Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo
The paracrine effects of multipotent mesenchymal stromal cells (MSCs) are mediated by their secretome composed by soluble factors (i.e., cytokines, growth factors, hormones) and extracellular vesicles (EVs). E... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 14, 2020 Category: Stem Cells Authors: Anastasia Cheng, Dongsic Choi, Maximilien Lora, Dominique Shum-Tim, Janusz Rak and In és Colmegna Tags: Research Source Type: research
Hypoxia-preconditioned adipose-derived stem cells combined with scaffold promote urethral reconstruction by upregulation of angiogenesis and glycolysis
Tissue engineering is a promising alternative for urethral reconstruction, and adipose-derived stem cells (ADSCs) are widely used as seeding cells. Hypoxia preconditioning can significantly enhance the therape... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 11, 2020 Category: Stem Cells Authors: Xiang Wan, Min-kai Xie, Huan Xu, Zi-wei Wei, Hai-jun Yao, Zhong Wang and Da-chao Zheng Tags: Research Source Type: research
Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs
Skeletal muscle is a complex and heterogeneous tissue accounting for approximately 40% of body weight. Excessive ectopic lipid accumulation in the muscle fascicle would undermine the integrity of skeletal musc... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 11, 2020 Category: Stem Cells Authors: Xin Zhang, Wenjuan Sun, Linjuan He, Liqi Wang, Kai Qiu and Jingdong Yin Tags: Research Source Type: research
Endothelial progenitor cells promote osteogenic differentiation in co-cultured with mesenchymal stem cells via the MAPK-dependent pathway
The role of bone tissue engineering is to regenerate tissue using biomaterials and stem cell-based approaches. Combination of two or more cell types is one of the strategies to promote bone formation. Endothel... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 11, 2020 Category: Stem Cells Authors: Chu Xu, Haijie Liu, Yuanjia He, Yuanqing Li and Xiaoning He Tags: Research Source Type: research
Autologous adipose mesenchymal stem cell administration in arteriosclerosis and potential for anti-aging application: a retrospective cohort study
Arteriosclerosis is an age-related disease and a leading cause of cardiovascular disease. In animal experiments, mesenchymal stem cells and its culture-conditioned medium have been shown to be promising tools ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 11, 2020 Category: Stem Cells Authors: Hiroki Ohta, Xiaolan Liu and Miho Maeda Tags: Research Source Type: research
MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1
Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplan... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 10, 2020 Category: Stem Cells Authors: Svitlana Melnik, Jessica Gabler, Simon I. Dreher, Nicole Hecht, Nina Hofmann, Tobias Gro ßner and Wiltrud Richter Tags: Research Source Type: research
A smart scaffold composed of three-dimensional printing and electrospinning techniques and its application in rat abdominal wall defects
Biological composite scaffolds are increasingly being used in abdominal wall reconstruction but still have certain shortcomings. The present study describes here a novel three-dimensional (3D) scaffold fabrica... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 10, 2020 Category: Stem Cells Authors: Zhi Yang, Zhicheng Song, Xin Nie, Kaijin Guo and Yan Gu Tags: Research Source Type: research
Regulatory T cell induction by mesenchymal stem cells depends on the expression of TNFR2 by T cells
Mesenchymal stem/stromal cells can modulate the effector immune cells especially T lymphocytes. Due to this important feature, they can regulate the development of a variety of disorders including inflammatory... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 10, 2020 Category: Stem Cells Authors: Sina Naserian, Sara Shamdani, Nassim Arouche and Georges Uzan Tags: Short report Source Type: research
Dissecting molecular mechanisms underlying H2O2-induced apoptosis of mouse bone marrow mesenchymal stem cell: role of Mst1 inhibition
Bone marrow mesenchymal stem cell (BM-MSC) has been shown to treat pulmonary arterial hypertension (PAH). However, excessive reactive oxygen species (ROS) increases the apoptosis of BM-MSCs, leading to poor su... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 9, 2020 Category: Stem Cells Authors: Qian Zhang, Xianfeng Cheng, Haizhou Zhang, Tao Zhang, Zhengjun Wang, Wenlong Zhang and Wancheng Yu Tags: Research Source Type: research
Allogeneic human umbilical cord Wharton ’s jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo
The transplantation of human umbilical cord blood (UCB) CD34+ cells has been successfully used to treat hematological disorders but one major limitation has been the low cell numbers available. Mesenchymal ste... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 9, 2020 Category: Stem Cells Authors: Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas and Ariff Bongso Tags: Research Source Type: research
Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome
During development, excessive osteogenic differentiation of mesenchymal progenitor cells (MPC) within the cranial sutures can lead to premature suture fusion or craniosynostosis, leading to craniofacial and co... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 9, 2020 Category: Stem Cells Authors: Clara Pribadi, Esther Camp, Dimitrios Cakouros, Peter Anderson, Carlotta Glackin and Stan Gronthos Tags: Research Source Type: research
Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease
Chronic kidney disease (CKD) is a global public health problem. Cell therapy using pluripotent stem cells represents an attractive therapeutic approach for the treatment of CKD. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 9, 2020 Category: Stem Cells Authors: Patr ícia de Carvalho Ribeiro, Fernando Henrique Lojudice, Ida Maria Maximina Fernandes-Charpiot, Maria Alice Sperto Ferreira Baptista, Stanley de Almeida Araújo, Gloria Elisa Florido Mendes, Mari Cleide Sogayar, Mario Abbud-Filho and Heloisa Cristina C Tags: Research Source Type: research
circAKT3 positively regulates osteogenic differentiation of human dental pulp stromal cells via miR-206/CX43 axis
Human dental pulp stromal cells (hDPSCs) are promising sources of mesenchymal stem cells (MSCs) for bone tissue regeneration. Circular RNAs (circRNAs) have been demonstrated to play critical roles in stem cell... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 9, 2020 Category: Stem Cells Authors: Bo Zhang, Sibei Huo, Xiao Cen, Xuefeng Pan, Xinqi Huang and Zhihe Zhao Tags: Research Source Type: research
Regenerative capacity of the corneal transition zone for endothelial cell therapy
The corneal endothelium located on the posterior corneal surface is responsible for regulating stromal hydration. This is contributed by a monolayer of corneal endothelial cells (CECs), which are metabolically... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 4, 2020 Category: Stem Cells Authors: Nicole Ming Sie, Gary Hin-Fai Yam, Yu Qiang Soh, Matthew Lovatt, Deepinder Dhaliwal, Viridiana Kocaba and Jodhbir S. Mehta Tags: Review Source Type: research
Single-cell RNA sequencing of equine mesenchymal stromal cells from primary donor-matched tissue sources reveals functional heterogeneity in immune modulation and cell motility
The efficacy of mesenchymal stromal cell (MSC) therapy is thought to depend on the intrinsic heterogeneity of MSC cultures isolated from different tissue sources as well as individual MSCs isolated from the sa... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - December 4, 2020 Category: Stem Cells Authors: Rebecca M. Harman, Roosheel S. Patel, Jennifer C. Fan, Jee E. Park, Brad R. Rosenberg and Gerlinde R. Van de Walle Tags: Research Source Type: research
