Conceptual disorganization and dissociative symptoms in women with first episode psychosis
Bleuler in his book “Dementia Praecox, or the group of the schizophrenias” described basic forms of mental disorganization in schizophrenia related to “loosening of associations” (Bleuler, 1950). In this historical context disorganized symptoms are currently understood as important factors of cognitive disturba nces in schizophrenia, especially in patients with first episode psychosis (Minor and Lysaker, 2014). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: Tereza Petraskova Touskova, Petr Bob, Ondrej Pec, Jiri Raboch, Paul Lysaker Tags: Letter to the editor Source Type: research

Aberrant cerebellar-default-mode functional connectivity underlying auditory verbal hallucinations in schizophrenia revealed by multi-voxel pattern analysis of resting-state functional connectivity MRI data
Auditory verbal hallucinations (AVH) are common in patients with schizophrenia. Previous functional magnetic resonance imaging (fMRI) studies have repeatedly suggested that critical abnormalities underlying AVH are not entirely confined to particular brain regions or functional networks but rather involve functional connectivity (FC) among brain regions dispersed across multiple functional systems (Alonso-Solis et al. 2017; Cui et al. 2017). However, conventional FC analyses, such as seed-based correlation analysis and independent component analysis, typically restrict targets of investigation to specific seed regions or f...
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: Takashi Itahashi, Masaru Mimura, Sayaka Hasegawa, Masayuki Tani, Nobumasa Kato, Ryu-ichiro Hashimoto Tags: Letter to the Editor Source Type: research

Validation of an algorithm-based definition of treatment resistance in patients with schizophrenia
We examined the accuracy of an algorithm-based definition of TRS based on clozapine prescription and/or meeting algorithm-based eligibility criteria for clozapine against a gold standard definition using case notes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: Olesya Ajnakina, Henriette Thisted Horsdal, John Lally, James H. MacCabe, Robin M. Murray, Christiane Gasse, Theresa Wimberley Source Type: research

“Schizophrenia” and “psychosis” in Italian national newspapers: Do these terms convey different messages?
Dear Editor, the diagnostic label “schizophrenia” has been found to be associated with high levels of stigma and discrimination repeatedly (Read et al., 2013). Furthermore, misrepresentations of this disorder in the media contribute to negative attitudes toward those with this diagnosis (Joseph et al., 2015; Yang and Parrott, 20 17; Dubugras et al., 2011; Magliano et al., 2011; Thys et al., 2013; Athanasopoulou and Välimäki, 2014; Rodrigues-Silva et al., 2017). Several authors have suggested the use of the term “psychosis” as an acceptable alternative to “schizophrenia” (Carpen...
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: L. Magliano, R. Marassi Tags: Letter to the editor Source Type: research

Preliminary evidence for neural responsiveness to infants in mothers with schizophrenia and the implications for healthy parenting
Schizophrenia is a severe mental illness that may significantly affect maternal sensitive behaviour. Neural correlates of maternal behaviour represent a potentially valuable means of differentiating objectively between healthy mothers expressing variations in maternal sensitivity. As mothers with schizophrenia (MWS) show deficits in behavioural responses to infants compared to healthy mothers, we explored whether maternal brain responses to infant stimuli would be significantly reduced in MWS. We also examined whether differences in maternal behaviour between healthy and ill mothers (during play interactions with own infan...
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: K.M. Abel, R.E. Elliott, D. Downey, H. Strachan, A. Elmadih, A. Wieck, S. Williams, J. Crowell, M.W. Wan Source Type: research

Associations of independent living and labor force participation with impairment indicators in schizophrenia and bipolar disorder at 20-year follow-up
We examined these relationships at the 20-year follow-up assessment of a first-admission sample. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: M. Strassnig, R. Kotov, L. Fochtmann, M. Kalin, E.J. Bromet, P.D. Harvey Source Type: research

Conceptual disorganization and dissociative symptoms in women with first episode psychosis
Bleuler in his book “Dementia Praecox, or the group of the schizophrenias” described basic forms of mental disorganization in schizophrenia related to “loosening of associations” (Bleuler, 1950). In this historical context disorganized symptoms are currently understood as important factors of cognitive disturba nces in schizophrenia, especially in patients with first episode psychosis (Minor and Lysaker, 2014). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: Tereza Petraskova Touskova, Petr Bob, Ondrej Pec, Jiri Raboch, Paul Lysaker Tags: Letter to the editor Source Type: research

