H3K9ac of TGF βRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy
Epidemiological investigation and our previous reports indicated that osteoarthritis had a fetal origin and was closely associated with intrauterine growth retardation (IUGR). Human Wharton ’s jelly-derived mes... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 4, 2021 Category: Stem Cells Authors: Yongjian Qi, Bin Li, Yinxian Wen, Xu Yang, Biao Chen, Zheng He, Zhe Zhao, Jacques Magdalou, Hui Wang and Liaobin Chen Tags: Research Source Type: research

Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 3, 2021 Category: Stem Cells Authors: Yun-Xing Fu, Jing Ji, Fang Shan, Jialing Li and Rong Hu Tags: Review Source Type: research

The angiogenic potential of CD271+ human adipose tissue-derived mesenchymal stem cells
Autologous fat grafting is often a crucial aspect of reconstructive and aesthetic surgeries, yet poor graft retention is a major issue with this technique. Enriching fat grafts with adipose tissue-derived mese... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 2, 2021 Category: Stem Cells Authors: Richard J. P. Smith, Alessandro Faroni, James R. Barrow, Jamie Soul and Adam J. Reid Tags: Research Source Type: research

Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?
A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing social, economic, and health problems. The COVID-19 triggers a lung infection with a multi... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 1, 2021 Category: Stem Cells Authors: Rodrigo N. Riedel, Antonio P érez-Pérez, Víctor Sánchez-Margalet, Cecilia L. Varone and Julieta L. Maymó Tags: Review Source Type: research

The effects of BMMSC treatment on lung tissue degeneration in elderly macaques
Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, ca... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 1, 2021 Category: Stem Cells Authors: Yu-kun Yang, Ye Li, Yan-ying Wang, Guang-ping Ruan, Chuan Tian, Qiang Wang, Huan-yu He, Gao-hong Zhu, Dong Fang, Mao Wang, Xiang-qing Zhu and Xing-hua Pan Tags: Research Source Type: research

Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and enhances adipogenic versus osteogenic differentiation in human bone marrow mesenchymal stem cells by sponging miR-431-5p
As one of the most common chronic diseases in the world, osteoporosis occurs especially in postmenopausal women. Circular RNAs (circRNAs) are emerging as major drivers in human disease. The aim of the present ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 1, 2021 Category: Stem Cells Authors: Feng Zhi, Yi Ding, Rong Wang, Yujiao Yang, Kaiming Luo and Fei Hua Tags: Research Source Type: research

Induction therapy with mesenchymal stromal cells in kidney transplantation: a meta-analysis
The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 1, 2021 Category: Stem Cells Authors: Lingfei Zhao, Chenxia Hu, Fei Han, Dajin Chen, Jun Cheng, Jianyong Wu, Wenhan Peng and Jianghua Chen Tags: Research Source Type: research

METTL3-mediated m6A modification regulates cell cycle progression of dental pulp stem cells
Dental pulp stem cells (DPSCs) are a promising cell source in endodontic regeneration and tissue engineering with limited self-renewal and pluripotency capacity. N6-methyladenosine (m6A) is the most prevalent, re... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - March 1, 2021 Category: Stem Cells Authors: Haiyun Luo, Wenjing Liu, Yanli Zhang, Yeqing Yang, Xiao Jiang, Shiqing Wu and Longquan Shao Tags: Research Source Type: research

Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling
Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 27, 2021 Category: Stem Cells Authors: Zhen-Xiong Jin, Xin-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao, Xiao-Feng Li and De-Zhi Tang Tags: Research Source Type: research

Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products
Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a perspective for therapeutic use in immune and inflammatory diseases. Indeed, immunomodulatory and anti-inflammatory properties, assoc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 26, 2021 Category: Stem Cells Authors: Miryam Mebarki, Camille Abadie, J érôme Larghero and Audrey Cras Tags: Review Source Type: research

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells
Mesenchymal stem cells (MSCs) have been utilized in treating acute graft-versus-host disease (aGvHD) as they show strong immunosuppressive capacity through the release of various mediators, including immunosup... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 26, 2021 Category: Stem Cells Authors: Weijiang Liu, Na Zhou, Yuanlin Liu, Wei Zhang, Xue Li, Yang Wang, Rongxiu Zheng and Yi Zhang Tags: Research Source Type: research

Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is an age-related disease with no cure. Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy for IPF treatment. Nevertheless, MSCs derived from patients... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 25, 2021 Category: Stem Cells Authors: Linli Shi, Qian Han, Yimei Hong, Weifeng Li, Gencheng Gong, Jiangyu Cui, Mengmeng Mao, Xiaoting Liang, Bei Hu, Xin Li, Qun Luo and Yuelin Zhang Tags: Research Source Type: research

Osteoclastic effects of mBMMSCs under compressive pressure during orthodontic tooth movement
This study aimed to inv... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 25, 2021 Category: Stem Cells Authors: Jing Wang, Delong Jiao, Xiaofeng Huang and Yuxing Bai Tags: Research Source Type: research

GPR4 signaling is essential for the promotion of acid-mediated angiogenic capacity of endothelial progenitor cells by activating STAT3/VEGFA pathway in patients with coronary artery disease
Patients with coronary artery disease (CAD) are characterized by a decline in vascular regeneration, which is related to the dysfunction of endothelial progenitor cells (EPCs). G-protein-coupled receptor 4 (GP... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 25, 2021 Category: Stem Cells Authors: Shun Ouyang, Yan Li, Xing Wu, Yan Wang, Fanmao Liu, Jianning Zhang, Yumin Qiu, Zhe Zhou, Zhichao Wang, Wenhao Xia and Xiufang Lin Tags: Research Source Type: research

Melatonin promotes bone marrow mesenchymal stem cell osteogenic differentiation and prevents osteoporosis development through modulating circ_0003865 that sponges miR-3653-3p
Little is known about the implications of circRNAs in the effects of melatonin (MEL) on bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoporosis (OP) progression. The aim of our stu... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - February 25, 2021 Category: Stem Cells Authors: Xudong Wang, Taiqiu Chen, Zhihuai Deng, Wenjie Gao, Tongzhou Liang, Xianjian Qiu, Bo Gao, Zizhao Wu, Jincheng Qiu, Yuanxin Zhu, Yanbo Chen, Zhancheng Liang, Hang Zhou, Caixia Xu, Anjing Liang, Peiqiang Su & hellip; Tags: Research Source Type: research