Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - May 1, 2018 Category: Psychiatry Source Type: research
Clinical Highlights in this issue
This current issue of Schizophrenia Research highlights the diversity, depth, and scope of efforts to better understand, characterize, and advance care for schizophrenia disorders. The research papers summarized below, as well as all articles in this issue, represent important new knowledge towards advancing the biology and treatment of schizophrenic disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 1, 2018 Category: Psychiatry Authors: John Torous, Matcheri Keshavan Source Type: research
Premature mortality among people with severe mental illness — New evidence from linked primary care data
This study aimed to estimate standardised mortality ratios (SMRs) for all-cause and cause-specific mortality in people with SMI drawn from linked primary and secondary care populations compared to the general population. SMRs were calculated using the indirect method for a United Kingdom population of almost four million between 2004 and 2013. (Source: Schizophrenia Research)
Source: Schizophrenia Research - May 1, 2018 Category: Psychiatry Authors: Ann John, Joanna McGregor, Ian Jones, Sze Chim Lee, James T.R. Walters, Michael J. Owen, Michael O'Donovan, Marcos DelPozo-Banos, Damon Berridge, Keith Lloyd Source Type: research
Resting-state network connectivity and metastability predict clinical symptoms in schizophrenia
The functional architecture of resting-state networks (RSNs) is defined by their connectivity and metastability. Disrupted RSN connectivity has been amply demonstrated in schizophrenia while the role of metastability remains poorly defined. Here, we undertake a comprehensive characterisation of RSN organization in schizophrenia and test its contribution to the clinical profile of this disorder. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 27, 2018 Category: Psychiatry Authors: Won Hee Lee, Gaelle E. Doucet, Evan Leibu, Sophia Frangou Source Type: research
Mental health multimorbidity and poor quality of life in patients with schizophrenia
While “dual diagnosis” involving both psychiatric and substance use disorders has long been a focus of schizophrenia research, recent studies have advocated for a shift of focus to multimorbidity, addressing comorbidity from both additional psychiatric disorders and substance use disorders. We hypothe sized that more extensive mental health multimorbity would be associated with poorer quality of life (QOL) and functioning, and that additional psychiatric comorbidity in schizophrenia would have similar adverse effects on QOL as substance use comorbidity. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 27, 2018 Category: Psychiatry Authors: Ish P. Bhalla, Elina A. Stefanovics, Robert A. Rosenheck Source Type: research
Modified cariprazine relapse prevention clinical trial results
Our study, “Long-term cariprazine treatment for the prevention of relapse in patients with schizophrenia: A randomized, double-blind, placebo-controlled trial,” was previously published in Schizophrenia Research (Durgam et al., 2016). As a courtesy, we would like to alert your readers that some of the publ ished results from this study (RGH-MD-06) differ slightly from information in the cariprazine (VRAYLAR©) package insert (Vraylar [package insert], 2017). Due to results of additional analyses requested by the US FDA, the Kaplan-Meier cumulative rate of relapse curve in the VRAYLAR package insert (F ig. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 26, 2018 Category: Psychiatry Authors: Willie Earley, Hua Guo, Rachel Luchini Tags: Letter to the Editor Source Type: research
Spared and impaired sleep-dependent memory consolidation in schizophrenia
Cognitive deficits in schizophrenia are the strongest predictor of disability and effective treatment is lacking. This reflects our limited mechanistic understanding and consequent lack of treatment targets. In schizophrenia, impaired sleep-dependent memory consolidation correlates with reduced sleep spindle activity, suggesting sleep spindles as a potentially treatable mechanism. In the present study we investigated whether sleep-dependent memory consolidation deficits in schizophrenia are selective. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 26, 2018 Category: Psychiatry Authors: Bengi Baran, David Correll, Tessa C. Vuper, Alexandra Morgan, Simon J. Durrant, Dara S. Manoach, Robert Stickgold Source Type: research
Plasma cytokines in minimally treated schizophrenia
In this study, we examined a large sample of antipsychotic-na ïve/free schizophrenia patients (N = 75) in comparison with healthy controls (N = 102). Plasma cytokines (Interleukins ([IL] 2, 4, 6, 10, 17), Tumor necrosis factor [TNF] and Interferon gamma [IFN-g]) were assessed using cytometric bead array assay. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 26, 2018 Category: Psychiatry Authors: Sunil Vasu Kalmady, Venkataram Shivakumar, Dania Jose, Vasanthapuram Ravi, Matcheri S. Keshavan, Bangalore N. Gangadhar, Ganesan Venkatasubramanian Source Type: research
Predictors of ‘all-cause discontinuation’ of initial oral antipsychotic medication in first episode psychosis
Discontinuation of the initial oral antipsychotic prescribed for a first episode of psychosis (FEP) can derail outcome. Our objective was to examine the rate of and time to all-cause discontinuation of the first antipsychotic prescribed and the factors influencing such discontinuation. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 26, 2018 Category: Psychiatry Authors: Sally Mustafa, Ridha Joober, Martin Lepage, Srividya Iyer, Jai Shah, Ashok Malla Source Type: research
Altered brain cannabinoid 1 receptor mRNA expression across postnatal development in the MAM model of schizophrenia
Altered cannabinoid 1 receptor (CB1R) expression has been reported in the brain of subjects with schizophrenia, a developmental mental illness that usually emerges in late adolescence/early adulthood. However, the developmental period at which changes in the CB1R expression appear in schizophrenia is unknown. To gain insight into this factor, we assessed the postnatal developmental trajectory of CB1R expression in the methylazoxymethanol (MAM) model of schizophrenia. Using in situ hybridization with film and grain analyses, CB1R messenger RNA (mRNA) levels were quantified in multiple brain regions, including the medial pre...