Aberrant cerebellar-default-mode functional connectivity underlying auditory verbal hallucinations in schizophrenia revealed by multi-voxel pattern analysis of resting-state functional connectivity MRI data
Auditory verbal hallucinations (AVH) are common in patients with schizophrenia. Previous functional magnetic resonance imaging (fMRI) studies have repeatedly suggested that critical abnormalities underlying AVH are not entirely confined to particular brain regions or functional networks but rather involve functional connectivity (FC) among brain regions dispersed across multiple functional systems (Alonso-Solis et al. 2017; Cui et al. 2017). However, conventional FC analyses, such as seed-based correlation analysis and independent component analysis, typically restrict targets of investigation to specific seed regions or f...
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: Takashi Itahashi, Masaru Mimura, Sayaka Hasegawa, Masayuki Tani, Nobumasa Kato, Ryu-ichiro Hashimoto Tags: Letter to the Editor Source Type: research

Validation of an algorithm-based definition of treatment resistance in patients with schizophrenia
We examined the accuracy of an algorithm-based definition of TRS based on clozapine prescription and/or meeting algorithm-based eligibility criteria for clozapine against a gold standard definition using case notes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: Olesya Ajnakina, Henriette Thisted Horsdal, John Lally, James H. MacCabe, Robin M. Murray, Christiane Gasse, Theresa Wimberley Source Type: research

“Schizophrenia” and “psychosis” in Italian national newspapers: Do these terms convey different messages?
Dear Editor, the diagnostic label “schizophrenia” has been found to be associated with high levels of stigma and discrimination repeatedly (Read et al., 2013). Furthermore, misrepresentations of this disorder in the media contribute to negative attitudes toward those with this diagnosis (Joseph et al., 2015; Yang and Parrott, 20 17; Dubugras et al., 2011; Magliano et al., 2011; Thys et al., 2013; Athanasopoulou and Välimäki, 2014; Rodrigues-Silva et al., 2017). Several authors have suggested the use of the term “psychosis” as an acceptable alternative to “schizophrenia” (Carpen...
Source: Schizophrenia Research - February 19, 2018 Category: Psychiatry Authors: L. Magliano, R. Marassi Tags: Letter to the editor Source Type: research

Clinical trajectories in the ultra-high risk for psychosis population
Traditionally, research in the ultra-high risk (UHR) for psychosis population has focused on the treatment of existing symptomatology and prevention of transition to psychosis. Recently, there has been an increase in focus on outcomes in individuals who do not transition to psychosis. However, there is a lack of standardised definitions of remission, recovery, recurrence and relapse in UHR, resulting in the inability to generalise and replicate outcomes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 18, 2018 Category: Psychiatry Authors: Andrea Polari, Suzie Lavoie, Hok-Pan Yuen, Paul Amminger, Gregor Berger, Eric Chen, Lieuwe deHaan, Jessica Hartmann, Connie Markulev, Fritha Melville, Dorien Nieman, Merete Nordentoft, Anita Riecher-R össler, Stefan Smesny, John Stratford, Swapna Verma, Source Type: research

Traumatic life event exposure and psychotic-like experiences: A multiple mediation model of cognitive-based mechanisms
Several cognitive mechanisms have been proposed to account for the relationship between exposure to traumatic life events (TLEs) and the entire psychosis spectrum. However, only few of these mechanisms have been empirically tested and those that have been tested have not considered multiple mechanisms simultaneously. The purpose of this study was to examine whether perceived stress, dissociation, negative self-schemas, negative other-schemas, and/or external locus of control mediated the association between TLEs and psychotic-like experiences (PLEs). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 18, 2018 Category: Psychiatry Authors: Lauren E. Gibson, Lauren E. Reeves, Shanna Cooper, Thomas M. Olino, Lauren M. Ellman Source Type: research

Clinical trajectories in the ultra-high risk for psychosis population
Traditionally, research in the ultra-high risk (UHR) for psychosis population has focused on the treatment of existing symptomatology and prevention of transition to psychosis. Recently, there has been an increase in focus on outcomes in individuals who do not transition to psychosis. However, there is a lack of standardised definitions of remission, recovery, recurrence and relapse in UHR, resulting in the inability to generalise and replicate outcomes. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 18, 2018 Category: Psychiatry Authors: Andrea Polari, Suzie Lavoie, Hok-Pan Yuen, Paul Amminger, Gregor Berger, Eric Chen, Lieuwe deHaan, Jessica Hartmann, Connie Markulev, Fritha Melville, Dorien Nieman, Merete Nordentoft, Anita Riecher-R össler, Stefan Smesny, John Stratford, Swapna Verma, Source Type: research

