miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia
Inflammatory smooth muscle cells (iSMCs) generated from adventitial stem/progenitor cells (AdSPCs) have been recognised as a new player in cardiovascular disease, and microRNA-214-3p (miR-214-3p) has been impl... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 3, 2020 Category: Stem Cells Authors: Shiping He, Feng Yang, Mei Yang, Weiwei An, Eithne Margaret Maguire, Qishan Chen, Rui Xiao, Wei Wu, Li Zhang, Wen Wang and Qingzhong Xiao Tags: Research Source Type: research
Circular RNA SIPA1L1 regulates osteoblastic differentiation of stem cells from apical papilla via miR-204-5p/ALPL pathway
Osteogenesis is a complex biological process which requires the coordination of multiple molecular mechanisms. This research aimed to explore the biological role and underlying regulatory mechanism of circSIPA... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 2, 2020 Category: Stem Cells Authors: Yuzhi Li, Minxia Bian, Zhou Zhou, Xiao Wu, Xingyun Ge, Tong Xiao and Jinhua Yu Tags: Research Source Type: research
Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2
Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 2, 2020 Category: Stem Cells Authors: Maitane Ortiz-Virumbrales, Ram ón Menta, Laura M. Pérez, Ornella Lucchesi, Pablo Mancheño-Corvo, Álvaro Avivar-Valderas, Itziar Palacios, Angel Herrero-Mendez, Wilfried Dalemans, Olga de la Rosa and Eleuterio Lombardo Tags: Research Source Type: research
Congenital muscular dystrophy-associated inflammatory chemokines provide axes for effective recruitment of therapeutic adult stem cell into muscles
Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness. The two most prevalent forms of CMD, collagen VI-related ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 2, 2020 Category: Stem Cells Authors: Vitali Alexeev, Jacquelyn Olavarria, Paolo Bonaldo, Luciano Merlini and Olga Igoucheva Tags: Research Source Type: research
miRNA-126-3p carried by human umbilical cord mesenchymal stem cell enhances endothelial function through exosome-mediated mechanisms in vitro and attenuates vein graft neointimal formation in vivo
The aim of this study was to determine whether the combination of MSC implantation with miRNA-126-3p overexpression would further improve the surgical results after vein grafting. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - November 2, 2020 Category: Stem Cells Authors: Qingxi Qu, Limei Wang, Weidong Bing, Yanwen Bi, Chunmei Zhang, Xuanxuan Jing and Linghong Liu Tags: Research Source Type: research
The combination of trehalose and glycerol: an effective and non-toxic recipe for cryopreservation of human adipose-derived stem cells
Adipose-derived stem cells (ADSCs) promote tissue regeneration and repair. Cryoprotective agents (CPAs) protect cells from cryodamage during cryopreservation. Safe and efficient cryopreservation of ADSCs is cr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 31, 2020 Category: Stem Cells Authors: Tian-Yu Zhang, Poh-Ching Tan, Yun Xie, Xiao-Jie Zhang, Pei-Qi Zhang, Yi-Ming Gao, Shuang-Bai Zhou and Qing-Feng Li Tags: Research Source Type: research
NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation
Understanding the biology underlying the mechanisms and pathways regulating pancreatic β cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progr... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 29, 2020 Category: Stem Cells Authors: Idil I. Aigha and Essam M. Abdelalim Tags: Review Source Type: research
Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation
Efficient osteogenic differentiation of mesenchymal stem cells (MSCs) is a critical step in the treatment of bone defects and skeletal disorders, which present challenges for cell-based therapy and regenerativ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 28, 2020 Category: Stem Cells Authors: Mahsa Ghorbaninejad, Maliheh Khademi-Shirvan, Samaneh Hosseini and Mohamadreza Baghaban Eslaminejad Tags: Review Source Type: research
Development and validation of a novel stem cell subtype for bladder cancer based on stem genomic profiling
Bladder cancer (BLCA) is the fifth most common type of cancer worldwide, with high recurrence and progression rates. Although considerable progress has been made in the treatment of BLCA through accurate typin... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 28, 2020 Category: Stem Cells Authors: Chaozhi Tang, Jiakang Ma, Xiuli Liu and Zhengchun Liu Tags: Research Source Type: research
Autologous peripheral blood-derived stem cells transplantation for treatment of no-option angiitis-induced critical limb ischemia: 10-year management experience
Previous studies have demonstrated that no-option angiitis-induced critical limb ischemia (NO-AICLI) could be significantly improved by transplantation of peripheral blood-derived stem cells (PBDSCs). Addition... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 28, 2020 Category: Stem Cells Authors: Gang Fang, Xiaolang Jiang, Yuan Fang, Tianyue Pan, Hao Liu, Bichen Ren, Zheng Wei, Shiyang Gu, Bin Chen, Junhao Jiang, Yun Shi, Daqiao Guo, Peng Liu, Weiguo Fu and Zhihui Dong Tags: Research Source Type: research
Treating primary immunodeficiencies with defects in NK cells: from stem cell therapy to gene editing
Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both. Some of these rare diseases are caused by aberration... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 27, 2020 Category: Stem Cells Authors: C. Eguizabal, L. Herrera, M. Ingl és-Ferrándiz and J. C. Izpisua Belmonte Tags: Review Source Type: research
RNA-seq reveals tight junction-relevant erythropoietic fate induced by OCT4 in human hair follicle mesenchymal stem cells
Human hair follicle mesenchymal stem cells (hHFMSCs) isolated from hair follicles possess multilineage differentiation potential. OCT4 is a gene critically associated with pluripotency properties. The cell mor... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 27, 2020 Category: Stem Cells Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu Tags: Research Source Type: research
microRNA-375 released from extracellular vesicles of bone marrow mesenchymal stem cells exerts anti-oncogenic effects against cervical cancer
Cervical cancer is the most prevalent gynecological malignancies accompanied by high mortality, where finding a more effective therapeutic option for cervical cancer is necessary. The inhibitory role of microR... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 27, 2020 Category: Stem Cells Authors: Feng Ding, Jinhua Liu and Xiaofei Zhang Tags: Research Source Type: research
miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway
We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 26, 2020 Category: Stem Cells Authors: Yuchen Li, Jinju Wang, Shuzhen Chen, Pei Wu, Shancai Xu, Chunlei Wang, Huaizhang Shi and Ji Bihl Tags: Research Source Type: research
Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids
Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral vector for gene deli... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - October 23, 2020 Category: Stem Cells Authors: Helena Meyer-Berg, Lucia Zhou Yang, Mar ía Pilar de Lucas, Alberto Zambrano, Stephen C. Hyde and Deborah R. Gill Tags: Short report Source Type: research
