Connectivity of the precuneus-posterior cingulate cortex with the anterior cingulate cortex-medial prefrontal cortex differs consistently between control subjects and first-episode psychosis patients during a movie stimulus
Functional connectivity is altered in psychotic disorders. Multiple findings concentrate on the default mode network, anchored on the precuneus-posterior cingulate cortex (PC-PCC). However, the nature of the alterations varies between studies and connectivity alterations have not been studied during an ecologically valid natural stimulus. In the present study, we investigated the functional and structural connectivity of a PC-PCC region, where functioning differentiated first-episode psychosis patients from control subjects during free viewing of a movie in our earlier study. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 26, 2018 Category: Psychiatry Authors: Eva Rikandi, Teemu M äntylä, Maija Lindgren, Tuula Kieseppä, Jaana Suvisaari, Tuukka T. Raij Source Type: research

Aberrant within- and between-network connectivity of the mirror neuron system network and the mentalizing network in first episode psychosis
It has been suggested that the mentalizing network and the mirror neuron system network support important social cognitive processes that are impaired in schizophrenia. However, the integrity and interaction of these two networks have not been sufficiently studied, and their effects on social cognition in schizophrenia remain unclear. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 26, 2018 Category: Psychiatry Authors: Eugenie Choe, Tae Young Lee, Minah Kim, Ji-Won Hur, Youngwoo Bryan Yoon, Kang-Ik K. Cho, Jun Soo Kwon Source Type: research

Replication of GWAS identified miR-137 and its target gene polymorphisms in Schizophrenia of South Indian population and meta-analysis with Psychiatric Genomics Consortium
Schizophrenia is a complex psychiatric disorder involving multiple genes each contributing a small risk. Genome-wide association studies (GWASs) have identified hundreds of risk loci for schizophrenia including miR-137, a miRNA shown to be involved in neuronal development. Several genes regulated by miR-137 were also reported as top risk genes associated with schizophrenia and has been hypothesised that the dysregulation of miR-137 and its target could be involved in the aetiology of schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 26, 2018 Category: Psychiatry Authors: Ravi Sudesh, Anbupalam Thalamuthu, Sujit John, Rangaswamy Thara, Bryan Mowry, Arasamabattu Kannan Munirajan Source Type: research

Increased complement component 4 (C4) gene expression in the cingulate cortex of rats exposed to late gestation immune activation
The largest genetic study of schizophrenia confirmed the strong genetic association with the major histocompatibility complex (MHC) locus (Ripke et al., 2011). Whilst the link between schizophrenia and the MHC locus is not yet fully elucidated, there is significant interest in immune dysfunction as an underlying pathology in schizophrenia. Recently Sekar et al. (2016) presented strong evidence for a role of complement component 4 (C4) in schizophrenia by showing that some of the variation in the MHC locus in schizophrenia is linked to the C4 gene. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 26, 2018 Category: Psychiatry Authors: Ryan J. Duchatel, Crystal L. Meehan, Lauren R. Harms, Patricia T. Michie, Mark J. Bigland, Doug W. Smith, Phillip Jobling, Deborah M. Hodgson, Paul A. Tooney Tags: Letter to the editor Source Type: research

Negative voice-content as a full mediator of a relation between childhood adversity and distress ensuing from hearing voices
This study aimed to test the hypotheses that levels of childhood adversity would predict levels of negative voice-content, and that negative voice-content would partially mediate a relation between childhood adversity and voice-related distress. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 24, 2018 Category: Psychiatry Authors: Cherise Rosen, Simon McCarthy-Jones, Nev Jones, Kayla A. Chase, Rajiv P. Sharma Source Type: research

Accidental deaths among persons with schizophrenia: A nationwide population-based cohort study
Persons with schizophrenia have a shorter life expectancy by 15 –20years compared to the background population, but little is known about deaths caused by accidents. We aimed to investigate the rates of accidental death among persons with schizophrenia and compare these rates with those of the background population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 24, 2018 Category: Psychiatry Authors: Line Amalie Aarestrup Hellemose, Thomas Munk Laursen, Janne Tidselbak Larsen, Anita Toender Source Type: research