Traumatic life event exposure and psychotic-like experiences: A multiple mediation model of cognitive-based mechanisms
Several cognitive mechanisms have been proposed to account for the relationship between exposure to traumatic life events (TLEs) and the entire psychosis spectrum. However, only few of these mechanisms have been empirically tested and those that have been tested have not considered multiple mechanisms simultaneously. The purpose of this study was to examine whether perceived stress, dissociation, negative self-schemas, negative other-schemas, and/or external locus of control mediated the association between TLEs and psychotic-like experiences (PLEs). (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 18, 2018 Category: Psychiatry Authors: Lauren E. Gibson, Lauren E. Reeves, Shanna Cooper, Thomas M. Olino, Lauren M. Ellman Source Type: research

N-methyl-d-aspartate-type glutamate receptor modulators and related medications for the enhancement of auditory system plasticity in schizophrenia
Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) information processing. Auditory mismatch negativity (MMN) can be both a target engagement biomarker for the NMDAR and a proxy measure of neurophysiological plasticity. This review covers the evidence for using NMDAR modulator and related compounds for enhancement of cognition, with a particular focus on early auditory processing/plasticity....
Source: Schizophrenia Research - February 17, 2018 Category: Psychiatry Authors: Joshua T. Kantrowitz Source Type: research

Response to Lex Wunderink's query as to whether the development of supersensitivity could explain the greater risk of relapse in individuals with a longer duration of treatment with antipsychotic medication
In our recent study of a cohort of 544 individuals experiencing a first episode of psychosis, we conducted an analysis of predictors of outcome following discontinuation of antipsychotic medication (Bowtell et al., 2017). Of the 61% who had a trial of discontinuation, it was found that 34.0% (N=113) experienced a subsequent relapse in a median follow up time of 372days. Cannabis abuse disorder (HR 1.62; CI: 1.09 –2.40; P=0.02) and a longer duration, in months, of antipsychotic treatment prior to discontinuation (HR: 1.05; CI: 1.01–1.08; P=0.01) were associated with an increased risk of relapse. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 17, 2018 Category: Psychiatry Authors: Meghan Bowtell, Aswin Ratheesh, Brian O'Donoghue Tags: Letter to the editor Source Type: research

Toxoplasmosis, but not borreliosis, is associated with psychiatric disorders and symptoms
Infection by the parasite Toxoplasma, which affects about 33% of world population, is associated with increased risk of several mental health disorders, the most strongly with schizophrenia (Torrey et al., 2007; Torrey et al., 2012; Yolken et al., 2017). It is, however, unknown whether toxoplasmosis really plays a special role in the etiopathogenesis of these disorders and whether schizophrenia is associated with this infection the most strongly, or whether this association has just been the most intensively studied for historical reasons. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 17, 2018 Category: Psychiatry Authors: Jaroslav Flegr, Ji ří Horáček Tags: Letter to the Editor Source Type: research

N-methyl-d-aspartate-type glutamate receptor modulators and related medications for the enhancement of auditory system plasticity in schizophrenia
Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) information processing. Auditory mismatch negativity (MMN) can be both a target engagement biomarker for the NMDAR and a proxy measure of neurophysiological plasticity. This review covers the evidence for using NMDAR modulator and related compounds for enhancement of cognition, with a particular focus on early auditory processing/plasticity....
Source: Schizophrenia Research - February 17, 2018 Category: Psychiatry Authors: Joshua T. Kantrowitz Source Type: research

Response to Lex Wunderink's query as to whether the development of supersensitivity could explain the greater risk of relapse in individuals with a longer duration of treatment with antipsychotic medication
In our recent study of a cohort of 544 individuals experiencing a first episode of psychosis, we conducted an analysis of predictors of outcome following discontinuation of antipsychotic medication (Bowtell et al., 2017). Of the 61% who had a trial of discontinuation, it was found that 34.0% (N=113) experienced a subsequent relapse in a median follow up time of 372days. Cannabis abuse disorder (HR 1.62; CI: 1.09 –2.40; P=0.02) and a longer duration, in months, of antipsychotic treatment prior to discontinuation (HR: 1.05; CI: 1.01–1.08; P=0.01) were associated with an increased risk of relapse. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 17, 2018 Category: Psychiatry Authors: Meghan Bowtell, Aswin Ratheesh, Brian O'Donoghue Tags: Letter to the editor Source Type: research

