Deficit of entropy modulation of the EEG in schizophrenia associated to cognitive performance and symptoms. A replication study
Spectral entropy (SE) is a measurement from information theory field that provides an estimation of EEG regularity and may be useful as a summary of its spectral properties. Previous studies using small samples reported a deficit of EEG entropy modulation in schizophrenia during cognitive activity. The present study is aimed at replicating this finding in a larger sample, to explore its cognitive and clinical correlates and to discard antipsychotic treatment as the main source of that deficit. We included 64 schizophrenia patients (21 first episodes, FE) and 65 healthy controls. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 5, 2017 Category: Psychiatry Authors: Vicente Molina, Alejandro Bachiller, Javier Gomez-Pilar, Alba Lubeiro, Roberto Hornero, Benjam ín Cea-Cañas, César Valcárcel, Mahmoun-Karim Haidar, Jesús Poza Source Type: research

Sodium valproate and clozapine induced neutropenia: A case control study using register data
The use of clozapine is limited due to the occurrence of neutropenia, and the rare but life threatening adverse event of agranulocytosis. There is little epidemiological research into clinical factors that may impact on this risk. We conducted a case control study examining the clinical risk factors for neutropenia patients treated with clozapine. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 4, 2017 Category: Psychiatry Authors: Steffi Malik, John Lally, Olesya Ajnakina, Megan Pritchard, Amir Krivoy, Fiona Gaughran, Hitesh Shetty, Robert J. Flanagan, James H. MacCabe Source Type: research

Hemoencephalography self-regulation training and its impact on cognition: A study with schizophrenia and healthy participants
Cognitive impairments in schizophrenia are strongly correlated to functional outcome and recovery rates, with no pharmacological agent approved for its treatment. Neurofeedback has emerged as a non-pharmacological approach to enhance neuroplasticity, which consists in inducing voluntary control of brain responses through operant conditioning. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 4, 2017 Category: Psychiatry Authors: J.S. Gomes, D.V. Ducos, A. Gadelha, B.B. Ortiz, A.M. Van Deusen, H.T. Akiba, L.S.P. Guimaraes, Q. Cordeiro, A.P. Trevizol, A. Lacerda, A.M. Dias Tags: Letter to the Editor Source Type: research

Effects of peer social interaction on performance during computerized cognitive remediation therapy in patients with early course schizophrenia: A pilot study
Recent studies show that computer-based training enhances cognition in schizophrenia; furthermore, socialization has also been found to improve cognitive functions. It is generally believed that non-social cognitive remediation using computer exercises would be a pre-requisite for therapeutic benefits from social cognitive training. However, it is also possible that social interaction by itself enhances non-social cognitive functions; this possibility has scarcely been explored in schizophrenia patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 4, 2017 Category: Psychiatry Authors: Luis R. Sandoval, Betzamel L ópez González, William S. Stone, Synthia Guimond, Cristina Torres Rivas, David Sheynberg, Susan S. Kuo, Shaun Eack, Matcheri S. Keshavan Source Type: research

Sodium valproate and clozapine induced neutropenia: A case control study using register data
The use of clozapine is limited due to the occurrence of neutropenia, and the rare but life threatening adverse event of agranulocytosis. There is little epidemiological research into clinical factors that may impact on this risk. We conducted a case control study examining the clinical risk factors for neutropenia patients treated with clozapine. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 4, 2017 Category: Psychiatry Authors: Steffi Malik, John Lally, Olesya Ajnakina, Megan Pritchard, Amir Krivoy, Fiona Gaughran, Hitesh Shetty, Robert J. Flanagan, James H. MacCabe Source Type: research

