Overlooked fatal infectious diseases after long-term antipsychotic use in patients with psychiatric illness
There is mounting evidence that indicates a relation between antipsychotic medication use and sudden cardiac deaths (Ray et al., 2009; Ray et al., 2001). Antipsychotic medications have a high affinity for the cardiac potassium channel which can lead to fatal electrical activity and cause severe arrhythmia such as long QT syndrome (Teodorescu et al., 2013). Additionally, there are increasing reports which suggest a correlation between antipsychotic medications and inflammatory activity (Bedrossian et al., 2016; Tonhajzerova et al., 2015). (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 8, 2017 Category: Psychiatry Authors: Liliang Li, Xing Ye, Ziqin Zhao, Pan Gao, Yan Jiang Source Type: research

Cognitive remediation can improve negative symptoms and social functioning in first-episode schizophrenia: A randomized controlled trial
Meta-analyses have reported that the effects of cognitive remediation might go beyond improvement in cognition to include unexpected benefits for schizophrenia patients such as negative symptom reduction and improvements in functioning. In addition, some evidence indicated that these potentially beneficial effects are also present in the initial course of schizophrenia, but work in this area is still developing. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 8, 2017 Category: Psychiatry Authors: Joseph Ventura, Kenneth L. Subotnik, Denise Gretchen-Doorly, Laurie Casaus, Michael Boucher, Gerhard S. Hellemann, Keith H. Nuechterlein Source Type: research

Aripiprazole-induced tardive dyskinesia in patients with schizophrenia: A case report of twins
Indisputably, tardive dyskinesia (TD) is the most important and latent irreversible side effect of antipsychotic treatment (Bergman et al., 2017). Muller et al. reports that having a family history of TD may contribute to an individual developing TD, but found no correlation between family history of schizophrenia and TD (Muller et al., 2001). The risk for developing aripiprazole-induced TD remains unknown. To date, only a small fraction of TD has been reportedly caused by aripiprazole, and to our knowledge, this is the first case report of twin schizophrenic patients with TD. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 8, 2017 Category: Psychiatry Authors: Shenglin She, Qijie Kuang, Yingjun Zheng Source Type: research

Meta-analysis of adult height and birth length in schizophrenia
As a group, people with schizophrenia have a number of subtle anatomical abnormalities as well as physiological abnormalities that precede antipsychotic treatment. Some studies have also found shorter birth length or shorter adult height in people with schizophrenia compared to control subjects. We performed a systematic review and meta-analysis of studies of birth length and adult height in schizophrenia, following PRISMA guidelines (Prospero Registration # CRD42016043718). (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 7, 2017 Category: Psychiatry Authors: Keely Latham, Brian Kirkpatrick Source Type: research

Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder
Although Theory of Mind (ToM) impairment has been observed in patients with a wide range of mental disorders, the similarity and uniqueness of these deficits across diagnostic groups has not been thoroughly investigated. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 7, 2017 Category: Psychiatry Authors: Yan-yu Wang, Yi Wang, Ying-min Zou, Ke Ni, Xue Tian, Hong-wei Sun, Simon S.Y. Lui, Eric F.C. Cheung, John Suckling, Raymond C.K. Chan Source Type: research

Meta-analysis of adult height and birth length in schizophrenia
As a group, people with schizophrenia have a number of subtle anatomical abnormalities as well as physiological abnormalities that precede antipsychotic treatment. Some studies have also found shorter birth length or shorter adult height in people with schizophrenia compared to control subjects. We performed a systematic review and meta-analysis of studies of birth length and adult height in schizophrenia, following PRISMA guidelines (Prospero Registration # CRD42016043718). (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 7, 2017 Category: Psychiatry Authors: Keely Latham, Brian Kirkpatrick Source Type: research

Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder
Although Theory of Mind (ToM) impairment has been observed in patients with a wide range of mental disorders, the similarity and uniqueness of these deficits across diagnostic groups has not been thoroughly investigated. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 7, 2017 Category: Psychiatry Authors: Yan-yu Wang, Yi Wang, Ying-min Zou, Ke Ni, Xue Tian, Hong-wei Sun, Simon S.Y. Lui, Eric F.C. Cheung, John Suckling, Raymond C.K. Chan Source Type: research