Toxoplasmosis, but not borreliosis, is associated with psychiatric disorders and symptoms
Infection by the parasite Toxoplasma, which affects about 33% of world population, is associated with increased risk of several mental health disorders, the most strongly with schizophrenia (Torrey et al., 2007; Torrey et al., 2012; Yolken et al., 2017). It is, however, unknown whether toxoplasmosis really plays a special role in the etiopathogenesis of these disorders and whether schizophrenia is associated with this infection the most strongly, or whether this association has just been the most intensively studied for historical reasons. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 17, 2018 Category: Psychiatry Authors: Jaroslav Flegr, Ji ří Horáček Tags: Letter to the Editor Source Type: research

Frontal and temporal cortical volume, white matter tract integrity, and hemispheric asymmetry in schizotypal personality disorder
Abnormalities in temporal and frontal cortical volume, white matter tract integrity, and hemispheric asymmetry have been implicated in schizophrenia-spectrum disorders. Schizotypal personality disorder can provide insight into vulnerability and protective factors in these disorders without the confounds associated with chronic psychosis. However, multimodal imaging and asymmetry studies in SPD are sparse. Thirty-seven individuals with SPD and 29 healthy controls (HC) received clinical interviews and 3T magnetic resonance T1-weighted and diffusion tensor imaging scans. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 14, 2018 Category: Psychiatry Authors: Chi C. Chan, Philip R. Szeszko, Edmund Wong, Cheuk Y. Tang, Caitlin Kelliher, Justin D. Penner, M. Mercedes Perez-Rodriguez, Daniel R. Rosell, Margaret McClure, Panos Roussos, Antonia S. New, Larry J. Siever, Erin A. Hazlett Source Type: research

Musical deficits and cortical thickness in people with schizophrenia
Investigation of acquired amusia caused by brain damage suggested that cortical lesions of the right hemisphere contributed to musical deficits. We previously reported reduced musical ability in schizophrenia; these deficits were correlated with clinical manifestations such as cognitive dysfunction and negative symptoms. However, the neural substrate underlying the musical disability in schizophrenia remains unclear. We investigated the relationship between musical deficits and cortical thickness in patients with schizophrenia using structural MRI. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 14, 2018 Category: Psychiatry Authors: Ryosuke Fujito, Masayoshi Minese, Sanae Hatada, Naoto Kamimura, Shigeru Morinobu, Donna J. Lang, William G. Honer, Ken Sawada Source Type: research

Frontal and temporal cortical volume, white matter tract integrity, and hemispheric asymmetry in schizotypal personality disorder
Abnormalities in temporal and frontal cortical volume, white matter tract integrity, and hemispheric asymmetry have been implicated in schizophrenia-spectrum disorders. Schizotypal personality disorder can provide insight into vulnerability and protective factors in these disorders without the confounds associated with chronic psychosis. However, multimodal imaging and asymmetry studies in SPD are sparse. Thirty-seven individuals with SPD and 29 healthy controls (HC) received clinical interviews and 3T magnetic resonance T1-weighted and diffusion tensor imaging scans. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 14, 2018 Category: Psychiatry Authors: Chi C. Chan, Philip R. Szeszko, Edmund Wong, Cheuk Y. Tang, Caitlin Kelliher, Justin D. Penner, M. Mercedes Perez-Rodriguez, Daniel R. Rosell, Margaret McClure, Panos Roussos, Antonia S. New, Larry J. Siever, Erin A. Hazlett Source Type: research

Musical deficits and cortical thickness in people with schizophrenia
Investigation of acquired amusia caused by brain damage suggested that cortical lesions of the right hemisphere contributed to musical deficits. We previously reported reduced musical ability in schizophrenia; these deficits were correlated with clinical manifestations such as cognitive dysfunction and negative symptoms. However, the neural substrate underlying the musical disability in schizophrenia remains unclear. We investigated the relationship between musical deficits and cortical thickness in patients with schizophrenia using structural MRI. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 14, 2018 Category: Psychiatry Authors: Ryosuke Fujito, Masayoshi Minese, Sanae Hatada, Naoto Kamimura, Shigeru Morinobu, Donna J. Lang, William G. Honer, Ken Sawada Source Type: research

