Genomic Breakpoint Characterization and Transcriptome Analysis of Metastatic, Recurrent Desmoplastic Small Round Cell Tumor
Sarcoma. 2023 Jul 6;2023:6686702. doi: 10.1155/2023/6686702. eCollection 2023.ABSTRACTDesmoplastic small round cell tumor (DSRCT) is a rare pediatric cancer caused by the EWSR1-WT1 fusion oncogene. Despite initial response to chemotherapy, DSRCT has a recurrence rate of over 80% leading to poor patient prognosis with a 5-year survival rate of only 15-25%. Owing to the rarity of DSRCT, sample scarcity is a barrier in understanding DSRCT biology and developing effective therapies. Utilizing a novel pair of primary and recurrent DSRCTs, we present the first map of DSRCT genomic breakpoints and the first comparison of gene exp...
Source: Sarcoma - July 17, 2023 Category: Cancer & Oncology Authors: Justin W Magrath Dane A Flinchum Alifiani B Hartono Ilon N Goldberg Madelyn Espinosa-Cotton Krzysztof Moroz Nai-Kong V Cheung Sean B Lee Source Type: research
