Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances
Changes in inflammatory cascades have been implicated in the underlying pathophysiology of psychosis. Translocator protein 18  kDa (TSPO) has been used to assess neuroinflammatory processes in psychotic disorders. Nonetheless, it is unclear whether TSPO, a mitochondrial protein, can be interpreted as a general marker for inflammation in diseases involving psychosis. To address this question, we investigated TSPO signalin g in representative mouse models for psychosis with inflammatory disturbances. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 2, 2018 Category: Psychiatry Authors: Daisuke Fukudome, Lindsay N. Hayes, Travis E. Faust, Catherine A. Foss, Mari A. Kondo, Brian J. Lee, Atsushi Saito, Shin-ichi Kano, Jennifer M. Coughlin, Atsushi Kamiya, Martin G. Pomper, Akira Sawa, Minae Niwa Source Type: research

Disrupted salience processing involved in motivational deficits for real-life activities in patients with schizophrenia
This study aimed to identify impairment of the salience network that underlies motivational deficits seen in patients with schizophrenia in real-life situations. During the functional magnetic resonance imaging scan, 20 patients with schizophrenia and 20 normal controls performed a task mimicking real-life situations, in which an avatar proposed participation in a daily activity with either an intrinsic or extrinsic reward. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 2, 2018 Category: Psychiatry Authors: Byung-Hoon Kim, Yu-Bin Shin, Sunghyon Kyeong, Seon-Koo Lee, Jae-Jin Kim Source Type: research

Birth experiences, trauma responses and self-concept in postpartum psychotic-like experiences
The frequency of psychotic-like experiences (PLEs) amongst new mothers is beginning to be explored but the mechanisms underlying such experiences are yet to be understood. First time mothers (N=10,000) receiving maternity care via the UK National Health Service were contacted postnatally via Emma's Diary, an online resource for mothers. Measures assessed birth experience, trauma appraisals, post-traumatic stress symptoms, adjustment to motherhood, self-concept clarity and PLEs (in the form of hallucinations and delusions). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 2, 2018 Category: Psychiatry Authors: Lyndsey Holt, William Sellwood, Pauline Slade Source Type: research

Effective connectivity within a triple network brain system discriminates schizophrenia spectrum disorders from psychotic bipolar disorder at the single-subject level
Schizophrenia spectrum disorders (SSD) and psychotic bipolar disorder share a number of genetic and neurobiological features, despite a divergence in clinical course and outcome trajectories. We studied the diagnostic classification potential that can be achieved on the basis of the structure and connectivity within a triple network system (the default mode, salience and central executive network) in patients with SSD and psychotic bipolar disorder. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 2, 2018 Category: Psychiatry Authors: Lena Palaniyappan, Gopikrishna Deshpande, Pradyumna Lanka, D. Rangaprakash, Sarina Iwabuchi, Susan Francis, Peter F. Liddle Source Type: research

Patterns in adolescent cannabis use predict the onset and symptom structure of schizophrenia-spectrum disorder
This study investigated adolescent cannabis use as a risk factor for schizophrenia spectrum disorder (SSD). Motives for early cannabis use and resulting usage patterns were examined alongside clinical measures of SSD onset and symptomatology.Participants (N  = 178) were recruited for two samples, 1: healthy controls (HC) with cannabis use, 2: schizophrenia patients (SSD) with cannabis use. Structured interviews of participants and family informants were used to obtain diagnostic and biographical information. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 2, 2018 Category: Psychiatry Authors: C. Shahzade, J. Chun, L.E. DeLisi, T.C. Manschreck Source Type: research

Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances
Changes in inflammatory cascades have been implicated in the underlying pathophysiology of psychosis. Translocator protein 18  kDa (TSPO) has been used to assess neuroinflammatory processes in psychotic disorders. Nonetheless, it is unclear whether TSPO, a mitochondrial protein, can be interpreted as a general marker for inflammation in diseases involving psychosis. To address this question, we investigated TSPO signalin g in representative mouse models for psychosis with inflammatory disturbances. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 2, 2018 Category: Psychiatry Authors: Daisuke Fukudome, Lindsay N. Hayes, Travis E. Faust, Catherine A. Foss, Mari A. Kondo, Brian J. Lee, Atsushi Saito, Shin-ichi Kano, Jennifer M. Coughlin, Atsushi Kamiya, Martin G. Pomper, Akira Sawa, Minae Niwa Source Type: research