The aprosody of schizophrenia: Computationally derived acoustic phonetic underpinnings of monotone speech
Acoustic phonetic methods are useful in examining some symptoms of schizophrenia; we used such methods to understand the underpinnings of aprosody. We hypothesized that, compared to controls and patients without clinically rated aprosody, patients with aprosody would exhibit reduced variability in: pitch (F0), jaw/mouth opening and tongue height (formant F1), tongue front/back position and/or lip rounding (formant F2), and intensity/loudness. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 12, 2018 Category: Psychiatry Authors: Michael T. Compton, Anya Lunden, Sean D. Cleary, Luca Pauselli, Yazeed Alolayan, Brooke Halpern, Beth Broussard, Anthony Crisafio, Leslie Capulong, Pierfrancesco Maria Balducci, Francesco Bernardini, Michael A. Covington Source Type: research

C4A mRNA expression in PBMCs predicts the presence and severity of delusions in schizophrenia and bipolar disorder with psychosis
Altered immune function is an established finding in psychotic disorders such as schizophrenia and bipolar disorder with psychosis, though its role in their development and progression remains to be understood. Evidence suggests altered JAK-STAT1 pathway activity in peripheral blood cells from participants with schizophrenia compared to controls. Activation of this pathway leads to increased expression of complement component 4A (C4A), which has recently been implicated in schizophrenia. Here, we examine mRNA expression of C4A in peripheral blood cells from participants with schizophrenia, bipolar disorder and controls. (S...
Source: Schizophrenia Research - February 12, 2018 Category: Psychiatry Authors: Jennifer K. Melbourne, Cherise Rosen, Benjamin Feiner, Rajiv P. Sharma Source Type: research

The aprosody of schizophrenia: Computationally derived acoustic phonetic underpinnings of monotone speech
Acoustic phonetic methods are useful in examining some symptoms of schizophrenia; we used such methods to understand the underpinnings of aprosody. We hypothesized that, compared to controls and patients without clinically rated aprosody, patients with aprosody would exhibit reduced variability in: pitch (F0), jaw/mouth opening and tongue height (formant F1), tongue front/back position and/or lip rounding (formant F2), and intensity/loudness. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 12, 2018 Category: Psychiatry Authors: Michael T. Compton, Anya Lunden, Sean D. Cleary, Luca Pauselli, Yazeed Alolayan, Brooke Halpern, Beth Broussard, Anthony Crisafio, Leslie Capulong, Pierfrancesco Maria Balducci, Francesco Bernardini, Michael A. Covington Source Type: research

C4A mRNA expression in PBMCs predicts the presence and severity of delusions in schizophrenia and bipolar disorder with psychosis
Altered immune function is an established finding in psychotic disorders such as schizophrenia and bipolar disorder with psychosis, though its role in their development and progression remains to be understood. Evidence suggests altered JAK-STAT1 pathway activity in peripheral blood cells from participants with schizophrenia compared to controls. Activation of this pathway leads to increased expression of complement component 4A (C4A), which has recently been implicated in schizophrenia. Here, we examine mRNA expression of C4A in peripheral blood cells from participants with schizophrenia, bipolar disorder and controls. (S...
Source: Schizophrenia Research - February 12, 2018 Category: Psychiatry Authors: Jennifer K. Melbourne, Cherise Rosen, Benjamin Feiner, Rajiv P. Sharma Source Type: research

Childhood adversities and cognitive deficits in first-episode psychosis
Childhood adversity refers to physical or emotional acts or situations that are potentially harmful to the child's development (Akmatov, 2011). Adversity is associated with an elevated risk for a wide range of adult psychiatric disorders and has sustained negative effects (Gilbert et al., 2009). In psychotic illnesses, childhood adversity has been associated with earlier first admissions, hospitalizations, more medication, and self-harm (Schenkel et al., 2005). Severity of psychotic symptoms is increased in patients with schizophrenia who report abuse in childhood (Read et al., 2005), and childhood adversity, particularly ...
Source: Schizophrenia Research - February 8, 2018 Category: Psychiatry Authors: Isabel Morales-Mu ñoz, Jaana Suvisaari, Sebastian Therman, Minna Torniainen-Holm, Teemu Mäntylä, Eva Rikandi, Outi Mantere, Tuula Kieseppä, Maija Lindgren Tags: Letter to the Editor Source Type: research

