Integration and holistic analysis of multiple multidimensional soil data sets
We present a statistical workflow designed to effectively analyse complex, multidimensional systems, even in the presence of confounding variables. The developed methodology involves exploratory analysis to identify the presence of confounding variables, followed by data decomposition (including strategies for both compositional and non-compositional quantitative data) to minimise the influence of these confounding factors such as sampling site/location. These data processing methods then allow for common patterns to be highlighted in the data, including the identification of biomarkers and determination of non-trivial ass...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Lisa I Pilkington William Kerner Daniela Bertoldi Roberto Larcher Soon A Lee Matthew R Goddard Davide Albanese Pietro Franceschi Bruno Fedrizzi Source Type: research
A dual recognition-based strategy employing Ni-modified metal-organic framework for in situ screening of SIRT1 inhibitors from Chinese herbs
Talanta. 2024 Mar 27;274:125975. doi: 10.1016/j.talanta.2024.125975. Online ahead of print.ABSTRACTSirtuin1 (SIRT1), an NAD+-dependent histone deacetylase, plays a crucial role in regulating molecular signaling pathways. Recently, inhibition of SIRT1 rather than its activation shows the therapeutic potential for central nervous system disorder, however, the discovered SIRT1 inhibitors remains limited. In this work, a dual recognition-based strategy was developed to screen SIRT1 inhibitors from natural resources in situ. This approach utilized a Ni-modified metal-organic framework (Ni@Tyr@UiO-66-NH2) along with cell lysate ...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Xinlin Chen Lihong Hong Ying Wu Yucheng Gu Jianguang Luo Lingyi Kong Source Type: research
Hierarchically porous ZnO derived from zeolitic imidazolate frameworks for high-sensitive MEMS NO < sub > 2 < /sub > sensor
Talanta. 2024 Mar 25;274:125995. doi: 10.1016/j.talanta.2024.125995. Online ahead of print.ABSTRACTThree-dimensional (3D) porous metal oxide nanomaterials with controllable morphology and well-defined pore size have attracted extensive attention in the field of gas sensing. Herein, hierarchically porous ZnO-450 was obtained simply by annealing Zeolitic Imidazolate Frameworks (ZIF-90) microcrystals at an optimal temperature of 450 °C, and the effect of annealing temperature on the formation of porous nanostructure was discussed. Then the as-obtained ZnO-450 was employed as sensing materials to construct a Micro-Electro-Mec...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Dan Zhang Na Luo Zhenggang Xue Yueling Bai Jiaqiang Xu Source Type: research
Activates B lymphocytes and enhanced immune response: A promising adjuvant based on PLGA nanoparticle to improve the sensitivity of ZEN monoclonal antibody
Talanta. 2024 Apr 9;274:126005. doi: 10.1016/j.talanta.2024.126005. Online ahead of print.ABSTRACTIn preparing monoclonal antibodies by hybridoma cell technology, the quality of B lymphocytes used for cell fusion directly affects the sensitivity of monoclonal antibodies. To obtain B-lymphocytes producing high-quality specific antibodies for cell fusion during the immunization phase of the antigen, we prepared a TH2-Cell stimulatory delivery system as a novel adjuvant. Astragalus polysaccharide has a good ability to enhance antigenic immune response, and it was encapsulated in biocompatible materials PLGA as an immunostimul...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Chengchen Pang Bei Yuan Keyun Ren Haitao Xu Kunying Nie Chunlei Yu Zhanli Liu Yanyan Zhang Sibel A Ozkan Qingqing Yang Source Type: research
A stable and flexible Au@Ag NPs/PVA SERS platform for thiram residue detection on rough surface
Talanta. 2024 Mar 27;274:126008. doi: 10.1016/j.talanta.2024.126008. Online ahead of print.ABSTRACTFlexible and transparent surface-enhanced Raman scattering (SERS) substrates have gained great attention in analysis field as they offer a fast, non-destructive, and highly sensitive platform for in-situ detection. In this work, we present a facile one-pot strategy for synthesizing gold-cored silver shell nanoparticles (Au@Ag NPs) in the polyvinyl alcohol (PVA) colloid. With no other reducing agents, PVA can serve as both reducing and stabilizing agents for forming Au@Ag NPs. Besides, PVA acts as a scaffold to maintain SERS "...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Tao Shao Jinsong Xu Hang Zhong Yi Hu Jun Chen Source Type: research