Disrupted salience processing involved in motivational deficits for real-life activities in patients with schizophrenia
This study aimed to identify impairment of the salience network that underlies motivational deficits seen in patients with schizophrenia in real-life situations. During the functional magnetic resonance imaging scan, 20 patients with schizophrenia and 20 normal controls performed a task mimicking real-life situations, in which an avatar proposed participation in a daily activity with either an intrinsic or extrinsic reward. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 2, 2018 Category: Psychiatry Authors: Byung-Hoon Kim, Yu-Bin Shin, Sunghyon Kyeong, Seon-Koo Lee, Jae-Jin Kim Source Type: research

Adjunctive raloxifene for postmenopausal women with schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials
Raloxifene, a selective estrogen receptor modulator, has been used in treating postmenopausal women with schizophrenia with inconsistent results. This meta-analysis of randomized, double-blind, placebo-controlled trials (RCTs) examined its efficacy and safety for postmenopausal women with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 1, 2018 Category: Psychiatry Authors: Xiao-Min Zhu, Wei Zheng, Xiao-Hong Li, Dong-Bin Cai, Xin-Hu Yang, Gabor S. Ungvari, Chee H. Ng, Xiao-Ping Wang, Jayashri Kulkarni, Jasmin Grigg, Yu-Ping Ning, Yu-Tao Xiang Source Type: research

Editorial Board
(Source: Schizophrenia Research)
Source: Schizophrenia Research - February 1, 2018 Category: Psychiatry Source Type: research

In This issue
Krivoy and colleagues (pages 226-231) examined serum neurotrophins and glutamate levels as putative biomarkers for clozapine response in 89 chronic schizophrenia patients on clozapine (54 responders and 35 non-responders). Responders had higher mean BDNF l and higher serum glutamate levels. These findings suggest that serum glutamate and BDNF can discriminate between clozapine responders and non-responders. However, the question whether peripheral levels of BDNF and glutamate reflect their brain concentrations is unclear. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 1, 2018 Category: Psychiatry Tags: Invited commentary Source Type: research

Year-end review in Schizophrenia Research 2017
(Source: Schizophrenia Research)
Source: Schizophrenia Research - February 1, 2018 Category: Psychiatry Authors: Urvakhsh Meherwan Mehta Source Type: research

Adjunctive raloxifene for postmenopausal women with schizophrenia: A meta-analysis of randomized, double-blind, placebo-controlled trials
Raloxifene, a selective estrogen receptor modulator, has been used in treating postmenopausal women with schizophrenia with inconsistent results. This meta-analysis of randomized, double-blind, placebo-controlled trials (RCTs) examined its efficacy and safety for postmenopausal women with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 1, 2018 Category: Psychiatry Authors: Xiao-Ming Zhu, Wei Zheng, Xiao-Hong Li, Dong-Bin Cai, Xin-Hu Yang, Gabor S. Ungvari, Chee H. Ng, Xiao-Ping Wang, Jayashri Kulkarni, Jasmin Grigg, Yu-Ping Ning, Yu-Tao Xiang Source Type: research

Response to concerns over Cantillon et al. dopamine serotonin stabilizer RP5063 clinical trial's design, analyses and findings (SCHRES-D-17-00455) by Ahmed S Aboraya, MD, DrPh
Thank you for the opportunity to reply to Dr. Aboraya's letter, “Concerns Over Cantillon et al. Dopamine Serotonin Stabilizer RP5063 Clinical Trial's Design, Analyses and Findings.” (Aboraya 2017, Cantillon et al., 2017) After review of his comments and research into the issues raised, we stand by our data and conclusions and respond as follows: (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 21, 2018 Category: Psychiatry Authors: Marc Cantillon, Laxminarayan Bhat Tags: Letter to the editor Source Type: research

