Erratum to: Genetic Contributions to Biliary Atresia: A Developmental Cholangiopathy
Semin Liver Dis DOI: 10.1055/s-0043-1776036 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - October 12, 2023 Category: Gastroenterology Authors: Hellen, Dominick J. Karpen, Saul J. Tags: Erratum Source Type: research

Erratum to: Hepatitis Delta Infection: A Clinical Review
Semin Liver Dis DOI: 10.1055/s-0043-1776037 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - October 10, 2023 Category: Gastroenterology Authors: Pearlman, Brian Tags: Erratum Source Type: research

COVID-19 and Liver Disease: An Evolving Landscape
In conclusion, COVID-19 has significant implications in liver diseases; early recognition and treatments are important for improving patient outcomes. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - September 29, 2023 Category: Gastroenterology Authors: Zhu, Kai Tsai, Olivia Chahal, Daljeet Hussaini, Trana Yoshida, Eric M. Tags: Review Article Source Type: research

Genetic Contributions to Biliary Atresia: A Developmental Cholangiopathy
Semin Liver Dis DOI: 10.1055/a-2153-8927 Biliary atresia (BA) is the most prevalent serious liver disease of infancy and childhood, and the principal indication for liver transplantation in pediatrics. BA is best considered as an idiopathic panbiliary cholangiopathy characterized by obstruction of bile flow and consequent cholestasis presenting during fetal and perinatal periods. While several etiologies have been proposed, each has significant drawbacks that have limited understanding of disease progression and the development of effective treatments. Recently, modern genetic analyses have uncovered gene variants contribu...
Source: Seminars in Liver Disease - September 19, 2023 Category: Gastroenterology Authors: Hellen, Dominick J. Karpen, Saul J. Tags: Review Article Source Type: research

Research Progress on the Role and Mechanism of IL-37 in Liver Diseases
This article mainly reviews the biological characteristics of IL-37, which inhibits hepatitis, liver injury, and liver fibrosis by inhibiting inflammation, and inhibits the development of hepatocellular carcinoma (HCC) by regulating the immune microenvironment. Based on additional evidence, combining IL-37 with liver disease markers for diagnosis and treatment can achieve more significant effects, suggesting that IL-37 can be developed into a powerful tool for the clinical adjuvant treatment of liver diseases, especially HCC. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArtic...
Source: Seminars in Liver Disease - September 11, 2023 Category: Gastroenterology Authors: Jiang, Baoyi Zhou, Yulin Liu, Yanting He, Siqi Liao, Baojian Peng, Tieli Yao, Leyi Qi, Ling Tags: Review Article Source Type: research

Gut Microbiome-Centered Therapies for Alcohol-Associated Liver Disease
Semin Liver Dis DOI: 10.1055/a-2145-7331 Globally, liver disease caused by alcohol is becoming more prevalent each year. Misuse of alcohol causes a spectrum of liver diseases, such as liver steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The cornerstone of treatment is abstinence from alcohol. In spite of this, available treatment for alcohol-associated liver disease (ALD) shows limited effectiveness currently. There are numerous ways in which alcohol disrupts the gut–liver axis, including dysbiosis of the gut microbiome, disruption of mucus and epithelial cell barriers, impaired production...
Source: Seminars in Liver Disease - August 30, 2023 Category: Gastroenterology Authors: Ranjbarian, Tannaz Schnabl, Bernd Tags: Review Article Source Type: research

Hepatitis Delta Infection: A Clinical Review
In conclusion, given the severity of HDV disease and the paucity of treatments, there is a great unmet need for HDV therapies. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - August 30, 2023 Category: Gastroenterology Authors: Pearlman, Brian Tags: Review Article Source Type: research

Alcohol-Related Liver Disease: Is There a Safe Alcohol Consumption Limit for Liver Disease?
In conclusion, low-level alcohol consumption in the absence of liver disease is associated with a very small risk of developing ALD, but once ALD is present patients should be supported to achieve complete abstinence from alcohol. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - August 28, 2023 Category: Gastroenterology Authors: Pekarska, Katrina Parker, Richard Tags: Review Article Source Type: research