Increased resting-state global functional connectivity density of default mode network in schizophrenia subjects treated with electroconvulsive therapy
Modified electroconvulsive therapy (MECT) has been widely applied to help treat schizophrenia patients who are treatment-resistant to pharmaceutical therapy. Although the technique is increasingly prevalent, the underlying neural mechanisms have not been well clarified. We conducted a longitudinal study to investigate the alteration of global functional connectivity density (gFCD) in schizophrenia patients undergoing MECT using resting state fMRI (functional magnetic resonance imaging). Two groups of schizophrenia inpatients were recruited. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 6, 2017 Category: Psychiatry Authors: Huan Huang, Yuchao Jiang, Mengqing Xia, Yingying Tang, Tianhong Zhang, Huiru Cui, Junjie Wang, Yu Li, Lihua Xu, Adrian Curtin, Jianhua Sheng, Yuping Jia, Dezhong Yao, Chunbo Li, Cheng Luo, Jijun Wang Source Type: research

A history of obstetric complications is associated with the risk of progression from an at risk mental state to psychosis
Clinical criteria for diagnosing Clinical High Risk for psychosis are now available. However, an understanding of the factors modulating the risk of subsequent development of frank psychosis in “at risk” individuals remains elusive. The aim of the study was to identify associations between obstetric history and the development of psychotic disorders in individuals with an At Risk Mental State (ARMS). (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 5, 2017 Category: Psychiatry Authors: Magdalena Kotlicka-Antczak, Agnieszka Pawe łczyk, Tomasz Pawełczyk, Dominik Strzelecki, Natalia Żurner, Michał Seweryn Karbownik Source Type: research

Insights on insight
The study of insight in schizophrenia is not without controversy. To some it is merely “agreeing with the doctor” to others it is a redundant concept already encompassed in ‘delusions’ and the ‘therapeutic alliance’. Yet others can be put off by the apparent complexity of the concept, feeling that they lack the philosophical background to interrogate it adequately or the s tatistical expertise needed to extract from a mass of interrelated concepts a few important causal mechanisms. For those in the latter camp, Xavier et al. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 5, 2017 Category: Psychiatry Authors: Anthony S. David Source Type: research

Clinical characteristics of primary psychotic disorders with concurrent substance abuse and substance-induced psychotic disorders: A systematic review
Distinguishing between a primary psychotic disorder with concurrent substance abuse (PPD+SA) and a substance-induced psychotic disorder (SIPD) can be diagnostically challenging. We aimed to determine if these two diagnoses are clinically distinct, particularly in relation to psychopathology. In addition, we aimed to examine the specific clinical features of cannabis-induced psychotic disorder (CIPD) as compared to primary psychotic disorder with concurrent cannabis abuse (PPD+CA) and also to SIPD associated with any substance. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 5, 2017 Category: Psychiatry Authors: Lorna Wilson, Attila Szigeti, Angela Kearney, Mary Clarke Source Type: research

A history of obstetric complications is associated with the risk of progression from an at risk mental state to psychosis
Clinical criteria for diagnosing Clinical High Risk for psychosis are now available. However, an understanding of the factors modulating the risk of subsequent development of frank psychosis in “at risk” individuals remains elusive. The aim of the study was to identify associations between obstetric history and the development of psychotic disorders in individuals with an At Risk Mental State (ARMS). (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 5, 2017 Category: Psychiatry Authors: Magdalena Kotlicka-Antczak, Agnieszka Pawe łczyk, Tomasz Pawełczyk, Dominik Strzelecki, Natalia Żurner, Michał Seweryn Karbownik Source Type: research

Insights on insight
The study of insight in schizophrenia is not without controversy. To some it is merely “agreeing with the doctor” to others it is a redundant concept already encompassed in ‘delusions’ and the ‘therapeutic alliance’. Yet others can be put off by the apparent complexity of the concept, feeling that they lack the philosophical background to interrogate it adequately or the s tatistical expertise needed to extract from a mass of interrelated concepts a few important causal mechanisms. For those in the latter camp, Xavier et al. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 5, 2017 Category: Psychiatry Authors: Anthony S. David Source Type: research