A randomized controlled trial examining a cognitive behavioral therapy intervention enhanced with cognitive remediation to improve work and neurocognition outcomes among persons with schizophrenia spectrum disorders
This single blind, three-armed randomized controlled trial compared cognitive behavioral therapy (CBT) enhanced with cognitive remediation (CBT+CR) to CBT alone and an active control condition on work and neurocognition outcomes for persons with schizophrenia spectrum disorders. Seventy-five adult outpatients with schizophrenia or schizoaffective disorder were randomized to three study conditions (N=25 per group). The CBT intervention was the Indianapolis Vocational Intervention program (IVIP), consisting of weekly group and individual sessions focused on work-related content. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 5, 2018 Category: Psychiatry Authors: Marina Kukla, Morris D. Bell, Paul H. Lysaker Source Type: research

Non-invasive brain stimulation for negative symptoms in schizophrenia: An updated systematic review and meta-analysis
Schizophrenia is a mental disorder with significant socioeconomic burden. Although current pharmacological treatments are effective for treating positive symptoms, medications have little-to-no effect in the treatment of negative symptoms. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 4, 2018 Category: Psychiatry Authors: Caio Osoegawa, July Silveira Gomes, Ruth Bartelli Grigolon, Elisa Brietzke, Ary Gadelha, Acioly L.T. Lacerda, Álvaro Machado Dias, Quirino Cordeiro, Ronaldo Laranjeira, Danilo de Jesus, Zafiris Jeff Daskalakis, Jerome Brunelin, Joachim Cordes, Alisson Pa Source Type: research

Polygenic risk for schizophrenia affects working memory and its neural correlates in healthy subjects
Schizophrenia is a disorder with a high heritability. Patients as well as their first degree relatives display lower levels of performance in a number of cognitive domains compared to subjects without genetic risk. Several studies could link these aberrations to single genetic variants, however, only recently, polygenic risk scores as proxies for genetic risk have been associated with cognitive domains and their neural correlates.In the present study, a sample of healthy subjects (n=137) performed a letter version of the n-back task while scanned with 3-T fMRI. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 4, 2018 Category: Psychiatry Authors: Axel Krug, Bruno Dietsche, Rebecca Z öllner, Dilara Yüksel, Markus M. Nöthen, Andreas J. Forstner, Marcella Rietschel, Udo Dannlowski, Bernhard T. Baune, Robert Maier, Stephanie H. Witt, Tilo Kircher Source Type: research

Towards a comprehensive routine outcome monitoring program for people with psychotic disorders: The Pharmacotherapy Monitoring and Outcome Survey (PHAMOUS)
Patients with psychotic disorders are at risk of developing mental health and social problems, and physical disorders. To monitor and treat these problems when indicated, an annual routine outcome monitoring program, Pharmacotherapy Monitoring and Outcome Survey (PHAMOUS), was developed. This paper presents the background and content of PHAMOUS, implementation of PHAMOUS, characteristics of the patients screened in 2015, and the outcome of patients with three annual screenings between 2011 and 2015. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 4, 2018 Category: Psychiatry Authors: Agna A. Bartels-Velthuis, Ellen Visser, Johan Arends, Gerdina H.M. Pijnenborg, Lex Wunderink, Frederike J örg, Wim Veling, Edith J. Liemburg, Stynke Castelein, Henderikus Knegtering, Richard Bruggeman Source Type: research

Non-invasive brain stimulation for negative symptoms in schizophrenia: An updated systematic review and meta-analysis
Schizophrenia is a mental disorder with significant socioeconomic burden. Although current pharmacological treatments are effective for treating positive symptoms, medications have little-to-no effect in the treatment of negative symptoms. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 4, 2018 Category: Psychiatry Authors: Caio Osoegawa, July Silveira Gomes, Ruth Bartelli Grigolon, Elisa Brietzke, Ary Gadelha, Acioly L.T. Lacerda, Álvaro Machado Dias, Quirino Cordeiro, Ronaldo Laranjeira, Danilo de Jesus, Zafiris Jeff Daskalakis, Jerome Brunelin, Joachim Cordes, Alisson Pa Source Type: research