Negative voice-content as a full mediator of a relation between childhood adversity and distress ensuing from hearing voices
This study aimed to test the hypotheses that levels of childhood adversity would predict levels of negative voice-content, and that negative voice-content would partially mediate a relation between childhood adversity and voice-related distress. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 24, 2018 Category: Psychiatry Authors: Cherise Rosen, Simon McCarthy-Jones, Nev Jones, Kayla A. Chase, Rajiv P. Sharma Source Type: research

Accidental deaths among persons with schizophrenia: A nationwide population-based cohort study
Persons with schizophrenia have a shorter life expectancy by 15 –20years compared to the background population, but little is known about deaths caused by accidents. We aimed to investigate the rates of accidental death among persons with schizophrenia and compare these rates with those of the background population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 24, 2018 Category: Psychiatry Authors: Line Amalie Aarestrup Hellemose, Thomas Munk Laursen, Janne Tidselbak Larsen, Anita Toender Source Type: research

Childhood exposure to green space – A novel risk-decreasing mechanism for schizophrenia?
The objectives for this study were to determine if green space are associated with schizophrenia risk, and if different measures of green space associate differently with risk. We used satellite data from the Landsat program to quantify green space in a new data set for Denmark at 30 ×30m resolution for the years 1985–2013. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 22, 2018 Category: Psychiatry Authors: Kristine Engemann, Carsten B øcker Pedersen, Lars Arge, Constantinos Tsirogiannis, Preben Bo Mortensen, Jens-Christian Svenning Source Type: research

Disrupted network cross talk, hippocampal dysfunction and hallucinations in schizophrenia
This study integrates two resting-state functional magnetic resonance imaging (fMRI) analysis methods – amplitudes of low-frequency fluctuations (ALFF) and functional network connectivity (FNC) – to explore the hypotheses that (1) abnormal FNC between salience and sensory (visual/auditory) networks underlies hallucinations in schizophrenia, and (2) disrupted hippocampal oscillations (as measured by hippocampal ALFF) beget changes in FNC linked to hallucinations. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 20, 2018 Category: Psychiatry Authors: Stephanie M. Hare, Alicia S. Law, Judith M. Ford, Daniel H. Mathalon, Aral Ahmadi, Eswar Damaraju, Juan Bustillo, Aysenil Belger, Hyo Jong Lee, Bryon A. Mueller, Kelvin O. Lim, Gregory G. Brown, Adrian Preda, Theo G.M. van Erp, Steven G. Potkin, Vince D. Source Type: research

Early sustained recovery following first episode psychosis: Evidence from the AESOP10 follow-up study
To describe the characteristics of individuals with early sustained recovery following first episode psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 20, 2018 Category: Psychiatry Authors: J.M. Lappin, M. Heslin, B. Lomas, P.B. Jones, G.A. Doody, U.A. Reininghaus, T. Croudace, T. Craig, P. Fearon, R.M. Murray, P. Dazzan, C. Morgan Source Type: research

The Italian version of the 16-item prodromal questionnaire (iPQ-16): Field-test and psychometric features
Among current early screeners for psychosis-risk states, the Prodromal Questionnaire-16 items (PQ-16) is often used. We aimed to assess validity and reliability of the Italian version of the PQ-16 in a young adult help-seeking population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 20, 2018 Category: Psychiatry Authors: Pelizza Lorenzo, Azzali Silvia, Paterlini Federica, Garlassi Sara, Scazza Ilaria, Simona Pupo, Raballo Andrea Source Type: research

Disrupted network cross talk, hippocampal dysfunction and hallucinations in schizophrenia
This study integrates two resting-state functional magnetic resonance imaging (fMRI) analysis methods – amplitudes of low-frequency fluctuations (ALFF) and functional network connectivity (FNC) – to explore the hypotheses that (1) abnormal FNC between salience and sensory (visual/auditory) networks underlies hallucinations in schizophrenia, and (2) disrupted hippocampal oscillations (as measured by hippocampal ALFF) beget changes in FNC linked to hallucinations. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 20, 2018 Category: Psychiatry Authors: Stephanie M. Hare, Alicia S. Law, Judith M. Ford, Daniel H. Mathalon, Aral Ahmadi, Eswar Damaraju, Juan Bustillo, Aysenil Belger, Hyo Jong Lee, Bryon A. Mueller, Kelvin O. Lim, Gregory G. Brown, Adrian Preda, Theo G.M. van Erp, Steven G. Potkin, Vince D. Source Type: research