Clinical characteristics of primary psychotic disorders with concurrent substance abuse and substance-induced psychotic disorders: A systematic review
Distinguishing between a primary psychotic disorder with concurrent substance abuse (PPD+SA) and a substance-induced psychotic disorder (SIPD) can be diagnostically challenging. We aimed to determine if these two diagnoses are clinically distinct, particularly in relation to psychopathology. In addition, we aimed to examine the specific clinical features of cannabis-induced psychotic disorder (CIPD) as compared to primary psychotic disorder with concurrent cannabis abuse (PPD+CA) and also to SIPD associated with any substance. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 5, 2017 Category: Psychiatry Authors: Lorna Wilson, Attila Szigeti, Angela Kearney, Mary Clarke Source Type: research

Further angles to this story: Time consumption in mind-reading, psychosis risk and phenomenology of social cognition
Our everyday, pragmatic immersion in the social world strongly relies on a series of face to-face encounters with others, whose mental states are seamlessly disclosed to us in the immediacy of such interaction. This is why the recent study by Zhang et al. (2017) is so informative, particularly for the purpose of enriching our understanding of social cognition in early psychosis. The study focuses on a feature which is rather familiar to any clinician dealing with the field of early detection: clinical high risk (CHR) and schizophrenia (Sz) subjects, spend considerably more time (i.e. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 4, 2017 Category: Psychiatry Authors: Andrea Raballo Tags: Letter to the Editor Source Type: research

Brief assessment of schizotypal traits: A multinational study
The Schizotypal Personality Questionnaire-Brief (SPQ-B) was developed with the aim of examining variations in healthy trait schizotypy, as well as latent vulnerability to psychotic-spectrum disorders. No previous study has studied the cross-cultural validity of the SPQ-B in a large cross-national sample. The main goal of the present study was to analyze the reliability and the internal structure of SPQ-B scores in a multinational sample of 28,426 participants recruited from 14 countries. The mean age was 22.63years (SD=7.08; range 16 –68years), 37.7% (n=10,711) were men. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 4, 2017 Category: Psychiatry Authors: Eduardo Fonseca-Pedrero, Javier Ortu ño-Sierra, Beatriz Lucas-Molina, Martin Debbané, Raymond C.K. Chan, David C. Cicero, Lisa C. Zhang, Colleen Brenner, Emma Barkus, Richard J. Linscott, Thomas Kwapil, Neus Barrantes-Vidal, Alex Cohen, Adrian Raine, Mi Source Type: research

Further angles to this story: Time consumption in mind-reading, psychosis risk and phenomenology of social cognition
Our everyday, pragmatic immersion in the social world strongly relies on a series of face to-face encounters with others, whose mental states are seamlessly disclosed to us in the immediacy of such interaction. This is why the recent study by Zhang et al. (2017) is so informative, particularly for the purpose of enriching our understanding of social cognition in early psychosis. The study focuses on a feature which is rather familiar to any clinician dealing with the field of early detection: clinical high risk (CHR) and schizophrenia (Sz) subjects, spend considerably more time (i.e. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 4, 2017 Category: Psychiatry Authors: Andrea Raballo Tags: Letter to the Editor Source Type: research

Brief assessment of schizotypal traits: A multinational study
The Schizotypal Personality Questionnaire-Brief (SPQ-B) was developed with the aim of examining variations in healthy trait schizotypy, as well as latent vulnerability to psychotic-spectrum disorders. No previous study has studied the cross-cultural validity of the SPQ-B in a large cross-national sample. The main goal of the present study was to analyze the reliability and the internal structure of SPQ-B scores in a multinational sample of 28,426 participants recruited from 14 countries. The mean age was 22.63years (SD=7.08; range 16 –68years), 37.7% (n=10,711) were men. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 4, 2017 Category: Psychiatry Authors: Eduardo Fonseca-Pedrero, Javier Ortu ño-Sierra, Beatriz Lucas-Molina, Martin Debbané, Raymond C.K. Chan, David C. Cicero, Lisa C. Zhang, Colleen Brenner, Emma Barkus, Richard J. Linscott, Thomas Kwapil, Neus Barrantes-Vidal, Alex Cohen, Adrian Raine, Mi Source Type: research

