Commentary on the published position statement regarding the pathogenesis of fetal basal ganglia- thalamic hypoxic-ischaemic injury
S Afr Med J. 2023 Dec 31;114(1):6-10. doi: 10.7196/SAMJ.2024.v114i1.1584.NO ABSTRACTPMID:38525619 | DOI:10.7196/SAMJ.2024.v114i1.1584 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: J Anthony J Smith L Murray G F Kirsten G Gericke Y Kara V Davies D Pearce R Van Toorn M M Lippert J W Lotz S Andronikou B Alheit L Van Wyk A S Ebrahim B S Schifrin Source Type: research

National Health Laboratory Service (NHLS) changes the method of LDL-cholesterol calculation in South Africa
S Afr Med J. 2023 Dec 31;114(1):16. doi: 10.7196/SAMJ.2024.v114i1.1573.NO ABSTRACTPMID:38525620 | DOI:10.7196/SAMJ.2024.v114i1.1573 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: T Pillay H M Rossouw N Steyn A Carelse Source Type: research

Ensuring access to palliative care for cervical cancer patients
S Afr Med J. 2023 Dec 31;114(1):3-4. doi: 10.7196/SAMJ.2024.v114i1.1572.NO ABSTRACTPMID:38525621 | DOI:10.7196/SAMJ.2024.v114i1.1572 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: F Ooko Source Type: research

Improving health outcomes and quality at the subdistrict level: Evaluation of the '3 feet model' in Waterberg District, Limpopo Province, South Africa
CONCLUSION: While not advocating for a cut-and-paste approach to improving quality and outcomes, positive experiences in Waterberg District suggest that the principles and mechanisms of action of the 3 feet model have wider relevance for policy and practice, especially as emphasis shifts towards the subdistrict as a core unit of population health and wellbeing in SA.PMID:38525622 | DOI:10.7196/SAMJ.2023.v113i11.1558 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: H Schneider F Mukinda J Cupido J Wessels P Kupa P Leboho N Nkoana N Bosch Y Pillay Source Type: research

The advantages of rare disease biobanking: A localised source of genetic knowledge to benefit the South African rare disease community and related stakeholders worldwide
S Afr Med J. 2023 Dec 4;113(12):9. doi: 10.7196/SAMJ.2023.v113i12.1507.NO ABSTRACTPMID:38525623 | DOI:10.7196/SAMJ.2023.v113i12.1507 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: M Dercksen E H Conradie C J Hendriksz H Malherbe B C Vorster Source Type: research

Recurrent venous thrombosis - an unusual first presentation of autoimmune polyendocrinopathy syndrome type 3B
S Afr Med J. 2023 Dec 31;114(1):17-21. doi: 10.7196/SAMJ.2024.v114i1.1477.ABSTRACTA 45-year-old female presented with unprovoked recurrent venous thromboembolism (VTE), in unusual sites, and pancytopenia, posing a complex diagnostic challenge. Work-up for inherited thrombophilia, antiphospholipid syndrome (APLS) and paroxysmal nocturnal haemoglobinuria were unremarkable. Investigations revealed autoimmune thyroid disease, and a mixed iron/vitamin B12 deficiency due to pernicious anaemia and resultant atrophic gastritis. Hyperhomocysteinaemia due to vitamin B12 deficiency was identified as a potential contributor to her rec...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: N Letete D Vaz P H Malishi J J Pogieter P Rheeder Source Type: research

POPIA does indeed apply to health research: A response to Bronstein and Nyachowe
This article critically analyses the authors' interpretation of section 3(2)(b) of POPIA and challenges two of its aspects.PMID:38525625 | DOI:10.7196/SAMJ.2023.v113i11.1345 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: D W Thaldar Source Type: research

Implementing E-MOTIVE for detection and treatment of postpartum haemorrhage in South Africa
S Afr Med J. 2023 Dec 4;113(12):24. doi: 10.7196/SAMJ.2023.v113i12.1164.ABSTRACTPostpartum haemorrhage is the leading cause of preventable maternal mortality in South Africa. In a significant breakthrough in the management of PPH, the E-MOTIVE trial found that a multifaceted health service intervention reduced severe PPH after vaginal delivery by 60% in 78 hospitals in Nigeria, Kenya, Tanzania and SA. The E-MOTIVE approach comprises objective blood loss measurement monitored every 15 minutes during the first hour after delivery to detect PPH early and trigger a bundle of first-line treatments, including massaging the uteru...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: M Singata-Madliki S Fawcus N Moran E Arends E Muller S Mandondo G J Hofmeyr Source Type: research