Polygenic risk for schizophrenia affects working memory and its neural correlates in healthy subjects
Schizophrenia is a disorder with a high heritability. Patients as well as their first degree relatives display lower levels of performance in a number of cognitive domains compared to subjects without genetic risk. Several studies could link these aberrations to single genetic variants, however, only recently, polygenic risk scores as proxies for genetic risk have been associated with cognitive domains and their neural correlates.In the present study, a sample of healthy subjects (n=137) performed a letter version of the n-back task while scanned with 3-T fMRI. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 4, 2018 Category: Psychiatry Authors: Axel Krug, Bruno Dietsche, Rebecca Z öllner, Dilara Yüksel, Markus M. Nöthen, Andreas J. Forstner, Marcella Rietschel, Udo Dannlowski, Bernhard T. Baune, Robert Maier, Stephanie H. Witt, Tilo Kircher Source Type: research

Towards a comprehensive routine outcome monitoring program for people with psychotic disorders: The Pharmacotherapy Monitoring and Outcome Survey (PHAMOUS)
Patients with psychotic disorders are at risk of developing mental health and social problems, and physical disorders. To monitor and treat these problems when indicated, an annual routine outcome monitoring program, Pharmacotherapy Monitoring and Outcome Survey (PHAMOUS), was developed. This paper presents the background and content of PHAMOUS, implementation of PHAMOUS, characteristics of the patients screened in 2015, and the outcome of patients with three annual screenings between 2011 and 2015. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 4, 2018 Category: Psychiatry Authors: Agna A. Bartels-Velthuis, Ellen Visser, Johan Arends, Gerdina H.M. Pijnenborg, Lex Wunderink, Frederike J örg, Wim Veling, Edith J. Liemburg, Stynke Castelein, Henderikus Knegtering, Richard Bruggeman Source Type: research

A quantitative systems pharmacology study on optimal scenarios for switching to paliperidone palmitate once-monthly
Long-acting injectable (LAI) antipsychotic formulations are increasingly used for improving patient compliance and long-term outcomes. Transitioning to LAIs raises questions regarding how optimum efficacy can be rapidly achieved while minimizing potential efficacy and safety concerns related to overlapping plasma levels of prior treatments and the new LAI. Ideally, randomized clinical trials would provide guidance regarding transition algorithms, but the number of studies and sample size required to address relevant questions makes this approach unachievable. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Hugo Geerts, Athan Spiros, Patrick Roberts, Larry Alphs Source Type: research

Leading causes of death among decedents with mention of schizophrenia on the death certificates in the United States
This study aims to determine the ranking of leading COD among U.S. decedents with mention of schizophrenia by age from 2000 to 2015. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Jin-Jia Lin, Fu-Weng Liang, Chung-Yi Li, Tsung-Hsueh Lu Source Type: research

Unraveling the insight paradox: One-year longitudinal study on the relationships between insight, self-stigma, and life satisfaction among people with schizophrenia spectrum disorders
The promotion of insight among people with schizophrenia spectrum disorders has posed a dilemma to service providers as higher insight has been linked to positive clinical outcomes but negative psychological outcomes. The negative meaning that people attached to the illness (self-stigma content) and the recurrence of such stigmatizing thoughts (self-stigma process) may explain why increased insight is associated with negative outcomes. The present study examined how the presence of high self-stigma content and self-stigma process may contribute to the negative association between insight and life satisfaction. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Floria H.N. Chio, Winnie W.S. Mak, Randolph C.H. Chan, Alan C.Y. Tong Source Type: research

Demographic and socioenvironmental predictors of premorbid marijuana use among patients with first-episode psychosis
We identified, in subjects with first-episode psychosis, demographic and socioenvironmental predictors of three variables pertaining to premorbid marijuana use: age at initiation of marijuana use, trajectories of marijuana use in the five years prior to onset of psychosis, and the cumulative “dose” of marijuana intake in that same premorbid period. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Luca Pauselli, Michael L. Birnbaum, Beatriz Paulina V ázquez Jaime, Enrico Paolini, Mary E. Kelley, Beth Broussard, Michael T. Compton Source Type: research

Patterns and predictors of trajectories for social and occupational functioning in patients presenting with first-episode non-affective psychosis: A three-year follow-up study
In this report, we aimed to investigate the patterns and baseline predictors of social-occupational functional trajectories over 3  years, utilizing growth mixture modeling (GMM) analysis, in a large representative Chinese young FEP cohort in Hong Kong. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Wing Chung Chang, Angel On Ki Chu, Vivian Wing Yan Kwong, Corine Sau Man Wong, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen Source Type: research

