Role of frontal white matter and corpus callosum on social function in schizophrenia
Patients with schizophrenia show severe impairment in social function and have difficulty in their daily social life. Although a recent large-scale multicenter study revealed alterations in white matter microstructures, the association between these anatomical changes and social dysfunction in schizophrenia remains unknown. Therefore, we investigated the association between the white matter integrity of regions of interest and social function in schizophrenia. A total of 149 patients with schizophrenia and 602 healthy comparison subjects (HCS) underwent DTI and completed the Picture Arrangement subtest of the Wechsler Adul...
Source: Schizophrenia Research - July 10, 2018 Category: Psychiatry Authors: Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Kentaro Morita, Kiyotaka Nemoto, Fumio Yamashita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Sinead Kelly, Neda Jahanshad, Noriko Kudo, Hirotsugu Azechi, Yoshiyuki Watanabe, Gary Donohoe, Paul M. T Source Type: research
Comment on ‘Conceptual disorganization and dissociative symptoms in women with first episode psychosis’ (Touskova et al., 2018)
Touskova, T.P. et al., are to be commended for mounting an impressive study assessing the relationship between dissociative symptoms and cognitive disorganization in women with first episode psychosis. Among the strengths of this study are the use of two dissociation measures – not only the frequently used Dissociative Experiences Scale (DES), but also the Somatoform Dissociation Questionnaire (SDQ-20), an important complement. One of the key findings was an inverse relationship between PANSS-measured cognitive disorganization (CD) and dissociation, of moderate strengt h (CD/DES = −0.35, CD/SDQ = −0.39). (Sou...
Source: Schizophrenia Research - July 10, 2018 Category: Psychiatry Authors: Andrew Moskowitz Tags: Letter to the editor Source Type: research
Second-generation LAI are associated to favorable outcome in a cohort of incident patients diagnosed with schizophrenia
Investigate the associations of long-acting injectable (LAI) second generation antipsychotic drugs with number of relapses, psychiatric admissions, days hospitalized, intentional self-harm events, and costs linked to hospitalizations in incident patients diagnosed with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 10, 2018 Category: Psychiatry Authors: Ren é Ernst Nielsen, Kristian Bjørn Hessellund, Jan Brink Valentin, Rasmus W. Licht Source Type: research
Revisiting the persistent negative symptoms proxy score using the Clinical Assessment Interview for Negative Symptoms
The present study aimed to validate a severity cut-off of negative symptoms for persistent negative symptoms (PNS) identification using the Clinical Assessment Interview for Negative Symptoms (CAINS). (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 9, 2018 Category: Psychiatry Authors: Ying Li, Wen-xiu Li, Ying-min Zou, Zhuo-ya Yang, Dong-jie Xie, Yin Yang, Simon S.Y. Lui, Gregory P. Strauss, Eric F.C. Cheung, Raymond C.K. Chan Source Type: research
The centrality of cognitive symptoms and metacognition within the interacting network of symptoms, neurocognition, social cognition and metacognition in schizophrenia
Schizophrenia involves a range of interrelated impairments in functioning due to symptoms and deficits in varying domains of cognition including neurocognition, social cognition and metacognition. Yet little is known whether certain symptoms or cognitive impairments play a more central role than others. To explore, we conducted a network analysis of five types of symptoms, six domains of neurocognition and multiple aspects of both social cognition and metacognition. Participants were 81 adults with a schizophrenia spectrum disorder in a non-acute phase of the disorder. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 9, 2018 Category: Psychiatry Authors: Ilanit Hasson-Ohayon, Gil Goldzweig, Adi Lavi-Rotenberg, Lauren Luther, Paul H. Lysaker Source Type: research
Shorter telomere length in schizophrenia: Evidence from a real-world population and meta-analysis of most recent literature
Schizophrenia is a severe, chronic mental disorder. Schizophrenia is visualized as an accelerated cellular aging syndrome characterized by early onset of cardiovascular disease causing premature mortality. In human aging involves alterations in telomere length (TL). To investigate the presence of TL shortening in schizophrenia and psychiatric syndromes associated, this condition was studied in leukocytes (LTL) of a sample of patients suffering from schizophrenia and other psychotic disorders, and compared with a group of non-psychiatric controls. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 9, 2018 Category: Psychiatry Authors: Patrizia Russo, Giulia Prinzi, Stefania Proietti, Palma Lamonaca, Alessandra Frustaci, Stefania Boccia, Rosarita Amore, Maria Lorenzi, Graziano Onder, Emanuele Marzetti, Vanessa Valdiglesias, Fiorella Guadagni, Maria Giovanna Valente, Gerland Lo Cascio, S Source Type: research
Congenital blindness is protective for schizophrenia and other psychotic illness. A whole-population study.
Congenital/early blindness is reportedly protective against schizophrenia. Using a whole-population cohort of 467,945 children born in Western Australia between 1980 and 2001, we examined prevalence of schizophrenia and psychotic illness in individuals with congenital/early blindness. Overall, 1870 children developed schizophrenia (0.4%) while 9120 developed a psychotic illness (1.9%). None of the 66 children with cortical blindness developed schizophrenia or psychotic illness. Eight of the 613 children with peripheral blindness developed a psychotic illness other than schizophrenia and fewer had developed schizophrenia. (...