Knowledge, attitudes and practices of oral HIV pre-exposure prophylaxis (PrEP) among healthcare workers in the Ekurhuleni District, South Africa
CONCLUSION: Among the healthcare workers tasked with generating demand and identifying clients eligible for HIV PrEP services, low knowledge of HIV PrEP and negative attitudes towards HIV PrEP may be barriers to the uptake of HIV PrEP. Training healthcare workers on HIV PrEP is recommended.PMID:38525627 | DOI:10.7196/SAMJ.2023.v113i12.1171 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: E Mahlare E Ramutshila A Musekiwa L Kuonza T Mabuto Source Type: research

The use of emergency medical services for palliative situations in Western Cape Province, South Africa: A retrospective, descriptive analysis of patient records
CONCLUSION: EMS in SA frequently encounter palliative situations for symptoms that may be managed within their scope of practice. Consequently, it appears that EMS have an important role to fulfil in the care of patients with palliative needs. Integrating EMS and palliative care may result in improved palliative care provision and, therefore, EMS and palliative care integration would be beneficial in SA.PMID:38525628 | DOI:10.7196/SAMJ.2023.v113i11.1136 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: C Gage B Spies K Crombie L Gwyther W Stassen Source Type: research

Pancreatic cancer mortality in South Africa: A case-control study
CONCLUSION: Smoking and certain occupations increased the risk of pancreatic cancer mortality. Further research is needed to evaluate the associations between other extrinsic and intrinsic factors and pancreatic cancer mortality.PMID:38525629 | DOI:10.7196/SAMJ.2024.v114i1.1132 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: M L Nhleko I Edoka E Musenge Source Type: research

Informal gold miners with mercury toxicity: Novel asymmetrical neurological presentations
S Afr Med J. 2023 Dec 4;113(12):20. doi: 10.7196/SAMJ.2023.v113i12.1127.ABSTRACTMercury is a highly toxic heavy metal that may cause neurological, respiratory, gastrointestinal and dermatological illnesses. Previously described neurological manifestations of mercury toxicity are symmetrical, and include a pancerebellar syndrome, generalised seizures and encephalopathy. Mercury is used in the gold mining process, and in artisanal or illicit gold mining, often without necessary protection. Here we describe the cases of two artisanal gold miners from western Johannesburg, South Africa, who presented with atypical neurological...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: J George E Sadiq I Moola S Maharaj A Mochan Source Type: research

The characteristics of dermatology inpatients seen at the quaternary Inkosi Albert Luthuli Central Hospital in Durban, South Africa, over a 5-year period - 2015 - 2020
CONCLUSION: A broad range of diagnoses is managed through the dermatology inpatient service, particularly as consultations. These services remain essential in the holistic management of patients.PMID:38525631 | DOI:10.7196/SAMJ.2024.v114i1.1098 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: L Mthembu J T Masuka K Duze A Mosam Source Type: research

Dyslipidaemia in patients with chronic kidney disease - a neglected cardiovascular risk factor
CONCLUSION: This cohort comprised a large proportion of patients classified as high or very high risk for ASCVD. Despite this, the use of LLT was inadequate, and <20% of patients were at target LDL-C levels. These data suggest a greater need for awareness of initiating LLT to achieve recommended target LDL-C levels in patients with CKD.PMID:38525632 | DOI:10.7196/SAMJ.2023.v113i11.1089 (Source: South African Medical Journal)
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: M R Essop F Seedat F J Raal Source Type: research

Antivirals for the treatment of mild and moderate COVID-19 in South Africa
S Afr Med J. 2023 Dec 4;113(12):33. doi: 10.7196/SAMJ.2023.v113i12.1066.ABSTRACTWhile the majority of COVID-19 cases in South Africa (SA) are mild, patients with severe COVID-19 requiring hospitalisation present with significant morbidity and mortality and place a substantial burden on healthcare services. Given the low vaccine uptake in SA and other low- and middle-income countries in sub-Saharan Africa, the high prevalence of comorbidities and limited healthcare system capacity, evidence-based interventions that reduce the risk of severe disease and death should be considered for implementation. Several antiviral classes...
Source: South African Medical Journal - March 25, 2024 Category: African Health Authors: R Perumal V Naidoo S Govender T N Gengiah Source Type: research