Early sustained recovery following first episode psychosis: Evidence from the AESOP10 follow-up study
To describe the characteristics of individuals with early sustained recovery following first episode psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 20, 2018 Category: Psychiatry Authors: J.M. Lappin, M. Heslin, B. Lomas, P.B. Jones, G.A. Doody, U.A. Reininghaus, T. Croudace, T. Craig, P. Fearon, R.M. Murray, P. Dazzan, C. Morgan Source Type: research

The Italian version of the 16-item prodromal questionnaire (iPQ-16): Field-test and psychometric features
Among current early screeners for psychosis-risk states, the Prodromal Questionnaire-16 items (PQ-16) is often used. We aimed to assess validity and reliability of the Italian version of the PQ-16 in a young adult help-seeking population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 20, 2018 Category: Psychiatry Authors: Pelizza Lorenzo, Azzali Silvia, Paterlini Federica, Garlassi Sara, Scazza Ilaria, Simona Pupo, Raballo Andrea Source Type: research

Comparisons of schizotypal traits across 12 countries: Results from the International Consortium for Schizotypy Research
Schizotypal traits are expressions of underlying vulnerability to psychotic disorders which have a potential impact on mental health status, neurocognition, quality of life, and daily functioning. To date, little research has examined epidemiologic landscape of schizotypal traits at the cross-national level. Our aim was to study the expression of schizotypal traits by sex, age, and country in a combined sample gathered from 12 countries. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 19, 2018 Category: Psychiatry Authors: Eduardo Fonseca-Pedrero, Raymond C.K. Chan, Martin Debban é, David Cicero, Lisa C. Zhang, Colleen Brenner, Emma Barkus, Richard J. Linscott, Thomas Kwapil, Neus Barrantes-Vidal, Alex Cohen, Adrian Raine, Michael T. Compton, Erin B. Tone, Julie Suhr, Jos Source Type: research

Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples
We validated the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 19, 2018 Category: Psychiatry Authors: Han-yu Zhou, Keri Ka-Yee Wong, Li-juan Shi, Xi-long Cui, Yun Qian, Wen-qing Jiang, Ya-song Du, Simon S.Y. Lui, Xue-rong Luo, Zheng-hui Yi, Eric F.C. Cheung, Anna R. Docherty, Raymond C.K. Chan Source Type: research

Comparisons of schizotypal traits across 12 countries: Results from the International Consortium for Schizotypy Research
Schizotypal traits are expressions of underlying vulnerability to psychotic disorders which have a potential impact on mental health status, neurocognition, quality of life, and daily functioning. To date, little research has examined epidemiologic landscape of schizotypal traits at the cross-national level. Our aim was to study the expression of schizotypal traits by sex, age, and country in a combined sample gathered from 12 countries. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 19, 2018 Category: Psychiatry Authors: Eduardo Fonseca-Pedrero, Raymond C.K. Chan, Martin Debban é, David Cicero, Lisa C. Zhang, Colleen Brenner, Emma Barkus, Richard J. Linscott, Thomas Kwapil, Neus Barrantes-Vidal, Alex Cohen, Adrian Raine, Michael T. Compton, Erin B. Tone, Julie Suhr, Jos Source Type: research

Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples
We validated the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 19, 2018 Category: Psychiatry Authors: Han-yu Zhou, Keri Ka-Yee Wong, Li-juan Shi, Xi-long Cui, Yun Qian, Wen-qing Jiang, Ya-song Du, Simon S.Y. Lui, Xue-rong Luo, Zheng-hui Yi, Eric F.C. Cheung, Anna R. Docherty, Raymond C.K. Chan Source Type: research

Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - March 16, 2018 Category: Psychiatry Source Type: research