Dextrin-assisted gel electromembrane extraction of chiral drugs: Improving the extraction efficiency and investigation of enantioselectivity of extraction
Talanta. 2024 Apr 4;274:126016. doi: 10.1016/j.talanta.2024.126016. Online ahead of print.ABSTRACTThe present study investigates the use of dextrins (maltodextrin, β-cyclodextrin, and hydroxypropyl-β-cyclodextrin) to improve the efficiency of the agarose-based gel electromembrane extraction technique for extracting chiral basic drugs (citalopram, hydroxyzine, and cetirizine). Additionally, it examines the enantioselectivity of the extraction process for these drugs. To achieve these, dextrins were incorporated into either the sample solution, the membrane, or the acceptor solution, and then the extraction procedure was p...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Mustafa Alawadi Ali Reza Fakhari Majid Maghsoudi Saeed Nojavan Source Type: research
Water bridges as the trigger in an amino functionalized Zn-MOF for highly selective and sensitive fluorescent sensing of water
Talanta. 2024 Apr 7;274:126068. doi: 10.1016/j.talanta.2024.126068. Online ahead of print.ABSTRACTWater is a fundamental element for life. The highly selective and sensitive sensing of water is always attractive for mankind in activities such as physiological processes study and extraterrestrial life exploration. Fluorescent MOFs with precise channels and functional groups might specifically recognize water molecules with hydrogen-bond interaction or coordination effects and work as water sensors. As a proof of concept, herein, an amino functionalized Zn-MOF (named as complex 1) with pores that just right for water molecul...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Ping Ju GuiXue Zhang Wenhui Lu Shuping Wang Anzhang Li Qingxiang Zhang Jingyi Xin Linglong Shen Long Jiang Ensheng Zhang Source Type: research
Engineering of a DNAzyme-Based dimeric G-quadruplex rolling circle amplification for robust analysis of lead ion
In this study, we introduced an innovative approach by integrating DNAzyme with rolling circle amplification (RCA) to propose an amplification sensing method termed DNAzyme-based dimeric-G-quadruplex (dimer-G4) RCA. This sensing approach allows for precise and high-fidelity Pb2⁺ detection. Strategically, in the presence of Pb2⁺, the DNAzyme undergoes substrate strand (S-DNA) cleavage, liberating its enzyme strand (E-DNA) to prime isothermal amplification. This initiates the RCA process, producing numerous dimer-G-Quadruplexes (dimer-G4) as the signal reporting transducers. Compared to conventional strategies using mono...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Yubo Peng Pengpeng Xue Wei Chen Jianguo Xu Source Type: research
Natural flavonols as probes for direct determination of borax: From conventional fluorescence analysis to paper-based smartphone sensing
Talanta. 2024 Apr 4;274:126053. doi: 10.1016/j.talanta.2024.126053. Online ahead of print.ABSTRACTBorax is strictly regulated in the food processing and pharmaceutical industry due to its physiological toxicity, and the development of a direct analytical method is essential for effectively monitoring the borax abuse. In this work, the fluorescence properties of flavonoids, including flavones, isoflavones and flavonols, were systematically investigated from aqueous to borax solutions, and it was found that the weak intrinsic fluorescence of flavonols could be pervasively sensitized by borax. A natural flavonol, morin, was s...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Jingtong Xia Jinying Huang Hairong Zhang Nan Zhang Fengyun Li Panpan Zhou Lei Zhou Qiaosheng Pu Source Type: research
Highly-sensitive optical thermometer developed based on an intervalence charge transfer mashup
Talanta. 2024 Apr 4;274:126054. doi: 10.1016/j.talanta.2024.126054. Online ahead of print.ABSTRACTOptical thermometers based on lanthanide thermal-coupled levels have attracted great attention owing to its fundamental importance in the fields of public health, biology, and integrated circuit. However, the inherent structural properties (shielded effect on 4f configurations, intense non-radiation relaxation) strictly suppress the sensing performance, limiting the relative temperature sensitivity (SR). To circumvent these limitations, we propose an intervalence charge transfer mashup strategy by inducing d0 electron configur...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Zhihua Liu Yunzhong Zhu Rui Hao Shaopeng Lin Decai Ma Biao Wang Source Type: research
Single cell glycan-linkages profiling for hepatocellular carcinoma early diagnosis using lanthanide encoded bacteriophage MS2 based ICP-MS