Metacognitive Reflection and Insight Therapy for Early Psychosis: A preliminary study of a novel integrative psychotherapy
Poor insight impedes treatment in early phase psychosis (EPP). This manuscript outlines preliminary findings of an investigation of the novel metacognitively oriented integrative psychotherapy, Metacognitive Reflection and Insight Therapy, for individuals with early phase psychosis (MERIT-EP). Twenty adults with EPP and poor insight were randomized to either six months of MERIT-EP or treatment as usual (TAU). Therapists were trained and therapy was successfully delivered under routine, outpatient conditions. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 3, 2017 Category: Psychiatry Authors: Jenifer L. Vohs, Bethany L. Leonhardt, Alison V. James, Michael M. Francis, Alan Breier, Nikki Mehdiyoun, Andrew C. Visco, Paul H. Lysaker Source Type: research

Gender differences in motives for physical activity across the stages of change in Ugandan outpatients with psychosis
The biopsychosocial benefits of physical activity (PA) for people with psychosis are nowadays well established (Firth et al., 2015). Translation and integration of these research findings from clinical trials to routine care is urgently required. Motivating people with psychosis to adopt an active lifestyle is however challenging (Vancampfort et al., 2015). There is a clear need for theoretical evidence that might assist health care professionals in facilitating this motivational process. Research from a high-income country (Belgium), where physical activity is an important aspect of the multidisciplinary treatment, demons...
Source: Schizophrenia Research - November 2, 2017 Category: Psychiatry Authors: Davy Vancampfort, Michel Probst, Joseph Firth, Simon Rosenbaum, Tine Van Damme, James Mugisha Tags: Letter to the editor Source Type: research

In this issue
an old phenomenon, that of hyperprolactinemia, is revisited. While it had only before been studied as a dopaminergic side-effect of antipsychotic medication (Crespo-Facorro et al., 2017--in this issue and see commentary by (Osser, in this issue), now maybe similarly produced, but rather in response to stress and in no surprise, with a different response in females than males (Ittig et al., 2017--in this issue). (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 1, 2017 Category: Psychiatry Authors: Lynn E. DeLisi Source Type: research

Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - November 1, 2017 Category: Psychiatry Source Type: research

Length during early childhood and later development of non-affective psychotic disorder
The neurodevelopmental hypothesis of schizophrenia suggests schizophrenia to be partly understood as a consequence of early disruption in the nervous system (Owen et al., 2011). Further, the first three years of life is an important period in human development during which a substantial part of length progress and development of the central nervous system takes place (Thompson, 2001; Cooke et al., 2011). To our knowledge only one study (Perrin et al., 2007) has examined length development at repeated times during the first years of life in relation to psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 30, 2017 Category: Psychiatry Authors: Annika Tiger, Christina Dalman, Susanne Wicks Tags: Letter to the Editor Source Type: research

Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls
This study aimed to examine comparatively the relationships between the whole range of motor abnormalities and cognitive impairments in the first-episode of psychosis (FEP), their unaffected siblings and healthy control subjects.Fifty FEP patients, 21 of their healthy siblings and 24 age- and sex matched healthy controls were included. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 30, 2017 Category: Psychiatry Authors: Manuel J. Cuesta, Lucia Moreno-Izco, Mar ía Ribeiro, Jose M. López-Ilundain, Pablo Lecumberri, Teresa Cabada, Ruth Lorente-Omeñaca, Ana M. Sánchez-Torres, M. Sol Gómez, Victor Peralta Source Type: research

