Bronchial involvement in granulomatosis with polyangiitis
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00136-0. doi: 10.1016/j.rmr.2024.02.006. Online ahead of print.NO ABSTRACTPMID:38461090 | DOI:10.1016/j.rmr.2024.02.006 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: R Batton P Le Guen A Cazes M-P Debray C Taill é Source Type: research
Synthetic cannabinoid overdose: Watch out for acute respiratory complications
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00135-9. doi: 10.1016/j.rmr.2024.02.005. Online ahead of print.NO ABSTRACTPMID:38461091 | DOI:10.1016/j.rmr.2024.02.005 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: M Underner J Perriot G Peiffer N Jaafari T Urban Source Type: research
Pulmonary lipofibroblasts in adults and alveolar regeneration in emphysema
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00145-1. doi: 10.1016/j.rmr.2024.02.015. Online ahead of print.ABSTRACTLipofibroblasts form a sub-population of fibroblasts located in the mesenchymal alveolar stem cell niche. They show close proximity with alveolar epithelial type 2 cells and play a key role in alveolar development and lung homeostasis. Their role in various diseases such as acute respiratory distress syndrome, pulmonary fibrosis and emphysema is progressively better understood. Through the activation of signaling pathways such as PPARg lipofibroblasts may help to induce endogenous alveolar regeneration.PMID:38461...
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: G Justeau M Toigo T Castro de Freitas B Ribeiro Baptista E Zana-Taieb L Boyer Source Type: research
Use of murine models for the study of obstructive sleep apnea syndrome in Down syndrome
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00140-2. doi: 10.1016/j.rmr.2024.02.010. Online ahead of print.ABSTRACTDown syndrome (DS), or trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21, leading to various characteristic physical features as well as developmental and cognitive delays. Obstructive sleep apnea syndrome (OSAS) is a common disorder in both adult and pediatric patients with DS. Several characteristics of DS may contribute to the development or worsening of OSAS. Numerous murine models of DS exist. A number of studies have explored apneas and the risk of upper airway obstr...
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: M Moreau A Madani R Dard T Bourgeois M-P d'Ortho C Delclaux N Janel B Matrot Source Type: research
Nerve growth factor (NGF) in pulmonary hypertension (PH)
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00137-2. doi: 10.1016/j.rmr.2024.02.007. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is the main pathology in lung circulation, characterized by increased pressure in pulmonary arteries and ultimately resulting in right heart failure with potentially fatal outcomes. Given the current lack of available curative treatments, it is of paramount importance to identify novel therapeutic targets. Due to its involvement in pulmonary arterial remodeling, hyperreactivity, and inflammation, our explorations have focused on the nerve growth factor (NGF), offering promising avenues...
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: C Bouchet C Guibert V Freund-Michel Source Type: research
Targeting the spliceosome: A new therapeutic strategy to counteract chemotherapy resistance in lung cancer?
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00143-8. doi: 10.1016/j.rmr.2024.02.013. Online ahead of print.ABSTRACTLung cancer is the first cancer-related cause of death worldwide. This is in partially due to therapeutic resistance, which occurs in around 70% of patients, especially those receiving platinum salts, the gold-standard chemotherapy. The massive deregulation of alternative transcript splicing processes observed in many cancers has led to the development of a new class of pharmacological agents aimed at inhibiting the activity of the splicing machinery (spliceosome). The molecular mechanisms by which these inhibito...
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: A Shreim S Gazzeri B Eymin Source Type: research
Severe complications of systemic treatment in thoracic oncology
This article, the last of a series dedicated to emergencies in onco-haematological patients, aims to present a clinical picture of the severe complications (side effects, immune-related adverse events) associated with systemic treatments, excluding infections and respiratory emergencies, with which general practitioners and specialists can be confronted. New toxicities are to be expected with the implementation of innovative therapeutic approaches, such as CAR-T cells, along with immunomodulators and antibody-drug conjugates.PMID:38461088 | DOI:10.1016/j.rmr.2024.02.014 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: T Berghmans M Brand ão M Ilzkovitz A-P Meert Source Type: research
Modeling T2 high severe asthma using human induced pluripotent stem cells (hiPSC)
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00142-6. doi: 10.1016/j.rmr.2024.02.012. Online ahead of print.ABSTRACTSevere asthma patients with persistent airflow obstruction are characterized by functional obstruction due to mucus plugs containing mucins, fibrin, and eosinophil derived Charcot- Leyden crystals. The molecular mechanisms underlying this endotype are not clearly understood. Developing new models is crucial to respiratory research insofar as critical differences exist between human and rodent airway epithelium. We (and other teams) have shown that it is possible to reconstitute in vitro a complex and functional a...
