Pyrazolopyridine Ligands in Transition-Metal-Catalyzed C –C and C–Heteroatom Bond-Forming Reactions
Conclusion [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - November 28, 2023 Category: Chemistry Authors: Kang, Eunsu Joo, Jung Min Tags: short review Source Type: research
Synthesis of ( –)-Virginiae Butanolide A (VB-A)
Synthesis DOI: 10.1055/a-2195-7907 The 2-(1′-hydroxyalkyl) paraconyl alcohols (–)-VB-A and (–)-SCB-5 are known as highly active signaling molecules within antibiotics production in Streptomyces sp. These γ-butyrolactone type compounds are epimeric at the 1′-OH-group. A direct synthesis of (–)-VB-A from (–)-SCB-5 that uses a late-stage inversion of the 1′-hydroxy group is not favored because of side reactions of the carbinol in β-position to the lactone C=O function. Therefore, an orthogonally protected 1,4-diol incorporating the central syn/anti 1′,2,3-stereotriad as described within the (–)-SCB-5 synth...
Source: Synthesis - November 28, 2023 Category: Chemistry Authors: Donges, Jonas Frank, Andrea Schollmeyer, Dieter Nubbemeyer, Udo Tags: paper Source Type: research
Linked PDF of Table of Contents
Synthesis 2023; 55: V- DOI: 10.1055/s-0040-1720099 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents (Source: Synthesis)
Source: Synthesis - November 28, 2023 Category: Chemistry Tags: table of contents Source Type: research
Recent Progress in Developing Thioether-Containing Ligands for Catalysis Applications
Conclusion [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - November 27, 2023 Category: Chemistry Authors: Bellemin-Laponnaz, St éphane Achard, Thierry Tags: short review Source Type: research
Electrochemical Hydro- and Deuterocarboxylation of Allenes
Synthesis DOI: 10.1055/a-2200-5332 Electrochemical hydrocarboxylation and deuterocarboxylation of allenes and carbon dioxide were achieved with H2O and D2O, respectively. This reaction generally affords good to excellent regioselectivity in the formation of diverse carboxylic acids. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - November 27, 2023 Category: Chemistry Authors: Ding, Cheng-Lin Zhong, Jun-Song Yan, Hong Ye, Ke-Yin Tags: feature Source Type: research
Rh(III)-Catalyzed Synthesis of Isocoumarins via C –H Activation of Phenacyl Phosphoniums with Iodonium Ylides
Synthesis DOI: 10.1055/s-0042-1751522 A phosphonium-assisted C–H cyclization with iodonium ylides has been developed under redox-neutral rhodium(III) catalysis, offering a wide variety of valuable isocoumarins in moderate to good yields. This transformation proceeds through C–H activation, carbene insertion, and nucleophilic addition processes. The reaction occurs under a low catalyst loading in a short reaction time and does not require an oxidant. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - November 23, 2023 Category: Chemistry Authors: Jiang, Lu Gao, Lei Li, Xiaofei Shao, Tingting Yao, Jinzhong Miao, Maozhong Zhou, Hongwei Tags: feature Source Type: research
An Efficient Copper-Mediated Route for the Synthesis of 2-Substituted Benzothiazoles from Dithioesters and Investigation of Their Antibacterial Activities
Synthesis DOI: 10.1055/a-2193-5436 An efficient one-pot synthesis of 2-aryl/2-aroylbenzothiazoles through copper-mediated condensation of 2-chloroanilines with dithioesters has been developed. The method provides good isolated yields and exhibits broad functional group tolerance, accommodating both electron-donating and electron-withdrawing groups on the substrates. A series of synthesized compounds was evaluated for their antibacterial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella paratyphi. Among the series, three compounds exhibited a significant inhibitory effect against the tested path...
Source: Synthesis - November 22, 2023 Category: Chemistry Authors: Sukrutha, Kodipura P. Kiran, Kuppalli R. Gunashree, Kodagahally T. Divyashree, Shivakumar Purusotham, Prerana Sreenivasa, Marikunte Y. Sadashiva, Maralinganadoddi P. Tags: paper Source Type: research
A Rearrangement of 4-Phenylbenzo[d]oxazoles to Phenanthridin-4-ols
Synthesis DOI: 10.1055/a-2193-5593 A new approach was developed for the synthesis of phenanthridin-4-ols and 4-hydroxyphenanthridin-6(5H)-one derivatives in 43–89% yields based on the AlCl3-mediated rearrangement of available 4-phenylbenzo[d]oxazoles and 4-phenyl-1,3-benzoxazol-2(3H)-one. The quantum chemical calculations were used to describe the mechanism and predict the thermodynamic parameters of the reaction under study. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - November 22, 2023 Category: Chemistry Authors: Shatsauskas, Anton L. Keyn, Ekaterina S. Stasyuk, Anton J. Kirnosov, Sergey A. Shuvalov, Vladislav Yu. Kostyuchenko, Anastasia S. Fisyuk, Alexander S. Tags: paper Source Type: research
Review of the Total Synthesis of the Aromatic Abietane Diterpenoid Ferruginol
Conclusion and Perspectives [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - November 21, 2023 Category: Chemistry Authors: Li, Mengran Chen, Peng Liu, Haoqi Huang, Jian Chen, Yang Tags: short review Source Type: research
Photoinduced Ligand-to-Metal Charge Transfer in Base-Metal Catalysis
Conclusion [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synthesis)
Source: Synthesis - November 21, 2023 Category: Chemistry Authors: Treacy, Sean M. Rovis, Tomislav Tags: review Source Type: research
Synthesis of New Structural Analogues of Natural Integrastatins with a Basic Epoxybenzo[7,8]oxocine Skeleton: Combined Experimental and Computational Study
Synthesis DOI: 10.1055/s-0042-1751521 In this work, the cyclization reactivity of various 3-acetyl-2-methylpyridines (including 3-acetyl-2-methylquinoline) containing both electron donor and acceptor substituents with salicylaldehyde into epoxybenzooxocino[4,3-b]pyridine derivatives was studied. The reactions were carried out in mild (under room temperature or reflux in 2-propanol) and harsh (in a sealed glass ampoule) conditions. It was shown that 3-acetyl-2-methylpyridines with an aryl substituent in the 4-position do not react with salicylaldehyde either under normal convection heating conditions or under more severe co...