Association between frailty and its individual components with the risk of falls in patients with schizophrenia spectrum disorders
Frailty is common among older people who carry an increased risk for poor outcomes, including falls, physical disabilities, infections, and mortality. However, the prevalence of frailty and the prognostic influence of frailty status are poorly understood in adults with schizophrenia. The present study aimed to assess the predictive ability of frailty and its individual components for the risk of falls in patients with chronic schizophrenia. Frailty status was assessed at baseline by using Fried frailty criteria after the enrollment of 561 patients with chronic schizophrenia. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Ming-Tsun Tsai, Shin-Min Lee, Hsing-Kang Chen, Bo-Jian Wu Source Type: research

Paranoia and anxiety: A cluster analysis in a non-clinical sample and the relationship with worry processes
Worry processes are implicated in paranoia and anxiety. However, clinical studies focused on patients with co-occurring paranoia and anxiety. As both paranoia and anxiety are distributed across clinical and non-clinical groups, an investigation on worry processes among non-clinical individuals will allow us to delineate the specific worry mechanisms in paranoia and anxiety respectively. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Xiaoqi Sun, Suzanne Ho-wai So, Chui-De Chiu, Raymond Chor-kiu Chan, Patrick Wing-leung Leung Source Type: research

Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome
22q11.2 deletion syndrome (22q11.2DS) is one of the most common copy number variants and confers a markedly increased risk for schizophrenia. As such, 22q11.2DS is a homogeneous genetic liability model which enables studies to delineate functional abnormalities that may precede disease onset. Mismatch negativity (MMN), a brain marker of change detection, is reduced in people with schizophrenia compared to healthy controls. Using dynamic causal modelling (DCM), previous studies showed that top-down effective connectivity linking the frontal and temporal cortex is reduced in schizophrenia relative to healthy controls in MMN ...
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Kit Melissa Larsen, Morten M ørup, Michelle Rosgaard Birknow, Elvira Fischer, Oliver Hulme, Anders Vangkilde, Henriette Schmock, William Frans Christiaan Baaré, Michael Didriksen, Line Olsen, Thomas Werge, Hartwig R. Siebner, Marta I. Garrido Source Type: research

A quantitative systems pharmacology study on optimal scenarios for switching to paliperidone palmitate once-monthly
Long-acting injectable (LAI) antipsychotic formulations are increasingly used for improving patient compliance and long-term outcomes. Transitioning to LAIs raises questions regarding how optimum efficacy can be rapidly achieved while minimizing potential efficacy and safety concerns related to overlapping plasma levels of prior treatments and the new LAI. Ideally, randomized clinical trials would provide guidance regarding transition algorithms, but the number of studies and sample size required to address relevant questions makes this approach unachievable. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Hugo Geerts, Athan Spiros, Patrick Roberts, Larry Alphs Source Type: research

Leading causes of death among decedents with mention of schizophrenia on the death certificates in the United States
This study aims to determine the ranking of leading COD among U.S. decedents with mention of schizophrenia by age from 2000 to 2015. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Jin-Jia Lin, Fu-Weng Liang, Chung-Yi Li, Tsung-Hsueh Lu Source Type: research

Unraveling the insight paradox: One-year longitudinal study on the relationships between insight, self-stigma, and life satisfaction among people with schizophrenia spectrum disorders
The promotion of insight among people with schizophrenia spectrum disorders has posed a dilemma to service providers as higher insight has been linked to positive clinical outcomes but negative psychological outcomes. The negative meaning that people attached to the illness (self-stigma content) and the recurrence of such stigmatizing thoughts (self-stigma process) may explain why increased insight is associated with negative outcomes. The present study examined how the presence of high self-stigma content and self-stigma process may contribute to the negative association between insight and life satisfaction. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Floria H.N. Chio, Winnie W.S. Mak, Randolph C.H. Chan, Alan C.Y. Tong Source Type: research

Demographic and socioenvironmental predictors of premorbid marijuana use among patients with first-episode psychosis
We identified, in subjects with first-episode psychosis, demographic and socioenvironmental predictors of three variables pertaining to premorbid marijuana use: age at initiation of marijuana use, trajectories of marijuana use in the five years prior to onset of psychosis, and the cumulative “dose” of marijuana intake in that same premorbid period. (Source: Schizophrenia Research)
Source: Schizophrenia Research - February 3, 2018 Category: Psychiatry Authors: Luca Pauselli, Michael L. Birnbaum, Beatriz Paulina V ázquez Jaime, Enrico Paolini, Mary E. Kelley, Beth Broussard, Michael T. Compton Source Type: research