Source: Schizophrenia Research - July 7, 2018 Category: Psychiatry Authors: Vera A. Morgan, Melanie Clark, Julie Crewe, Giulietta Valuri, David A. Mackey, Johanna C. Badcock, Assen Jablensky Tags: Letter to the Editor Source Type: research
Impact of lifestyle modification on some components of metabolic syndrome in persons with severe mental disorders: A meta-analysis
Metabolic syndrome (MS) is reportedly associated with high mortality from mostly cardiovascular causes in patients with severe mental disorders (SMD). Lifestyle interventions augment effective management of MS in patients with SMD. The present meta-analysis aims at updating the recent evidence on the effectiveness of lifestyle intervention for MS in patients with SMD. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 7, 2018 Category: Psychiatry Authors: Vinit Kumar Singh, Sneha Karmani, Palash Kumar Malo, H.G. Virupaksha, Daliboina Muralidhar, Ganesan Venkatasubramanian, Kesavan Muralidharan Source Type: research
Family burden predicts functional outcome in the early course of schizophrenia beyond psychiatric symptoms and baseline functioning
The goal of this study was to determine if family burden experienced by the families of individuals with a recent-onset of schizophrenia is associated with whether the individual is able to work or attend school during the first year of treatment. Forty-one participants with a recent first episode of schizophrenia and their families enrolled in two NIMH-funded protocols through the UCLA Aftercare Research Program completed a measure of family burden at baseline. Amount of work during this time was also recorded. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 7, 2018 Category: Psychiatry Authors: Nicole R. DeTore, Joseph Ventura, Kenneth L. Subotnik, Keith H. Nuechterlein Source Type: research
Dynamic prediction of transition to psychosis using joint modelling
Considerable research has been conducted seeking risk factors and constructing prediction models for transition to psychosis in individuals at ultra-high risk (UHR). Nearly all such research has only employed baseline predictors, i.e. data collected at the baseline time point, even though longitudinal data on relevant measures such as psychopathology have often been collected at various time points. Dynamic prediction, which is the updating of prediction at a post-baseline assessment using baseline and longitudinal data accumulated up to that assessment, has not been utilized in the UHR context. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 7, 2018 Category: Psychiatry Authors: H.P. Yuen, A. Mackinnon, J. Hartmann, G.P. Amminger, C. Markulev, S. Lavoie, M.R. Sch äfer, A. Polari, N. Mossaheb, M. Schlögelhofer, S. Smesny, I.B. Hickie, G. Berger, E.Y.H. Chen, L. de Haan, D.H. Nieman, M. Nordentoft, A. Riecher-Rössler, S. Verma, Source Type: research
Exploring the relationship between the anticipation and experience of pleasure in people with schizophrenia: An experience sampling study
It has been hypothesised that a reduction in anticipatory pleasure contributes to reduced levels of functioning in people with schizophrenia. Previous research on anticipatory pleasure, however, reports mixed findings and has not yet examined the link between anticipatory pleasure and activity. The aim of this study is to examine how pleasure anticipation is related to difficulties engaging in activity in people with schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 6, 2018 Category: Psychiatry Authors: Clementine J. Edwards, Matteo Cella, Richard Emsley, Nicholas Tarrier, Til H.M. Wykes Source Type: research
Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia
Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 6, 2018 Category: Psychiatry Authors: Leah H. Rubin, Siyi Li, Li Yao, Sarah K. Keedy, James L. Reilly, Scot K. Hill, Jeffrey R. Bishop, C. Sue Carter, Hossein Pournajafi-Nazarloo, Lauren L. Drogos, Elliot Gershon, Godfrey D. Pearlson, Carol A. Tamminga, Brett A. Clementz, Matcheri S. Keshavan Source Type: research
Striatal cerebral blood flow, executive functioning, and fronto-striatal functional connectivity in clinical high risk for psychosis
Patients at clinical high risk (CHR) for psychosis exhibit increased striatal cerebral blood flow (CBF) during the resting state and impaired cognitive function. However, the relation between CBF and cognitive impairment is unknown. We therefore studied the association between striatal CBF and executive functioning and evaluated the functional connectivity (FC) between dorsal striatum and the frontal cortex in CHR. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 5, 2018 Category: Psychiatry Authors: Daniela Hubl, Frauke Schultze-Lutter, Martinus Hauf, Thomas Dierks, Andrea Federspiel, Michael Kaess, Chantal Michel, Benno G. Schimmelmann, Jochen Kindler Source Type: research
Schizophrenia and epilepsy as a result of maternally inherited CNTN6 copy number variant
Copy number variants have made important contributions to understanding neuropsychiatric disorders, including schizophrenia. Deletions in genes encoding neuronal cell adhesion molecules have identified widely varied neurodevelopmental phenotypes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 5, 2018 Category: Psychiatry Authors: Cecilia Juan-Perez, Sarah Farrand, Dennis Velakoulis Source Type: research
Maternal and paternal cannabis use during pregnancy and the risk of psychotic-like experiences in the offspring
Cannabis use continues to increase among pregnant women. Gestational cannabis exposure has been associated with various adverse outcomes. However, it remains unclear whether cannabis use during pregnancy increases the risk for offspring psychotic-like experiences. In this prospective cohort, we examined the relationship between parental cannabis use during pregnancy and offspring psychotic-like experiences. Comparisons were made between maternal and paternal cannabis use during pregnancy to investigate causal influences of intra-uterine cannabis exposure during foetal neurodevelopmental. (Source: Schizophrenia Research)
Source: Schizophrenia Research - July 5, 2018 Category: Psychiatry Authors: Koen Bolhuis, Steven A. Kushner, Selda Yalniz, Manon H.J. Hillegers, Vincent W.V. Jaddoe, Henning Tiemeier, Hanan El Marroun Source Type: research
