Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats
Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action r... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Yang Wang, Xunwei Lai, Depeng Wu, Bin Liu, Nanxiang Wang and Limin Rong Tags: Research Source Type: research
Conditioned medium-preconditioned EPCs enhanced the ability in oligovascular repair in cerebral ischemia neonatal rats
Oligovascular niche mediates interactions between cerebral endothelial cells and oligodendrocyte precursor cells (OPCs). Disruption of OPC-endothelium trophic coupling may aggravate the progress of cerebral wh... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Ning Zhou, Lei Wang, Ping Fu, Zihao Cui, Yuhang Ge, Feiyu Jiang, Jing Liu, Chao Ren, Zuo Luan, Hongbin Fan and Ruiqin Yao Tags: Research Source Type: research
Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway
Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we ai... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Xiong Shu, Kai-Yue Cao, Hui-Qi Liu, Long Yu, Li-Xin Sun, Zhi-Hua Yang, Cheng-Ai Wu and Yu-Liang Ran Tags: Research Source Type: research
JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA methylation
Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone regeneration. Our previous study confirmed th... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Shuanglin Peng, Sirong Shi, Gang Tao, Yanjing Li, Dexuan Xiao, Lang Wang, Qing He, Xiaoxiao Cai and Jingang Xiao Tags: Research Source Type: research
Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration
Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction of the pancreatic β cells. The transplantation of mesenchymal stromal/stem cells (MSC) was reported to rescue the damaged pancreati... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Rahul Khatri, Sebastian Friedrich Petry and Thomas Linn Tags: Research Source Type: research
Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis
Cerebral ischemia-reperfusion (I/R) injury, the most common form of stroke, has high mortality and often brings persistent and serious brain dysfunction among survivors. Administration of adipose-derived mesen... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 5, 2021 Category: Stem Cells Authors: Yamei Zhang, Junying Liu, Mi Su, Xin Wang and Chenchen Xie Tags: Research Source Type: research
NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells
Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD+)-dependent sirtuins (SIRTs). SIRTs regulate functi... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 5, 2021 Category: Stem Cells Authors: Yun Xu, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Azadeh Zahabi, Karl Welte, Tatsuya Morishima and Julia Skokowa Tags: Research Source Type: research
Novel live cell fluorescent probe for human-induced pluripotent stem cells highlights early reprogramming population
Despite recent rapid progress in method development and biological understanding of induced pluripotent stem (iPS) cells, there has been a relative shortage of tools that monitor the early reprogramming proces... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 5, 2021 Category: Stem Cells Authors: Sandhya Sriram, Nam-Young Kang, Subha Subramanian, Tannistha Nandi, Samydurai Sudhagar, Qiaorui Xing, Gerine Jin-Ling Tong, Allen Kuan-Liang Chen, Thekkeparambil Chandrabose Srijaya, Patrick Tan, Yuin-Han Loh, Young-Tae Chang and Shigeki Sugii Tags: Method Source Type: research
Melatonin activates ABCA1 via the BiP/NRF1 pathway to suppress high-cholesterol-induced apoptosis of mesenchymal stem cells
Retarded wound healing in patients with obesity contributes to a risk of complications associated with vascular insufficiency and oxidative stress. The high cholesterol levels of patients with obesity are asso... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 5, 2021 Category: Stem Cells Authors: Jun Sung Kim, Young Hyun Jung, Hyun Jik Lee, Chang Woo Chae, Gee Euhn Choi, Jae Ryong Lim, Seo Yihl Kim, Joo Eun Lee and Ho Jae Han Tags: Research Source Type: research
MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway
Mesenchymal stem cells (MSCs) are favourable treatments for ischaemic diseases; however, MSCs from diabetic patients are not useful for this purpose. Recent studies have shown that the expression of miR-34a is... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 5, 2021 Category: Stem Cells Authors: Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu and Zhuoqi Zhang Tags: Research Source Type: research
Enhanced cell survival and therapeutic benefits of IL-10-expressing multipotent mesenchymal stromal cells for muscular dystrophy
Multipotent mesenchymal stromal cells (MSCs) are potentially therapeutic for muscle disease because they can accumulate at the sites of injury and act as immunosuppressants. MSCs are attractive candidates for ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 4, 2021 Category: Stem Cells Authors: Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Yuki Oda, Hiromi Hayashita-Kinoh, Shin ’ichi Takeda and Takashi Okada Tags: Research Source Type: research
Mesenchymal stromal cells as prophylaxis for graft-versus-host disease in haplo-identical hematopoietic stem cell transplantation recipients with severe aplastic anemia? —a systematic review and meta-analysis
Mesenchymal stromal cells (MSCs) are an emerging prophylaxis option for graft-versus-host disease (GVHD) in haplo-identical hematopoietic stem cell transplantation (haplo-HSCT) recipients with severe aplastic ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 4, 2021 Category: Stem Cells Authors: Ruonan Li, Jingke Tu, Jingyu Zhao, Hong Pan, Liwei Fang and Jun Shi Tags: Research Source Type: research
Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation
A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There ar... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 4, 2021 Category: Stem Cells Authors: Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang and Xueran Chen Tags: Research Source Type: research
STAT3 activation by catalpol promotes osteogenesis-angiogenesis coupling, thus accelerating osteoporotic bone repair
Bone fracture repair has gained a lot of attention due to the high incidence of delayed union or even nonunion especially in osteoporotic patients, resulting in a dreadful impact on the quality of life. Howeve... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 4, 2021 Category: Stem Cells Authors: Liang Chen, Ri-Yan Zhang, Jun Xie, Jia-Yi Yang, Kang-Hao Fang, Chen-Xuan Hong, Rong-Bo Yang, Najeeb Bsoul and Lei Yang Tags: Research Source Type: research
Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model
Novel therapeutic strategies for the healing of nonunion, which has serious effects on the quality of life of patients, are needed. We evaluated the therapeutic effect of local transplantation of human stromal... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 4, 2021 Category: Stem Cells Authors: Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Ta Tags: Research Source Type: research
