The effects of CACNA1C gene polymorphism on prefrontal cortex in both schizophrenia patients and healthy controls
CACNA1C gene polymorphism rs2007044 has been reported to be associated with schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an exploratory functional magnetic resonance imaging (fMRI) study using an N-BACK task and a Stroop task in 194 subjects (55 schizophrenia patients and 139 healthy controls). Our whole brain analysis found that the risk allele was associated with reduced activation of the left inferior frontal gyrus (IFG) during the Stroop task (cluster size = 390 voxels, P (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 27, 2018 Category: Psychiatry Authors: Zhifang Zhang, Yanyan Wang, Qiumei Zhang, Wan Zhao, Xiongying Chen, Jinguo Zhai, Min Chen, Boqi Du, Xiaoxiang Deng, Feng Ji, Chuanyue Wang, Yutao Xiang, Dawei Li, Hongjie Wu, Qi Dong, Chuansheng Chen, Jun Li Source Type: research
Reducing auditory verbal hallucinations by means of fNIRS neurofeedback – A case study with a paranoid schizophrenic patient
Auditory verbal hallucinations (AVHs) are a core symptom of schizophrenias and are associated with increased activation in speech-relevant regions (e.g. Allen et al., 2012). As AVHs can be resistant to antipsychotic medications (25 –30% of patients) (Shergill et al., 1998), alternative intervention methods are needed. Neurofeedback (NF) constitutes an alternative approach, as it can modulate excitation levels and altered brain activity in the long-term (Butnik, 2005; Sterman, 1996). In a curative trial aimed at symptom reduc tion, we conducted a functional near-infrared spectroscopy (fNIRS)-based NF training of posterior...
Source: Schizophrenia Research - September 27, 2018 Category: Psychiatry Authors: Helena Storchak, Justin Hudak, Florian B. Haeussinger, David Rosenbaum, Andreas J. Fallgatter, Ann-Christine Ehlis Source Type: research
Basic auditory processing deficits and their association with auditory emotion recognition in schizophrenia
Individuals with schizophrenia are impaired in their ability to recognize emotions based on vocal cues and these impairments are associated with poor global outcome. Basic perceptual processes, such as auditory pitch processing, are impaired in schizophrenia and contribute to difficulty identifying emotions. However, previous work has focused on a relatively narrow assessment of auditory deficits and their relation to emotion recognition impairment in schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 26, 2018 Category: Psychiatry Authors: Michael S. Kraus, Trina M. Walker, L. Fredrik Jarskog, Robert A. Millet, Richard S.E. Keefe Source Type: research
Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects
This study investigated gut microbiome composition in 50 individuals, including 25 persons with chronic schizophrenia and 25 demographically-matched non-psychiatric comparison subjects (NCs). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 26, 2018 Category: Psychiatry Authors: Tanya T. Nguyen, Tomasz Kosciolek, Yadira Maldonado, Rebecca E. Daly, Averria Sirkin Martin, Daniel McDonald, Rob Knight, Dilip V. Jeste Source Type: research
Deciphering reward-based decision-making in schizophrenia: A meta-analysis and behavioral modeling of the Iowa Gambling Task
Patients with schizophrenia (SZP) have been reported to exhibit impairments in reward-based decision-making, but results are heterogeneous with multiple potential confounds such as age, intelligence level, clinical symptoms or medication, making it difficult to evaluate the robustness of these impairments. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 25, 2018 Category: Psychiatry Authors: Linda T. Betz, Paolo Brambilla, Andrej Ilankovic, Preethi Premkumar, Myung-Sun Kim, St éphane Raffard, Sophie Bayard, Hikaru Hori, Kyoung-Uk Lee, Seung Jae Lee, Nikolaos Koutsouleris, Joseph Kambeitz Source Type: research
Hearing spirits? Religiosity in individuals at risk for psychosis —Results from the Brazilian SSAPP cohort
In the last decades, biological and environmental factors related to psychosis were investigated in individuals at ultra-risk for psychosis (UHR) to predict conversion. Although religion relates to psychosis in a variety of ways, it is understudied in subclinical samples. Therefore, we assessed the interplay between religion and prodromal symptoms in 79 UHR and 110 control individuals. They were interviewed with the Duke University Religion Index and the Structured Interview for Prodromal Syndromes (SIPS). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 25, 2018 Category: Psychiatry Authors: Alexandre Andrade Loch, Elder Lanzani Freitas, Lucas Hort êncio, Camille Chianca, Tania Maria Alves, Maurício Henriques Serpa, Julio Cesar Andrade, Martinus Theodorus van de Bilt, Wagner Farid Gattaz, Wulf Rössler Source Type: research
Using Google Maps to display the pattern of coauthor collaborations on the topic of schizophrenia: A systematic review between 1937 and 2017
This study aimed to investigate the pattern of coauthor collaborations in schizophrenia research. We conducted a bibliometric study of international scientific publications on schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 24, 2018 Category: Psychiatry Authors: Tsair-Wei Chien, Hsien-Yi Wang, Yu Chang, Wei-Chih Kan Source Type: research
Editorial Board]
(Source: Schizophrenia Research)
Source: Schizophrenia Research - September 22, 2018 Category: Psychiatry Source Type: research
Insight and risk of suicidal behaviour in two first-episode psychosis cohorts: Effects of previous suicide attempts and depression