Length during early childhood and later development of non-affective psychotic disorder
The neurodevelopmental hypothesis of schizophrenia suggests schizophrenia to be partly understood as a consequence of early disruption in the nervous system (Owen et al., 2011). Further, the first three years of life is an important period in human development during which a substantial part of length progress and development of the central nervous system takes place (Thompson, 2001; Cooke et al., 2011). To our knowledge only one study (Perrin et al., 2007) has examined length development at repeated times during the first years of life in relation to psychosis. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 30, 2017 Category: Psychiatry Authors: Annika Tiger, Christina Dalman, Susanne Wicks Tags: Letter to the Editor Source Type: research

Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls
This study aimed to examine comparatively the relationships between the whole range of motor abnormalities and cognitive impairments in the first-episode of psychosis (FEP), their unaffected siblings and healthy control subjects.Fifty FEP patients, 21 of their healthy siblings and 24 age- and sex matched healthy controls were included. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 30, 2017 Category: Psychiatry Authors: Manuel J. Cuesta, Lucia Moreno-Izco, Mar ía Ribeiro, Jose M. López-Ilundain, Pablo Lecumberri, Teresa Cabada, Ruth Lorente-Omeñaca, Ana M. Sánchez-Torres, M. Sol Gómez, Victor Peralta Source Type: research

Genetically determined schizophrenia is not associated with impaired glucose homeostasis
Here, we used data from large genome-wide association studies to test the presence of causal relationships, conducting a Mendelian randomization analysis; and shared molecular mechanisms, calculating the genetic correlation, among schizophrenia, type 2 diabetes (T2D), and impaired glucose homeostasis. Although our Mendelian randomization analysis was well-powered, no causal relationship was observed between schizophrenia and T2D, or traits related to glucose impaired homeostasis. Similarly, we did not observe any global genetic overlap among these traits. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 29, 2017 Category: Psychiatry Authors: Renato Polimanti, Joel Gelernter, Dan J. Stein Source Type: research

Speech illusions and working memory performance in non-clinical psychosis
The objective of the current study is to better understand this empirical gap. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 28, 2017 Category: Psychiatry Authors: Tina Gupta, Jordan E. DeVylder, Randy P. Auerbach, Jason Schiffman, Vijay A. Mittal Source Type: research

Risk of gastrointestinal Hypomotility in schizophrenia and schizoaffective disorder treated with antipsychotics: A retrospective cohort study
The risk of gastrointestinal hypomotility (GIHM) with the use of antipsychotic medications in patients with schizophrenia remains inadequately recognized. The aim of this study was to explore the incidence of GIHM and its risks in patients with schizophrenia treated with antipsychotics. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 27, 2017 Category: Psychiatry Authors: Hsing-Kang Chen, Chia-Jung Hsieh Source Type: research

Predictors of aggression in 3.322 patients with affective disorders and schizophrenia spectrum disorders evaluated in an emergency department setting
The aim of this study is to determine odds of aggression and associated factors in patients with schizophrenia-spectrum disorders (SSD) and affective disorders who were evaluated in an emergency department setting. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 25, 2017 Category: Psychiatry Authors: Emily A. Blanco, Laura M. Duque, Vivekananda Rachamallu, Eunice Yuen, John M. Kane, Juan A. Gallego Source Type: research

Examining speed of processing of facial emotion recognition in individuals at ultra-high risk for psychosis: Associations with symptoms and cognition
This study aimed to extend current knowledge on emotion recognition deficits in UHR individuals by examining: 1) whether UHR would display significantly slower facial emotion recognition than healthy controls, 2) whether an association between emotion recognition accuracy and emotion recognition latency is present in UHR, 3) the relationships between emotion recognition accuracy, neurocognition and psychopathology in UHR. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 25, 2017 Category: Psychiatry Authors: Louise Birkedal Glenth øj, Birgitte Fagerlund, Nikolaj Bak, Carsten Hjorthøj, Maja Gregersen, Tina Dam Kristensen, Christina Wenneberg, Kristine Krakauer, Joseph Ventura, Jens Richardt Møllegaard Jepsen, Merete Nordentoft Tags: Letter to the Editor Source Type: research