The Early Psychosis Screener (EPS): Quantitative validation against the SIPS using machine learning
Machine learning techniques were used to identify highly informative early psychosis self-report items and to validate an early psychosis screener (EPS) against the Structured Interview for Psychosis-risk Syndromes (SIPS). The Prodromal Questionnaire –Brief Version (PQ-B) and 148 additional items were administered to 229 individuals being screened with the SIPS at 7 North American Prodrome Longitudinal Study sites and at Columbia University. Fifty individuals were found to have SIPS scores of 0, 1, or 2, making them clinically low risk (CLR) c ontrols; 144 were classified as clinically high risk (CHR) (SIPS 3–5...
Source: Schizophrenia Research - January 19, 2018 Category: Psychiatry Authors: B.B. Brodey, R.R. Girgis, O.V. Favorov, J. Addington, D.O. Perkins, C.E. Bearden, S.W. Woods, E.F. Walker, B.A. Cornblatt, G. Brucato, B. Walsh, K.A. Elkin, I.S. Brodey Source Type: research

A systematic review and discussion of symptom specific cognitive behavioural approaches to delusions and hallucinations
Studies on cognitive behavioural therapy for psychosis (CBTp) have developed from evaluating generic approaches to focusing on specific symptoms. The evidence for targeted studies on delusions and hallucinations was reviewed. We included randomized controlled trials (RCTs) examining the effect of individualized CBT-based interventions focusing either on delusions or on hallucinations. Twelve suitable RCTs were identified. Four RCTs focused on delusions, of which three took a focused approach targeting mechanisms assumed causal to persecutory delusions. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 16, 2018 Category: Psychiatry Authors: Tania M. Lincoln, Emmanuelle Peters Source Type: research

Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: A cross-sectional study
In this study, we first compared the difference of gut microbiota between schizophrenia patients and healthy controls by 16S rRNA sequencing. We further explored whether gut microbiota can be used as a biomarker to assist in the diagnosis of schizophrenia. We restricted inclusion criteria strictly to control confounding bias. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 16, 2018 Category: Psychiatry Authors: Yang Shen, Jintian Xu, Zhiyong Li, Yichen Huang, Ye Yuan, Jixiang Wang, Meng Zhang, Songnian Hu, Ying Liang Source Type: research

A systematic review and discussion of symptom specific cognitive behavioural approaches to delusions and hallucinations
Studies on cognitive behavioural therapy for psychosis (CBTp) have developed from evaluating generic approaches to focusing on specific symptoms. The evidence for targeted studies on delusions and hallucinations was reviewed. We included randomized controlled trials (RCTs) examining the effect of individualized CBT-based interventions focusing either on delusions or on hallucinations. Twelve suitable RCTs were identified. Four RCTs focused on delusions, of which three took a focused approach targeting mechanisms assumed causal to persecutory delusions. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 16, 2018 Category: Psychiatry Authors: Tania M. Lincoln, Emmanuelle Peters Source Type: research

Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: A cross-sectional study
In this study, we first compared the difference of gut microbiota between schizophrenia patients and healthy controls by 16S rRNA sequencing. We further explored whether gut microbiota can be used as a biomarker to assist in the diagnosis of schizophrenia. We restricted inclusion criteria strictly to control confounding bias. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 16, 2018 Category: Psychiatry Authors: Yang Shen, Jintian Xu, Zhiyong Li, Yichen Huang, Ye Yuan, Jixiang Wang, Meng Zhang, Songnian Hu, Ying Liang Source Type: research

A new window into psychosis: The rise digital phenotyping, smartphone assessment, and mobile monitoring
This commentary piece discusses recent advances in the use of mobile technologies like smartphone and wearable sensors for schizophrenia research. By framing both the opportunities as well as challenges for the field, this piece aims to frame the both current and future research efforts. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 12, 2018 Category: Psychiatry Authors: John Torous, Matcheri Keshavan Source Type: research

Abundance of ribosomal RNA gene copies in the genomes of schizophrenia patients
The ribosome is a critical component of the translation machinery. The key component of ribosomes is ribosomal RNA (rRNA). Dysregulation of rRNA biogenesis has been implicated in some human diseases. One of the factors affecting rRNA biogenesis is the ribosomal RNA genes (rDNA) copy number in the genome. The aim of this study was to examine the rDNA copy number (CN) variation in the genomes of patients with schizophrenia (SZ) compared to healthy controls (HC). (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 11, 2018 Category: Psychiatry Authors: I.V. Chestkov, E.M. Jestkova, E.S. Ershova, V.E. Golimbet, T.V. Lezheiko, N.Y. Kolesina, L.N. Porokhovnik, N.A. Lyapunova, V.L. Izhevskaya, S.I. Kutsev, N.N. Veiko, S.V. Kostyuk Source Type: research

