Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation [Basic Sciences]
Conclusions—Although microhemorrhages are small in size, the brain responds to a single bleed with an inflammatory response that involves brain-resident and blood-derived cells, persists for weeks, and may impact the adjacent brain microenvironment. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Sung Ji Ahn, Josef Anrather, Nozomi Nishimura, Chris B. Schaffer Tags: Animal Models of Human Disease, Inflammation, Imaging, Intracranial Hemorrhage Original Contributions Source Type: research
Taurine Reduces tPA (Tissue-Type Plasminogen Activator)-Induced Hemorrhage and Microvascular Thrombosis After Embolic Stroke in Rat [Basic Sciences]
Conclusions—Our results suggest that taurine in combination with tPA may be a clinically feasible approach toward future attempts at combination stroke therapy. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Rong Jin, Adam Y. Xiao, Shan Liu, Min Wang, Guohong Li Tags: Animal Models of Human Disease, Ischemic Stroke Original Contributions Source Type: research
Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice [Basic Sciences]
Conclusions—miR-141-3p is increased with poststroke isolation. Inhibition of miR-141-3p improved mortality, neurological deficits, and decreased infarct volumes. Importantly, these therapeutic effects occurred in aged animals, the population most at risk for stroke and poststroke isolation. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Rajkumar Verma, Rodney M. Ritzel, Nia M. Harris, Juneyoung Lee, TaeHee Kim, Gopal Pandi, Raghu Vemuganti, Louise D. McCullough Tags: Basic Science Research, Ischemia, Translational Studies Original Contributions Source Type: research
Impact of Transcranial Doppler Ultrasound on Logistics and Outcomes in Stroke Thrombolysis [Clinical Sciences]
Background and Purpose—Diagnostic transcranial Doppler ultrasound (TCD) is commonly used in patients with acute stroke before or during treatment with intravenous thrombolysis (IVT). We aimed to assess how much TCD delays IVT initiation and whether TCD influences outcomes.Methods—We analyzed data from the SITS-ISTR (Safe Implementation of Thrombolysis in Stroke–International Stroke Thrombolysis Register) collected from December 2002 to December 2011. Outcomes were door-to-needle time, symptomatic intracerebral hemorrhage, functional outcome per the modified Rankin Scale, and mortality at 3 months.Results—In hospita...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Michael V. Mazya, Niaz Ahmed, Elsa Azevedo, Antoni Davalos, Laura Dorado, Michal Karlinski, Svetlana Lorenzano, Jiři Neumann, Danilo Toni, Tiago P. Moreira Tags: Ultrasound, Health Services, Ischemic Stroke Original Contributions Source Type: research
Efficacy of Endovascular Therapy in Acute Ischemic Stroke Depends on Age and Clinical Severity [Clinical Sciences]
Background and Purpose—Efficacy of endovascular treatment (EVT) for ischemic stroke because of large vessel occlusion may depend on patients’ age and stroke severity; we, therefore, developed a prognosis score based on these variables and examined whether EVT efficacy differs between patients with good, intermediate, or poor prognostic score.Methods—A total of 4079 patients with an acute ischemic stroke were identified from the Paris Stroke Consortium registry. We developed the stroke checkerboard (SC) score (SC score=1 point per decade ≥50 years of age and 2 points per 5 points on the National Institutes of Health...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Raphael Le Bouc, Frederic Clarencon, Elena Meseguer, Bertrand Lapergue, Arturo Consoli, Guillaume Turc, Olivier Naggara, Duc Long Duong, Jerome Servan, Peggy Reiner, Marc Antoine Labeyrie, Mathieu Fisselier, Raphael Blanc, Wassim Farhat, Christine Pires, Tags: Revascularization, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial [Clinical Sciences]
Conclusions—In this secondary analysis from SOCRATES, fewer primary end points occurred on ticagrelor treatment than on aspirin in patients receiving aspirin before randomization, but there was no significant treatment-by-prior-aspirin interaction. A new study will investigate the benefit-risk of combining ticagrelor and aspirin in patients with acute cerebral ischemia (URL: https://www.clinicaltrials.gov. Unique identifier: NCT03354429).Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT01994720. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: K.S. Lawrence Wong, Pierre Amarenco, Gregory W. Albers, Hans Denison, J. Donald Easton, Scott R. Evans, Peter Held, Anders Himmelmann, Scott E. Kasner, Mikael Knutsson, Per Ladenvall, Kazuo Minematsu, Carlos A. Molina, Yongjun Wang, S. Claiborne Johnston Tags: Ischemic Stroke Original Contributions Source Type: research
Similar Outcomes for Contact Aspiration and Stent Retriever Use According to the Admission Clot Burden Score in ASTER [Clinical Sciences]
Conclusions—First-line mechanical thrombectomy with contact aspiration compared with stent retriever did not result in an increased successful reperfusion rate in acute ischemic stroke patients with large vessel occlusion of the anterior circulation according to the admission CBS. The latter, however, seems to be a reliable prognostic indicator of angiographic and clinical outcome. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Francois Zhu, Bertrand Lapergue, Maeva Kyheng, Raphael Blanc, Julien Labreuche, Malek Ben Machaa, Alain Duhamel, Gautier Marnat, Suzana Saleme, Vincent Costalat, Serge Bracard, Sebastien Richard, Hubert Desal, Mikael Mazighi, Arturo Consoli, Michel Piotin Tags: Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Beyond Large Vessel Occlusion Strokes [Clinical Sciences]
Conclusions—Distal intracranial occlusions can be treated safely and successfully with endovascular therapy. These results need to be corroborated by larger prospective controlled studies. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Jonathan A. Grossberg, Leticia C. Rebello, Diogo C. Haussen, Mehdi Bouslama, Meredith Bowen, Clara M. Barreira, Samir R. Belagaje, Michael R. Frankel, Raul G. Nogueira Tags: Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