Hippocampus volume reduction in psychosis spectrum could be ameliorated by vitamin D
Numerous neuroimaging studies report brain changes in psychosis patients compared to controls. Recently, in large consortia collaborations, the hippocampus was demonstrated as one of the most affected cortical structures in schizophrenia (van Erp et al., 2016) and in bipolar disorder (Hibar et al., 2016). In schizophrenia there are indications of a positive correlation between the right hippocampus and serum vitamin D (Shivakumar et al., 2015) and that the hippocampus has a different aging trajectory in patients compared to controls (Pujol et al., 2014). (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 16, 2018 Category: Psychiatry Authors: Tiril P. Gurholt, Mari Nerhus, K åre Osnes, Akiah O. Berg, Ole A. Andreassen, Ingrid Melle, Ingrid Agartz Tags: Letter to the editor Source Type: research

Increased long-term mortality after myocardial infarction in patients with schizophrenia
Ischemic heart disease increases mortality in patients with schizophrenia. This nationwide study explored short-term and long-term mortality rates in patients with schizophrenia experiencing myocardial infarction (MI) compared to controls from the general population experiencing MI, as well as patients with schizophrenia and people from the general population not experiencing MI. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 16, 2018 Category: Psychiatry Authors: Pirathiv Kugathasan, Thomas Munk Laursen, Simon Gr øntved, Svend Eggert Jensen, Jørgen Aagaard, René Ernst Nielsen Source Type: research

Dietary patterns and physical activity in people with schizophrenia and increased waist circumference
People with severe mental disorders die 10 –25years earlier than people in the Western background population, mainly due to lifestyle related diseases, with cardiovascular disease (CVD) being the most frequent cause of death. Major contributors to this excess morbidity and mortality are unhealthy lifestyle factors including tobacco smoking , unhealthy eating habits and lower levels of physical activity. The aim of this study was to investigate the dietary habits and levels of physical activity in people with schizophrenia spectrum disorders and overweight and to compare the results with the current recommendations an...
Source: Schizophrenia Research - March 16, 2018 Category: Psychiatry Authors: Ane Storch Jakobsen, Helene Speyer, Hans Christian Brix N ørgaard, Mette Karlsen, Carsten Hjorthøj, Jesper Krogh, Ole Mors, Merete Nordentoft, Ulla Toft Source Type: research

Hippocampus volume reduction in psychosis spectrum could be ameliorated by vitamin D
Numerous neuroimaging studies report brain changes in psychosis patients compared to controls. Recently, in large consortia collaborations, the hippocampus was demonstrated as one of the most affected cortical structures in schizophrenia (van Erp et al., 2016) and in bipolar disorder (Hibar et al., 2016). In schizophrenia there are indications of a positive correlation between the right hippocampus and serum vitamin D (Shivakumar et al., 2015) and that the hippocampus has a different aging trajectory in patients compared to controls (Pujol et al., 2014). (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 16, 2018 Category: Psychiatry Authors: Tiril P. Gurholt, Mari Nerhus, K åre Osnes, Akiah O. Berg, Ole A. Andreassen, Ingrid Melle, Ingrid Agartz Tags: Letter to the editor Source Type: research

Increased long-term mortality after myocardial infarction in patients with schizophrenia
Ischemic heart disease increases mortality in patients with schizophrenia. This nationwide study explored short-term and long-term mortality rates in patients with schizophrenia experiencing myocardial infarction (MI) compared to controls from the general population experiencing MI, as well as patients with schizophrenia and people from the general population not experiencing MI. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 16, 2018 Category: Psychiatry Authors: Pirathiv Kugathasan, Thomas Munk Laursen, Simon Gr øntved, Svend Eggert Jensen, Jørgen Aagaard, René Ernst Nielsen Source Type: research

Dietary patterns and physical activity in people with schizophrenia and increased waist circumference
People with severe mental disorders die 10 –25years earlier than people in the Western background population, mainly due to lifestyle related diseases, with cardiovascular disease (CVD) being the most frequent cause of death. Major contributors to this excess morbidity and mortality are unhealthy lifestyle factors including tobacco smoking , unhealthy eating habits and lower levels of physical activity. The aim of this study was to investigate the dietary habits and levels of physical activity in people with schizophrenia spectrum disorders and overweight and to compare the results with the current recommendations an...
Source: Schizophrenia Research - March 16, 2018 Category: Psychiatry Authors: Ane Storch Jakobsen, Helene Speyer, Hans Christian Brix N ørgaard, Mette Karlsen, Carsten Hjorthøj, Jesper Krogh, Ole Mors, Merete Nordentoft, Ulla Toft Source Type: research

