Topics
(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - July 31, 2016 Category: Perinatology & Neonatology Source Type: research
Table of Contents
(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - July 31, 2016 Category: Perinatology & Neonatology Source Type: research
Perinatal management: What has been learned through the network?
The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN) has examined the effects of various obstetrical perinatal interventions and neonatal delivery room practices on the newborn with particular focus on those born preterm. Studies exploring the effects and safety of various antepartum maternal medications and the effects of the route and timing of delivery are examined. The NRN has contributed key studies to the evidence base for the International Liaison Committee on Resuscitation neonatal resuscitation guidelines. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - July 31, 2016 Category: Perinatology & Neonatology Authors: Sanjay Chawla, Elizabeth E. Foglia, Vishal Kapadia, Myra H. Wyckoff Source Type: research
Inhaled nitric oxide therapy for pulmonary disorders of the term and preterm infant
This article provides an overview of the pertinent biology and chemistry of nitric oxide, discusses potential toxicities, and reviews the results of pertinent clinical investigations and large randomized clinical trials including neurodevelopmental follow-up in term and preterm neonates. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - July 28, 2016 Category: Perinatology & Neonatology Authors: Gregory M. Sokol, Girija G. Konduri, Krisa P. Van Meurs Source Type: research
Improving publication rates in a collaborative clinical trials research network
Unpublished results can bias biomedical literature, favoring positive over negative findings, primary over secondary analyses, and can lead to duplicate studies that unnecessarily endanger subjects and waste resources. The Neonatal Research Network ʼs (NRN) publication policies for approving, reviewing, and tracking abstracts and papers work to combat these problems. In 2003, the NRN restricted investigators with unfinished manuscripts from proposing new ones and in 2010, urged authors to complete long-outstanding manuscripts. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - July 12, 2016 Category: Perinatology & Neonatology Authors: Stephanie Wilson Archer, Waldemar A. Carlo, William E. Truog, David K. Stevenson, Krisa P. Van Meurs, Pablo J. S ánchez, Abhik Das, Uday Devaskar, Leif D. Nelin, Carolyn M. Petrie Huitema, Margaret M. Crawford, Rosemary D. Higgins, for the Eunice Kennedy Source Type: research
Recent controversies on comparative effectiveness research investigations: Challenges, opportunities, and pitfalls
The purpose of comparative effectiveness research (CER) is to improve health outcomes by developing and disseminating evidence-based information about which currently available interventions and practices are most effective for patients. Randomized Controlled Trials (RCT) are the hallmark of scientific proof, and have been used to compare interventions used in variable ways by different clinicians (comparative effectiveness RCTs, CER-RCTs). But such CER-RCTs have at times generated controversy. Usually the background for the CER-RCT is a range of “standard therapy” or “standard of care.” This may have been adopted ...
Source: Seminars in Perinatology - July 12, 2016 Category: Perinatology & Neonatology Authors: Haresh Kirpalani, William E. Truog, Carl T. D ’Angio, Michael Cotten Source Type: research
Improving publication rates in a collaborative clinical trials research network
Unpublished results can bias biomedical literature, favoring positive over negative findings, primary over secondary analyses, and can lead to duplicate studies that unnecessarily endanger subjects and waste resources. The Neonatal Research Networkʼs (NRN) publication policies for approving, reviewing, and tracking abstracts and papers work to combat these problems. In 2003, the NRN restricted investigators with unfinished manuscripts from proposing new ones and in 2010, urged authors to complete long-outstanding manuscripts. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - July 12, 2016 Category: Perinatology & Neonatology Authors: Stephanie Wilson Archer, Waldemar A. Carlo, William E. Truog, David K. Stevenson, Krisa P. Van Meurs, Pablo J. Sánchez, Abhik Das, Uday Devaskar, Leif D. Nelin, Carolyn M. Petrie Huitema, Margaret M. Crawford, Rosemary D. Higgins, for the Eunice Kennedy Source Type: research
Recent controversies on comparative effectiveness research investigations: Challenges, opportunities, and pitfalls
The purpose of comparative effectiveness research (CER) is to improve health outcomes by developing and disseminating evidence-based information about which currently available interventions and practices are most effective for patients. Randomized Controlled Trials (RCT) are the hallmark of scientific proof, and have been used to compare interventions used in variable ways by different clinicians (comparative effectiveness RCTs, CER-RCTs). But such CER-RCTs have at times generated controversy. Usually the background for the CER-RCT is a range of “standard therapy” or “standard of care.” This may have been adopted ...
Source: Seminars in Perinatology - July 12, 2016 Category: Perinatology & Neonatology Authors: Haresh Kirpalani, William E. Truog, Carl T. D’Angio, Michael Cotten Source Type: research
Changing definitions of long-term follow-up: Should “long term” be even longer?
There have been amazing changes in outcomes of preterm (PT) infants in the past decades. Whereas early studies reported only survival rates, Dr. Julius Hess published the first outcome study of PT infants in Chicago in 1953. Dr. Lubchenco then published the 10-year follow-up of premature infants born in 1947 –1953 and identified a 68% handicap rate. As a result of these early studies, the importance of evaluating NICU graduates both for surveillance and as an outcome of trials was recognized. During the 1970s, there was a gradual expansion in the number of follow-up programs in the United States (US) with an increasing n...
Source: Seminars in Perinatology - July 10, 2016 Category: Perinatology & Neonatology Authors: Susan R. Hintz, Jamie E. Newman, Betty R. Vohr Source Type: research
Changing definitions of long-term follow-up: Should “long term” be even longer?
There have been amazing changes in outcomes of preterm (PT) infants in the past decades. Whereas early studies reported only survival rates, Dr. Julius Hess published the first outcome study of PT infants in Chicago in 1953. Dr. Lubchenco then published the 10-year follow-up of premature infants born in 1947–1953 and identified a 68% handicap rate. As a result of these early studies, the importance of evaluating NICU graduates both for surveillance and as an outcome of trials was recognized. During the 1970s, there was a gradual expansion in the number of follow-up programs in the United States (US) with an increasing nu...
Source: Seminars in Perinatology - July 10, 2016 Category: Perinatology & Neonatology Authors: Susan R. Hintz, Jamie E. Newman, Betty R. Vohr Source Type: research
The Neonatal Research Network: History since 2003, future directions and challenges
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neontal Research Network (NRN) was established in 1986 in response to the need for rigorous studies to guide care and management of sick and premature newborns. The network is comprise of clinical centers that perform clinical protocols to investigate the safety and efficay of treatment and management strategies for newborn infants as well as a data cordinating center. Infrastructure is set up for observational and interventional studies as well as neurodevelopmental follow-up of patients. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 28, 2016 Category: Perinatology & Neonatology Authors: Rosemary D. Higgins, Seetha Shankaran Source Type: research
Hypothermia for neonatal hypoxic –ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field
We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 22, 2016 Category: Perinatology & Neonatology Authors: Seetha Shankaran, Girija Natarajan, Lina Chalak, Athina Pappas, Scott A. McDonald, Abbot R. Laptook Source Type: research
Hypothermia for neonatal hypoxic–ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field
We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - June 22, 2016 Category: Perinatology & Neonatology Authors: Seetha Shankaran, Girija Natarajan, Lina Chalak, Athina Pappas, Scott A. McDonald, Abbot R. Laptook Source Type: research