Hemoencephalography self-regulation training and its impact on cognition: A study with schizophrenia and healthy participants
Cognitive impairments in schizophrenia are strongly correlated to functional outcome and recovery rates, with no pharmacological agent approved for its treatment. Neurofeedback has emerged as a non-pharmacological approach to enhance neuroplasticity, which consists in inducing voluntary control of brain responses through operant conditioning. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 4, 2017 Category: Psychiatry Authors: J.S. Gomes, D.V. Ducos, A. Gadelha, B.B. Ortiz, A.M. Van Deusen, H.T. Akiba, L.S.P. Guimaraes, Q. Cordeiro, A.P. Trevizol, A. Lacerda, A.M. Dias Tags: Letter to the Editor Source Type: research

Effects of peer social interaction on performance during computerized cognitive remediation therapy in patients with early course schizophrenia: A pilot study
Recent studies show that computer-based training enhances cognition in schizophrenia; furthermore, socialization has also been found to improve cognitive functions. It is generally believed that non-social cognitive remediation using computer exercises would be a pre-requisite for therapeutic benefits from social cognitive training. However, it is also possible that social interaction by itself enhances non-social cognitive functions; this possibility has scarcely been explored in schizophrenia patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 4, 2017 Category: Psychiatry Authors: Luis R. Sandoval, Betzamel L ópez González, William S. Stone, Synthia Guimond, Cristina Torres Rivas, David Sheynberg, Susan S. Kuo, Shaun Eack, Matcheri S. Keshavan Source Type: research

Childhood unusual experiences in community Child and Adolescent Mental Health Services in South East London: Prevalence and impact
Distressing ‘psychotic-like’ or unusual experiences (UEDs) signify increased mental health risk in the general population, including greater likelihood and severity of co-occurring non-psychotic mental health problems, and, from fourteen years of age, increased risk of a future psychotic illness. Healthcare guidelines for under eighteens recommend psychological intervention for UEDs, to reduce current distress and adverse functional impact, and, potentially, future mental health risk. Children tend not to report UEDs unless directly asked, indicating a need for routine screening. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 2, 2017 Category: Psychiatry Authors: Kimberley Gin, Partha Banerjea, Chris Abbott, Sophie Browning, Karen Bracegirdle, Richard Corrigall, Suzanne Jolley Source Type: research

Modelling the neuromotor abnormalities of psychotic illness: Putative mechanisms and systems dysfunction
Limitations in access to antipsychotic-na ïve patients and in the incisiveness of studies that can be conducted on them, together with the inevitability of subsequent antipsychotic treatment, indicate an enduring role for animal models that can inform on the pathobiology of neuromotor abnormalities in schizophrenia and related psychotic il lness. This review focusses particularly on genetically modified mouse models that involve genes associated with risk for schizophrenia and with mechanisms implicated in the neuromotor abnormalities evident in psychotic patients, as well as developmental models that seek to mirror t...
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: John L. Waddington, Colm M. O'Tuathaigh Source Type: research

Schizophrenia and creativity: A meta-analytic review
The present study investigated the relationship between creativity and schizophrenia with a 3-level multilevel meta-analytic approach. Analyses with 200 effect sizes obtained from 42 studies found a mean effect size of r= −0.324, 95%CI [−0.42, −0.23]. Further analyses focused on moderators and indicated that the relationship between schizophrenia and creativity is moderated by type of creativity measure, the content of creativity measure, the severity of schizophrenia, and patient status. The negative mean effe ct size was stronger with semantic-category or verbal-letter fluency tasks than the divergent t...
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: Selcuk Acar, Xiao Chen, Nur Cayirdag Source Type: research

Personality traits in recent-onset-of-psychosis patients compared to a control sample by gender
Personality traits in recent onset of psychosis (ROP) patients are an under-researched area. Our aim was to examine clinical and clinically significant personality traits in ROP patients compared with a healthy control sample by gender. Data were obtained from 94 ROP patients and a control sample matched in gender and age. The Millon Clinical Multiaxial Inventory and a sociodemographic scale were used. T for independent samples, U-Mann-Whitney and Fisher tests were applied to make comparisons. All personality traits were significantly higher in ROP than control participants in the general sample, except histrionic, narciss...
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: Julia Sevilla-Llewellyn-Jones, Pablo Cano-Dom ínguez, Antonia de-Luis-Matilla, Alberto Espina-Eizaguirre, Berta Moreno-Küstner, Susana Ochoa Source Type: research

Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives
Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: Zhi Li, Chao Yan, Qin-yu Lv, Zheng-hui Yi, Jian-ye Zhang, Jin-hong Wang, Simon S.Y. Lui, Yi-feng Xu, Eric F.C. Cheung, Raquel E. Gur, Ruben C. Gur, Raymond C.K. Chan Source Type: research

Efficacy of fronto-temporal transcranial direct current stimulation for refractory auditory verbal hallucinations in schizophrenia: A randomized, double-blind, sham-controlled study
In this study, using a randomized, double-blind, sham-controlled design (RCT), we sought to examine the effect of add-on tDCS [anode corresponding to left dorsolateral prefrontal cortex and cathode to left temporo-parietal junction; 2-mA, twice-daily sessions for 5-days] to treat refractory AVH in schizophrenia patients (N=25); following this RCT phase, patients that had (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: Anushree Bose, Venkataram Shivakumar, Sri Mahavir Agarwal, Sunil V. Kalmady, Sonia Shenoy, Vanteemar S. Sreeraj, Janardhanan C. Narayanaswamy, Ganesan Venkatasubramanian Source Type: research

Modelling the neuromotor abnormalities of psychotic illness: Putative mechanisms and systems dysfunction
Limitations in access to antipsychotic-na ïve patients and in the incisiveness of studies that can be conducted on them, together with the inevitability of subsequent antipsychotic treatment, indicate an enduring role for animal models that can inform on the pathobiology of neuromotor abnormalities in schizophrenia and related psychotic il lness. This review focusses particularly on genetically modified mouse models that involve genes associated with risk for schizophrenia and with mechanisms implicated in the neuromotor abnormalities evident in psychotic patients, as well as developmental models that seek to mirror t...
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: John L. Waddington, Colm M. O'Tuathaigh Source Type: research

Schizophrenia and creativity: A meta-analytic review
The present study investigated the relationship between creativity and schizophrenia with a 3-level multilevel meta-analytic approach. Analyses with 200 effect sizes obtained from 42 studies found a mean effect size of r= −0.324, 95%CI [−0.42, −0.23]. Further analyses focused on moderators and indicated that the relationship between schizophrenia and creativity is moderated by type of creativity measure, the content of creativity measure, the severity of schizophrenia, and patient status. The negative mean effe ct size was stronger with semantic-category or verbal-letter fluency tasks than the divergent t...
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: Selcuk Acar, Xiao Chen, Nur Cayirdag Source Type: research

Personality traits in recent-onset-of-psychosis patients compared to a control sample by gender
Personality traits in recent onset of psychosis (ROP) patients are an under-researched area. Our aim was to examine clinical and clinically significant personality traits in ROP patients compared with a healthy control sample by gender. Data were obtained from 94 ROP patients and a control sample matched in gender and age. The Millon Clinical Multiaxial Inventory and a sociodemographic scale were used. T for independent samples, U-Mann-Whitney and Fisher tests were applied to make comparisons. All personality traits were significantly higher in ROP than control participants in the general sample, except histrionic, narciss...
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: Julia Sevilla-Llewellyn-Jones, Pablo Cano-Dom ínguez, Antonia de-Luis-Matilla, Alberto Espina-Eizaguirre, Berta Moreno-Küstner, Susana Ochoa Source Type: research

Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives
Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: Zhi Li, Chao Yan, Qin-yu Lv, Zheng-hui Yi, Jian-ye Zhang, Jin-hong Wang, Simon S.Y. Lui, Yi-feng Xu, Eric F.C. Cheung, Raquel E. Gur, Ruben C. Gur, Raymond C.K. Chan Source Type: research

