Combining Spot Sign and Intracerebral Hemorrhage Score to Estimate Functional Outcome [Brief Report]
Conclusions—In the PREDICT cohort, a prognostic score adding the computed tomographic angiography–based spot sign to the established ICH score did not improve functional outcome prediction compared with the ICH score. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Hauke Schneider, Thien J. Huynh, Andrew M. Demchuk, Dar Dowlatshahi, David Rodriguez-Luna, Yolanda Silva, Richard Aviv, Imanuel Dzialowski Tags: Computerized Tomography (CT), Imaging, Prognosis, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Brief Reports Source Type: research
Relation of RhoA in Peripheral Blood Mononuclear Cells With Severity of Aneurysmal Subarachnoid Hemorrhage and Vasospasm [Brief Report]
Conclusions—Our preliminary results indicate that RhoA expression and activity in peripheral blood mononuclear cells might be related with aSAH severity and cerebral vasospasm. RhoA is a potential biomarker of the risks associated with aSAH. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Maria del Carmen Gonzalez–Montelongo, Juan Jose Egea–Guerrero, Francisco Murillo–Cabezas, Rafaela Gonzalez–Montelongo, Zaida Ruiz de Azua–Lopez, Ana Rodriguez–Rodriguez, Angel Vilches–Arenas, Antonio Castellano, J Tags: Basic Science Research, Biomarkers Brief Reports Source Type: research
Misdiagnosis of Cerebral Vein Thrombosis in the Emergency Department [Brief Report]
Conclusions—In a large, heterogeneous multistate cohort, probable misdiagnosis of CVT occurred in 1 of 30 patients but was not associated with the adverse clinical outcomes included in our study. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Ava L. Liberman, Gino Gialdini, Ekaterina Bakradze, Abhinaba Chatterjee, Hooman Kamel, Alexander E. Merkler Tags: Quality and Outcomes, Thrombosis Brief Reports Source Type: research
Synergistic Effects of Enriched Environment and Task-Specific Reach Training on Poststroke Recovery of Motor Function [Basic Sciences]
Conclusions—Task-specific reach training and environmental enrichment have synergistic effects in rats that persist long after rehabilitation ends, and this recovery is predicted by infarct volume and rehabilitation intensity. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Matthew Strider Jeffers, Dale Corbett Tags: Animal Models of Human Disease, Rehabilitation, Ischemic Stroke Original Contributions Source Type: research
Role of Myeloid Lineage Cell Autophagy in Ischemic Brain Injury [Basic Sciences]
In this study, we investigated the roles of myeloid cell autophagy in ischemic brain injury.Methods—Focal cerebral ischemia was induced via transient middle cerebral artery occlusion in mice with autophagy-deficient myeloid lineage cells (Atg5flox/flox LysMCre+) and in their littermate controls (Atg5flox/flox). Infarct volume, neurological function, inflammatory cell infiltration, and proinflammatory cytokine expression levels were evaluated.Results—Mice lacking autophagy in myeloid lineage cells had a lower survival rate for 14 days than control mice (20% versus 70%; P (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Masakazu Kotoda, Hajime Furukawa, Takeshi Miyamoto, Masaaki Korai, Fumiaki Shikata, Atsushi Kuwabara, Xiaoxing Xiong, Caleb Rutledge, Rona G. Giffard, Tomoki Hashimoto Tags: Cerebral Aneurysm, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Early Blood-Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules [Basic Sciences]
Conclusions—Early BBBD in focal cerebral ischemia initiates multifocally in the distal capillary and venular bed of the cerebral microvasculature. It is closely associated with perimicrovascular vasogenic edema and microglial activation and predicts the extent of final infarction. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Angelika Hoffmann, Tassilo Dege, Reiner Kunze, Anne–Sophie Ernst, Holger Lorenz, Laura–Ines Bohler, Thomas Korff, Hugo H. Marti, Sabine Heiland, Martin Bendszus, Xavier Helluy, Mirko Pham Tags: Biomarkers, Vascular Biology, Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Ischemic Stroke Original Contributions Source Type: research
Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury [Basic Sciences]
Conclusions—Our findings suggest that brain ischemia activates and diversifies T-cell responses locally, which exacerbates ischemic brain injury. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Wei-Na Jin, Rayna Gonzales, Yan Feng, Kristofer Wood, Zhi Chai, Jing-Fei Dong, Antonio La Cava, Fu-Dong Shi, Qiang Liu Tags: Ischemic Stroke Original Contributions Source Type: research
Cost-Effectiveness of Left Atrial Appendage Closure With the WATCHMAN Device Compared With Warfarin or Non-Vitamin K Antagonist Oral Anticoagulants for Secondary Prevention in Nonvalvular Atrial Fibrillation [Clinical Sciences]
Conclusions—Upfront procedure costs initially make LAAC higher cost than warfarin and the non–vitamin K antagonist oral anticoagulants, but within 10 years, LAAC delivers more quality-adjusted life years and has lower total costs, making LAAC the most cost-effective treatment strategy for secondary prevention of stroke in atrial fibrillation. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Vivek Y. Reddy, Ronald L. Akehurst, Stacey L. Amorosi, Meghan B. Gavaghan, Deanna S. Hertz, David R. Holmes Jr Tags: Atrial Fibrillation, Cost-Effectiveness Original Contributions Source Type: research
Long-Term Outcomes in Patients Aged
Background and Purpose—We aimed to determine whether subjects aged ≤70 years who were treated with intravenous glyburide (RP-1127; BIIB093; glibenclamide) would have better long-term outcomes than those who received placebo.Methods—GAMES-RP (Glyburide Advantage in Malignant Edema and Stroke–Remedy Pharmaceuticals) was a prospective, double-blind, randomized, placebo-controlled phase 2 clinical trial. Eighty-six participants, aged 18 to 80 years, who presented to 18 centers with large hemispheric infarction (baseline diffusion-weighted imaging volumes, 82–300 cm3) randomized within 10 hours of symptom onset were e...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Kevin N. Sheth, Nils H. Petersen, Ken Cheung, Jordan J. Elm, Holly E. Hinson, Bradley J. Molyneaux, Lauren A. Beslow, Gordon K. Sze, J. Marc Simard, W. Taylor Kimberly Tags: Treatment, Ischemic Stroke Original Contributions Source Type: research
Association of Blood Pressure With Short- and Long-Term Functional Outcome After Stroke Thrombectomy [Clinical Sciences]
This study aims to assess the association of BP changes during general anesthesia versus conscious sedation with functional outcome after mechanical thrombectomy.Methods—SIESTA (Sedation vs Intubation for Endovascular Stroke Treatment) was a monocentric randomized trial of general anesthesia versus conscious sedation during mechanical thrombectomy involving BP target protocols. In this post hoc analysis, BP measurements were divided into 4 phases: preintervention, prerecanalization, postrecanalization, and postintervention. We examined the association between BP and functional outcomes (defined by improvement of 24-hour ...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Silvia Schonenberger, Lorenz Uhlmann, Matthias Ungerer, Johannes Pfaff, Simon Nagel, Christina Klose, Martin Bendszus, Wolfgang Wick, Peter A. Ringleb, Meinhard Kieser, Markus A. Mohlenbruch, Julian Bosel Tags: Ischemic Stroke Original Contributions Source Type: research
Cost-Effectiveness of Patent Foramen Ovale Closure Versus Medical Therapy for Secondary Stroke Prevention [Clinical Sciences]
