Robust expansion and functional maturation of human hepatoblasts by chemical strategy
Chemically strategies to generate hepatic cells from human pluripotent stem cells (hPSCs) for the potential clinical application have been improved. However, producing high quality and large quantities of hepa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 25, 2021 Category: Stem Cells Authors: Tingcai Pan, Jiawang Tao, Yan Chen, Jiaye Zhang, Anteneh Getachew, Yuanqi Zhuang, Ning Wang, Yingying Xu, Shenglin Tan, Ji Fang, Fan Yang, Xianhua Lin, Kai You, Yi Gao and Yin-xiong Li Tags: Research Source Type: research

Differential SOD2 and GSTZ1 profiles contribute to contrasting dental pulp stem cell susceptibilities to oxidative damage and premature senescence
Dental pulp stem cells (DPSCs) are increasingly being advocated as viable cell sources for regenerative medicine-based therapies. However, significant heterogeneity in DPSC expansion and multi-potency capabili... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 17, 2021 Category: Stem Cells Authors: Nadia Y. A. Alaidaroos, Amr Alraies, Rachel J. Waddington, Alastair J. Sloan and Ryan Moseley Tags: Research Source Type: research

Biological characteristics of stem cells derived from burned skin —a comparative study with umbilical cord stem cells
Burned human skin, which is routinely excised and discarded, contains viable mesenchymal stromal/stem cells (burn-derived mesenchymal stromal/stem cells; BD-MSCs). These cells show promising potential to enabl... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 17, 2021 Category: Stem Cells Authors: Reinhard Dolp, Gertraud Eylert, Christopher Auger, Ayesha Aijaz, Yufei Andy Chen, Saeid Amini-Nik, Alexandra Parousis, Andrea-Kaye Datu and Marc G. Jeschke Tags: Research Source Type: research

Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3+ T reg induction capacity
Mesenchymal stem cells (MSCs) exhibit active abilities to suppress or modulate deleterious immune responses by various molecular mechanisms. These cells are the subject of major translational efforts as cellul... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 17, 2021 Category: Stem Cells Authors: Yi Yu, Alejandra Vargas Valderrama, Zhongchao Han, Georges Uzan, Sina Naserian and Estelle Oberlin Tags: Research Source Type: research

Fetal liver hematopoiesis: from development to delivery
Clinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for many hematological diseases; however, therapeutic applications are hampered by donor availability. In vivo, HSC exist in... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 17, 2021 Category: Stem Cells Authors: Kyle Lewis, Momoko Yoshimoto and Takanori Takebe Tags: Review Source Type: research

The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells
Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-directional differentiation, and paracrine and immune regulation. As a result of these properties, the MSCs have great clinical... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 17, 2021 Category: Stem Cells Authors: Wanhao Yan, Shu Diao and Zhipeng Fan Tags: Review Source Type: research

Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVEC angiogenesis in vitro
As a large capillary network, the human placenta plays an important role throughout pregnancy. Placental vascular development is complex and delicate and involves many types of placental cells, such as trophob... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 17, 2021 Category: Stem Cells Authors: Haiying Ma, Shenglu Jiang, Lili Du, Jinfang Liu, Xiaoyan Xu, Xiaomei Lu, Ling Ma, Hua Zhu, Jun Wei and Yanqiu Yu Tags: Research Source Type: research

Silencing Smad7 potentiates BMP2-induced chondrogenic differentiation and inhibits endochondral ossification in human synovial-derived mesenchymal stromal cells
Bone morphogenetic protein 2 (BMP2) is a promising chondrogenic growth factor for cartilage tissue-engineering, but it also induces robust endochondral ossification. Human synovial-derived mesenchymal stromal ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 15, 2021 Category: Stem Cells Authors: Pengcheng Xiao, Zhenglin Zhu, Chengcheng Du, Yongsheng Zeng, Junyi Liao, Qiang Cheng, Hong Chen, Chen Zhao and Wei Huang Tags: Research Source Type: research

Mesenchymal stem cells modified by FGF21 and GLP1 ameliorate lipid metabolism while reducing blood glucose in type 2 diabetic mice
The purpose of this study was to investigate the therapeutic effects of genetically modified mesenchymal stem cells (MSCs) in the treatment of type 2 diabetes mellitus (T2DM) in order to identify a new method ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 15, 2021 Category: Stem Cells Authors: Binghua Xue, Xiuxiao Xiao, Tingting Yu, Xinhua Xiao, Jing Xie, Qiuhe Ji, Li Wang, Tao Na, Shufang Meng, Lingjia Qian and Haifeng Duan Tags: Research Source Type: research

Correction to: Human embryonic stem cell-derived extracellular vesicles alleviate retinal degeneration by upregulating Oct4 to promote retinal M üller cell retrodifferentiation via HSP90
An amendment to this paper has been published and can be accessed via the original article. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 15, 2021 Category: Stem Cells Authors: Yifeng Ke, Xiaoe Fan, Rui Hao, Lijie Dong, Min Xue, Liangzhang Tan, Chunbo Yang, Xiaorong Li and Xinjun Ren Tags: Correction Source Type: research

Editor ’s Note: Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury
(Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 15, 2021 Category: Stem Cells Authors: Virginie Neirinckx, Gulistan Agirman, C écile Coste, Alice Marquet, Valérie Dion, Bernard Rogister, Rachelle Franzen and Sabine Wislet Tags: Editor's Note Source Type: research

Retraction Note: microRNA-140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5
This arcticle has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13287-016-0438-5. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 15, 2021 Category: Stem Cells Authors: Lihui Yu, Ying Lu, Xiaocui Han, Wenyue Zhao, Jiazhi Li, Jun Mao, Bo Wang, Jie Shen, Shujun Fan, Lu Wang, Mei Wang, Lianhong Li, Jianwu Tang and Bo Song Tags: Retraction Note Source Type: research

Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction
Stroke serves as a prevalent cerebrovascular disorder with severe cerebral ischemia/reperfusion (CIR) injury, in which neural stem cells (NSCs) play critical roles in the recovery of cerebral function. Circula... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Bo Yang, Li ’e Zang, Jingwen Cui and Linlin Wei Tags: Research Source Type: research

Human amniotic mesenchymal stem cells to promote/suppress cancer: two sides of the same coin
Cancer is a leading cause of death in both developed and developing countries, and because of population growth and aging, it is a growing medical burden worldwide. With robust development in medicine, the use... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali and Hassan Niknejad Tags: Review Source Type: research

Co-culture of ASCs/EPCs and dermal extracellular matrix hydrogel enhances the repair of full-thickness skin wound by promoting angiogenesis
The repair of large-scale full-thickness skin defects represents a challenging obstacle in skin tissue engineering. To address the most important problem in skin defect repair, namely insufficient blood supply... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 12, 2021 Category: Stem Cells Authors: Shuang Lin, Xiaoning He and Yuanjia He Tags: Research Source Type: research