Erratum - Transition-Metal-Free Cascade C –N Bond Formation: An Effective Strategy for the Synthesis of β-Carboline N-Fused Imidazolium Acetates and Estimation of their Light-Emitting Properties
Synthesis DOI: 10.1055/s-0040-1720082 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Synthesis)
Source: Synthesis - August 9, 2023 Category: Chemistry Authors: Singh, Manpreet Vaishali, Vaishali Deepika, Deepika Jyoti, Jyoti Sharma, Shubham Banyal, Naveen Kumar, Prashant Budhalakoti, Bharti Malakar, Chandi C. Singh, Virender Tags: errata Source Type: research
Rh-Catalyzed C –H Functionalization of the (Pyrazol-5-yl)pyridine Core of GBT-440
Synthesis DOI: 10.1055/a-2116-6734 The Rh-catalyzed cross dehydrogenative coupling (CDC)/alkylation of the pyrazolylpyridine unit of GBT-440 proceeded smoothly under ambient conditions and selectively on the pyrazole unit while directed by the pyridine. The scope of these reactions was established by employing simple as well as conjugated olefins for CDC and various diazo esters and the TIPS-EBX reagent for alkylation. At the outset, a focused small molecule library around the bis-heterocyclic core of GBT-440 was developed via C–H functionalization. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, German...
Source: Synthesis - August 8, 2023 Category: Chemistry Authors: Kalshetti, Rupali G. Halnor, Swapnil V. Ramana, Chepuri V. Tags: special topic Source Type: research
Transition-Metal-Free Cascade C –N Bond Formation: An Effective Strategy for the Synthesis of β-Carboline N-Fused Imidazolium Acetates and Estimation of their Light-Emitting Properties
Synthesis DOI: 10.1055/s-0041-1738447 A simple, efficient, and practical metal-free protocol has been devised to synthesize imidazopyrido[3,4-b]indole-based fluorophores decorated with carbazole/β-carboline/pyridine scaffolds via three consecutive C–N bond formations in a single operation. A wide range of aromatic amines (2-aminopyridines, 3-aminocarbazole, and anilines) were successfully applied to synthesize the complex imidazolium ions. The significant features of this strategy include high efficiency, mild and environmentally benign reaction conditions, no chromatographic purification, and broad substrate scope with...
Source: Synthesis - August 8, 2023 Category: Chemistry Authors: Singh, Manpreet Vaishali, Vaishali Deepika, Deepika Jyoti, Jyoti Sharma, Shubham Kumar, Naveen Kumar, Prashant Budhalakoti, Bharti Malakar, Chandi C. Singh, Virender Tags: paper Source Type: research
Sustainable Ru(II)-Catalyzed ortho-C(sp2) –H Hydroxyalkylation of Phthalazinones Using Ethyl Glyoxalate: Access to α,α′-Arylcarboxy sec-Alcohols
Synthesis DOI: 10.1055/a-2114-5426 An operationally simple and expeditious protocol for Ru(II)-catalyzed ortho-C(sp2)–H hydroxyalkylation of phthalazinones using commercially available ethyl glyoxalate in 2-Me-THF is reported. This greener approach involves the imine nitrogen on the phthalazinones as a directing group to effect the regioselective hydroxyalkylation. Ample examples of biologically relevant hydroxyalkylated phthalazinones were prepared, and relevant controlled studies were performed to decipher the reaction mechanism. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme...
Source: Synthesis - August 7, 2023 Category: Chemistry Authors: Ramkumar, Alagumalai Gandhi, Thirumanavelan Tags: special topic Source Type: research
Synthesis of Quinoline and Quinolin-2(1H)-one Derivatives via Nickel Boride Promoted Reductive Cyclization
Synthesis DOI: 10.1055/a-2116-5206 A mild and efficient approach for the synthesis of diversely substituted quinoline and quinolin-2-one derivatives is disclosed. In situ generated nickel boride proved to be an effective promoter of the reductive cyclization reaction. Broad substrate scope, mild reaction conditions, consistent yield, and a wide range of functional group tolerance are the other notable features of the newly discovered reaction. A large number of quinoline and quinolin-2-one derivatives may be prepared from milligram to multigram scale employing this intramolecular reductive cyclization protocol. [...] Georg...
Source: Synthesis - August 7, 2023 Category: Chemistry Authors: Sarkar, Rumpa Samanta, Surya Kanta Menon, Anila M. Chopra, Deepak Ganguly, Debabani Bera, Mrinal K. Tags: paper Source Type: research
Scalable, Stereocontrolled, Total Synthesis of Carolacton
Synthesis DOI: 10.1055/a-2105-2774 A route for the scalable, stereocontrolled, total synthesis of carolacton is presented starting from commercially available S-Roche ester, d-ribose, and a known allylic alcohol. Key transformations in the total synthesis include a [3,3]-Claisen rearrangement, Sharpless asymmetric epoxidation–methyl ring-opening, or Leighton asymmetric crotylation, Evans aldol–reductive deoxygenation, and ring closing metathesis (RCM). The total synthesis of carolacton (151 mg isolated, 9.2% overall yield) was completed in 23 linear steps. Additionally, 56 mg of the carolacton C15–C16 cis-olefin isom...