Oxytocin and sexual function in males and females with schizophrenia
In people with schizophrenia, social affiliative function, including sexual behavior, is often impaired. Approximately 50% of persons with schizophrenia experience sexual dysfunction, though clinicians underestimate this (Dossenbach et al., 2005). Sexual dysfunction may be related to symptoms, psychosocial factors, and psychotropic medications (de Boer et al., 2015), and can impact physical health, quality of life, and medication adherence. Therefore, this is an important aspect of treatment for this population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 15, 2018 Category: Psychiatry Authors: H.J. Wehring, R.W. Buchanan, S. Feldman, W.T. Carpenter, R.P. McMahon, E. Weiner, J.M. Gold, H.A. Adams, G.P. Strauss, L.H. Rubin, D.L. Kelly Tags: Letter to the editor Source Type: research

Montreal Cognitive Assessment as a screening instrument for cognitive impairments in schizophrenia
This study evaluates the clinical utility of the Montreal Cognitive Assessment (MoCA) in detecting cognitive impairments in schizophrenia and its relationship with functional outcome and demographic characters. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 14, 2018 Category: Psychiatry Authors: Zixu Yang, Nur Amirah Abdul Rashid, Yue Feng Quek, Max Lam, Yuen Mei See, Yogeswary Maniam, Justin Dauwels, Bhing Leet Tan, Jimmy Lee Source Type: research

Clozapine-induced cardiomyopathy and myocarditis monitoring: A systematic review
The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language articles to synthesize an evidence-based approach for myocarditis and cardiomyopathy monitoring. Articles published from January 1988 through February 2017 were identified through a search of Ovid MEDLINE, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus, and Google Scholar. (Source...
Source: Schizophrenia Research - March 13, 2018 Category: Psychiatry Authors: Kristen N. Knoph, Robert J. Morgan, Brian A. Palmer, Kathryn M. Schak, Amanda C. Owen, Megan R. Leloux, Mayur Patel, Jonathan G. Leung Source Type: research

Psychotic disorders in sexually abused youth: A prospective matched-cohort study
This study used administrative databases from a Child Protection Agency and a public health care system. It aimed to investigate the prevalence of psychotic disorders in sexually abused youth between the first substantiated report of sexual abuse and the beginning of adulthood. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 13, 2018 Category: Psychiatry Authors: Catherine Bourgeois, Tania Lecomte, Isabelle Daigneault Source Type: research

Clozapine-induced cardiomyopathy and myocarditis monitoring: A systematic review
The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language articles to synthesize an evidence-based approach for myocarditis and cardiomyopathy monitoring. Articles published from January 1988 through February 2017 were identified through a search of Ovid MEDLINE, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus, and Google Scholar. (Source...
Source: Schizophrenia Research - March 13, 2018 Category: Psychiatry Authors: Kristen N. Knoph, Robert J. Morgan, Brian A. Palmer, Kathryn M. Schak, Amanda C. Owen, Megan R. Leloux, Mayur Patel, Jonathan G. Leung Source Type: research

Psychotic disorders in sexually abused youth: A prospective matched-cohort study
This study used administrative databases from a Child Protection Agency and a public health care system. It aimed to investigate the prevalence of psychotic disorders in sexually abused youth between the first substantiated report of sexual abuse and the beginning of adulthood. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 13, 2018 Category: Psychiatry Authors: Catherine Bourgeois, Tania Lecomte, Isabelle Daigneault Source Type: research

Dimensions of insight in schizophrenia: Exploratory factor analysis of items from multiple self- and interviewer-rated measures of insight
Insight in schizophrenia is regarded as a multidimensional construct that comprises aspects such as awareness of the disorder and recognition of the need for treatment. The proposed number of underlying dimensions of insight is variable in the literature. In an effort to identify a range of existing dimensions of insight, we conducted a factor analysis on combined items from multiple measures of insight. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 10, 2018 Category: Psychiatry Authors: Susanna Konsztowicz, Norbert Schmitz, Martin Lepage Source Type: research

