Neonatal herpes simplex virus infections
Neonatal herpes simplex virus (HSV) is an uncommon but devastating infection in the newborn, associated with significant morbidity and mortality. The use of PCR for identification of infected infants and acyclovir for treatment has significantly improved the prognosis for affected infants. The subsequent use of suppressive therapy with oral acyclovir following completion of parenteral treatment of acute disease has further enhanced the long-term prognosis for these infants. This review article will discuss the epidemiology, risk factors and routes of acquisition, clinical presentation, and evaluation of an infant suspected...
Source: Seminars in Perinatology - March 12, 2018 Category: Perinatology & Neonatology Authors: Swetha G. Pinninti, David W. Kimberlin Source Type: research
Introduction
Congenital and perinatal infections remain an important cause of mortality and morbidity in neonates, and the epidemiology, diagnosis, treatment, and prevention of these infections continues to change. Congenital infections are acquired from the mother in-utero either by transplacental spread to the bloodstream or by direct extension. Perinatal infections typically are transmitted during labor or delivery from the mother or in the early neonatal period from nosocomial transmission. In this issue of Seminars in Perinatology, experts review many of the most common and important congenital and perinatal infections in the neon...
Source: Seminars in Perinatology - March 8, 2018 Category: Perinatology & Neonatology Authors: Shannon A. Ross Source Type: research
Update on the management of hepatitis B and C infections in the neonatal period
Hepatitis B virus and hepatitis C virus have received a significant amount of attention in recent years, and both viruses share a significant amount of similarities with one another beyond just that they both primarily target the liver. In recent years, cases of both infections have been fueled by a nationwide epidemic of injection drug use. Most relevant to this audience, they are both transmitted from mother to child. The increased cases in young adults combined with mother to child transmission translate into more exposed infants that will need to be managed and followed. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - March 8, 2018 Category: Perinatology & Neonatology Authors: Claudia M. Espinosa, Ravi Jhaveri Source Type: research
Neonatal nonpolio enterovirus and parechovirus infections
Nonpolio enteroviruses and parechoviruses are frequent causes of neonatal infection. Clinical manifestations of infection range from asymptomatic infection to mild infection without sequelae to septic shock with muiltiorgan failure. Neonates with clinically apparent infection typically have mothers and/or other contacts with recent symptoms consistent with a viral illness. Severe neonatal infection with nonpolio enterovirus or parechovirus cannot be differentiated clinically from serious bacterial infection. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - March 8, 2018 Category: Perinatology & Neonatology Authors: Nada Harik, Roberta L. DeBiasi Source Type: research
Introduction
Congenital and perinatal infections remain an important cause of mortality and morbidity in neonates, and the epidemiology, diagnosis, treatment, and prevention of these infections continues to change. Congenital infections are acquired from the mother in-utero either by transplacental spread to the bloodstream or by direct extension. Perinatal infections typically are transmitted during labor or delivery from the mother or in the early neonatal period from nosocomial transmission. In this issue of Seminars in Perinatology, experts review many of the most common and important congenital and perinatal infections in the neon...
Source: Seminars in Perinatology - March 8, 2018 Category: Perinatology & Neonatology Authors: Shannon A. Ross Source Type: research
Update on the management of hepatitis B and C infections in the neonatal period
Hepatitis B virus and hepatitis C virus have received a significant amount of attention in recent years, and both viruses share a significant amount of similarities with one another beyond just that they both primarily target the liver. In recent years, cases of both infections have been fueled by a nationwide epidemic of injection drug use. Most relevant to this audience, they are both transmitted from mother to child. The increased cases in young adults combined with mother to child transmission translate into more exposed infants that will need to be managed and followed. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - March 8, 2018 Category: Perinatology & Neonatology Authors: Claudia M. Espinosa, Ravi Jhaveri Source Type: research
Neonatal nonpolio enterovirus and parechovirus infections
Nonpolio enteroviruses and parechoviruses are frequent causes of neonatal infection. Clinical manifestations of infection range from asymptomatic infection to mild infection without sequelae to septic shock with muiltiorgan failure. Neonates with clinically apparent infection typically have mothers and/or other contacts with recent symptoms consistent with a viral illness. Severe neonatal infection with nonpolio enterovirus or parechovirus cannot be differentiated clinically from serious bacterial infection. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - March 8, 2018 Category: Perinatology & Neonatology Authors: Nada Harik, Roberta L. DeBiasi Source Type: research
Adverse outcomes of pregnancy-associated Zika virus infection
The spread of Zika virus to the Americas was accompanied by surge in the number of infants with CNS abnormalities leading to a declaration of a health emergency by the WHO. This was accompanied by significant responses from governmental health agencies in the United States and Europe that resulted in significant new information described in the natural history of this perinatal infection in a very short period of time. Although much has been learned about Zika virus infection during pregnancy, limitations of current diagnostics and the challenges for accurate serologic diagnosis of acute Zika virus infection has restricted...
Source: Seminars in Perinatology - March 6, 2018 Category: Perinatology & Neonatology Authors: William J. Britt Source Type: research
Congenital cytomegalovirus infection
Each year, thousands of children are born with or develop permanent disabilities such as hearing loss, vision loss, motor and cognitive deficits from congenital CMV infection (cCMV). However, awareness of cCMV and its associated sequelae is very low in pregnant women and healthcare providers. Both targeted and universal approaches to screen newborns for CMV infection are now achievable due to recent scientific advances including the development of a rapid, high-throughput method for detecting CMV in saliva, the efficacy of antiviral treatment in symptomatic infants, and the demonstration of cost effectiveness of CMV screen...
Source: Seminars in Perinatology - March 1, 2018 Category: Perinatology & Neonatology Authors: Karen B. Fowler, Suresh B. Boppana Source Type: research
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Source: Seminars in Perinatology - February 24, 2018 Category: Perinatology & Neonatology Source Type: research
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Source: Seminars in Perinatology - February 24, 2018 Category: Perinatology & Neonatology Source Type: research
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Source: Seminars in Perinatology - February 24, 2018 Category: Perinatology & Neonatology Source Type: research
