Clinical Utility of Electronic Alberta Stroke Program Early Computed Tomography Score Software in the ENCHANTED Trial Database [Clinical Sciences]
Background and Purpose—Clinical utility of electronic Alberta Stroke Program Early CT Score (e-ASPECTS), an automated system for quantifying signs of infarction, was evaluated in a large database of thrombolyzed patients with acute ischemic stroke.Methods—All baseline noncontrast computed tomographic scans of patients with anterior circulation acute ischemic stroke who participated in the alteplase dose arm of the randomized controlled trial ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) were reviewed; poor quality and large (>6 mm) slice thickness were excluded. Included scans had e-ASPECTS...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Simon Nagel, Xia Wang, Cheryl Carcel, Thompson Robinson, Richard I. Lindley, John Chalmers, Craig S. Anderson Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Magnetic Resonance Imaging Selection for Endovascular Stroke Therapy [Clinical Sciences]
Conclusions—Workflow in GOLIATH demonstrates that magnetic resonance imaging selection for endovascular therapy can be accomplished rapidly and within a similar time frame as computed tomography-based selection.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT02317237. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Claus Z. Simonsen, Albert J. Yoo, Mads Rasmussen, Kristina E. Sorensen, Thabele Leslie–Mazwi, Grethe Andersen, Leif H. Sorensen Tags: Magnetic Resonance Imaging (MRI), Revascularization, Ischemic Stroke Original Contributions Source Type: research
Prediction of Tissue Outcome and Assessment of Treatment Effect in Acute Ischemic Stroke Using Deep Learning [Clinical Sciences]
Background and Purpose—Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This volume assessment is currently based on fixed thresholds and single imagine modalities, limiting accuracy. We wish to develop and validate a predictive model capable of automatically identifying and combining acute imaging features to accurately predict final lesion volume.Methods—Using acute magnetic resonance imaging, we developed and trained a deep convolutional neural network (CNNdeep) to predict final imaging outcome. A total of 222 patients were included, of which 187 were treated with...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Anne Nielsen, Mikkel Bo Hansen, Anna Tietze, Kim Mouridsen Tags: Magnetic Resonance Imaging (MRI), Treatment, Quality and Outcomes, Statements and Guidelines, Ischemic Stroke Original Contributions Source Type: research
Progression of White Matter Hyperintensities Preceded by Heterogeneous Decline of Microstructural Integrity [Clinical Sciences]
Conclusions—Impaired microstructural integrity preceded conversion into WMH and continuously declined over time, suggesting a continuous disease process of white matter integrity loss that can be detected using diffusion tensor imaging even years before WMH become visible on conventional neuroimaging. Differences in microstructural integrity between participants with mild versus severe WMH suggest heterogeneity of both NAWM and WMH, which might explain the clinical variability observed in patients with similar small vessel disease severity. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Esther M.C. van Leijsen, Mayra I. Bergkamp, Ingeborg W.M. van Uden, Mohsen Ghafoorian, Helena M. van der Holst, David G. Norris, Bram Platel, Anil M. Tuladhar, Frank-Erik de Leeuw Tags: Etiology, Cardiovascular Disease, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Vascular Disease Original Contributions Source Type: research
Intravenous Recombinant Tissue-Type Plasminogen Activator [Clinical Sciences]
Conclusions—In this population, previous IVT improved functional outcome and survival at 3 months in patients treated by MT. While waiting for randomized controlled trials, this result encourages not to avoid IVT before MT. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Marc Ferrigno, Nicolas Bricout, Didier Leys, Laurent Estrade, Charlotte Cordonnier, Thomas Personnic, Maeva Kyheng, Hilde Henon Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Association of Basilar Bifurcation Aneurysms With Age, Sex, and Bifurcation Geometry [Clinical Sciences]
Background and Purpose—Basilar artery (BA) bifurcation aneurysms are common, but the correlation between BA bifurcation morphology and aneurysm formation remains to be established. Our purpose was to determine the association of BA bifurcation aneurysms with patient age, sex, bifurcation angle, and branch diameter.Methods—Three-dimensional angiographic data of 195 patients were used, including 59 patients with BA bifurcation aneurysms and 136 control subjects. The angles formed between left and right posterior cerebral arteries (φ1) and between posterior cerebral artery and BA (the smaller angle defined as φ2 and the...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Xue-Jing Zhang, Bu-Lang Gao, Tian-Xiao Li, Wei-Li Hao, Song-Shi Wu, Dong-Hai Zhang Tags: Basic Science Research, Cerebral Aneurysm Original Contributions Source Type: research
Perimesencephalic Hemorrhage [Clinical Sciences]
