DUSP5 promotes osteogenic differentiation through SCP1/2 ‐dependent phosphorylation of SMAD1
DUSP5 promotes the osteogenic differentiation of mesenchymal stromal cells (MSCs) by repressing SMAD1 signaling pathway in a SCP1/2-dependent manner. The linker region of DUSP5 occupies the phosphatase domain of SCP1/2 and thereby releases the inhibitory effect of SCP1/2 on SMAD1 signaling. Additionally,Dusp5 overexpression could effectively ameliorate osteopenia of mice. AbstractDual-specificity phosphatases (DUSPs) are defined by their capability to dephosphorylate both phosphoserine/phosphothreonine (pSer/pThr) and phosphotyrosine (pTyr). DUSP5, a member of DUSPs superfamily, is located in the nucleus and plays cruciall...
Source: Stem Cells - July 10, 2021 Category: Stem Cells Authors: Xuejiao Liu,
Xuenan Liu,
Yangge Du,
Menglong Hu,
Yueming Tian,
Zheng Li,
Longwei Lv,
Xiao Zhang,
Yunsong Liu,
Yongsheng Zhou,
Ping Zhang Tags: Tissue ‐Specific Stem Cells Source Type: research
Corrigendum
(Source: Stem Cells)
Source: Stem Cells - July 6, 2021 Category: Stem Cells Tags: CORRIGENDUM Source Type: research
Bone marrow ‐derived progenitor cells contribute to remodeling of the postpartum uterus
In conclusion, BM-derived progenitors were found to have a novel nonhematopoietic cellular contribution to postpartum uterus remodeling. This contribution may have an important functional role in p hysiological as well as pathological postpartum endometrial regeneration.© AlphaMed Press 2021Significance StatementThe uterus undergoes significant tissue regeneration in the postpartum period following parturition where endometrial stem cells are thought to play an important role. Here we show that bone marrow-derived progenitor cells actively participate in postpartum uterus remodeling in the mouse, undergoing dynamic change...
Source: Stem Cells - July 5, 2021 Category: Stem Cells Authors: Reshef Tal,
Jacqueline Kisa,
Nafeesa Abuwala,
Harvey J. Kliman,
Shafiq Shaikh,
Alice Y. Chen,
Fang Lyu,
Hugh S. Taylor Tags: Tissue ‐Specific Stem Cells Source Type: research
Hematopoietic Stem Cell Derived Functional Osteoblasts Exhibit Therapeutic Efficacy in a Murine Model of Osteogenesis Imperfecta
This study unequivocally establishes that transplanting HSCs can improve the clinical outcomes in OI due to the ability of HSCs to differentiate into osteoblasts, which lay down normal collagen. Therefore, HSC transplantation holds enormous translational potential and could become the therapy of choice for bone repair in OI and other bone diseases. (Source: Stem Cells)
Source: Stem Cells - July 5, 2021 Category: Stem Cells Authors: In ‐Hong Kang,
Uday K. Baliga,
Yongren Wu,
Shikhar Mehrotra,
Hai Yao,
Amanda C. LaRue,
Meenal Mehrotra Tags: Regenerative Medicine Source Type: research
Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis ‐related genes in mouse embryonic stem cells
MGA bearing two distinct DNA-binding domains is a scaffolding component of PRC1.6 that prevents precocious and ectopic onset of meiosis in germ cells and ESCs, respectively. Here, we demonstrate that both Mga domains repress distinct sets of meiosis-related genes in ESCs. Our data also identifiedMeiosin as a linchpin molecule between positive and negative regulations of meiotic onset. AbstractAlthough the physiological meaning of the high potential of mouse ESCs for meiotic entry is not understood, a rigid safeguarding system is required to prevent ectopic onset of meiosis. PRC1.6, a non-canonical PRC1, is known for its su...
Source: Stem Cells - July 5, 2021 Category: Stem Cells Authors: Kousuke Uranishi,
Masataka Hirasaki,
Yuka Kitamura,
Yosuke Mizuno,
Masazumi Nishimoto,
Ayumu Suzuki,
Akihiko Okuda Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
Cytokine and epigenetic regulation of programmed death ‐ligand 1 in stem cell differentiation and cancer cell plasticity
SOX2-mediated reprogramming of fibroblasts or cancer plasticity of lung cancer cells inhibits programmed death-ligand 1 (PD-L1) expression (upper). SOX2 expression is negatively associated with PD-L1 as well as HBEGF/EGFR and TGF- β signaling molecules (middle). SOX2 interacts with HDAC1, which silences PD-L1 expression (lower left). TGF-β induces PD-L1 expression via MEK pathway, while HBEGF/EGFR enhances PD-L1 expression through MEK and AKT pathways (lower right). AbstractProgrammed death-ligand 1 (PD-L1), an immune checkpoint ligand, is recognized as a potential target for cancer immunotherapy as well as for the induc...
