research

Early Improvement in Work Productivity Predicts Future Clinical Course in Depressed Outpatients: Findings From the CO-MED Trial.
CONCLUSIONS: In this secondary analysis, self-reported work productivity improved in depressed patients with antidepressant treatment even after accounting for depressive symptom reduction. Early improvement in work productivity is associated with much higher remission rates after 3 and 7 months of treatment. PMID: 27523501 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 13, 2016 Category: Psychiatry Authors: Jha MK, Minhajuddin A, Greer TL, Carmody T, Rush AJ, Trivedi MH Tags: Am J Psychiatry Source Type: research

Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia.
CONCLUSIONS: Down-regulation of the ARP2/3 complex signaling pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton, would compromise the structural stability of spines, leading to their loss. In concert with findings from deletion of the ARP2/3 complex in mice, these findings support the idea that spine deficits in the DLPFC may contribute to subcortical hyperdopaminergia in schizophrenia. PMID: 27523502 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 13, 2016 Category: Psychiatry Authors: Datta D, Arion D, Roman KM, Volk DW, Lewis DA Tags: Am J Psychiatry Source Type: research

Kahlbaum, Hecker, and Kraepelin and the Transition From Psychiatric Symptom Complexes to Empirical Disease Forms.
Abstract The nosology for major psychiatric disorders developed by Emil Kraepelin in the 1890s has substantially shaped psychiatry. His theories, however, did not arise de novo, being strongly influenced by Karl Kahlbaum and Ewald Hecker. From the 1860-1880s, they articulated a paradigm shift in the conceptualization of psychiatric diagnosis, from symptom-based syndromes, popular since the late 18th century, to proto-disease entities. This effort was influenced by parallel developments in general medicine, especially the rise of bacterial theories of disease where different syndromes had distinctive symptoms, cour...
Source: The American Journal of Psychiatry - August 13, 2016 Category: Psychiatry Authors: Kendler KS, Engstrom EJ Tags: Am J Psychiatry Source Type: research

The Triple Play: Pubescent Boys, Pot, and Paranoia.
PMID: 27477132 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Thurstone C Tags: Am J Psychiatry Source Type: research

The Strange Case of Smoking and Schizophrenia-The Epidemiology Detectives Are on the Trail.
PMID: 27477133 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Laursen TM, McGrath JJ Tags: Am J Psychiatry Source Type: research

Overt and Hidden Bias in Large Observational Studies.
PMID: 27477134 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Cheng Y Tags: Am J Psychiatry Source Type: research

Further Investigation of Ketamine.
PMID: 27477135 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Freedman R Tags: Am J Psychiatry Source Type: research

Late-Life Depression: A Role for Accelerometer Technology in Diagnosis and Management.
PMID: 27477136 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Vahia IV, Sewell DD Tags: Am J Psychiatry Source Type: research

Personality Disorders in the Basque Region of Spain: Applicability of DSM-5's Alternative Criteria for Personality Disorders.
PMID: 27477137 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Ozamiz Etxebarria N, Ortiz Jauregi A, Guimon Ugartechea J, Escobar JI Tags: Am J Psychiatry Source Type: research

Addressing Difficulties in the Study of Dose-Response Relationships of SSRIs in Depression: Response to Hieronymus and Eriksson.
PMID: 27477138 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Jakubovski E, Bloch MH Tags: Am J Psychiatry Source Type: research

Inclusion of Flexible-Dose Trials in the Meta-Analysis of SSRI Dose-Dependency.
PMID: 27477139 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Hieronymus F, Eriksson E Tags: Am J Psychiatry Source Type: research

Challenges Facing the Identification of Neurobiologically Distinct Psychosis Subtypes: Response to Neuhaus.
PMID: 27477140 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Clementz BA, (on behalf of the B-SNIP principal investigators) Tags: Am J Psychiatry Source Type: research

Importance of Control Biotypes to Distinguish Distinct Psychosis Biotypes.
PMID: 27477141 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Neuhaus AH Tags: Am J Psychiatry Source Type: research

Persistent Depersonalization/Derealization Disorder Induced by Synthetic Cannabinoids.
PMID: 27477142 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Dadi G, Dervaux A, Krebs MO, Gaillard R, Laqueille X, Plaze M Tags: Am J Psychiatry Source Type: research

Boundaries and Boundary Violations in Psychoanalysis, Second Editionby Glen O. Gabbard, M.D. Washington, D.C., American Psychiatric Association Publishing, 2016, 195 pp., $69.00 (paperback).
PMID: 27477143 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Hoffman L Tags: Am J Psychiatry Source Type: research

Long-Term Outcomes in Psychopathology Research: Rethinking the Scientific Agendaedited by Evelyn J. Bromet, Ph.D. New York, Oxford University Press, 2015, 360 pp., $89.95 (hardcover).
PMID: 27477144 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Raedler TJ Tags: Am J Psychiatry Source Type: research

Treating Nonepileptic Seizures: Therapist Guide; Taking Control of Your Seizures: WorkbookTreating Nonepileptic Seizures, by W. Curt LaFrance, Jr., and Jeffrey Peter Wincze. New York, Oxford University Press, 2015, 192 pp., $55.00 (paperback). Taking Control of Your Seizures, by Joel M. Reiter, Donna Andrews, Charlotte Reiter, and W. Curt LaFrance, Jr. New York, Oxford University Press, 2015, 336 pp., $49.95 (paperback).
PMID: 27477145 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Authors: Rothberg B Tags: Am J Psychiatry Source Type: research