Conclusions—PFO closure for cryptogenic strokes in the right setting is cost-effective, producing benefit in QALYs gained and potential cost savings. However, patient selection remains vitally important as marginal declines in treatment effectiveness can dramatically affect cost-effectiveness. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Michelle H. Leppert, Sharon N. Poisson, John D. Carroll, David E. Thaler, Chong H. Kim, Karen D. Orjuela, P. Michael Ho, James F. Burke, Jonathan D. Campbell Tags: Treatment, Cost-Effectiveness, Ischemic Stroke, Embolism Original Contributions Source Type: research
Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review [Clinical Sciences]
Background and Purpose—In patients with transient ischemic attack/ischemic stroke, microbleed burden predicts intracerebral hemorrhage (ICH), and ischemic stroke, but implications for antiplatelet treatment are uncertain. Previous cohort studies have had insufficient follow-up to assess the time course of risks, have not stratified risks by antithrombotic use, and have not reported extracranial bleeds or functional outcome of ICH versus ischemic stroke.Methods—In 2 independent prospective cohorts with transient ischemic attack/ischemic stroke (Oxford Vascular Study/mainly white; University of Hong Kong/mainly Chinese),...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Kui Kai Lau, Caroline E. Lovelock, Linxin Li, Michela Simoni, Sergei Gutnikov, Wilhelm Kuker, Henry Ka Fung Mak, Peter M. Rothwell Tags: Magnetic Resonance Imaging (MRI), Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Computed Tomographic Perfusion Predicts Poor Outcomes in a Randomized Trial of Endovascular Therapy [Clinical Sciences]
Conclusions—The majority of patients with CTP imaging in the ESCAPE trial had penumbral patterns, which were associated with better outcomes overall. Patients with penumbra treated with endovascular therapy had the greatest odds of good functional outcome. Nonpenumbral patients were much less likely to achieve good outcomes. (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Robert Wannamaker, Taurian Guinand, Bijoy K. Menon, Andrew Demchuk, Mayank Goyal, Donald Frei, Aditya Bharatha, Tudor G. Jovin, Jai Shankar, Timo Krings, Blaise Baxter, Christine Holmstedt, Richard Swartz, Dar Dowlatshahi, Richard Chan, Donatella Tampieri Tags: Ischemic Stroke Original Contributions Source Type: research
Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy [Clinical Sciences]
Background and Purpose—For suspected large vessel occlusion patients efficient transfer to centers that provide endovascular therapy (ET) is critical to maximizing treatment opportunity. Our objective was to examine associations between transfer time, modes of transfer, ET, and outcomes within a hub-and-spoke telestroke network.Methods—Patients with ischemic stroke were included if transferred to a single hub hospital between January 2011 and October 2015 with National Institutes of Health Stroke Scale>6, onset (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Robert W. Regenhardt, Adam P. Mecca, Stephanie A. Flavin, Gregoire Boulouis, Arne Lauer, Kori Sauser Zachrison, James Boomhower, Aman B. Patel, Joshua A. Hirsch, Lee H. Schwamm, Thabele M. Leslie-Mazwi Tags: Revascularization, Quality and Outcomes, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Blood Pressure-Attained Analysis of ATACH 2 Trial [Clinical Sciences]
Background and Purpose—We compared the rates of death or disability, defined by modified Rankin Scale score of 4 to 6, at 3 months in patients with intracerebral hemorrhage according to post-treatment systolic blood pressure (SBP)–attained status.Methods—We divided 1000 subjects with SBP ≥180 mm Hg who were randomized within 4.5 hours of symptom onset as follows: SBP (Source: Stroke)
Source: Stroke - May 25, 2018 Category: Neurology Authors: Adnan I. Qureshi, Yuko Y. Palesch, Lydia D. Foster, William G. Barsan, Joshua N. Goldstein, Daniel F. Hanley, Chung Y. Hsu, Claudia S. Moy, Mushtaq H. Qureshi, Robert Silbergleit, Jose I. Suarez, Kazunori Toyoda, Haruko Yamamoto, on behalf of ATACH 2 Tri Tags: Statements and Guidelines, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Contributions Source Type: research
