Cover (pms 180 & k)
(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 22, 2017 Category: Pathology Source Type: research
Masthead
(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 22, 2017 Category: Pathology Source Type: research
Editorial board
(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 22, 2017 Category: Pathology Source Type: research
Table of contents
(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 22, 2017 Category: Pathology Source Type: research
Topics
(Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 22, 2017 Category: Pathology Source Type: research
Histopathology of Fungal Diseases of the Lung
Fungal pneumonias can be a diagnostic problem. However, their recognition is important as they can pose a significant health risk, especially in the immunocompromised host. While many of these infections are accompanied by necrotizing or non-necrotizing granulomas, some might be characterized by cellular interstitial pneumonia, intra-alveolar frothy material or only minimal inflammatory change. Much of the tissue reaction is dependent on the immune status of the patient and the type of fungal organism. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 13, 2017 Category: Pathology Authors: Anja C. Roden, Audrey N. Schuetz Tags: Review article Source Type: research
Histopathology of Parasitic Infections of the Lung
Parasitic infections are important but uncommonly encountered causes of pulmonary disease in most resource-rich settings. Given that infections are generally diagnosed using conventional microbiology methods, many pathologists are uncomfortable identifying parasites in histological and cytological preparations. However, with increased global travel, pulmonary parasitic infections such as cysticercosis, malaria, paragonimiasis, and schistosomiasis may be encountered by pathologists outside of endemic areas. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 9, 2017 Category: Pathology Authors: Jennifer M. Boland, Bobbi S. Pritt Tags: Review article Source Type: research
Introduction to “Non-Epithelial Lesions of the Breast” Issue
"When you hear hoofbeats, think of horses, not zebras. ” This advice is commonly given to medical trainees, especially when making esoteric, textbook diagnoses and missing more obvious, common diagnoses. However, the reverse is also true for diagnosticians. While calculations of probability may argue otherwise, the improbable diagnoses must at least b e considered until the findings in any given case rule them out. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 7, 2017 Category: Pathology Authors: Kimberly H. Allison Tags: Editorial Source Type: research
The Pathology of Pulmonary Bacterial Infection
In its role as a portal between the ambient environment and the internal milieu, the lung is the most frequent site of bacterial infection. A variety of factors predispose to pulmonary bacterial infection, including distortions in lung anatomy, decreased mucociliary clearance, and abnormal immunity. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 7, 2017 Category: Pathology Authors: Richard L. Kradin, Subbha Digumarthy Tags: Review article Source Type: research
Pathology of Pulmonary Tuberculosis and Non-tuberculous Mycobacterial Lung Disease: Facts, Misconceptions, and Practical Tips for Pathologists
Most pathologists are familiar with the microscopic features of tuberculosis and the need to examine special stains for acid-fast bacteria (AFB) in cases of granulomatous lung disease. However, misconceptions do exist, including the concept that finding AFB in “caseating granulomas” confirms the diagnosis of tuberculosis. This dogma is attributable to the high prevalence of tuberculosis in many countries, as well as unfamiliarity with the microscopic spectrum of non-tuberculous mycobacterial lung disease. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 7, 2017 Category: Pathology Authors: Deepali Jain, Subha Ghosh, Lucileia Teixeira, Sanjay Mukhopadhyay Tags: Review article Source Type: research
Histopathology of Viral Infections of the Lung
Lower respiratory viral infections are a significant source of morbidity and mortality worldwide, causing an estimated 3.9 million deaths each year.1 In particular, viruses cause up to 50% of community-acquired pneumonia (CAP) in children and adults, and predispose patients to secondary bacterial pneumonia.1,2 Those at risk for more severe disease include the very young, very old, immunocompromised, and patients with pre-existing respiratory conditions. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - June 7, 2017 Category: Pathology Authors: Bobbi S. Pritt, Marie Christine Aubry Source Type: research
Next Generation Immunohistochemistry: Emerging Substitutes to Genetic Testing?
The identification of at-risk kindreds facilitates screening and risk reduction strategies for patients with hereditary cancer predisposition syndromes. Recently, immunohistochemistry (IHC) has emerged as a cost-effective strategy for detecting or inferring the presence of mutations in both tumors and the germline of patients presenting with tumors associated with hereditary cancer predisposition syndromes. In this review we discuss the use of novel IHC markers, including PRKAR1A, β-catenin, SDHB, fumarate hydratase and 2SC, HRASQ61R, BAP1, parafibromin and glucagon, which have either established applications or show prom...
Source: Seminars in Diagnostic Pathology - June 5, 2017 Category: Pathology Authors: Juliana Andrici, Anthony J Gill, Jason L Hornick Tags: Review article Source Type: research
Merkel Cell Carcinoma, Melanoma, Metastatic Mimics of Breast Cancer
Merkel cell carcinoma and melanoma can each occur primarily in breast skin, or metastasize to the breast. The breast is a rare site of metastasis of essentially any and every type of tumor, including carcinomas, sarcomas, and hematolymphoid neoplasms, and 10 –30% of breast metastases may represent the initial presentation of disease. Although metastases generally recapitulate histologic features of the primary tumor, they are diagnostically challenging given their rarity and morphologic overlap with breast carcinoma, including special types of breast cancer. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 30, 2017 Category: Pathology Authors: Megan L. Troxell Tags: Review article Source Type: research
Cutaneous/Subcutaneous Mesenchymal Proliferations of the Breast
Cutaneous mesenchymal “spindle cell” lesions arising in the vicinity of the breast represent a complex clinical and diagnostic scenario which may overlap histopathologically and immunohistochemically with mammary spindle cell proliferations, potentially impacting management and overall prognostication. In this review , we suggest a pattern-based approach to assist in the evaluation of these lesions. A comprehensive description of each entity is accompanied by a cutaneous and mammary differential diagnosis. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 29, 2017 Category: Pathology Authors: Lurmag Y. Orta, Jessica N. Beyda, Garrett T. Desman Tags: Review article Source Type: research
Lipomatous Tumors of the Breast: A Contemporary Review
Breast tumors with lipomatous or liposarcomatous components are infrequently encountered, but can be a source of diagnostic difficulty if the context of the fatty differentiation is not recognised. Among the true adipocytic tumors, lipoma is the most common lipomatous tumor arising in the breast. Several mammary spindle cell tumors may show adipocytic differentiation, including fibroepithelial tumors and myofibroblastoma. Liposarcomatous components most often arise in malignant phyllodes tumors, as opposed to primary liposarcomas of the breast which are believed to be uncommon. (Source: Seminars in Diagnostic Pathology)
Source: Seminars in Diagnostic Pathology - May 29, 2017 Category: Pathology Authors: J. Jordi Rowe, Alison L. Cheah, Benjamin C. Calhoun Tags: Review article Source Type: research
