The effect of finasteride and dutasteride on the synthesis of neurosteroids by glioblastoma cells
Publication date: Available online 20 December 2019Source: SteroidsAuthor(s): Pinacho-Garcia Luis Manuel, Valdez Ricardo A, Navarrete Araceli, Cabeza Marisa, Segovia Jose, Romano Marta CAbstractGlioblastoma (GBM) is the most aggressive local brain tumor and effective treatments are lacking. Many studies have proposed an important participation of steroid hormones in the development of gliomas. Evidence was provided by statistics analysis where the incidence in adult population is 50% higher in men than in women. Female patients have a better prognosis for survival compared to male patients with GBM. Also, the expression of...
Source: Steroids - December 21, 2019 Category: Drugs & Pharmacology Source Type: research
Cytotoxic steroidal saponins from the rhizome of Anemarrhena asphodeloides
Publication date: Available online 20 December 2019Source: SteroidsAuthor(s): Yun-Fang Zhao, Jing Zhou, Min-Jie Zhang, Min Zhang, Xue-Feng HuangAbstractTwo novel steroidal saponins, timosaponin V and W (1 and 2), together with seven known steroidal saponins (3-9), were isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, 1H-1H COSY, and NOESY), and MS analyses. The cytotoxic activities of the isolates were evaluated. Compound 1 showed a significant cytotoxic activity against MCF-7 and HepG2 cell lines with IC50 values of 2.16±0.19 μM a...
Source: Steroids - December 21, 2019 Category: Drugs & Pharmacology Source Type: research
Two new hydroperoxy steroids from the South China Sea gorgonian Rumphella sp.
Publication date: Available online 20 December 2019Source: SteroidsAuthor(s): Fang-Zhou Yin, Min Yang, Song-Wei Li, Meng-Jun Wu, Xia-Juan Huan, Ze-Hong Miu, Hong Wang, Yue-Wei GuoAbstractTwo new hydroperoxy steroids, namely, xidaosteroids A and B (1 and 2), along with five known related compounds 3–7, were isolated from the South China Sea gorgonian Rumphella sp.. Their structures were established by extensive spectroscopic analyses and comparison of the spectral data with those reported in the literature. In bioassay, compound 3 showed weak cytotoxicities against SNU-398 and Capan-1 cells.Graphical abstract: (Source: Steroids)
Source: Steroids - December 21, 2019 Category: Drugs & Pharmacology Source Type: research
Guest editorial: 11th international meeting on rapid responses to steroid hormones RRSH2018
Publication date: February 2020Source: Steroids, Volume 154Author(s): Brian J. Harvey (Source: Steroids)
Source: Steroids - December 18, 2019 Category: Drugs & Pharmacology Source Type: research
Steroid hormone receptors: a south american perspective
Publication date: Available online 10 December 2019Source: SteroidsAuthor(s): Patricia V. Elizalde, Cecilia J. Proietti (Source: Steroids)
Source: Steroids - December 12, 2019 Category: Drugs & Pharmacology Source Type: research
Protein kinase D2 Regulates Epithelial Sodium Channel Activity and Aldosterone Non-Genomic Responses in Renal Cortical Collecting Duct Cells
Publication date: Available online 11 December 2019Source: SteroidsAuthor(s): Warren Thomas, Ruth Dooley, Sinead Quinn, Manuel Yusef Robles, Brian J. HarveyAbstractProtein kinase D2 (PKD2) is a serine/ threonine protein kinase which plays an important role in vesicle fission at the trans-Golgi network (TGN) to coordinate subcellular trafficking with gene expression. We found that in the rat kidney, PKD2 is specifically expressed in collecting duct principal cells predominantly at the apical membrane and with lower basal expression in cytosolic compartments. When rats were maintained on a Na+ depleted diet (<0.87mmol Na...
Source: Steroids - December 12, 2019 Category: Drugs & Pharmacology Source Type: research
11th International Meeting on Rapid Responses to Steroid Hormones RRSH2018
Publication date: Available online 7 December 2019Source: SteroidsAuthor(s): Brian Harvey (Source: Steroids)
Source: Steroids - December 7, 2019 Category: Drugs & Pharmacology Source Type: research
Stanazolol derived ELISA as a sensitive forensic tool for the detection of multiple 17α-methylated anabolics
Publication date: Available online 5 December 2019Source: SteroidsAuthor(s): Lukáš Huml, Dominika Havlová, Ondřej Longin, Eliška Staňková, Barbora Holubová, Martin Kuchař, Elena Prokudina, Zdeňka Rottnerová, Tomáš Zimmermann, Pavel Drašar, Oldřich Lapčík, Michal JurášekAbstractTwo valuable forensic tools based on enzyme-linked immunoassays (ELISAs) for the analysis of 17α-methylated steroids were developed using haptens of stanazolol and its conjugates with biotin. Haptens containing terminal carboxylic group were conjugated to bovine serum albumin (BSA), rabbit serum albumin (RSA) or ovalbumin (OVA). E...
