Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Heart Disease [Brief Report]
Background and Purpose—There is growing evidence about the importance of vitamin D for cardiovascular health. Therefore, we examined the relationship between dietary vitamin D intake and risk of mortality from stroke and coronary heart disease in Japanese population.Methods—A prospective study encompassing 58 646 healthy Japanese adults (23 099 men and 35 547 women) aged of 40 to 79 years in whom dietary vitamin D intake was determined via a self-administered food frequency questionnaire. The median follow-up period was 19.3 years (1989–2009). The hazard ratios and 95% confidence intervals of mortality were calcu...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Haytham A. Sheerah, Ehab S. Eshak, Renzhe Cui, Hironori Imano, Hiroyasu Iso, Akiko Tamakoshi Tags: Cardiovascular Disease, Diet and Nutrition, Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Brief Reports Source Type: research
Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis [Basic Science]
Conclusions—CoW regulatory regions link IA-associated SNPs to genes with a potential role in the development of IAs. Our data refine previous predictions on SNPs associated with IA and provide a substantial resource from which candidates for follow-up studies can be prioritized. (Source: Stroke)
Source: Stroke - January 22, 2018 Category: Neurology Authors: Melanie D. Laarman, Marit W. Vermunt, Rachel Kleinloog, Jelkȷe J. de Boer–Bergsma, Netherlands Brain Bank, Gabriel J.E. Rinkel, Menno P. Creyghton, Michal Mokry, Jeroen Bakkers, Ynte M. Ruigrok Tags: Computational Biology, Epigenetics, Gene Expression & Regulation, Cerebral Aneurysm, Intracranial Hemorrhage Original Contributions Source Type: research
Impact of Prehospital Triage Scales to Detect Large Vessel Occlusion on Resource Utilization and Time to Treatment [Clinical Sciences]
Conclusions—Implementation of prehospital triage based on stroke severity scales would have strong impact on patient flow and distribution. The benefit of earlier thrombectomy for patients with LVO may outweigh the harm associated with delayed access to thrombolysis for some patients without LVO. Randomized trials using clinical stroke severity scales as a triage tool are needed to confirm our findings. (Source: Stroke)
Source: Stroke - January 22, 2018 Category: Neurology Authors: Ludwig Schlemm, Martin Ebinger, Christian H. Nolte, Matthias Endres Tags: Revascularization, Health Services, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Neuroimaging Identifies Patients Most Likely to Respond to a Restorative Stroke Therapy [Clinical Sciences]
Background and Purpose—Patient heterogeneity reduces statistical power in clinical trials of restorative therapies. Valid predictors of treatment responsiveness are needed, and several have been studied with a focus on corticospinal tract (CST) injury. We studied performance of 4 such measures for predicting behavioral gains in response to motor training therapy.Methods—Patients with subacute-chronic hemiparetic stroke (n=47) received standardized arm motor therapy, and change in arm Fugl-Meyer score was calculated from baseline to 1 month post-therapy. Injury measures calculated from baseline magnetic resonance imagin...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Jessica M. Cassidy, George Tran, Erin B. Quinlan, Steven C. Cramer Tags: Biomarkers, Imaging, Rehabilitation, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Efficacy and Safety of Individualized Coaching After Stroke: the LAST Study (Life After Stroke) [Clinical Sciences]
Background and Purpose—The evidence for interventions to prevent functional decline in the long term after stroke is lacking. The aim of this trial was to evaluate the efficacy and safety of an 18-month follow-up program of individualized regular coaching on physical activity and exercise.Methods—This was a multicentre, pragmatic, single-blinded, randomized controlled trial. Adults (age ≥18 years) with first-ever or recurrent stroke, community dwelling, with modified Rankin Scale (Source: Stroke)
Source: Stroke - January 22, 2018 Category: Neurology Authors: Torunn Askim, Birgitta Langhammer, Hege Ihle-Hansen, Mari Gunnes, Stian Lydersen, Bent Indredavik, on behalf of the LAST Collaboration Group* Tags: Exercise, Lifestyle, Secondary Prevention, Compliance/Adherence, Rehabilitation Original Contributions Source Type: research