Predictors of aggression in 3.322 patients with affective disorders and schizophrenia spectrum disorders evaluated in an emergency department setting
The aim of this study is to determine odds of aggression and associated factors in patients with schizophrenia-spectrum disorders (SSD) and affective disorders who were evaluated in an emergency department setting. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 25, 2017 Category: Psychiatry Authors: Emily A. Blanco, Laura M. Duque, Vivekananda Rachamallu, Eunice Yuen, John M. Kane, Juan A. Gallego Source Type: research

Examining speed of processing of facial emotion recognition in individuals at ultra-high risk for psychosis: Associations with symptoms and cognition
This study aimed to extend current knowledge on emotion recognition deficits in UHR individuals by examining: 1) whether UHR would display significantly slower facial emotion recognition than healthy controls, 2) whether an association between emotion recognition accuracy and emotion recognition latency is present in UHR, 3) the relationships between emotion recognition accuracy, neurocognition and psychopathology in UHR. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 25, 2017 Category: Psychiatry Authors: Louise Birkedal Glenth øj, Birgitte Fagerlund, Nikolaj Bak, Carsten Hjorthøj, Maja Gregersen, Tina Dam Kristensen, Christina Wenneberg, Kristine Krakauer, Joseph Ventura, Jens Richardt Møllegaard Jepsen, Merete Nordentoft Tags: Letter to the Editor Source Type: research

Motor dysfunction as an intermediate phenotype across schizophrenia and other psychotic disorders: Progress and perspectives
Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks has been proposed as core pathophysiological mechanism underlying the expression of PMA. However, it is unclear at present if such mechanisms are a common within schizophrenia and other psychotic disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 24, 2017 Category: Psychiatry Authors: Dusan Hirjak, Katharina M. Kubera, Philipp A. Thomann, Robert C. Wolf Source Type: research

Omega-3 fatty acid supplementation may prevent loss of gray matter thickness in the left parieto-occipital cortex in first episode schizophrenia: A secondary outcome analysis of the OFFER randomized controlled study
The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containing 2.2g/d of eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) or placebo (olive oil). Participants underwent MRI scanning twice to assess changes in cortical thickness: at the beginning and at the end of intervention. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 24, 2017 Category: Psychiatry Authors: Tomasz Pawe łczyk, Ewa Piątkowska-Janko, Piotr Bogorodzki, Piotr Gębski, Marta Grancow-Grabka, Elżbieta Trafalska, Natalia Żurner, Agnieszka Pawełczyk Source Type: research

Improving individual predictions: Machine learning approaches for detecting and attacking heterogeneity in schizophrenia (and other psychiatric diseases)
Psychiatric diseases are very heterogeneous both in clinical manifestation and etiology. With the recent rise of using machine learning techniques to attempt to diagnose and prognose these disorders, the issue of heterogeneity becomes increasingly important. With the growing interest in personalized medicine, it becomes even more important to not only classify someone as a patient with a certain disorder, its treatment needs a more precise definition of the underlying neurobiology, since different biological origins of the same disease may require (very) different treatments. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 24, 2017 Category: Psychiatry Authors: Hugo G. Schnack Source Type: research

Intra-individual variability and psychotic-like experiences in adolescents: Findings from the ALSPAC cohort
Clinical and epidemiological studies have demonstrated associations between elevated intra-individual variability (IIV) of reaction time and psychotic disorders. However, little attention has been paid to the relationship between performance stability and psychotic-like experiences (PLE) in adolescence, before psychotic disorder onset. Data from 6702 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to address this issue. Children took part in a semi-structured clinical interview regarding psychotic symptoms at age 12 and 18, and reaction time variability was assessed at age 13 and 15. (S...
Source: Schizophrenia Research - October 24, 2017 Category: Psychiatry Authors: Simon Wallace, Richard J. Linscott Source Type: research

Motor dysfunction as an intermediate phenotype across schizophrenia and other psychotic disorders: Progress and perspectives
Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks has been proposed as core pathophysiological mechanism underlying the expression of PMA. However, it is unclear at present if such mechanisms are a common within schizophrenia and other psychotic disorders. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 24, 2017 Category: Psychiatry Authors: Dusan Hirjak, Katharina M. Kubera, Philipp A. Thomann, Robert C. Wolf Source Type: research

