Umbilical giant condyloma acuminatum
A 71-year-old man presented with a 4-month history of a slow-growing, violaceous vegetation in the umbilical area (figure 1). There was no history of immunosuppression or treatment for other disorders. The lesion was 5 cm in diameter, involving and overflowing the umbilicus, and had a bad odour. Suspecting a metastasis or urachus cancer, we surgically removed the whole lesion. Histopathology analysis diagnosed a low-grade giant condyloma acuminatum (figure 2), and an 8-week course of topical 5% imiquimod led to complete remission. The patient did not present other condylomata. There are a few cases in the literature of umb...
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: DErme, A. M., Fidanzi, C., Janowska, A., Dini, V., Romanelli, M., Zucchi, V., Viacava, P., Bagnoni, G. Tags: Research letter Source Type: research
Probenecid in the treatment of neurosyphilis in men who have sex with men: a commentary
Probenecid is a uricosuric drug, which inhibits the renal excretion of procaine penicillin via inhibition of the organic anion transporter (OAT-1) system in the proximal renal tubule producing higher plasma and cerebrospinal fluid (CSF) penicillin levels.1 2 Oral probenecid is recommended to be used with intramuscular procaine penicillin for the treatment of neurosyphilis. Rates of syphilis and neurosyphilis have increased significantly over the past 20 years particularly in men who have sex with men (MSM). There are several issues for clinicians to consider when prescribing probenecid to MSM with neurosyphilis. First, the...
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Richardson, D., Goldmeier, D. Tags: Research letter Source Type: research
Epidemiological trends in notified syphilis diagnoses during the COVID-19 pandemic in Brazil
How the COVID-19 pandemic is affecting the incidence of syphilis remains unclear.1–4 We extracted data from the Brazilian Unified Health System public disease notification database to compare the mean number of syphilis cases reported from March to December 2017–2019 with those reported the same period of 2020. In all Brazilian macroregions, the incidence rates of syphilis per million population increased significantly during the COVID-19 pandemic, reaching +157% in the Southeast (table 1). The mean increase was +78% overall, corresponding to an additional 161 incident cases per million population. Table 1Incid...
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Maia, C. M. F., Marques, N. P., Dias, V. O., Martelli, D. R. B., Oliveira, E. A., Martelli-Junior, H. Tags: COVID-19 Research letter Source Type: research
Sexual transmission of infections across Europe: appraising the present, scoping the future
Conclusions: The survey indicated substantial variability and identified key improvement targets: fighting barriers to effective service provision and access, increasing diagnostic capability and taking leadership in driving up the quality of care. We must not forget the STI-related needs of the many people who will be living with HIV for decades into the future. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Geretti, A. M., Mardh, O., de Vries, H. J. C., Winter, A., McSorley, J., Seguy, N., Vuylsteke, B., Gokengin, D. Tags: Review Source Type: research
Evaluation of a laboratory-developed multiplex real-time PCR assay for diagnosis of syphilis, herpes and chancroid genital ulcers in four public health laboratories in the USA
Conclusions
The GUD M-PCR assay performed well in four independent PHLs and 12 suspected syphilis cases were identified in this study. The M-PCR assay could provide improved diagnostic options for GUD infections in state and local PHLs. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Koralur, M., Chen, C. Y., Pillay, A., White, B., Pettus, K., Chi, K.-H., Stringer, J., Aroh, C., Dasu, T., Bhattacharyya, S., Perkins, K., Chen, J., Riner, D., Soehnlen, M., Cao, W., Gaynor, A. M., Kersh, E. N. Tags: Short reports Source Type: research
Hospitalisations for pelvic inflammatory disease in young Aboriginal women living in remote Australia: the role of chlamydia and gonorrhoea
Conclusion
Our study demonstrates the importance of calculating the fraction of PID related to chlamydia and gonorrhoea in the local context, demonstrating the major contribution gonorrhoea makes to PID hospitalisations among Australian Aboriginal women living in remote settings. To significantly and sustainably reduce the unacceptable rate of PID in this population, strategies are urgently needed to improve timely testing and treatment and recognition and management of PID in primary care. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Causer, L., Liu, B., Watts, C., McManus, H., Donovan, B., Ward, J., Guy, R., On behalf of the TTANGO2 Collaboration, Shephard, Mak, Kaldor, Fairley, Persing, Atkinson, Armstrong, Speers, Whiley, Maher, Regan, Anderson, Hengel, Tangey, Badman, Tabrizi, Wan Tags: Short reports Source Type: research
A model to predict adherence to antiretroviral therapy among people living with HIV
Conclusions
Our model accurately estimates ART adherence behaviours. The prediction tool can help identify individuals at greater risk for poor adherence and guide tailored interventions to optimise adherence. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Chen, H., Long, R., Hu, T., Chen, Y., Wang, R., Liu, Y., Liu, S., Xu, C., Yu, X., Chang, R., Wang, H., Zhang, K., Hu, F., Cai, Y. Tags: Original research Source Type: research
Incident urogenital and anorectal Chlamydia trachomatis in women: the role of sexual exposure and autoinoculation: a multicentre observational study (FemCure)