Knowing when to stop: Aberrant precision and evidence accumulation in schizophrenia
Predictive coding and active inference formulations of the dysconnection hypothesis suggest that subjects with schizophrenia (SZ) hold unduly precise prior beliefs to compensate for a failure of sensory attenuation. This implies that SZ subjects should both initiate responses prematurely during evidence-accumulation tasks and fail to inhibit their responses at long stop-signal delays. SZ and healthy control subjects were asked to report the timing of billiards-ball collisions and were occasionally required to withhold their responses. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 10, 2018 Category: Psychiatry Authors: Roberto Limongi, Bartosz Bohaterewicz, Magdalena Nowicka, Aleksandra Plewka, Karl J. Friston Source Type: research

Lymphoma following clozapine exposure: More information needed
Clozapine is the drug of choice for treatment resistant schizophrenia and has demonstrated superiority to other antipsychotics; however, its adverse event profile precludes use as a first line agent.(Meltzer, 2012) The carcinogenicity of clozapine remains unknown due to conflicting data. A systematic review concluded that antipsychotics as a class cannot be considered carcinogenic in humans, despite rodent data suggesting the contrary.(Fond et al., 2012) Notably, authors highlight that clozapine, specifically, may be associated with an increased risk of leukemia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 9, 2018 Category: Psychiatry Authors: Jonathan G. Leung, Jason N. Barreto, Carrie A. Thompson Tags: Letter to the Editor Source Type: research

Diminished activation of the right Inferior Parietal Lobule as a neural substrate of impaired cartoon-jokes comprehension in schizophrenia outpatients
Impairments related to humor comprehension may be considered one of the most specific phenomena related to communication disorders in schizophrenia (Adamczyk et al., 2016). Despite behavioral evidence, to the best of our knowledge, there are only two neuroimaging (fMRI) studies to date concerning humor processing in schizophrenia. The first, a pictorial visual joke task study on the relatives of individuals with schizophrenia revealed Prefrontal Cortex hypofunction during Theory of Mind humor processing (Marjoram et al., 2006). (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 9, 2018 Category: Psychiatry Authors: Przemys ław Adamczyk, Miroslaw Wyczesany, Aleksandra Domagalik, Kamil Cepuch, Artur Daren, Tadeusz Marek Tags: Letter to the Editor Source Type: research

Lymphoma following clozapine exposure: More information needed
Clozapine is the drug of choice for treatment resistant schizophrenia and has demonstrated superiority to other antipsychotics; however, its adverse event profile precludes use as a first line agent.(Meltzer, 2012) The carcinogenicity of clozapine remains unknown due to conflicting data. A systematic review concluded that antipsychotics as a class cannot be considered carcinogenic in humans, despite rodent data suggesting the contrary.(Fond et al., 2012) Notably, authors highlight that clozapine, specifically, may be associated with an increased risk of leukemia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 9, 2018 Category: Psychiatry Authors: Jonathan G. Leung, Jason N. Barreto, Carrie A. Thompson Tags: Letter to the Editor Source Type: research

Diminished activation of the right Inferior Parietal Lobule as a neural substrate of impaired cartoon-jokes comprehension in schizophrenia outpatients
Impairments related to humor comprehension may be considered one of the most specific phenomena related to communication disorders in schizophrenia (Adamczyk et al., 2016). Despite behavioral evidence, to the best of our knowledge, there are only two neuroimaging (fMRI) studies to date concerning humor processing in schizophrenia. The first, a pictorial visual joke task study on the relatives of individuals with schizophrenia revealed Prefrontal Cortex hypofunction during Theory of Mind humor processing (Marjoram et al., 2006). (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 9, 2018 Category: Psychiatry Authors: Przemys ław Adamczyk, Miroslaw Wyczesany, Aleksandra Domagalik, Kamil Cepuch, Artur Daren, Tadeusz Marek Tags: Letter to the Editor Source Type: research