Omega-3 fatty acid supplementation may prevent loss of gray matter thickness in the left parieto-occipital cortex in first episode schizophrenia: A secondary outcome analysis of the OFFER randomized controlled study
The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containing 2.2g/d of eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) or placebo (olive oil). Participants underwent MRI scanning twice to assess changes in cortical thickness: at the beginning and at the end of intervention. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 24, 2017 Category: Psychiatry Authors: Tomasz Pawe łczyk, Ewa Piątkowska-Janko, Piotr Bogorodzki, Piotr Gębski, Marta Grancow-Grabka, Elżbieta Trafalska, Natalia Żurner, Agnieszka Pawełczyk Source Type: research

Improving individual predictions: Machine learning approaches for detecting and attacking heterogeneity in schizophrenia (and other psychiatric diseases)
Psychiatric diseases are very heterogeneous both in clinical manifestation and etiology. With the recent rise of using machine learning techniques to attempt to diagnose and prognose these disorders, the issue of heterogeneity becomes increasingly important. With the growing interest in personalized medicine, it becomes even more important to not only classify someone as a patient with a certain disorder, its treatment needs a more precise definition of the underlying neurobiology, since different biological origins of the same disease may require (very) different treatments. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 24, 2017 Category: Psychiatry Authors: Hugo G. Schnack Source Type: research

Intra-individual variability and psychotic-like experiences in adolescents: Findings from the ALSPAC cohort
Clinical and epidemiological studies have demonstrated associations between elevated intra-individual variability (IIV) of reaction time and psychotic disorders. However, little attention has been paid to the relationship between performance stability and psychotic-like experiences (PLE) in adolescence, before psychotic disorder onset. Data from 6702 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to address this issue. Children took part in a semi-structured clinical interview regarding psychotic symptoms at age 12 and 18, and reaction time variability was assessed at age 13 and 15. (S...
Source: Schizophrenia Research - October 24, 2017 Category: Psychiatry Authors: Simon Wallace, Richard J. Linscott Source Type: research

Psychosocial factors associated with physical activity behavior among patients with psychosis
This study aims to explore the associations between theoretical constructs in relation to physical activity behavior based on psychological theories to examine reasons for physical inactivity in psychosis population. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 22, 2017 Category: Psychiatry Authors: Jenny T.M. Lee, Eunice Y.L. Law, Lincoln L.H. Lo, Jingxia Lin, Edwin H.M. Lee, Christy L.M. Hui, Catherine S.Y. Chong, Sherry K.W. Chan, William T.L. Lo, Eric Y.H. Chen Source Type: research

Social Recovery Therapy in improving activity and social outcomes in early psychosis: Current evidence and longer term outcomes
Social Recovery Therapy (SRT) is a cognitive behavioural therapy which targets young people with early psychosis who have complex problems associated with severe social disability. This paper provides a narrative overview of current evidence for SRT and reports new data on a 2year follow-up of participants recruited into the Improving Social Recovery in Early Psychosis (ISREP) trial. (Source: Schizophrenia Research)
Source: Schizophrenia Research - October 22, 2017 Category: Psychiatry Authors: David Fowler, Jo Hodgekins, Paul French Source Type: research

Sensorimotor gating deficits in “two-hit” models of schizophrenia risk factors
Genetic and environmental models of neuropsychiatric disease have grown exponentially over the last 20years. One measure that is often used to evaluate the translational relevance of these models to human neuropsychiatric disease is prepulse inhibition of startle (PPI), an operational measure of sensorimotor gating. Deficient PPI characterizes several neuropsychiatric disorders but has been most extensively studied in schizophrenia. It has become a useful tool in translational neuropharmacological and molecular genetics studies because it can be measured across species using almost the same experimental parameters. (Source...
Source: Schizophrenia Research - October 22, 2017 Category: Psychiatry Authors: Asma Khan, Susan B. Powell Source Type: research