Source: Steroids - December 6, 2019 Category: Drugs & Pharmacology Source Type: research
The role of estrogen in intervertebral disc degeneration
Publication date: Available online 6 December 2019Source: SteroidsAuthor(s): Lin-Yu Jin, Xiao-Xing Song, Xin-Feng LiAbstractIntervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays a crucial role in the metabolic dysfunction of others musculoskeletal structures, such as bone, muscle, and tendon. In this review, we attempt to describe ...
Source: Steroids - December 6, 2019 Category: Drugs & Pharmacology Source Type: research
21-benzylidene digoxin decreases proliferation by inhibiting the egfr/erk signaling pathway and induces apoptosis in hela cells
Publication date: Available online 6 December 2019Source: SteroidsAuthor(s): Marco Túlio C. Pessôa, Jéssica M.M. Valadares, Sayonarah C. Rocha, Simone C. Silva, Jeff P. McDermott, Gladis Sánchez, Fernando P. Varotti, Cristóforo Scavone, Rosy I.M.A. Ribeiro, José A.F.P. Villar, Gustavo Blanco, Leandro A. BarbosaAbstractCardiotonic steroids (CTS) are agents traditionally known for their capacity to bind to the Na,K-ATPase (NKA), affecting the ion transport and the contraction of the heart. Natural CTS have been shown to also have effects on cell signaling pathways. With the goal of developing a new CTS derivative , we ...
Source: Steroids - December 6, 2019 Category: Drugs & Pharmacology Source Type: research
Endogenous steroid hormones in hair: investigations on different hair types, pigmentation effects and correlation to nails
In this study, a liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous identification and quantification of seven steroid hormones (cortisone, cortisol, 11-deoxycortisol, androstenedione, 11-deoxycorticosterone, testosterone, progesterone) in hair. Cortisol, cortisone, androstenedione, testosterone and progesterone were detected and quantified in authentic hair samples of different individuals. Significantly higher concentrations for body hair were found for cortisone and testosterone compared to scalp hair. Furthermore, missing correlations for the majority of steroids betw...
Source: Steroids - December 4, 2019 Category: Drugs & Pharmacology Source Type: research
Heterocyclic Steroids: Efficient Routes for Annulation of Pentacyclic Steroidal Pyrimidines
Publication date: Available online 2 December 2019Source: SteroidsAuthor(s): M. Monier, Ahmed El-Mekabaty, Doaa Abdel-Latif, Başak Doğru Mert, Khaled M. ElattarAbstractSteroids are components of cell membranes, signaling molecules and are a type of secondary metabolites as a result of their high impact of biological significance. The present review described the literature reports of pentacyclic steroidal pyrimidines as a type of heterocyclic steroids. The main sections included the synthesis of the investigated steroids fused at rings-A or B or D of steroid skeleton, synthesis of binary or linked-type pyrimidines, pyrim...
Source: Steroids - December 3, 2019 Category: Drugs & Pharmacology Source Type: research
Polyhydroxylated sterols from Monascus purpureus-fermented rice
Publication date: February 2020Source: Steroids, Volume 154Author(s): Jin-Jie Li, Xiang-Jian Zhong, Xin Wang, Xi-Miao Yang, Jian-Yu Yue, Xuan Zhang, Jia-Chen Liu, Kai-Qi Wang, Xiao-Ya ShangAbstractUsing a cell-based cytotoxicity assay, two new polyhydroxylated sterols, 16(S),22(S)-epoxy-3β,5α,6β,20(R),23(R),25-hexahydroxy-7-ergostene and 3β,7β,8α,25-tetrahydroxy-5,22E-ergostadiene were isolated from the ethyl acetate portion of the ethanolic extract of Monascus purpureus. Their structures were elucidated by spectroscopic analysis and in comparison with those reported in the literature. Both compounds showed cytotoxic...
Source: Steroids - November 29, 2019 Category: Drugs & Pharmacology Source Type: research
LncRNA-MALAT1 promotes osteogenic differentiation through regulating ATF4 by sponging miR-214: Implication of steroid-induced avascular necrosis of the femoral head
ConclusionMALAT1 was down-regulated, while miR-214 was elevated in SANFH tissues. MALAT1 promoted osteogenesis differentiation by sponging miR-214 to upregulate ATF4. (Source: Steroids)
Source: Steroids - November 26, 2019 Category: Drugs & Pharmacology Source Type: research
Anabolic/anticatabolic and adaptogenic effects of 24-epibrassinolide on Lupinus angustifolius: causes and consequences
Publication date: Available online 21 November 2019Source: SteroidsAuthor(s): Olga L. Kandelinskaya, Helena R. Grischenko, Vladimir A. Кhripach, Vladimir N. Zhabinskii, Lylia E. Kartizhova, Yuriy K. Shashko, Olga V. Kosmachevskaya, Elvira I. Nasybullina, Alexey F. TopunovAbstractLupinus angustifolius L. is a legume culture known as a source of valuable feed protein and the N2-fixator for improving soil fertility. However, its low ecological resistance does not allow for a stable yield of the crop. Earlier, we have shown that steroid phytohormone 24-epibrassinolide (EBR) increases the tolerance of lupine to chlorine ions b...
Source: Steroids - November 21, 2019 Category: Drugs & Pharmacology Source Type: research