The role of insight dimensions – illness recognition (IR), symptoms relabelling (SR), treatment compliance (TC) - in suicide risk in first-episode psychosis (FEP) remains unclear. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 22, 2018 Category: Psychiatry Authors: Javier-David Lopez-Morinigo, Marta Di Forti, Olesja Ajnakina, Benjamin D. Wiffen, Kevin Morgan, Gillian A. Doody, Peter B. Jones, Rosa Ayesa-Arriola, Manuel Canal-Rivero, Benedicto Crespo-Facorro, Robin M. Murray, Paola Dazzan, Craig Morgan, Rina Dutta, A Source Type: research
Left prefrontal high-frequency rTMS may improve movement disorder in schizophrenia patients with predominant negative symptoms – A secondary analysis of a sham-controlled, randomized multicenter trial
Recent research suggests that different first- and second-generation antipsychotics bear risk for extrapyramidal side effects (EPS) including akathisia, acute dystonic reactions, parkinsonism and neuroleptic malignant syndrome, occurring within days or weeks after initiation of an antipsychotic medication or after dosage escalation (Hasan et al., 2013; Leucht et al., 2013). High-frequency rTMS of the primary motor cortex has the potential to improve motor function in patients with Parkinson's disease (Lefaucheur, 2005). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 21, 2018 Category: Psychiatry Authors: Daniel Kamp, Christina Engelke, Thomas Wobrock, Wolfgang W ölwer, Georg Winterer, Christian Schmidt-Kraepelin, Wolfgang Gaebel, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Göran Hajak, Christian Ohmann, Pablo E. Verde, Marcella Tags: Letter to the Editor Source Type: research
Metabolic abnormalities and low dietary Omega 3 are associated with symptom severity and worse functioning prior to the onset of psychosis: Findings from the North American Prodrome Longitudinal Studies Consortium
In this study, we evaluate demographic information, cardiometabolic indices, symptoms and functioning in an antipsychotic free cohort at Clinical High Risk (CHR) for psychosis from the NAPLS Omega 3 fatty acid clinical trial. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 21, 2018 Category: Psychiatry Authors: Kristin S. Cadenhead, Amedeo Minichino, Skylar Kelsven, Jean Addington, Carrie Bearden, Tyrone D. Cannon, Barbara A. Cornblatt, Dan Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, Ming Tsuang, Elaine F. Walker, Scott W. Woods, Jeff Yao, Source Type: research
A potential role for adjunctive omega-3 polyunsaturated fatty acids for depression and anxiety symptoms in recent onset psychosis: Results from a 16 week randomized placebo-controlled trial for participants concurrently treated with risperidone
Omega-3 treatment studies for multi-episode schizophrenia or clinical high risk for conversion to psychosis states have had variable, and often negative, results. To examine adjunctive omega-3 treatment for recent onset psychosis, participants aged 15 –40 years with recent onset schizophrenia-spectrum (n = 46) or bipolar (n = 4) disorders and current psychotic symptoms were treated for 16 weeks with risperidone and randomly-assigned omega-3 (EPA 740 mg and DHA 400 mg daily) or matching placebo. The primary outcome measure was th e Brief Psychiatric Rating Scale (BPRS) total score. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 19, 2018 Category: Psychiatry Authors: Delbert G. Robinson, Juan A. Gallego, Majnu John, Lauren A. Hanna, Jian-Ping Zhang, Michael L. Birnbaum, Jessica Greenberg, Melissa Naraine, Bart D. Peters, Robert K. McNamara, Anil K. Malhotra, Philip R. Szeszko Source Type: research
Oral health in psychosis: An unmet need
Yang et al. (2018) have conducted an important and timely meta-analysis indicating that patients with psychosis are more likely to have missing, decayed or filled teeth, than general population samples. This health disparity is staggering and clearly unacceptable, and yet it has received very little attention in research and clinical arenas, evidenced by the identification of only nine eligible studies in this meta-analysis. It was revealing that none of the studies were conducted in the United States or United Kingdom, areas with otherwise strong psychosis-related research outputs. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 19, 2018 Category: Psychiatry Authors: J.E. Palmier-Claus, D. Shiers, P. French, R. Harris, L. Laverty Tags: Letter to the Editor Source Type: research
Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial
The effects of intranasal oxytocin, a neuropeptide involved in prosocial behavior and modulation of neural networks underlying social cognition and emotion regulation, have been studied in schizophrenia. We tested the hypothesis that twice-daily intranasal oxytocin administered for 12-weeks would improve tertiary and exploratory outcomes of self-reported social symptoms, empathy and introspective accuracy from the Jarskog et al. (2017) randomized controlled trial. Sixty-eight stable outpatients with schizophrenia or schizoaffective disorder were randomized to receive oxytocin (24 IU twice daily) or placebo. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 19, 2018 Category: Psychiatry Authors: Tate Halverson, L. Fredrik Jarskog, Cort Pedersen, David Penn Source Type: research
GLP-1 agonists for metabolic disorders in schizophrenia
Patients with schizophrenia have a 2- to 3-fold higher mortality rate compared with the general population. A high prevalence of obesity, cardiometabolic disorders, and type 2 diabetes among these patients largely explains the increased cardiovascular risk (Correll et al., 2017). (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 19, 2018 Category: Psychiatry Authors: Youssef Kouidrat, Ali Amad Tags: Letter to the Editor Source Type: research