Rare variant analysis in multiply affected families, association studies and functional analysis suggest a role for the ITG Β4 gene in schizophrenia and bipolar disorder
Recent results imply that rare variants contribute to the risk of schizophrenia. Exome sequence data from the UK10K project was used to identify three rare, amino acid changing variants in the ITGB4 gene which segregated with schizophrenia in two families: rs750367954, rs147480547 and rs145976111. Association analysis was carried out in the exome-sequenced Swedish schizophrenia study and in UCL schizophrenia and bipolar cases and controls genotyped for these variants. A gene-wise weighted burden test was performed on a trio sample of schizophrenia cases and their parents. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 9, 2018 Category: Psychiatry Authors: N.L. O'Brien, A. Fiorentino, D. Curtis, C. Rayner, C. Petrosellini, M. Al Eissa, N.J. Bass, A. McQuillin, S.I. Sharp Source Type: research

Chronotropic incompetence of the heart is associated with exercise intolerance in patients with schizophrenia
This study investigated whether cardiac autonomic dysfunction (CADF) in schizophrenia is related to chronotropic incompetence, an established cardiovascular risk marker.We investigated thirty-two patients suffering from paranoid schizophrenia and thirty-two control subjects matched for a ge, sex, body mass index and fat free mass. A cardiopulmonary exercise test (CPET) was performed to study heart rate responses to exercise as well as submaximal (ventilatory threshold 1, VT1) and maximal endurance capacities (peak oxygen consumption, VO2peak; peak power output, Ppeak). (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Marco Herbsleb, Andy Schumann, Berend Malchow, Christian Puta, P. Christian Schulze, Holger W. Gabriel, Karl-J ürgen Bär Source Type: research

Paranoid beliefs and realistic expectations of victimization: Data from the survey of police-public encounters
The anticipation of threat or victimization is a core feature of paranoia. Cognitive theories of paranoia suggest that paranoid thoughts may arise as a psychological response to trauma exposure, which likewise may lead to greater anticipation of subsequent victimization. Little is known, however, about the relation between paranoid beliefs and anticipated victimization when accounting for past victimization experience. The present study aimed to address whether the experiences of past victimization contribute to the link between paranoid beliefs and the anticipation of threat or victimization, with a particular focus on ex...
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Hyun-Jin Jun, Boyoung Nam, Lisa Fedina, Melissa Edmondson Smith, Jason Schiffman, Bruce Link, Jordan E. DeVylder Source Type: research

Association between sleep, childhood trauma and psychosis-like experiences
Psychosis-like experiences (PLEs), or attenuated positive symptoms of psychosis, present along a severity continuum and have been associated with distressing thoughts and impairments in functioning. Although knowledge of the clinical importance of PLEs is expanding, risk factors for their expression are still poorly understood. Sleep disturbances are one known factor that exacerbate PLEs expression and distress, and trauma exposure is associated with occurrence of PLEs, as well as increased risk of later sleep difficulties. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Nicole D. Andorko, Zachary B. Millman, Elizabeth Klingaman, Deborah Medoff, Emily Kline, Jordan DeVylder, Gloria Reeves, Jason Schiffman Source Type: research

Clozapine use in early psychosis
In this study, we aimed to determine; the proportion of young people with a first episode of psychosis (FEP) who would be considered eligible for clozapine treatment, the theoretical delay in commencing clozapine and to compare the outcomes of those treated with clozapine to those who were eligible but not treated with clozapine. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Kristen Thien, Meghan Bowtell, Scott Eaton, Melissa Bardell-Williams, Linglee Downey, Aswin Ratheesh, Patrick McGorry, Brian O'Donoghue Source Type: research

Early treatment resistance in a Latin-American cohort of patients with schizophrenia
Failure to respond to antipsychotic medication in schizophrenia is a common clinical scenario with significant morbidity. Recent studies have highlighted that many patients present treatment-resistance from disease onset. We here present an analysis of clozapine prescription patterns, used as a real-world proxy marker for treatment-resistance, in a cohort of 1195 patients with schizophrenia from a Latin-American cohort, to explore the timing of emergence of treatment resistance and possible subgroup differences. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Cristian Mena, Alfonso Gonzalez-Valderrama, Barbara Iruretagoyena, Juan Undurraga, Nicolas A. Crossley Source Type: research