In this study, we present an innovative approach which contributed to the early diagnosis of HCC. By lanthanide encoding signal amplification to map glycan-linkages at the single-cell level, the minute quantities of "soft" glycan-linkages on single cell surface were converted into "hard" elemental tags through the use of an MS2 signal amplifier. Harnessing the power of lanthanides encoded within MS2, we achieve nearly three orders of magnitude signal amplification. These encoded tags are subsequently quantified using single-cell inductively coupled plasma mass spectrometry (SC-ICP-MS). Linear discriminant analysis (LDA) id...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Yong Liang Zhen Liu Dongliang Zuo Shi Chen Jianbin Chen Xiaowen Yan Pingguo Liu Qiuquan Wang Source Type: research
Dicyanoisophorone-based near-infrared fluorescent probe with large Stokes shift for the monitoring and bioimaging of hypochlorite
In this study, a novel ClO--selective fluorescent probe, DCP-ClO, was synthesized with dicyanoisophorone-xanthene unit as parent fluorophore, which displayed excellent selectivity towards ClO-, near-infrared emission (755 nm), large Stokes shift (100 nm), real-time response to ClO-, high sensitivity (LOD = 3.95 × 10-8 M), and low cytotoxicity. The recognition mechanism of DCP-ClO towards ClO- was confirmed to be a typical ICT process by HPLC-MS, HR-MS, 1H NMR and theoretical calculations. Meanwhile, DCP-ClO demonstrated remarkable efficacy in monitoring ClO- levels in water samples and eye-catching ability in imaging endo...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Yingkai Gao Chuanfeng Fan Jian Gao Xintong Yang Xiaochun Wang Fei Li Jin Zhou Haifeng Yu Yi Huang Yingying Shan Li Chen Source Type: research
Volatile carbonyl metabolites analysis of nanoparticle exposed lung cells in an organ-on-a-chip system
Talanta. 2024 Apr 7;274:126066. doi: 10.1016/j.talanta.2024.126066. Online ahead of print.ABSTRACTThe evaluation of nanoparticles (NPs) cytotoxicity is crucial for advancing nanotechnology and assessing environmental pollution. However, existing methods for NPs cytotoxicity evaluation suffer from limited accuracy and inadequate information content. In the study, we developed a novel detection platform that enables the identification of cellular carbonyl metabolites at the organ level. The platform is integrated with a cell co-culture lung organ chip (LOC) and a micropillar concentrator. Notably, our work represents the suc...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Jinlong Liu Meiyan Qin Yimin Shi Rui Jiang Zizhen Wang Lingqian Zhang Yang Zhao Hang Gao Mingxiao Li Chengjun Huang Source Type: research
A TICT-AIE activated dual-channel fluorescence-on probe to reveal the dynamics mechanosensing of lipid droplets during ferroptosis
In this study, we designed and synthesized a fluorescent probe, TPE-V1, to enable real-time monitoring of LDs' viscosity using a dual-channel fluorescence-on model (red channel at 617 nm and NIR channel at 710 nm). The fluorescent imaging of using TPE-V1 was achieved due to the integrated mechanisms of the twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE). Through dual-emission channel fluorescence imaging, we observed the enhanced mechanical energy of LDs triggering cellular mechanosensing, including ferroptosis and cell deformation. Theoretical calculations confirmed the probe's behavio...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Ao Yu Wei Zhang Qiangsheng Zhang Kunlong Yang Xiongbo Liu Hongtao Liu Jialin Xie Yan Feng Jianwei Li Chunman Jia Source Type: research
Integration and holistic analysis of multiple multidimensional soil data sets
We present a statistical workflow designed to effectively analyse complex, multidimensional systems, even in the presence of confounding variables. The developed methodology involves exploratory analysis to identify the presence of confounding variables, followed by data decomposition (including strategies for both compositional and non-compositional quantitative data) to minimise the influence of these confounding factors such as sampling site/location. These data processing methods then allow for common patterns to be highlighted in the data, including the identification of biomarkers and determination of non-trivial ass...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Lisa I Pilkington William Kerner Daniela Bertoldi Roberto Larcher Soon A Lee Matthew R Goddard Davide Albanese Pietro Franceschi Bruno Fedrizzi Source Type: research