Quality of life disparities between persons with schizophrenia and their professional caregivers: Network analysis in a National Cohort
Disparities between mental health patients and their professional caregivers in quality of life appraisals have been identified, however, the structure that such disparities assume is unknown. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 8, 2018 Category: Psychiatry Authors: Anat Rotstein, David Roe, Marc Gelkopf, Efrat Shadmi, Stephen Z. Levine Source Type: research

Monocyte activation detected prior to a diagnosis of schizophrenia in the US Military New Onset Psychosis Project (MNOPP)
We examined peripheral biomarkers of bacterial translocation, soluble CD14 (sCD14) and lipopolysaccharide binding protein (LBP), and of general inflammation, C-reactive protein (CRP), in a unique, pre-onset study of schizophrenia. This sample was composed of 80 case-control matched pairs of US military service members from whom blood samples were obtained at time of entry to service, before a psychiatric diagnosis was made. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 6, 2018 Category: Psychiatry Authors: Natalya S. Weber, Kristin L. Gressitt, David N. Cowan, David W. Niebuhr, Robert H. Yolken, Emily G. Severance Source Type: research

Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia
Childhood-onset schizophrenia (COS) is a rare, severe form of the adult-onset disorder (AOS). Our previous resting-state fMRI study identified attenuated functional connectivity in COS compared with controls. Here, we ask whether COS and AOS patients and their siblings exhibit similar abnormalities of functional connectivity. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 6, 2018 Category: Psychiatry Authors: Rebecca E. Watsky, Stephen J. Gotts, Rebecca A. Berman, Harrison M. McAdams, Xueping Zhou, Dede Greenstein, Francois M. Lalonde, Peter Gochman, Liv S. Clasen, Lorie Shora, Anna E. Ord óñez, Nitin Gogtay, Alex Martin, Deanna M. Barch, Judith L. Rapoport, Source Type: research

Monocyte activation detected prior to a diagnosis of schizophrenia in the US Military New Onset Psychosis Project (MNOPP)
We examined peripheral biomarkers of bacterial translocation, soluble CD14 (sCD14) and lipopolysaccharide binding protein (LBP), and of general inflammation, C-reactive protein (CRP), in a unique, pre-onset study of schizophrenia. This sample was composed of 80 case-control matched pairs of US military service members from whom blood samples were obtained at time of entry to service, before a psychiatric diagnosis was made. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 6, 2018 Category: Psychiatry Authors: Natalya S. Weber, Kristin L. Gressitt, David N. Cowan, David W. Niebuhr, Robert H. Yolken, Emily G. Severance Source Type: research

Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia
Childhood-onset schizophrenia (COS) is a rare, severe form of the adult-onset disorder (AOS). Our previous resting-state fMRI study identified attenuated functional connectivity in COS compared with controls. Here, we ask whether COS and AOS patients and their siblings exhibit similar abnormalities of functional connectivity. (Source: Schizophrenia Research)
Source: Schizophrenia Research - January 6, 2018 Category: Psychiatry Authors: Rebecca E. Watsky, Stephen J. Gotts, Rebecca A. Berman, Harrison M. McAdams, Xueping Zhou, Dede Greenstein, Francois M. Lalonde, Peter Gochman, Liv S. Clasen, Lorie Shora, Anna E. Ord óñez, Nitin Gogtay, Alex Martin, Deanna M. Barch, Judith L. Rapoport, Source Type: research

A comparison of conversion rates, clinical profiles and predictors of outcomes in two independent samples of individuals at clinical high risk for psychosis in China
In a previous epidemiological study, we reported on the ascertainment and outcomes of “clinical high risk” (CHR) individuals at the Shanghai Mental Health Center (SMHC, “2011 cohort”). The current study compares demographic and clinical characteristics, including conversion rates, of this sample with a subsequently recruited, independent CHR sample and with published data fro m western samples. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 26, 2017 Category: Psychiatry Authors: Huijun Li, TianHong Zhang, LiHua Xu, YingYing Tang, HuiRu Cui, YanYan Wei, XiaoChen Tang, Kristen A. Woodberry, Daniel I. Shapiro, ChunBo Li, Larry J. Seidman, JiJun Wang Source Type: research

Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response
Sensorimotor gating measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) has been proposed as one of the most promising electrophysiological endophenotypes of schizophrenia. During the past decade, a number of publications have reported significant associations between genetic polymorphisms and PPI in samples of schizophrenia patients and healthy volunteers. However, an overall evaluation of the robustness of these results has not been published so far. Therefore, we performed the first meta-analysis of published and unpublished associations between gene polymorphisms and PPI of ASR. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 26, 2017 Category: Psychiatry Authors: Boris B. Quednow, Kenechi Ejebe, Michael Wagner, Stella G. Giakoumaki, Panos Bitsios, Veena Kumari, Panos Roussos Source Type: research

A comparison of conversion rates, clinical profiles and predictors of outcomes in two independent samples of individuals at clinical high risk for psychosis in China
In a previous epidemiological study, we reported on the ascertainment and outcomes of “clinical high risk” (CHR) individuals at the Shanghai Mental Health Center (SMHC, “2011 cohort”). The current study compares demographic and clinical characteristics, including conversion rates, of this sample with a subsequently recruited, independent CHR sample and with published data fro m western samples. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 26, 2017 Category: Psychiatry Authors: Huijun Li, TianHong Zhang, LiHua Xu, YingYing Tang, HuiRu Cui, YanYan Wei, XiaoChen Tang, Kristen A. Woodberry, Daniel I. Shapiro, ChunBo Li, Larry J. Seidman, JiJun Wang Source Type: research

Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response
Sensorimotor gating measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) has been proposed as one of the most promising electrophysiological endophenotypes of schizophrenia. During the past decade, a number of publications have reported significant associations between genetic polymorphisms and PPI in samples of schizophrenia patients and healthy volunteers. However, an overall evaluation of the robustness of these results has not been published so far. Therefore, we performed the first meta-analysis of published and unpublished associations between gene polymorphisms and PPI of ASR. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 26, 2017 Category: Psychiatry Authors: Boris B. Quednow, Kenechi Ejebe, Michael Wagner, Stella G. Giakoumaki, Panos Bitsios, Veena Kumari, Panos Roussos Source Type: research

Complement system biomarkers in first episode psychosis
Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases. Here we explored whether complement dysregulation occurred in first episode psychosis (FEP) and whether this provides a source of biomarkers. Eleven complement analytes (C1q, C3, C4, C5, factor B [FB], terminal complement complex [TCC], factor H [FH], FH-related proteins [FHR125], Properdin, C1 inhibitor [C1inh], soluble complement receptor 1 [CR1]) plus C-reactive protein (CRP) were measured in serum from 136 firs...
Source: Schizophrenia Research - December 24, 2017 Category: Psychiatry Authors: Maja Kopczynska, Wioleta Zelek, Samuel Touchard, Fiona Gaughran, Marta Di Forti, Valeria Mondelli, Robin Murray, Michael C. O'Donovan, B. Paul Morgan Source Type: research

Latent class cluster analysis of symptom ratings identifies distinct subgroups within the clinical high risk for psychosis syndrome
This study applied latent class cluster analysis (LCCA) to symptom ratings from the North American Prodrome Longitudinal Studies 1 and 2 (NAPLS 1 and 2). These analyses produced evidence for three to five subgroups within the CHR-P syndrome. Differences in negative and disorganized symptoms distinguished among the subgroups. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 23, 2017 Category: Psychiatry Authors: Arthur T. Ryan, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Scott W. Woods, Tyrone D. Cannon, Elaine F. Walker Source Type: research

The brief negative symptom scale (BNSS): Sensitivity to treatment effects
The Brief Negative Symptom Scale (BNSS) grew out of a recommendation by the NIMH-sponsored Consensus Development Conference on Negative Symptoms that a scale based on contemporary concepts be developed. We assessed sensitivity to change of the BNSS in a trial of MIN-101, which showed efficacy for negative symptoms (PANSS pentagonal model) at daily doses of 32 and 64mg/day. Using mixed-effects model for repeated measures, we examined change in BNSS total score and in the BNSS factors of anhedonia/avolition/asociality (AAA), and expressivity (EXP). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Brian Kirkpatrick, Jay B. Saoud, Gregory P. Strauss, Anthony O. Ahmed, Kazunori Tatsumi, Mark Opler, Remy Luthringer, Michael Davidson Source Type: research