The Role of Endoplasmic Reticulum Stress Response in Liver Regeneration
Semin Liver Dis DOI: 10.1055/a-2129-8977 Exposure to hepatotoxic chemicals is involved in liver disease–related morbidity and mortality worldwide. The liver responds to damage by triggering compensatory hepatic regeneration. Physical agent or chemical-induced liver damage disrupts hepatocyte proteostasis, including endoplasmic reticulum (ER) homeostasis. Post–liver injury ER experiences a homeostatic imbalance, followed by active ER stress response signaling. Activated ER stress response causes selective upregulation of stress response genes and downregulation of many hepatocyte genes. Acetaminophen overdose, carbon te...
Source: Seminars in Liver Disease - August 18, 2023 Category: Gastroenterology Authors: Deshmukh, Kshitij Apte, Udayan Tags: Review Article Source Type: research

FXR Friend-ChIPs in the Enterohepatic System
In conclusion, one of the greatest unmet needs in the field is understanding the underlying mechanism of intestinal versus hepatic FXR function. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - August 11, 2023 Category: Gastroenterology Authors: Meadows, Vik Yang, Zhenning Basaly, Veronia Guo, Grace L. Tags: Review Article Source Type: research

Angiocrine Signaling in Sinusoidal Health and Disease
In conclusion, sinusoidal endotheliopathy is recognized in liver disease and promising preclinical studies are paving the path toward LSEC-specific pharmacotherapies. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - August 11, 2023 Category: Gastroenterology Authors: Cooper, Shawna A. Kostallari, Enis Shah, Vijay H. Tags: Review Article Source Type: research

Pediatric and Adult Liver Disease in Alpha-1 Antitrypsin Deficiency
In conclusion, AATD is an increasingly appreciated pediatric and adult liver disorder that is becoming an attractive target for modern pharmacologic strategies. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - August 9, 2023 Category: Gastroenterology Authors: Ruiz, Mathias Lacaille, Florence Schrader, Christina Pons, Monica Socha, Piotr Krag, Aleksander Sturm, Ekkehard Bouchecareilh, Marion Strnad, Pavel Tags: Review Article Source Type: research

How to Identify Advanced Nonalcoholic Fatty Liver Disease in the Primary Care Setting
Semin Liver Dis DOI: 10.1055/s-0043-1770984 Nonalcoholic fatty liver disease (NAFLD) affects 30 to 40% of the population globally and is increasingly considered the most common liver disease. Patients with type 2 diabetes, obesity, and cardiovascular diseases are at especially increased risk for NAFLD. Although most patients with NAFLD do not have progressive liver disease, some patients progress to cirrhosis, liver cancer, and liver mortality. Given the sheer number of patients with NAFLD, the burden of disease is enormous. Despite this large and increasing burden, identification of NAFLD patients at risk for progressive ...
Source: Seminars in Liver Disease - July 6, 2023 Category: Gastroenterology Authors: Golabi, Pegah Shah, Dipam Younossi, Zobair M. Tags: Review Article Source Type: research

Genetic and Epigenetic Basis of Drug-Induced Liver Injury
In conclusion, these studies provide useful information in risk alleles identification and on implementation of personalized medicine. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - July 5, 2023 Category: Gastroenterology Authors: Singh, Snigdha Kumar, P.V.S.N. Kiran Kumar, J. Pradeep Tomo, Sojit Yadav, Dharamveer Sharma, Praveen Rao, Mahadev Banerjee, Mithu Tags: Review Article Source Type: research

HNF4 α in Hepatocyte Health and Disease
Semin Liver Dis DOI: 10.1055/a-2097-0660 Hepatocyte nuclear factor 4 α (HNF4α) is a highly conserved member of the nuclear receptor superfamily expressed at high levels in the liver, kidney, pancreas, and gut. In the liver, HNF4α is exclusively expressed in hepatocytes, where it is indispensable for embryonic and postnatal liver development and for normal liver function in adults. It is considered a master regulator of hepatic differentiation because it regulates a significant number of genes involved in hepatocyte-specific functions. Loss of HNF4α expression and function is associated with the progression of chronic l...
Source: Seminars in Liver Disease - July 5, 2023 Category: Gastroenterology Authors: Kotulkar, Manasi Robarts, Dakota R. Apte, Udayan Tags: Review Article Source Type: research