[Use of time of a nurse involved in breaking the diagnosis of lung cancer and navigating patients in the healthcare system: Experience of an academic thoracic oncology ward].
We describe the way a nurse, assuming the role of assisting the doctor when a diagnosis of cancer is revealed and coordinating the care of patients in a teaching hospital, uses her time. One thousand and forty-one patients were supported by the nurse during 6515 procedures over 4.27 years. The median (interquartile range) number of interventions per patient was 3 (7). Helping to break news of cancer and the coordination of care represented approximately 20 and 80% of the working time of the nurse, respectively. The nurse spent 43% of her time without the doctor and more than half of this duration was dedicated to meetings ...
Source: Revue des Maladies Respiratoires - November 11, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Epidemiology of primary lung cancer among non-smokers in Senegal].
CONCLUSION: The proportion of primary bronchopulmonary cancers diagnosed among non-smokers is increasing in Dakar. An analytical study of suspected risk factors would be helpful for prevention. PMID: 30413327 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - November 11, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Omalizumab and allergen immunotherapy: A clinical report and review of the literature].
CONCLUSIONS: There are only a few publications evaluating the efficacy of the association of these two biotherapies in the management of severe allergic asthma. In addition there is, as yet, no common protocol for the administration of the two prescriptions. This approach to treatment would benefit from standardization in order to optimize the management of severe allergic asthma. PMID: 30396780 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - November 8, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Two cases of hot tub lung disease: Environmental investigations].
CONCLUSIONS: These cases represent two of the typical presentations of hot tub lung, with a possible HP to an antigen other than MAC, which may have been enhanced by chronic exposure to multiple microorganisms. PMID: 30396781 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - November 8, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Pulmonary fibrosis associated with hereditary fibrosing poikiloderma caused by FAM111B mutation: A case report].
CONCLUSION: This case illustrates the fibrosing pulmonary involvement associated with POIKTMP and confirms its extreme severity. It is found only in adults and is universally fatal after a variable time. It highlights the necessity for a systematic screening as soon as the diagnosis of POIKTMP is confirmed in order to establish specialised respiratory management. PMID: 30341002 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 22, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Trans-vocal cord prostheses - preliminary experience treating benign laryngotracheal stenosis in adults].
CONCLUSION: These preliminary results are encouraging. Transcordal prostheses in benign laryngotracheal stenosis have a complementary or alternative role compared to surgery with a palliative or even curative objective. PMID: 30337136 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 21, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Risk factors for thromboembolic disease in young women-the role of hormones].
Authors: Tromeur C, Le Mao R, Jego P, El-Kouri D, Gruel Y, Pan-Petesch B, Bertoletti L, Morange PE, Lemoigne E, Paleiron N, Leroyer C, Couturaud F Abstract Hormonal exposure in young women increases the risk of venous thromboembolic disease (VTE). Thrombophilia testing is often proposed in women of childbearing age before the initiation of contraception. However, the presence of a familial history of VTE has the potential to be more accurate than the presence of inherited thrombophilia. OBJECTIVE: To demonstrate an association between the risk of VTE in young women with hormonal exposure (pregnancy or oral cont...
Source: Revue des Maladies Respiratoires - October 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Bronchial laser].
Authors: Gonin F PMID: 30318430 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Asthma and post-traumatic stress disorder].
Authors: Underner M, Peiffer G, Perriot J, Jaafari N PMID: 30318431 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Drug-induced interstitial pneumonitis due to avelumab: A case report].
CONCLUSION: Avelumab can induce interstitial lung disease. The mechanism is uncertain and requires further studies. Monitoring of respiratory function and CT scanning are necessary for its early management. PMID: 30318432 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Autoimmune-related bleeding occurring during combined immunotherapy for lung cancer - Case report].
CONCLUSIONS: This case emphasizes that special consideration should be given to patients with VKA treatment planned to receive immunotherapy. PMID: 30318433 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Surprising adenomegaly].
Authors: Darchambeau L, Werion A, Detournay S, Beniuga G, Fremault A PMID: 30318434 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Evaluation of surgical practice in the treatment of lung cancer in France from the PMSI national database].
The objective of the study was to evaluate the quality of surgical management of lung cancer in different regions using hospital mortality as an indicator. METHOD: From the national database of the Program of Medical Information Systems (PMSI), data on all patients who had undergone surgery for lung cancer were extracted as well as the characteristics of the centers. The main outcome criterion was hospital mortality. Logistic models allowed an estimation of the risk standardized mortality rate for each center. RESULTS: From January 1, 2015 to December 31, 2015, 10,675 patients underwent surgery for lung cancer in 1...
Source: Revue des Maladies Respiratoires - October 6, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Active smoking: A major risk factor for human non-communicable diseases in a hospital survey].