Source: Synthesis - August 7, 2023 Category: Chemistry Authors: Bian, Chuan-Cai Li, Yong-Qiang Yang, Hao-ran Yu, Xiao-Ming Tags: paper Source Type: research
Synthesis of 2,2-Disubstituted and 2,2,3-Trisubstituted 1,4-Dioxane-Derived Building Blocks
Synthesis DOI: 10.1055/a-2092-9205 An approach to the preparation of 2,2-disubstituted and 2,2,3-trisubstituted 1,4-dioxane-derived building blocks is described. The reaction sequence commenced from dimethyl- or spirocyclobutyl-substituted oxiranes bearing an additional benzyloxy group as the starting materials. The key step of the 1,4-dioxane ring construction included oxirane ring opening with ethylene glycol monolithium salt, followed by the two-step cyclization of the diols obtained. The utility of the method was demonstrated by multigram preparation (up to 300 g; 30 g average scale of the final products) of 2,2-dimeth...
Source: Synthesis - August 2, 2023 Category: Chemistry Authors: Bondarenko, Andriy V. Kozyriev, Yevhenii K. Vashchenko, Bohdan V. Grygorenko, Oleksandr O. Tags: paper Source Type: research
Molybdenum-Mediated One-Pot Synthesis of 2-Hydroxypyrimidines from Isoxazoles
Synthesis DOI: 10.1055/a-2107-4492 A one-pot procedure towards substituted 2-hydroxypyrimidines from commercially available isoxazoles is reported. The process involves cleavage of the isoxazole N–O bond mediated by Mo2(OAc)4, then in situ hydrolysis of the resulting β-amino enone to the reactive 1,3-dicarbonylated intermediate, followed by hydroxypyrimidine formation in the presence of urea. Moderate to excellent yields are obtained, leading to functionalized hydroxypyrimidines. By using readily available isoxazoles, a wide range of new diverse polysubstituted hydroxypyrimidines may be prepared by this method. [...] Ge...
Source: Synthesis - August 1, 2023 Category: Chemistry Authors: Rochelle, Servane Beaumont, St éphane Tags: paper Source Type: research
A New One-Pot Synthesis of 3,6-Disubstituted Pyridazines Starting from β-Nitro-β,γ-Unsaturated Ketones
Synthesis DOI: 10.1055/a-2114-7673 A new one-pot preparation of 3,6-disubstituted pyridazines starting from β-nitro-β,γ-unsaturated ketones and hydrazine monohydrate is presented. The protocol entails two sequential steps, leading to the isolation of the title targets in satisfactory overall yields tolerating a good variety of additional functionalities. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - July 31, 2023 Category: Chemistry Authors: Khan, Muhammad E. I. Yuan, Lixia Petrini, Marino Palmieri, Alessandro Tags: paper Source Type: research
Synthesis of 3-Aminoalkylated Indoles Using Heterogeneous MgFe2O4 Nanoparticles Under Microwave Irradiation in One-Pot Three-Component System
Synthesis DOI: 10.1055/a-2117-9649 A series of 3-aminoalkylated indoles are efficiently synthesised in a one-pot three-component reaction under microwave irradiation. Magnesium ferrite (MgFe2O4) nanoparticles (10 mol%) have been used as heterogeneous catalyst, which may easily be recovered by application of an external magnet and the recovered catalyst can be reused at least for five runs without affecting the efficiency of the catalyst. The solvent-free protocol developed has advantages of less reaction time, high yields, and easy workup, and the protocol is applicable to various acid base sensitive functional groups pres...
Source: Synthesis - July 31, 2023 Category: Chemistry Authors: Gupta, Deeksha Singh, Prabal P. Tags: paper Source Type: research
Co(OAc)2/TBHP as a Highly Active Catalytic System for the Selective Oxidation of Aromatic Amines to Nitro Derivatives
Synthesis DOI: 10.1055/a-2110-8622 An efficient cobalt-catalyzed protocol for the selective oxidation of anilines using a combination of inexpensive tert-butyl hydroperoxide and Co(OAc)2·4H2O without any ligand has been developed, providing the nitroarene products in good to excellent yields (up to 96%). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - July 27, 2023 Category: Chemistry Authors: Wu, Liqiong Yao, Lifeng Yin, Weiyan Yu, Junxia Tags: paper Source Type: research
Titanium-Catalyzed Intermolecular Hydroaminoalkylation of Terminal Alkynes
Synthesis DOI: 10.1055/a-2111-9910 Terminal alkynes undergo intermolecular hydroaminoalkylation reactions with secondary amines in the presence of titanium catalysts and depending on the catalyst and the structure of the substrates, allylic amines and/or imines are formed as products in moderate yields. In addition, the desired allylamines can also be obtained from a convenient reaction sequence consisting of an initial hydroaminoalkylation of trimethylsilyl-protected alkynes and a subsequent protodesilylation that selectively delivers γ-unsubstituted allylamines. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stu...
Source: Synthesis - July 27, 2023 Category: Chemistry Authors: Thye, Hermann Fornfeist, Felix Geik, Dennis Schl üschen, Levi L. Schmidtmann, Marc Doye, Sven Tags: feature Source Type: research
Linked PDF of Table of Contents
Synthesis 2023; 55: V- DOI: 10.1055/s-0040-1720080 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents (Source: Synthesis)
Source: Synthesis - July 27, 2023 Category: Chemistry Tags: table of contents Source Type: research
Activation of Diazo Compounds by Fluorinated Triarylborane Catalysts
Conclusions [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Synthesis)
Source: Synthesis - July 26, 2023 Category: Chemistry Authors: Pramanik, Milan Melen, Rebecca L. Tags: short review Source Type: research
Ni- and Pd-Catalyzed Enantioselective 1,2-Dicarbofunctionalization of Alkenes
Conclusion [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - July 25, 2023 Category: Chemistry Authors: Kang, Taeho Apolinar, Omar Engle, Keary M. Tags: review Source Type: research