Conclusions
After initial treatment, an alternate anatomical site CT infection increased the risk for an incident CT in women, especially when also sex was reported. This may suggest a key role for autoinoculation in the re-establishment or persistence of urogenital and anorectal chlamydia infections. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Dukers-Muijrers, N. H. T. M., Schim van der Loeff, M., Wolffs, P., Bruisten, S. M., Götz, H. M., Heijman, T., Zondag, H., Lucchesi, M., De Vries, H., Hoebe, C. J. P. A. Tags: Original research Source Type: research
Molecular characterisation and antibiotic susceptibility of meningococcal isolates from healthy men who have sex with men
Conclusions
Serogroup B meningococcal carriage identified from oral and anal specimens among healthy MSM was the most frequent serogroup identified in this study. Molecular evaluation revealed a degree of similarity among strains belonging to the same clonal complex. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Neri, A., Palmieri, A., Prignano, G., Giuliani, M., Latini, A., Fazio, C., Vacca, P., Ambrosio, L., Ciammaruconi, A., Fillo, S., Anselmo, A., Fortunato, A., Lista, R., Stefanelli, P. Tags: Open access Original research Source Type: research
Intensified partner notification and repeat testing can improve the effectiveness of screening in reducing Chlamydia trachomatis prevalence: a mathematical modelling study
Conclusion
A reduction in C. trachomatis prevalence could be achieved if the level of testing as observed in the ACCEPt intervention arm can be maintained at a population level. More substantial reductions can be achieved with intensified case management comprising retesting of those treated and treatment of partners of infected individuals. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Hui, B. B., Hocking, J. S., Braat, S., Donovan, B., Fairley, C. K., Guy, R., Spark, S., Yeung, A., Low, N., Regan, D. Tags: Original research Source Type: research
Preferences for chlamydia testing and management in Hong Kong: a discrete choice experiment
Conclusion
To design effective chlamydia testing and management services, it is vital to respond to patient needs and preferences. For people living in Hong Kong, cost and staff attitude were the most important factors for deciding whether to test or be managed for chlamydia, respectively. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Ong, J. J., Fairley, C. K., Hocking, J. S., Turner, K. M. E., Booton, R., Tse, D., Wong, W. W. C. W. Tags: Original research Source Type: research
Sexual exposure and sexual behaviour in the interval between gonorrhoea treatment and test of cure: a cross-sectional cohort study
Conclusion
Sexual activity after receiving treatment for gonorrhoea and prior to a ToC evaluation was common. This was associated with previous infection history and specific behavioural characteristics. Knowledge of these factors can help guide safe sex counselling at the time of treatment. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: Ayinde, O., Ross, J. D. C. Tags: Original research Source Type: research
Quantifying heterogeneity in sexual behaviour and distribution of STIs before and after pre-exposure prophylaxis among men who have sex with men
Conclusions: MSM engaged in more high-risk sexual behaviour and gonorrhoea diagnoses increased after PrEP was introduced. Chlamydia and syphilis diagnoses have become more concentrated in a high-risk subgroup. Monitoring the impact of increasing PrEP coverage on sexual behaviour and STI incidence is important. Improved STI prevention is needed, especially for high-risk MSM. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - August 22, 2022 Category: Sexual Medicine Authors: van Wees, D. A., Diexer, S., Rozhnova, G., Matser, A., den Daas, C., Heijne, J., Kretzschmar, M. Tags: Editor's choice Original research Source Type: research
What do young people want? (from a sexual health service)
The COVID-19 pandemic challenged us to rethink and reconfigure the services we provide to our patients. Traditional open-access, walk-in clinics were no longer possible, and early on in the pandemic, in mid-2020, it was identified that there was a disproportionately larger effect on young people (YP) accessing sexual health services compared with those aged 18 and over.1 Novel ways aimed at maintaining access of YP into services included WhatsApp for contact to clinic, telephone triage and safeguarding assessment, video calls, postal kit testing, and allowing specific populations access to face-to-face appointments in clin...
Source: Sexually Transmitted Infections - July 25, 2022 Category: Sexual Medicine Authors: LeVoir, H., Cochrane, E., Ashby, J., Herbert, S. Tags: BASHH column Source Type: research
Research news in clinical context
Bone loss in young women living with HIV receiving intramuscular depot medroxyprogesterone acetate and initiating TDF-containing antiretroviral therapy Tenofovir disoproxil fumarate (TDF) and intramuscular depot medroxyprogesterone acetate (DMPA-IM) are independently associated with bone loss.1 2 This cohort study conducted in Uganda in 2016–2017 assessed the combined effects of DMPA-IM and TDF initiation on bone mineral density (BMD) in women aged 18–35.3 Participants (n=521) were classified based on HIV status, TDF use and DMPA-IM use. Compared with use of TDF alone, concurrent use of DMPA-IM resulted in grea...
Source: Sexually Transmitted Infections - July 25, 2022 Category: Sexual Medicine Authors: Tan, R. K. J., Daskalopoulou, M., Thomson-Glover, R. Tags: Perspectives Source Type: research