Efficacy of fronto-temporal transcranial direct current stimulation for refractory auditory verbal hallucinations in schizophrenia: A randomized, double-blind, sham-controlled study
In this study, using a randomized, double-blind, sham-controlled design (RCT), we sought to examine the effect of add-on tDCS [anode corresponding to left dorsolateral prefrontal cortex and cathode to left temporo-parietal junction; 2-mA, twice-daily sessions for 5-days] to treat refractory AVH in schizophrenia patients (N=25); following this RCT phase, patients that had (Source: Schizophrenia Research)
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Authors: Anushree Bose, Venkataram Shivakumar, Sri Mahavir Agarwal, Sunil V. Kalmady, Sonia Shenoy, Vanteemar S. Sreeraj, Janardhanan C. Narayanaswamy, Ganesan Venkatasubramanian Source Type: research

Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - September 1, 2017 Category: Psychiatry Source Type: research

Paradoxical elevation of systemic inflammatory markers and physical activity in patients with schizophrenia
Dear Editor, (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 30, 2017 Category: Psychiatry Authors: Renato Oliveira Silva, Isabel A. Amato, Amilton Santos, Vanessa C. Bobbo, Guilherme A. Nogueira, Licio A. Velloso, Paulo Dalgalarrondo Tags: Letter to the Editor Source Type: research

Cultural factors in first episode psychosis treatment engagement
Specialized First Episode Psychosis (FEP) services have been conceptualized in part around the issue of engagement. Creating treatment that is easier to access, with more frequent contacts, assertive outreach to clients between appointments, and an explicit youth-oriented culture could make services more attractive to those most in need of care. However, engagement has remained a mostly fuzzy, peripheral construct rather than the object of study in itself. As we recognize the importance of treatment engagement, we must prepare to address it more rigorously within psychosis and schizophrenia research. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 29, 2017 Category: Psychiatry Authors: Emily Kline, Latoya Thomas Tags: Invited commentary Source Type: research

Interaction of Brain-Derived Neurotrophic Factor Val66Met genotype and history of stress in regulation of prepulse inhibition in mice
The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism results in reduced activity-dependent BDNF release and has been implicated in schizophrenia. However, effects of the polymorphism on functional dopaminergic and N-methyl-d-aspartate (NMDA) receptor-associated activity remain unclear. We used prepulse inhibition, a measure of sensorimotor gating which is disrupted in schizophrenia, and assessed the effects of acute treatment with the dopamine receptor agonist, apomorphine (APO), and the NMDA receptor antagonist, MK-801. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 29, 2017 Category: Psychiatry Authors: Maarten van den Buuse, John Juan Wen Lee, Emily J. Jaehne Source Type: research

Commentary: Cultural factors in first episode psychosis treatment engagement
Specialized First Episode Psychosis (FEP) services have been conceptualized in part around the issue of engagement. Creating treatment that is easier to access, with more frequent contacts, assertive outreach to clients between appointments, and an explicit youth-oriented culture could make services more attractive to those most in need of care. However, engagement has remained a mostly fuzzy, peripheral construct rather than the object of study in itself. As we recognize the importance of treatment engagement, we must prepare to address it more rigorously within psychosis and schizophrenia research. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 29, 2017 Category: Psychiatry Authors: Emily Kline, Latoya Thomas Tags: Invited commentary Source Type: research

Covariation between motor signs and negative symptoms in drug-naive subjects with schizophrenia-spectrum disorders before and after antipsychotic treatment
ObjectiveTo examine the covariation between negative symptoms and motor signs in a broad sample of drug-na ïve subjects with schizophrenia-spectrum psychoses before and after inception of antipsychotic medication. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 29, 2017 Category: Psychiatry Authors: Victor Peralta, Elena Garc ía de Jalón, María S. Campos, Manuel J. Cuesta Source Type: research