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: E Ahmed S Assou F Foisset C Bourdais M Vanheerswynghels A Petit A S Gamez D Gras P Chanez J de Vos H Hammad A Bourdin B Lambrecht Source Type: research
Bronchial involvement in granulomatosis with polyangiitis
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00136-0. doi: 10.1016/j.rmr.2024.02.006. Online ahead of print.NO ABSTRACTPMID:38461090 | DOI:10.1016/j.rmr.2024.02.006 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: R Batton P Le Guen A Cazes M-P Debray C Taill é Source Type: research
Synthetic cannabinoid overdose: Watch out for acute respiratory complications
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00135-9. doi: 10.1016/j.rmr.2024.02.005. Online ahead of print.NO ABSTRACTPMID:38461091 | DOI:10.1016/j.rmr.2024.02.005 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: M Underner J Perriot G Peiffer N Jaafari T Urban Source Type: research
Pulmonary lipofibroblasts in adults and alveolar regeneration in emphysema
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00145-1. doi: 10.1016/j.rmr.2024.02.015. Online ahead of print.ABSTRACTLipofibroblasts form a sub-population of fibroblasts located in the mesenchymal alveolar stem cell niche. They show close proximity with alveolar epithelial type 2 cells and play a key role in alveolar development and lung homeostasis. Their role in various diseases such as acute respiratory distress syndrome, pulmonary fibrosis and emphysema is progressively better understood. Through the activation of signaling pathways such as PPARg lipofibroblasts may help to induce endogenous alveolar regeneration.PMID:38461...
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: G Justeau M Toigo T Castro de Freitas B Ribeiro Baptista E Zana-Taieb L Boyer Source Type: research
Use of murine models for the study of obstructive sleep apnea syndrome in Down syndrome
Rev Mal Respir. 2024 Mar 8:S0761-8425(24)00140-2. doi: 10.1016/j.rmr.2024.02.010. Online ahead of print.ABSTRACTDown syndrome (DS), or trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21, leading to various characteristic physical features as well as developmental and cognitive delays. Obstructive sleep apnea syndrome (OSAS) is a common disorder in both adult and pediatric patients with DS. Several characteristics of DS may contribute to the development or worsening of OSAS. Numerous murine models of DS exist. A number of studies have explored apneas and the risk of upper airway obstr...
Source: Revue des Maladies Respiratoires - March 9, 2024 Category: Respiratory Medicine Authors: M Moreau A Madani R Dard T Bourgeois M-P d'Ortho C Delclaux N Janel B Matrot Source Type: research
Antimicrobial peptides: A new alternative for the treatment of aspergillosis
Rev Mal Respir. 2024 Mar 7:S0761-8425(24)00141-4. doi: 10.1016/j.rmr.2024.02.011. Online ahead of print.ABSTRACTAspergillus fumigatus is the predominant fungal species causing pulmonary aspergillosis. The present-day anti-aspergillosis arsenal is limited, with a number of molecules occasioning severe side effects (amphotericin B) or provoking significant drug interactions (azole derivatives). Moreover, the recent emergence of azole-resistant A. fumigatus strains is a cause for concern. In this context, antimicrobial peptides (AMPs) are emerging as a promising therapeutic approach and alternative or complement to convention...
Source: Revue des Maladies Respiratoires - March 8, 2024 Category: Respiratory Medicine Authors: C Rochard J Bigot V Balloy C Hennequin J Guitard Source Type: research
Perioperative smoking cessation (conventional smoking and e-cigarettes) in 2023. A narrative review of the literature
CONCLUSIONS: Smoking represents a major source of health-related complications. Smoking cessation must therefore remain a priority in the management of medical and surgical patients.PMID:38429192 | DOI:10.1016/j.rmr.2024.02.001 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 1, 2024 Category: Respiratory Medicine Authors: M Mestdag S Degey E Deflandre Source Type: research
Electromagnetic navigation bronchoscopy guided micro-wave ablation: A new loco-regional therapy for pulmonary malignancy
Rev Mal Respir. 2024 Feb 29:S0761-8425(24)00134-7. doi: 10.1016/j.rmr.2024.02.004. Online ahead of print.NO ABSTRACTPMID:38429193 | DOI:10.1016/j.rmr.2024.02.004 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - March 1, 2024 Category: Respiratory Medicine Authors: B Bondue D Leduc Source Type: research