Authors: Ben Ayed H, Ben Hmida M, Ben Jemaa M, Trigui M, Jedidi J, Karray R, Mejdoub Y, Kassis M, Feki H, Yaich S, Damak J Abstract INTRODUCTION: Tobacco is the main preventable cause of death worldwide. Our study aimed to determine the role of tobacco in the occurrence of non-communicable diseases (NCDs). METHODS: We conducted a retrospective study including all NCDs patients during 2015-2016. NCDs include cardiovascular diseases (CVD), chronic respiratory diseases (CRD), cancers (CS) and diabetes mellitus (DM). RESULTS: We identified 3643 cases of NCDs (43%) among 8478 hospitalizations, all diseases combi...
Source: Revue des Maladies Respiratoires - October 4, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon gamma release assay tests for the diagnosis of latent and active tuberculosis in hemodialysis patients or solid organ transplant recipients].
Authors: Henry B, Bourgarit A PMID: 30268409 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 2, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Long-term oxygen therapy: mortality rate, short-term predictive mortality factors].
CONCLUSIONS: Mortality at one year with LTOT was about 25%. Factors predictive of mortality at one year included coronary insufficiency, reduction of the left ventricular ejection fraction and osteoporosis. LTOT seems to reduce hospitalizations due to exacerbations of COPD. PMID: 30266456 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - October 1, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[From vaccine's manufacturing to its availability in pharmacy].
Authors: Soubeyrand B Abstract After a brief overview of vaccine industry and the regulatory requirements for biologics, the biological and pharmaceutical manufacturing of vaccine is presented. Vaccine production specificities are discussed. They show that, despite recent efforts and progress, a lasting match between vaccine's demand and supply "at any time and in any place" remains a challenge, for reasons inherent in biological production, which is a production in tense flow, structurally delicate (control of the biological hazard), and weakly reactive. PMID: 30266457 [PubMed - as supplied by publis...
Source: Revue des Maladies Respiratoires - October 1, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[IoNESCO trial: Immune neoajuvant therapy in early stage non-small cell lung cancer].
Authors: Mignard X, Antoine M, Moro-Sibilot D, Dayen C, Mennecier B, Gervais R, Amour E, Milleron B, Morin F, Zalcman G, Wislez M Abstract BACKGROUND: Programmed cell death-ligand 1 (PD-L1) is a checkpoint receptor that facilitates immune evasion by tumor cells, through interaction with programmed cell death-1 (PD-1), a receptor expressed by T-cells. Durvalumab is an anti-PD-L1 monoclonal antibody that blocks PD-L1 interaction with PD-1 on T-cells, countering the tumor's immune-evading tactics. Phase I/II studies demonstrated durable responses and manageable tolerability in heavily pre-treated patients with non-sma...
Source: Revue des Maladies Respiratoires - September 25, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Introduction-Epidemiology of latent and active tuberculosis].
Authors: Maitre T, Robert J, Veziris N PMID: 30241683 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 24, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Pulmonary tuberculosis: Radiological evolution of broncho-pulmonary lesions at the end of treatment].
CONCLUSION: The persistence of signs of activity on the CT scan at the end of treatment of tuberculosis do not necessarily correspond to an absence of cure but to a radiological delay. This imaging is nevertheless useful to make an assessment of any subsequent changes in the bronchial tree and to estimate the risk of later complications. PMID: 30236440 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 22, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon gamma release assay tests and nontuberculous mycobacteria].
Authors: Andréjak C, Barras E PMID: 30220488 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Sarcoid-like granulomatosis in cancer patients treated with immune checkpoints inhibitors].
CONCLUSIONS: Knowledge of this toxicity is crucial as the clinical signs and radiological patterns may suggest tumour progression. PMID: 30220489 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Near-drowning associated Aeromonas pneumonia].
CONCLUSION: Rapid respiratory deterioration following near-drowning should raise the suspicion of pulmonary infection with the bacteria usually found in the respiratory tract during ventilation but without overlooking the possibility of unusual organisms, particularly Aeromonas.It is usuallysensitive to third generation cephalosporins and fluoroquinolones. Ideally, Aeromonas should be sought in pulmonary aspirates and samples of the water where immersion occurred. PMID: 30220490 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon gamma release assay tests for the diagnosis of active tuberculosis].
Authors: Blanc FX, Dirou S, Morin J, Veziris N PMID: 30220491 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon gamma release assay tests and HIV infection].
Authors: Gerin M, Bourgarit A PMID: 30224209 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon gamma release assay (IGRA) tests].
Authors: Le Palud P, Herrmann JL, Bergot E PMID: 30224210 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Steroids for community-acquired pneumonia: Should we go on searching or should we give up?]
Authors: Misset B PMID: 30224211 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon gamma release assay tests in children less than 15 years old].
Authors: Delacourt C, Guerin S, Pommelet V PMID: 30224212 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Tuberculosis contact tracing].