Conclusions—A single, high-quality computed tomography angiography is the preferred diagnostic strategy. Short-term complications are rare and often transient. Long-term outcome is excellent with respect to disability and death, but high-quality studies focused at neuropsychological sequelae are needed. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Liselore A. Mensing, Mervyn D.I. Vergouwen, Kamil G. Laban, Ynte M. Ruigrok, Birgitta K. Velthuis, Ale Algra, Gabriel J.E. Rinkel Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Multivessel Occlusion in Patients Subjected to Thrombectomy [Clinical Sciences]
Background and Purpose—Patients with embolic large-vessel occlusion may present with additional coincidental acute occlusions within or distant from the involved territory, referred to as multivessel occlusion (MVO). Purpose of this study was to assess prevalence of MVO, associated factors, and clinical relevance in patients undergoing endovascular stroke treatment.Methods—Image data of consecutive endovascular candidates (n=720) with direct access to angiography were extracted from a prospective registry. Prevalence of MVO was assessed with multimodal magnetic resonance imaging/computed tomography and confirmed by int...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Johannes Kaesmacher, Pascal J. Mosimann, Mattia Giarrusso, Marwan El-Koussy, Felix Zibold, Eike Piechowiak, Tomas Dobrocky, Raphael Meier, Simon Jung, Sebastian Bellwald, Marcel Arnold, Pasquale Mordasini, Urs Fischer, Jan Gralla Tags: Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Declining Rate and Severity of Hospitalized Stroke From 2004 to 2013 [Clinical Sciences]
Background and Purpose—Stroke is a leading cause of morbidity and disability. We assessed trends in rates of hospitalized stroke and stroke severity on admission in a prospective national registry of stroke from 2004 to 2013.Methods—All 6693 acute ischemic strokes and intracerebral hemorrhage in the National Acute Stroke Israeli participants ≥20 years old were included. Data were prospectively collected in 2004 (February–March), 2007 (March–April), 2010 (April–May), and 2013 (March–April). Rates of hospitalized stroke from 2004 to 2013 were studied using generalized linear models assuming a quasi-Poisson erro...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Silvia Koton, Diklah Geva, Jonathan Y. Streifler, Sagi Harnof, Yoav Pougach, Olga Azrilin, Shoshana Hadar, Natan M. Bornstein, David Tanne Tags: Cardiovascular Disease, Epidemiology, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia [Clinical Sciences]
Conclusions—Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. Mechanisms underlying white matter alterations are shared with cerebrovascular disease, and inherited differences in white matter microstructure impact on Alzheimer disease and major depressive disorder. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Daniel J. Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Longitudinal Change of Perceived Salt Intake and Stroke Risk in a Chinese Population [Clinical Sciences]
Conclusions—Change in salt intake was associated with the stroke risk. These data support the dietary recommendation to the reduction of salt intake. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Yun Li, Zhe Huang, Cheng Jin, Aijun Xing, Yesong Liu, Chunmei Huangfu, Alice H. Lichtenstein, Katherine L. Tucker, Shouling Wu, Xiang Gao Tags: Diet and Nutrition, Epidemiology, Lifestyle, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease [Clinical Sciences]
Conclusions—Our Mendelian randomization study provides evidence to suggest that T2D may be causally associated with CSVD, in particular with lacunar stroke and FA. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Junfeng Liu, Loes Rutten-Jacobs, Ming Liu, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Population-Based Assessment of the Long-Term Risk of Seizures in Survivors of Stroke [Clinical Sciences]
Background and Purpose—We sought to determine the long-term risk of seizures after stroke according to age, sex, race, and stroke subtype.Methods—We performed a retrospective cohort study using administrative claims from 2 complementary patient data sets. First, we analyzed data from all emergency department visits and hospitalizations in California, Florida, and New York from 2005 to 2013. Second, we evaluated inpatient and outpatient claims from a nationally representative 5% random sample of Medicare beneficiaries. Our cohort consisted of all adults at the time of acute stroke hospitalization without a prior history...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Alexander E. Merkler, Gino Gialdini, Michael P. Lerario, Neal S. Parikh, Nicholas A. Morris, Benjamin Kummer, Lauren Dunn, Michael E. Reznik, Santosh B. Murthy, Babak B. Navi, Zachary M. Grinspan, Costantino Iadecola, Hooman Kamel Tags: Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Stroke: Highlights of Selected Articles [Stroke: Highlights of Selected Articles]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Stroke: Highlights of Selected Articles Source Type: research
Secondary Stroke Prevention in Atrial Fibrillation [Editorials]
(Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: M. Edip Gurol Tags: Atrial Fibrillation, Secondary Prevention, Cerebrovascular Disease/Stroke Editorial Source Type: research