Source: Synthesis - November 21, 2023 Category: Chemistry Authors: Stalinskaya, Alena L. Chikunov, Semyon Y. Pustolaikina, Irina A. Gatilov, Yuri V. Kulakov, Ivan V. Tags: paper Source Type: research
Copper Nanoparticles on Montmorillonite K-10: A Versatile Catalyst for the One-Pot Synthesis of 3,5-Disubstituted Isoxazoles Using Various Methodologies
Synthesis DOI: 10.1055/a-2193-4701 A readily prepared and versatile heterogeneous catalyst composed of copper nanoparticles supported on montmorillonite K-10 (CuNPs/MK-10) has proven to be highly effective in catalyzing the synthesis of isoxazoles through various one-pot methodologies with high atom economy. These methodologies allow for the use of readily available starting materials, including aldehydes and alkynes through 1,3-dipolar cycloaddition reactions, as well as via cycloisomerization of ynones. Additionally, the CuNPs/MK-10 catalyst promoted the in situ formation of the ynones via an acyl Sonogashira coupling. F...
Source: Synthesis - November 20, 2023 Category: Chemistry Authors: Stabile, Santiago Bjerg, Esteban E. Radivoy, Gabriel Tags: paper Source Type: research
Synthesis of the Hexasaccharide Repeating Unit Corresponding to the Cell Wall O-Antigen of Providencia alcalifaciens O9:H8 Strain
Synthesis DOI: 10.1055/s-0042-1751517 A straightforward synthesis of the hexasaccharide repeating unit of the O-specific polysaccharide of Providencia alcalifaciens O9:H8 strain was achieved in very good yield by applying a stereo- and regioselective [4+2] block glycosylation strategy. The tetrasaccharide acceptor and disaccharide donor were synthesized by sequential stereo- and regioselective glycosylations. Thioglycoside and glycosyl trichloroacetimidate derivatives were used as glycosyl donors in the synthetic strategy. The glycosylation steps were high-yielding and gave satisfactory stereochemical outcomes. [...] Georg...
Source: Synthesis - November 20, 2023 Category: Chemistry Authors: Rana, Abhijit Misra, Anup Kumar Tags: paper Source Type: research
Photo-Induced Electrophilic Aromatic Substitution of Ferric Acyl Nitrene
Synthesis DOI: 10.1055/a-2183-0262 A photo-induced intramolecular electrophilic aromatic substitution (SEAr) of N-acyloxyamides using FeCl3 in 1,4-dioxane is reported for the synthesis of biologically interesting benzoxazin-3(4H)-ones. It is believed that irradiation with a blue LED facilitates the reaction, serving as a source of energy. The SEAr reaction pathway is ascribed to the electronic effects present in the aryl ring of the substrates. The reaction is also applicable for the synthesis of useful scaffolds possessing a quinolin-2-one core, such as an anticancer reagent and analogues of brexipiprazole and cilostamide...
Source: Synthesis - November 20, 2023 Category: Chemistry Authors: Hou, Ming Zhang, Zhide Lai, Xiaojing Zong, Qianshou Ren, Miaofeng Bai, Tianwen Qiu, Guanyinsheng Tags: paper Source Type: research
Activation of Stable and Recyclable Phenylpropiolate Glycoside (PPG) Donors by Iron Catalysis
Synthesis DOI: 10.1055/a-2193-4615 The glycosylation reaction is one of the important aspects of carbohydrate chemistry, where two different units are frequently linked through C–O bonds. In the pursuit of advancing this field, the design and development of sustainable catalytic methods for O-glycosylation, which can provide an alternate and effective tool to traditional protocols involving stoichiometric promoters and classical donors, are considered as highly challenging, yet important facets of glycochemistry. Herein, we report a simple and efficient Fe(III)-catalyzed method for O-glycosylation through the activation ...
Source: Synthesis - November 20, 2023 Category: Chemistry Authors: Aghi, Anjali Mishra, Saksham Kumar, Amit Tags: paper Source Type: research