2015 Annual Report of the American Board of Psychiatry and Neurology, Inc.
Authors: Abstract The following is an edited version of the 2015 Report of the American Board of Psychiatry and Neurology, Inc. The full report can be obtained from the American Board of Psychiatry and Neurology ( www.abpn.com ). PMID: 27477146 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 1, 2016 Category: Psychiatry Tags: Am J Psychiatry Source Type: research

Pain as a Predictor of Opioid Use Disorder in a Nationally Representative Sample.
CONCLUSIONS: Painful conditions contribute to the risk of prescription opioid use disorders. To help reduce the incidence of prescription opioid abuse and dependence among adults with moderate to severe pain, careful monitoring and consideration of nonopioid alternative treatments is warranted. PMID: 27444794 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 22, 2016 Category: Psychiatry Authors: Blanco C, Wall MM, Okuda M, Wang S, Iza M, Olfson M Tags: Am J Psychiatry Source Type: research

Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia.
CONCLUSIONS: To the authors' knowledge, this is the first demonstration that excitatory synapse density is lower selectively on parvalbumin interneurons in schizophrenia and predicts the activity-dependent down-regulation of parvalbumin and GAD67. Because the activity of parvalbumin interneurons is required for generation of cortical gamma oscillations and working memory function, these findings reveal a novel pathological substrate for cortical dysfunction and cognitive deficits in schizophrenia. PMID: 27444795 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 22, 2016 Category: Psychiatry Authors: Chung DW, Fish KN, Lewis DA Tags: Am J Psychiatry Source Type: research

Prevention of Firearm Suicide in the United States: What Works and What Is Possible.
CONCLUSIONS: Broadly reducing availability and access to firearms has lowered firearm suicide rates in other countries but does not appear feasible in the United States. Approaches restricting access of at-risk individuals to already purchased firearms by engaging the public and major stakeholders require urgent implementation and outcome evaluation for firearm suicide prevention. PMID: 27444796 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 22, 2016 Category: Psychiatry Authors: Mann JJ, Michel CA Tags: Am J Psychiatry Source Type: research

Efficacy of Quetiapine Monotherapy in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial.
CONCLUSION: Quetiapine monotherapy was efficacious in the treatment of PTSD. These findings suggest quetiapine as a single agent is effective in treating military PTSD. PMID: 27418378 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 15, 2016 Category: Psychiatry Authors: Villarreal G, Hamner MB, Cañive JM, Robert S, Calais LA, Durklaski V, Zhai Y, Qualls C Tags: Am J Psychiatry Source Type: research

Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.
CONCLUSIONS: Right unilateral ultrabrief pulse ECT, combined with venlafaxine, is a rapidly acting and highly effective treatment option for depressed geriatric patients, with excellent safety and tolerability. These data add to the evidence base supporting the efficacy of ECT to treat severe depression in elderly patients. PMID: 27418379 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 15, 2016 Category: Psychiatry Authors: Kellner CH, Husain MM, Knapp RG, McCall WV, Petrides G, Rudorfer MV, Young RC, Sampson S, McClintock SM, Mueller M, Prudic J, Greenberg RM, Weiner RD, Bailine SH, Rosenquist PB, Raza A, Kaliora S, Latoussakis V, Tobias KG, Briggs MC, Liebman LS, Geduldig Tags: Am J Psychiatry Source Type: research

A Brief Clinical Tool to Estimate Individual Patients' Risk of Depressive Relapse Following Remission: Proof of Concept.
CONCLUSIONS: A brief symptom scale can be used to identify patients who, despite full remission from a depressive episode, are at substantial risk of relapse within the next 6 months, and this can be used to provide a basis for personalizing the intensity of follow-up visits. PMID: 27418380 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 15, 2016 Category: Psychiatry Authors: Judd LL, Schettler PJ, Rush AJ Tags: Am J Psychiatry Source Type: research

A Novel Strategy for Continuation ECT in Geriatric Depression: Phase 2 of the PRIDE Study.
CONCLUSIONS: Additional ECT after remission (here operationalized as four continuation ECT treatments followed by further ECT only as needed) was beneficial in sustaining mood improvement for most patients. PMID: 27418381 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 15, 2016 Category: Psychiatry Authors: Kellner CH, Husain MM, Knapp RG, McCall WV, Petrides G, Rudorfer MV, Young RC, Sampson S, McClintock SM, Mueller M, Prudic J, Greenberg RM, Weiner RD, Bailine SH, Rosenquist PB, Raza A, Kaliora S, Latoussakis V, Tobias KG, Briggs MC, Liebman LS, Geduldig Tags: Am J Psychiatry Source Type: research

An Individualized Risk Calculator for Research in Prodromal Psychosis.
CONCLUSIONS: A risk calculator comparable in accuracy to those for cardiovascular disease and cancer is available to predict individualized conversion risks in newly ascertained clinical high-risk cases. Given that the risk calculator can be validly applied only for patients who screen positive on the Structured Clinical Interview for Psychosis Risk Syndromes, which requires training to administer, its most immediate uses will be in research on psychosis risk factors and in research-driven clinical (prevention) trials. PMID: 27363508 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - July 1, 2016 Category: Psychiatry Authors: Cannon TD, Yu C, Addington J, Bearden CE, Cadenhead KS, Cornblatt BA, Heinssen R, Jeffries CD, Mathalon DH, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Woods SW, Kattan MW Tags: Am J Psychiatry Source Type: research