Source: Schizophrenia Research - April 26, 2018 Category: Psychiatry Authors: Felipe V. Gomes, Jessica R. Edelson, David W. Volk, Anthony A. Grace Source Type: research
Decreased peripheral TNF alpha (TNF- α) mRNA expression in patients with treatment-resistant schizophrenia
Abnormalities in cytokine production have been implicated in schizophrenia. Among the compendium of cytokines studied in schizophrenia, the pro-inflammatory cytokine, tumor necrosis factor alpha (TNF- α) has been shown to be dysregulated in both post-mortem brain (Pandey et al., 2018) and peripheral blood (Francesconi et al., 2011; Pandey et al., 2015; Tian et al., 2014), although negative findings have also been reported (Dean et al., 2013; Erbagci et al., 2001; Fillman et al., 2014). Yet, no s tudy to our knowledge has examined TNF-α in individuals with treatment-resistant schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 26, 2018 Category: Psychiatry Authors: Md Shaki Mostaid, Christos Pantelis, Ian P. Everall, Chad A. Bousman Tags: Letter to the Editor Source Type: research
Patients participating to neurobiological research in early psychosis: A selected subgroup?
Selection bias could be an important limiting factor in psychiatric neurobiological research. The study aim was to compare, within an early psychosis program, patients who agreed to participate to neurobiological research with patients who refused. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 26, 2018 Category: Psychiatry Authors: Philippe Golay, Philipp S. Baumann, Raoul Jenni, Kim Q. Do, Philippe Conus Source Type: research
The effect of implementation of an early detection team: A nationwide register-based study of characteristics and help-seeking behavior in first-episode schizophrenia in Denmark
In an effort to make people with signs of psychosis seek help as early as possible, Region Zealand launched in 2012 an early detection team project as the first and only in Denmark. The project consisted of a combination of easy access and an information campaign targeting the public. This nation-wide study examined characteristics and help-seeking behavior of patients with first-episode schizophrenia (FES) in the early detection region in comparison with other Danish regions. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 26, 2018 Category: Psychiatry Authors: Lene Halling Hastrup, Ulrik Helt Haahr, Julie Nordgaard, Erik Simonsen Source Type: research
Inflammatory biomarkers in individuals at clinical high risk for psychosis (CHR-P): State or trait?
Studies linking neuro-inflammation to psychotic episodes has been rapidly expanding. Assessments of changes in inflammatory biomarkers in prodromal patients who subsequently convert to psychosis may help in predicting those likely to transition to psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 24, 2018 Category: Psychiatry Authors: Rita Khoury, Henry A. Nasrallah Source Type: research
Dysregulation of auditory neuroplasticity in schizophrenia
Schizophrenia is a complex brain syndrome characterized by an array of positive symptoms (delusions, hallucinations, disorganized speech), negative symptoms (alogia, apathy, avolition) and cognitive impairments (memory, executive functions). Although investigations of the cognitive deficits in schizophrenia have primarily concentrated on disturbances affecting higher-order cognitive processes, there is an increasing realization that schizophrenia also affects early sensory processing, which might, in fact, play a significant role in the development of higher-order cognitive impairments. (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 24, 2018 Category: Psychiatry Authors: Patrice Voss, Maryse E. Thomas, Gerson D. Guercio, Etienne de Villers-Sidani Source Type: research