Impaired reward responsiveness in schizophrenia
Anhedonia is a core negative symptom of schizophrenia. Schizophrenia patients report largely intact pleasure in consuming rewards, but have impairments in generating motivated behavior to pursue rewards, and show reduced fMRI activation of the reward pathway during presentation of rewarded stimuli. A computer based task measuring the development of a response bias in favor of rewarded stimuli permits assessment of reward-induced motivation. We hypothesized that subjects with schizophrenia would be impaired on this task. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Nicholas Taylor, Jeffrey P. Hollis, Sarah Corcoran, Robin Gross, Bruce Cuthbert, Lisette W. Swails, Erica Duncan Source Type: research

Changes in plasma levels of nitric oxide metabolites and negative symptoms after 16-week minocycline treatment in patients with schizophrenia
This study examined the effect of adjunctive minocycline on psychopathology and possibly relevant biomarkers in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Fang Liu, Bingkui Zhang, Liqin Xie, Ye Ruan, XiuFeng Xu, Yong Zeng, Louis Messina, Jingping Zhao, Xiaoduo Fan Source Type: research

Pupillary responses to a cognitive effort task in schizophrenia
Effort-based decision making paradigms are increasingly utilized to gain insight into the nature of motivation deficits. Although these tasks are being used to assess effort and motivation in schizophrenia, little work has been done to confirm that effort-based decision making tasks validly manipulate effort. In the current study, we adapted the effort component a cognitive effort-based decision making task (the Deck Choice Effort Task) for use with pupillometric assessment. We sought to confirm with psychophysiology that cognitive effort is manipulated. (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: L. Felice Reddy, Eric A. Reavis, Jonathan K. Wynn, Michael F. Green Source Type: research

Glucocorticoids and the risk of schizophrenia spectrum disorder in childhood and adolescence – A Danish nationwide study
Glucocorticoids can have psychosis as a potential side effect, but have also been suggested to yield protective effects due to anti-inflammatory properties. Nonetheless, knowledge is sparse on the association between glucocorticoid treatment and development of psychosis, which we aimed to study in this first large-scale longitudinal study.Among all individuals born in Denmark 1995 –2003 (n=597,257), we compared individuals who had redeemed ≥1 prescription for glucocorticoids to an active comparator group and a non-exposed group concerning subsequent development of schizophrenia spectrum disorders until 2013. (Sour...
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Brian Villumsen Broberg, Iris E. Sommer, Michael Eriksen Benros, Birte Yding Glenth øj, Christiane Gasse, Ole Köhler-Forsberg Source Type: research

Chronotropic incompetence of the heart is associated with exercise intolerance in patients with schizophrenia
This study investigated whether cardiac autonomic dysfunction (CADF) in schizophrenia is related to chronotropic incompetence, an established cardiovascular risk marker.We investigated thirty-two patients suffering from paranoid schizophrenia and thirty-two control subjects matched for a ge, sex, body mass index and fat free mass. A cardiopulmonary exercise test (CPET) was performed to study heart rate responses to exercise as well as submaximal (ventilatory threshold 1, VT1) and maximal endurance capacities (peak oxygen consumption, VO2peak; peak power output, Ppeak). (Source: Schizophrenia Research)
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Marco Herbsleb, Andy Schumann, Berend Malchow, Christian Puta, P. Christian Schulze, Holger W. Gabriel, Karl-J ürgen Bär Source Type: research

Paranoid beliefs and realistic expectations of victimization: Data from the survey of police-public encounters
The anticipation of threat or victimization is a core feature of paranoia. Cognitive theories of paranoia suggest that paranoid thoughts may arise as a psychological response to trauma exposure, which likewise may lead to greater anticipation of subsequent victimization. Little is known, however, about the relation between paranoid beliefs and anticipated victimization when accounting for past victimization experience. The present study aimed to address whether the experiences of past victimization contribute to the link between paranoid beliefs and the anticipation of threat or victimization, with a particular focus on ex...
Source: Schizophrenia Research - March 8, 2018 Category: Psychiatry Authors: Hyun-Jin Jun, Boyoung Nam, Lisa Fedina, Melissa Edmondson Smith, Jason Schiffman, Bruce Link, Jordan E. DeVylder Source Type: research