What do we know about insight into illness and its association with the underlying biology of schizophrenia?
Poor insight into illness is highly prevalent in schizophrenia patients (Amador et al., 1994; Amador and Kronengold, 1998; David, 1990; Sartorius et al., 1972) and has been associated with multiple clinical outcome measures, most notably treatment nonadherence (David et al., 1992; McEvoy et al., 1989; Perkins, 2002, Amador et al., 1993). Efforts to improve insight have been ineffective or at best partially effective, which has aroused significant interest to investigate neural substrates for impaired insight in schizophrenia in an effort to develop better treatment strategies. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 29, 2017 Category: Psychiatry Authors: Mujeeb U. Shad Source Type: research

Interaction of Brain-Derived Neurotrophic Factor Val66Met genotype and history of stress in regulation of prepulse inhibition in mice
The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism results in reduced activity-dependent BDNF release and has been implicated in schizophrenia. However, effects of the polymorphism on functional dopaminergic and N-methyl-d-aspartate (NMDA) receptor-associated activity remain unclear. We used prepulse inhibition, a measure of sensorimotor gating which is disrupted in schizophrenia, and assessed the effects of acute treatment with the dopamine receptor agonist, apomorphine (APO), and the NMDA receptor antagonist, MK-801. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 29, 2017 Category: Psychiatry Authors: Maarten van den Buuse, John Juan Wen Lee, Emily J. Jaehne Source Type: research

Commentary: Cultural factors in first episode psychosis treatment engagement
Specialized First Episode Psychosis (FEP) services have been conceptualized in part around the issue of engagement. Creating treatment that is easier to access, with more frequent contacts, assertive outreach to clients between appointments, and an explicit youth-oriented culture could make services more attractive to those most in need of care. However, engagement has remained a mostly fuzzy, peripheral construct rather than the object of study in itself. As we recognize the importance of treatment engagement, we must prepare to address it more rigorously within psychosis and schizophrenia research. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 29, 2017 Category: Psychiatry Authors: Emily Kline, Latoya Thomas Tags: Invited commentary Source Type: research

Covariation between motor signs and negative symptoms in drug-naive subjects with schizophrenia-spectrum disorders before and after antipsychotic treatment
ObjectiveTo examine the covariation between negative symptoms and motor signs in a broad sample of drug-na ïve subjects with schizophrenia-spectrum psychoses before and after inception of antipsychotic medication. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 29, 2017 Category: Psychiatry Authors: Victor Peralta, Elena Garc ía de Jalón, María S. Campos, Manuel J. Cuesta Source Type: research

CBT in the prevention of psychosis and other severe mental disorders in patients with an at risk mental state: A review and proposed next steps
Patients with an ‘At risk mental state’ (ARMS) for developing psychosis can be treated successfully with CBT to postpone and prevent the transition to a first psychotic episode. A characteristic of individuals that meet ARMS criteria is that they are still open for multiple explanations for extraordinary experie nces. CBT aims to normalize extraordinary experiences with education and to prevent delusional explanations. The treatment is not only effective, but also cost-saving in averting psychosis as well as in reducing disability adjusted life years at 18- and 48-month follow-up. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 28, 2017 Category: Psychiatry Authors: Mark van der Gaag, David van den Berg, Helga Ising Source Type: research

Profiling of experiential pleasure, emotional regulation and emotion expression in patients with schizophrenia
Emotion deficits may be the basis of negative symptoms in schizophrenia patients and they are prevalent in these patients. However, inconsistent findings about emotion deficits in schizophrenia suggest that there may be subtypes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 28, 2017 Category: Psychiatry Authors: Ying-min Zou, Ke Ni, Zhuo-ya Yang, Ying Li, Xin-lu Cai, Dong-jie Xie, Rui-ting Zhang, Fu-Chun Zhou, Wen-xiu Li, Simon S.Y. Lui, David H.K. Shum, Eric F.C. Cheung, Raymond C.K. Chan Source Type: research