Source: Stem Cells - June 29, 2021 Category: Stem Cells Authors: Ming ‐Han Kuo,
Pei‐Yu Chen,
Yi‐Ping Yang,
Ming‐Yi Zheng,
Chia‐Cheng Miao,
Kuo‐Chang Wen,
Kuo‐Ming Chang,
Shih‐Jie Chou,
Mong‐Lien Wang,
Shih‐Hwa Chiou,
Yu‐Ting Chou Tags: Cancer Stem Cells Source Type: research
A preview of selected articles
(Source: Stem Cells)
Source: Stem Cells - June 26, 2021 Category: Stem Cells Authors: Stuart P. Atkinson Tags: PREVIEWS Source Type: research
Cover Image
Subretinal transplantation of CRX+ cells intoPde6brd1 mice. CRX-GFP+ cells (green) co-express opsin red-green (pink) and locate in close juxtaposition to the host bipolar cells shown by G0 α immunostaining (white).See Zerti et al. beginning on page882. (Source: Stem Cells)
Source: Stem Cells - June 26, 2021 Category: Stem Cells Tags: COVER IMAGE Source Type: research
Issue Information
(Source: Stem Cells)
Source: Stem Cells - June 26, 2021 Category: Stem Cells Tags: ISSUE INFORMATION Source Type: research
A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair, generating improved genetically stable human induced pluripotent stem cells
In conclusion, we show synthetic mRNA transfection ofCYCLIN D1 repairs DNA during reprogramming resulting in significantly improved genetically stable footprint in human iPSC, enabling a new cell reprogramming method for more accurate and reliable generation of human iPSC for disease modeling and future clinical applications. (Source: Stem Cells)
Source: Stem Cells - June 26, 2021 Category: Stem Cells Authors: Ana Bel én Alvarez‐Palomo,
Jordi Requena‐Osete,
Raul Delgado‐Morales,
Victoria Moreno‐Manzano,
Carme Grau‐Bove,
Agueda M. Tejera,
Manel Juan Otero,
Carme Barrot,
Irene Santos‐Barriopedro,
Alejandro Vaquero,
Jovita Mezquita‐Pla,
S Tags: EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS Source Type: research
Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC ‐1α activation
MSCs transfered mitochondria to M φ, which elicited Mφ into anti-inflammatory phenotype and ameliorated kidney injury through activation of PGC-1α. AbstractMesenchymal stem cells (MSCs) have fueled ample translation for treatment of immune-mediated diseases. Our previous study had demonstrated that MSCs could elicit macrophages (M φ) into anti-inflammatory phenotypes, and alleviate kidney injury in diabetic nephropathy (DN) mice via improving mitochondrial function of Mφ, yet the specific mechanism was unclear. Recent evidence indicated that MSCs communicated with their microenvironment through exchanges of mitochondr...
Source: Stem Cells - June 26, 2021 Category: Stem Cells Authors: Yujia Yuan,
Longhui Yuan,
Lan Li,
Fei Liu,
Jingping Liu,
Younan Chen,
Jingqiu Cheng,
Yanrong Lu Tags: REGENERATIVE MEDICINE Source Type: research
DUSP5 promotes osteogenic differentiation through SCP1/2 ‐dependent phosphorylation of SMAD1
DUSP5 promotes the osteogenic differentiation of MSCs by repressing SMAD1 signaling pathway in a SCP1/2 dependent manner. The linker region of DUSP5 occupies the phosphatase domain of SCP1/2 and thereby releases the inhibitory effect of SCP1/2 on SMAD1 signaling. Additionally,Dusp5 overexpression could effectively ameliorate osteopenia of mice. AbstractDual-specificity phosphatases (DUSPs) are defined by their capability to dephosphorylates both phosphoserine/phosphothreonine (pSer/pThr) and phosphotyrosine (pTyr). DUSP5, a member of DUSPs superfamily, is located in the nucleus and plays crucially regulatory role in the si...
Source: Stem Cells - June 25, 2021 Category: Stem Cells Authors: Xuejiao Liu,
Xuenan Liu,
Yangge Du,
Menglong Hu,
Yueming Tian,
Zheng Li,
Longwei Lv,
Xiao Zhang,
Yunsong Liu,
Yongsheng Zhou,
Ping Zhang Tags: Tissue ‐Specific Stem Cells Source Type: research
Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme ‐2 and masR receptor‐dependent
Angiotensin converting enzyme-2 (ACE-2) contributes to human placenta mesenchymal stem cell (hPMSC)-induced protection against ischemic injury through MasR pathway. AbstractThromboembolic stroke remains a major cause of neurological disability and death. Current stroke treatments (aspirin, tissue plasminogen activator) are significantly limited by timing and risks for hemorrhage which have driven researchers to explore other approaches. Stem cell-based therapy appears to be an effective option for ischemic stroke. Besides trans-differentiation into neural cells, stem cells also provide acute protection via paracrine signal...
Source: Stem Cells - June 22, 2021 Category: Stem Cells Authors: Mansoureh Barzegar,
Shantel Vital,
Karen Y. Stokes,
Yuping Wang,
Jungmi Winny Yun,
Luke A. White,
Oleg Chernyshev,
Roger E. Kelley,
Jonathan S. Alexander Tags: Regenerative Medicine Source Type: research