Can we accurately classify schizophrenia patients from healthy controls using magnetic resonance imaging and machine learning? A multi-method and multi-dataset study
Machine learning is a powerful tool that has previously been used to classify schizophrenia (SZ) patients from healthy controls (HC) using magnetic resonance images. Each study, however, uses different datasets, classification algorithms, and validation techniques. Here, we perform a critical appraisal of the accuracy of machine learning methodologies used in SZ/HC classifications studies by comparing three machine learning algorithms (logistic regression [LR], support vector machines [SVMs], and linear discriminant analysis [LDA]) on three independent datasets (435 subjects total) using two tissue density estimates and co...
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Julie L. Winterburn, Aristotle N. Voineskos, Gabriel A. Devenyi, Eric Plitman, Camilo de la Fuente-Sandoval, Nikhil Bhagwat, Ariel Graff-Guerrero, Jo Knight, M. Mallar Chakravarty Source Type: research

Premorbid IQ subgroups in first episode non affective psychosis patients: Long-term sex differences in function and neurocognition
Low IQ has been associated with schizophrenia, even to the point of being posited as a possible causal factor for psychosis. However, individuals with normal and high IQ also develop psychotic illnesses. The aim of this study was to characterize premorbid IQ subgroups at first episode of psychosis (FEP). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Rosa Ayesa-Arriola, Esther Seti én-Suero, Karl David Neergaard, Àuria Albacete Belzunces, Fernando Contreras, Neeltje E.M. van Haren, Benedicto Crespo-Facorro Source Type: research

Is the prevalence of anti-N-methyl-d-aspartate receptor antibodies in schizophrenia overestimated?
We read with great interest the article by Chen et al. (2017), who screened for antibodies against N-methyl-d-aspartate receptors (NMDAR) in blood samples from schizophrenia patients. Anti-NMDAR antibodies have previously been detected in schizophrenia patients; for example, Zandi et al. (2011) found three positive cases among 29 schizophrenia patients. Identifying anti-NMDAR antibodies has a crucial impact on the management of schizophrenia: immunotherapy can be effective, and tumor removal is recommended when the tumor is associated with the genesis of antibodies (Dalmau et al., 2008). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Yukako Nakagami, Genichi Sugihara, Akio Ikeda, Toshiya Murai Tags: Letter to the Editor Source Type: research

Neuroanatomical heterogeneity of schizophrenia revealed by semi-supervised machine learning methods
Schizophrenia is associated with heterogeneous clinical symptoms and neuroanatomical alterations. In this work, we aim to disentangle the patterns of neuroanatomical alterations underlying a heterogeneous population of patients using a semi-supervised clustering method. We apply this strategy to a cohort of patients with schizophrenia of varying extends of disease duration, and we describe the neuroanatomical, demographic and clinical characteristics of the subtypes discovered. (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Nicolas Honnorat, Aoyan Dong, Eva Meisenzahl-Lechner, Nikolaos Koutsouleris, Christos Davatzikos Source Type: research

The brief negative symptom scale (BNSS): Sensitivity to treatment effects
The Brief Negative Symptom Scale (BNSS) grew out of a recommendation by the NIMH-sponsored Consensus Development Conference on Negative Symptoms that a scale based on contemporary concepts be developed. We assessed sensitivity to change of the BNSS in a trial of MIN-101, which showed efficacy for negative symptoms (PANSS pentagonal model) at daily doses of 32 and 64mg/day. Using mixed-effects model for repeated measures, we examined change in BNSS total score and in the BNSS factors of anhedonia/avolition/asociality (AAA), and expressivity (EXP). (Source: Schizophrenia Research)
Source: Schizophrenia Research - December 21, 2017 Category: Psychiatry Authors: Brian Kirkpatrick, Jay B. Saoud, Gregory P. Strauss, Anthony O. Ahmed, Kazunori Tatsumi, Mark Opler, Remy Luthringer, Michael Davidson Source Type: research