Texture Analysis of T1-Weighted and Fluid-Attenuated Inversion Recovery Images Detects Abnormalities That Correlate With Cognitive Decline in Small Vessel Disease [Clinical Sciences]
Conclusions—TP, which can be obtained from routine clinical images, are abnormal in SVD, and the degree of abnormality correlates with executive dysfunction and global cognition at baseline and decline during 5 years. TP may be useful to assess disease severity in clinically collected data. This needs testing in data clinically acquired across multiple sites. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Daniel J. Tozer, Eva Zeestraten, Andrew J. Lawrence, Thomas R. Barrick, Hugh S. Markus Tags: Imaging, Magnetic Resonance Imaging (MRI), Vascular Disease Original Contributions Source Type: research
Quantifying Infarct Growth and Secondary Injury Volumes [Clinical Sciences]
Conclusions—The contributions of IG and AD to lesion expansion can be measured separately over time through the use of image registration. This approach can be used to combine imaging outcome data from computed tomography and MRI. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: George W.J. Harston, Davide Carone, Fintan Sheerin, Mark Jenkinson, James Kennedy Tags: Imaging, Ischemic Stroke Original Contributions Source Type: research
Long-Term Prognosis of Patients With Transient Ischemic Attack or Stroke and Symptomatic Vascular Disease in Multiple Arterial Beds [Clinical Sciences]
Background and Purpose—Cerebrovascular, coronary, and peripheral vascular disease have common underlying arterial pathology and risk factors, but the clinical significance of multiple-territory disease in patients with transient ischemic attack (TIA)/ischemic stroke is unclear, particularly whether the number of clinically affected territories still predicts long-term outcome on current standard secondary prevention therapies.Methods—In a population-based study of 92 728 individuals in Oxfordshire, United Kingdom (Oxford Vascular Study), we studied patients presenting with TIA/ischemic stroke (2002–2014) in relatio...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Mirjam R. Heldner, Linxin Li, Nicola G. Lovett, Magdalena M. Kubiak, Shane Lyons, Peter M. Rothwell Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA), Vascular Disease Original Contributions Source Type: research
Baroreflex Impairment After Subarachnoid Hemorrhage Is Associated With Unfavorable Outcome [Clinical Sciences]
Conclusions—In SAH, early BRS was associated with 3-month outcome. This conclusion requires confirmation on a larger number of patients in a multicentre study. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Nathalie Nasr, Rita Gaio, Marek Czosnyka, Karol Budohoski, Xiuyun Liu, Joseph Donnelly, Marek Sykora, Peter Kirkpatrick, Anne Pavy-Le Traon, Christina Haubrich, Vincent Larrue, Peter Smielewski Tags: Autonomic Nervous System, Pathophysiology, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
High Serum Level of Matrix Metalloproteinase-7 Is Associated With Increased Risk of Spontaneous Subarachnoid Hemorrhage [Clinical Sciences]
Conclusions—High serum level of MMP-7 was associated with increased risk of incident spontaneous SAH, independently of the main risk factors for SAH. High serum levels of MMP-2 and MMP-9 did not predict SAH risk. (Source: Stroke)
Source: Stroke - June 25, 2018 Category: Neurology Authors: Martin Soderholm, Gunilla Nordin Fredrikson, Jan Nilsson, Gunnar Engstrom Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Original Contributions Source Type: research
17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage [Clinical Sciences]
Background and Purpose—Hematoma volume is an important determinant of clinical outcome in spontaneous intracerebral hemorrhage (ICH). We performed a genome-wide association study (GWAS) of hematoma volume with the aim of identifying novel biological pathways involved in the pathophysiology of primary brain injury in ICH.Methods—We conducted a 2-stage (discovery and replication) case-only genome-wide association study in patients with ICH of European ancestry. We utilized the admission head computed tomography to calculate hematoma volume via semiautomated computer-assisted technique. After quality control and imputatio...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Sandro Marini, William J. Devan, Farid Radmanesh, Laura Miyares, Timothy Poterba, Bȷorn M. Hansen, Bo Norrving, Jordi Jimenez–Conde, Eva Giralt–Steinhauer, Roberto Elosua, Elisa Cuadrado–Godia, Carolina Soriano, Jaume Roquer, Chri Tags: Genetics, Computerized Tomography (CT), Quality and Outcomes, Intracranial Hemorrhage Original Contributions Source Type: research
Effects of Blood Pressure in the Early Phase of Ischemic Stroke and Stroke Subtype on Poststroke Cognitive Impairment [Clinical Sciences]
This study was to investigate the impact of BP levels in the early phase of ischemic stroke and stroke subtype on PSCI.Methods—Seven hundred and ninety-six patients with acute ischemic stroke were included. Cognitive function was assessed after stroke onset using the Montreal Cognitive Assessment. Patients were divided into quintiles according to systolic BP and diastolic BP levels in the early phase. Subtype analyses were according to Trial of ORG 10172 in Acute Stroke Treatment classification (infarct cause) and Oxfordshire Community Stroke Project classification (infarct location).Results—After adjusting for multipl...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Mingli He, Jin’e Wang, Na Liu, Xiao Xiao, Shan Geng, Pin Meng, Niu Ji, Yong’an Sun, Bingchao Xu, Yingda Xu, Xinyu Zhou, Guanghui Zhang, Xiaobing He, Zenglin Cai, Zaipo Li, Bei Wang, Bei Xu, Rutai Hui, Yibo Wang Tags: High Blood Pressure, Cognitive Impairment, Ischemic Stroke Original Contributions Source Type: research