CBT in the prevention of psychosis and other severe mental disorders in patients with an at risk mental state: A review and proposed next steps
Patients with an ‘At risk mental state’ (ARMS) for developing psychosis can be treated successfully with CBT to postpone and prevent the transition to a first psychotic episode. A characteristic of individuals that meet ARMS criteria is that they are still open for multiple explanations for extraordinary experie nces. CBT aims to normalize extraordinary experiences with education and to prevent delusional explanations. The treatment is not only effective, but also cost-saving in averting psychosis as well as in reducing disability adjusted life years at 18- and 48-month follow-up. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 28, 2017 Category: Psychiatry Authors: Mark van der Gaag, David van den Berg, Helga Ising Source Type: research

Profiling of experiential pleasure, emotional regulation and emotion expression in patients with schizophrenia
Emotion deficits may be the basis of negative symptoms in schizophrenia patients and they are prevalent in these patients. However, inconsistent findings about emotion deficits in schizophrenia suggest that there may be subtypes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 28, 2017 Category: Psychiatry Authors: Ying-min Zou, Ke Ni, Zhuo-ya Yang, Ying Li, Xin-lu Cai, Dong-jie Xie, Rui-ting Zhang, Fu-Chun Zhou, Wen-xiu Li, Simon S.Y. Lui, David H.K. Shum, Eric F.C. Cheung, Raymond C.K. Chan Source Type: research

Accounting for group differences in study retention in a randomized trial of specialized treatment for first episode psychosis
Schizophrenia is a chronic disabling disorder for which current treatments are only partially effective. While the evaluation of novel interventions is a high priority, loss to follow-up is a major threat to validity. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 25, 2017 Category: Psychiatry Authors: Kyaw Sint, Robert Rosenheck, Delbert G. Robinson, Nina R. Schooler, Patricia Marcy, John M. Kane, Kim T. Mueser, Haiqun Lin, other RAISE ETP Investigators Source Type: research

Concerns about the design, analyses, and findings of the trial of dopamine serotonin stabilizer RP5063 by Cantillon and colleagues
I would like to comment on the recent clinical trial of dopamine serotonin stabilizer RP5063 by Cantillon and colleagues (Cantillon et al., 2017). First, although the description of rater training is not mandatory and its absence does not negate the findings of the study, it may be especially important to know how raters were trained for this trial because it was conducted across 22 sites in 5 countries, including sites with different languages and cultures. The author of the Positive and Negative Syndrome Scale (PANSS) recommended standardized training of raters so that the disparity in scoring among raters does not excee...
Source: Schizophrenia Research - August 25, 2017 Category: Psychiatry Authors: Ahmed Aboraya Tags: Letter to the Editor Source Type: research

Accounting for group differences in study retention in a randomized trial of specialized treatment for first episode psychosis
Schizophrenia is a chronic disabling disorder for which current treatments are only partially effective. While the evaluation of novel interventions is a high priority, loss to follow-up is a major threat to validity. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 25, 2017 Category: Psychiatry Authors: Kyaw Sint, Robert Rosenheck, Delbert G. Robinson, Nina R. Schooler, Patricia Marcy, John M. Kane, Kim T. Mueser, Haiqun Lin, other RAISE ETP Investigators Source Type: research

Concerns about the design, analyses, and findings of the trial of dopamine serotonin stabilizer RP5063 by Cantillon and colleagues
I would like to comment on the recent clinical trial of dopamine serotonin stabilizer RP5063 by Cantillon and colleagues (Cantillon et al., 2017). First, although the description of rater training is not mandatory and its absence does not negate the findings of the study, it may be especially important to know how raters were trained for this trial because it was conducted across 22 sites in 5 countries, including sites with different languages and cultures. The author of the Positive and Negative Syndrome Scale (PANSS) recommended standardized training of raters so that the disparity in scoring among raters does not excee...
Source: Schizophrenia Research - August 25, 2017 Category: Psychiatry Authors: Ahmed Aboraya Tags: Letter to the Editor Source Type: research

