Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment
Hair follicle (HF) development and growth are dependent on epithelial-mesenchymal interactions (EMIs). Dermal papilla (DP) cells are recognized as the key inductive mesenchymal player, but the ideal source of ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 15, 2021 Category: Stem Cells Authors: Carla M. Abreu, Rog ério P. Pirraco, Rui L. Reis, Mariana T. Cerqueira and Alexandra P. Marques Tags: Research Source Type: research
Radiation-induced toxicity in rectal epithelial stem cell contributes to acute radiation injury in rectum
Radiation-induced rectal epithelial damage is a very common side effect of pelvic radiotherapy and often compromise the life quality and treatment outcome in patients with pelvic malignancies. Unlike small bow... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 15, 2021 Category: Stem Cells Authors: Felipe Rodriguez Tirado, Payel Bhanja, Eduardo Castro-Nallar, Ximena Diaz Olea, Catalina Salamanca and Subhrajit Saha Tags: Research Source Type: research
Correction to: RNA-seq reveals tight junction-relevant erythropoietic fate induced by OCT4 in human hair follicle mesenchymal stem cells
An amendment to this paper has been published and can be accessed via the original article. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 15, 2021 Category: Stem Cells Authors: Xiaozhen Yu, Pengpeng Sun, Xingang Huang, Hua Chen, Weiqing Huang, Yingchun Ruan, Weina Jiang, Xiaohua Tan and Zhijing Liu Tags: Correction Source Type: research
Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors
Human induced pluripotent stem cells (hiPSCs) hold enormous promise in accelerating breakthroughs in understanding human development, drug screening, disease modeling, and cell and gene therapies. Their potent... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 13, 2021 Category: Stem Cells Authors: Breanna S. Borys, Tiffany Dang, Tania So, Leili Rohani, Tamas Revay, Tylor Walsh, Madalynn Thompson, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee and Michael S. Kallos Tags: Research Source Type: research
Donor heart preservation with hypoxic-conditioned medium-derived from bone marrow mesenchymal stem cells improves cardiac function in a heart transplantation model
In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients ’ survival rate. Bone marrow mesenchymal stem cells... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 13, 2021 Category: Stem Cells Authors: Pengyu Zhou, Hao Liu, Ximao Liu, Xiao Ling, Zezhou Xiao, Peng Zhu, Yufeng Zhu, Jun Lu and Shaoyi Zheng Tags: Research Source Type: research
Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells
Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear.... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 13, 2021 Category: Stem Cells Authors: Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga and Tomoaki Taguchi Tags: Research Source Type: research
Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease
Aging is known to slow the neurogenic capacity of the hippocampus, one of only two mammalian adult neurogenic niches. The reduction of adult-born neurons with age may initiate cognitive decline progression whi... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 13, 2021 Category: Stem Cells Authors: Nathalie Sumien, Matthew S. Wells, Akram Sidhu, Jessica M. Wong, Michael J. Forster, Qiao-Xi Zheng and Judith A. Kelleher-Andersson Tags: Short report Source Type: research
Subconjunctival injection of mesenchymal stem cells for corneal failure due to limbal stem cell deficiency: state of the art
Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 13, 2021 Category: Stem Cells Authors: Sara Galindo, Ana de la Mata, Marina L ópez-Paniagua, Jose M. Herreras, Inmaculada Pérez, Margarita Calonge and Teresa Nieto-Miguel Tags: Review Source Type: research
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD)
Chronic obstructive pulmonary disease (COPD) is an incurable and debilitating chronic disease characterized by progressive airflow limitation associated with abnormal levels of tissue inflammation. Therefore, ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 12, 2021 Category: Stem Cells Authors: Noridzzaida Ridzuan, Norashikin Zakaria, Darius Widera, Jonathan Sheard, Mitsuru Morimoto, Hirofumi Kiyokawa, Seoparjoo Azmel Mohd Isa, Gurjeet Kaur Chatar Singh, Kong-Yong Then, Ghee-Chien Ooi and Badrul Hisham Yahaya Tags: Research Source Type: research
Human foreskin-derived dermal stem/progenitor cell-conditioned medium combined with hyaluronic acid promotes extracellular matrix regeneration in diabetic wounds
Diabetic wounds remain a challenging clinical problem, which requires further treatment development. Published data showed that dermis-derived stem/progenitor cells (DSPCs) display superior wound healing in vi... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 9, 2021 Category: Stem Cells Authors: Yu Xin, Peng Xu, Xiangsheng Wang, Yunsheng Chen, Zheng Zhang and Yixin Zhang Tags: Research Source Type: research
Inflammatory cytokines-stimulated human muscle stem cells ameliorate ulcerative colitis via the IDO-TSG6 axis
Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue stem cells, especially mesenchymal stem cel... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 9, 2021 Category: Stem Cells Authors: Shengchao Zhang, Jiankai Fang, Zhanhong Liu, Pengbo Hou, Lijuan Cao, Yuyan Zhang, Rui Liu, Yanan Li, Qianwen Shang, Yongjing Chen, Chao Feng, Guan Wang, Gerry Melino, Ying Wang, Changshun Shao and Yufang Shi Tags: Research Source Type: research
Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomesticle
In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capac... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 9, 2021 Category: Stem Cells Authors: Wen Li, Shanshan Wang, Hui He, Jianbing Qin, Xiang Cheng, Heyan Zhao, Meiling Tian, Xinhua Zhang and Guohua Jin Tags: Research Source Type: research
Intravitreal autologous mesenchymal stem cell transplantation: a non-randomized phase I clinical trial in patients with retinitis pigmentosa
Retinitis pigmentosa (RP) is a progressive inherited retinal disease with great interest for finding effective treatment modalities. Stem cell-based therapy is one of the promising candidates. We aimed to inve... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 9, 2021 Category: Stem Cells Authors: Aekkachai Tuekprakhon, Siripakorn Sangkitporn, Adisak Trinavarat, Aulia Rahmi Pawestri, Visit Vamvanij, Monchai Ruangchainikom, Panya Luksanapruksa, Phitchapa Pongpaksupasin, Areerat Khorchai, Acharaporn Dambua, Patcharaporn Boonchu, Chonlada Yodtup, Mong Tags: Research Source Type: research
Deconstructing transcriptional variations and their effects on immunomodulatory function among human mesenchymal stromal cells
Mesenchymal stromal cell (MSC)-based therapies are being actively investigated in various inflammatory disorders. However, functional variability among MSCs cultured in vitro will lead to distinct therapeutic ... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 9, 2021 Category: Stem Cells Authors: Changbin Sun, Kehua Zhang, Jianhui Yue, Shufang Meng and Xi Zhang Tags: Research Source Type: research
Persistence of intramyocardially transplanted murine induced pluripotent stem cell-derived cardiomyocytes from different developmental stages
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are regarded as promising cell type for cardiac cell replacement therapy, but it is not known whether the developmental stage influences their per... (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - January 8, 2021 Category: Stem Cells Authors: Gabriel Peinkofer, Martina Maass, Kurt Pfannkuche, Agapios Sachinidis, Stephan Baldus, J ürgen Hescheler, Tomo Saric and Marcel Halbach Tags: Research Source Type: research