Psychosis subgroups differ in intrinsic neural activity but not task-specific processing
Individuals with psychosis often show high levels of intrinsic, or nonspecific, neural activity, but attenuated stimulus-specific activity. Clementz et al. (2016) proposed that one subgroup of psychosis cases has accentuated intrinsic activity (Biotype-2's) and a different subgroup (Biotype-1's) has diminished intrinsic activity, with both groups exhibiting varying degrees of cognitive deficits. This model was studied by assessing neural activity in psychosis probands (N=105) during baseline and a 5second period in preparation for a pro-/anti-saccade task. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Matthew E. Hudgens-Haney, Lauren E. Ethridge, Jennifer E. McDowell, Sarah K. Keedy, Godfrey D. Pearlson, Carol A. Tamminga, Matcheri S. Keshavan, John A. Sweeney, Brett A. Clementz Source Type: research

Temporal stability of self-disorders and longitudinal unfolding of symptom dimensions: A complementary analysis
Anomalous subjective experiences (i.e. self-disorders, SD) constitute a core, schizophrenia spectrum vulnerability phenotype. Indeed, they have been consistently identified in several clinical and familiar high-risk populations (Raballo and Parnas, 2011; Sass, 2014; Hur et al., 2014; Park and Nasrallah, 2014). Clinically they encompass subtle, yet pervasive experiential distortions, such as alterations of the stream of consciousness and of the cognitive-attentional or psychomotor flow, perplexity and failing grip on shared meanings, hyper-reflexivity and sense of solipsistic alienation from others (Parnas et al., 2005; Sas...
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Andrea Raballo, Antonio Preti Tags: Letter to the Editor Source Type: research

Inflammation, substance use, psychopathology, and cognition in phase 1 of the clinical antipsychotic trials of intervention effectiveness study
Schizophrenia has been associated with aberrant blood levels of inflammatory markers. However, patients with comorbid illicit drug use have been inadequately studied with respect to immune function. Furthermore, associations between inflammatory markers, psychopathology, and cognition have been inconsistently considered. We investigated relationships between inflammatory markers, comorbid marijuana and cocaine use, and psychopathology and cognition in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Brian J. Miller, Peter F. Buckley, Joseph P. McEvoy Source Type: research

Maternal infection and anemia as prenatal predisposing factors for schizophrenia: The link with zinc deficiency
According to this study, combined exposure to anemia and an infection increased the effect size to a 2.49-fold increased schizophrenia risk but the interaction analysis failed to provide evidence for multiplicative interactions between the two factors. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Rami Bou Khalil Tags: Letter to the Editor Source Type: research

Targeting recovery in first episode psychosis: The importance of neurocognition and premorbid adjustment in a 3-year longitudinal study
In this study we gathered sociodemographic, clinical and cognitive data to explore predictive variables of recovery after three years follow-up in a sample of 399 patients with a first episode of psychosis (FEP). (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Devi Treen Calvo, Sara Gim énez-Donoso, Esther Setién-Suero, Alba Toll Privat, Benedicto Crespo-Facorro, Rosa Ayesa Arriola Source Type: research

Do trauma-focussed psychological interventions have an effect on psychotic symptoms? A systematic review and meta-analysis
There is growing recognition of the relationship between trauma, posttraumatic stress disorder (PTSD) and psychosis. There may be overlaps in causal mechanisms involved in the development of PTSD and psychosis following traumatic or adverse events. Trauma-focussed treatments found to be effective in treating PTSD may therefore represent a new direction in the psychological treatment of psychosis. This systematic review examined the literature on trauma-focussed treatments conducted with people with schizophrenia spectrum or psychotic disorders to determine effects on psychotic symptoms. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Rachel M. Brand, Carla McEnery, Susan Rossell, Sarah Bendall, Neil Thomas Source Type: research

Psychosis subgroups differ in intrinsic neural activity but not task-specific processing
Individuals with psychosis often show high levels of intrinsic, or nonspecific, neural activity, but attenuated stimulus-specific activity. Clementz et al. (2016) proposed that one subgroup of psychosis cases has accentuated intrinsic activity (Biotype-2's) and a different subgroup (Biotype-1's) has diminished intrinsic activity, with both groups exhibiting varying degrees of cognitive deficits. This model was studied by assessing neural activity in psychosis probands (N=105) during baseline and a 5second period in preparation for a pro-/anti-saccade task. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Matthew E. Hudgens-Haney, Lauren E. Ethridge, Jennifer E. McDowell, Sarah K. Keedy, Godfrey D. Pearlson, Carol A. Tamminga, Matcheri S. Keshavan, John A. Sweeney, Brett A. Clementz Source Type: research

Temporal stability of self-disorders and longitudinal unfolding of symptom dimensions: A complementary analysis
Anomalous subjective experiences (i.e. self-disorders, SD) constitute a core, schizophrenia spectrum vulnerability phenotype. Indeed, they have been consistently identified in several clinical and familiar high-risk populations (Raballo and Parnas, 2011; Sass, 2014; Hur et al., 2014; Park and Nasrallah, 2014). Clinically they encompass subtle, yet pervasive experiential distortions, such as alterations of the stream of consciousness and of the cognitive-attentional or psychomotor flow, perplexity and failing grip on shared meanings, hyper-reflexivity and sense of solipsistic alienation from others (Parnas et al., 2005; Sas...
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Andrea Raballo, Antonio Preti Tags: Letter to the Editor Source Type: research

Inflammation, substance use, psychopathology, and cognition in phase 1 of the clinical antipsychotic trials of intervention effectiveness study
Schizophrenia has been associated with aberrant blood levels of inflammatory markers. However, patients with comorbid illicit drug use have been inadequately studied with respect to immune function. Furthermore, associations between inflammatory markers, psychopathology, and cognition have been inconsistently considered. We investigated relationships between inflammatory markers, comorbid marijuana and cocaine use, and psychopathology and cognition in patients with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Brian J. Miller, Peter F. Buckley, Joseph P. McEvoy Source Type: research

Maternal infection and anemia as prenatal predisposing factors for schizophrenia: The link with zinc deficiency
According to this study, combined exposure to anemia and an infection increased the effect size to a 2.49-fold increased schizophrenia risk but the interaction analysis failed to provide evidence for multiplicative interactions between the two factors. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Rami Bou Khalil Tags: Letter to the Editor Source Type: research

Targeting recovery in first episode psychosis: The importance of neurocognition and premorbid adjustment in a 3-year longitudinal study
In this study we gathered sociodemographic, clinical and cognitive data to explore predictive variables of recovery after three years follow-up in a sample of 399 patients with a first episode of psychosis (FEP). (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Devi Treen Calvo, Sara Gim énez-Donoso, Esther Setién-Suero, Alba Toll Privat, Benedicto Crespo-Facorro, Rosa Ayesa Arriola Source Type: research

Do trauma-focussed psychological interventions have an effect on psychotic symptoms? A systematic review and meta-analysis
There is growing recognition of the relationship between trauma, posttraumatic stress disorder (PTSD) and psychosis. There may be overlaps in casual mechanisms involved in the development of PTSD and psychosis following traumatic or adverse events. Trauma-focussed treatments found to be effective in treating PTSD may therefore represent a new direction in the psychological treatment of psychosis. This systematic review examined the literature on trauma-focussed treatments conducted with people with schizophrenia spectrum or psychotic disorders to determine effects on psychotic symptoms. (Source: Schizophrenia Research)
Source: Schizophrenia Research - August 24, 2017 Category: Psychiatry Authors: Rachel M. Brand, Carla McEnery, Susan Rossell, Sarah Bendall, Neil Thomas Source Type: research