Authors: Antoun F, Haustraete É, Charlois-Ou C PMID: 30224213 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon gamma release assay test in healthcare workers].
Authors: Lucet JC, Abiteboul D PMID: 30224214 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Practice recommendations for the use and interpretation of interferon gamma release assays in the diagnosis of latent and active tuberculosis].
Authors: Bergot E, Abiteboul D, Andréjak C, Antoun F, Barras E, Blanc FX, Bourgarit A, Charlois-Ou C, Delacourt C, Dirou S, Gerin M, Guerin S, Haustraete É, Henry B, Lucet JC, Maitre T, Morin J, Le Palud P, Pommelet V, Rivoisy C, Robert J, Veziris N, Herrmann JL PMID: 30224215 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Latent tuberculosis infection, from diagnosis to prognosis].
Authors: Fraisse P PMID: 30217572 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Corticosteroids in community acquired pneumonia: Where are we in 2018?]
Authors: Soumagne T, Rabbat A Abstract Community-acquired pneumonia (CAP) is a common infectious disease and one of the main causes of mortality worldwide. Despite an improvement in management globally, mortality remains high especially in severe forms of CAP. Adequate early antibiotics remain the cornerstone of the treatment but adjuvant corticosteroid administration is being considered to counterbalance the systemic inflammatory reaction and modulate the immune response. In the last ten years, several clinical trials and meta-analyses have been conducted in severe and non-severe CAP to assess the efficacy of cort...
Source: Revue des Maladies Respiratoires - September 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon gamma release assays and immunosuppressive drugs (including biologic therapy)].
Authors: Rivoisy C, Bourgarit A PMID: 30217574 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Interferon-gamma release assay tests in migrants].
Authors: Antoun F, Charlois-Ou C PMID: 30217575 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[A rare infectious etiology of COPD exacerbation].
Authors: Khalloufi A, Ouarssani A, Er-Rami M, Fellah H, Sebti F, Moudden MK Abstract Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder. Its exacerbation is infectious in more than half of the cases: with viral priority, while parasitic causes remain exceptional. In this work, we report a case of a COPD exacerbation caused by a visceral leishmaniasis (VL) complicated by a macrophage activation syndrome in an adult living in a Moroccan non-endemic region for this of leismaniasis form. In such atypical clinical feature, the diagnosis of VL was based on the myelogram after presence of periph...
Source: Revue des Maladies Respiratoires - September 15, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Toxicity of immune checkpoints inhibitors].
CONCLUSION: Additional studies are needed to better understand the clinical characteristics and chronology of these adverse effects and to clarify their pathophysiological mechanisms. PMID: 30213624 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 15, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Follow-up and evaluation of plans developed during pulmonary rehabilitation].
Authors: Péran L, Le Ber C, Pichon R, Cabillic M, Beaumont M Abstract BACKGROUND: Pulmonary rehabilitation inevitably contains two essential components: therapeutic education and exercise training. The principal aim of this study was to evaluate the evolution over a year of the realization of plans determined during a pulmonary rehabilitation program (PRP). METHODS: At the end of a PRP the patient made plans in accordance with his health condition. A telephone enquiry was undertaken at 3, 7 and 12 months to evaluate the progress of the plans, the motivation to perform them, dyspnoea and quality of life. ...
Source: Revue des Maladies Respiratoires - September 12, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Self medication with Annona muricata L. (corossol) as an anti-cancer agent in Reunion].
CONCLUSIONS: A quarter of patients treated by chemotherapy for a lung cancer in Reunion consume graviola regularly as self medication. The consequences of this intake, drug interactions and side effects are unknown and would be interesting to identify. PMID: 30195454 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 11, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Metacholine challenge: The D-dimer of asthma diagnosis?]
Authors: Taillé C PMID: 30189993 [PubMed - in process] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - September 9, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Small cell lung cancer and immuno-oncologic agents: End of the cisplatin  - etoposide era?]
[Small cell lung cancer and immuno-oncologic agents: End of the cisplatin - etoposide era?] Rev Mal Respir. 2018 Aug 30;: Authors: Pujol JL, Roch B Abstract In the setting of small cell lung cancer (SCLC), the development of immuno-oncological agents, particularly those targeting Programmed cell Death protein 1 (PD-1) and Programmed cell Death protein Ligand 1 (PD-L1), is still at an early stage. Two critical elements need to be considered : the current data are extracted from Phase I and Phase II trials and the level of evidence from phase III trials has not been reached as it has been ...
Source: Revue des Maladies Respiratoires - September 5, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[MET exon 14 splicing sites mutations: A new therapeutic opportunity in lung cancer].
Authors: Baldacci S, Kherrouche Z, Descarpentries C, Wislez M, Dansin E, Furlan A, Tulasne D, Cortot AB Abstract The mutations leading to MET exon 14 skipping represent a new class of molecular alterations described in various cancers. These alterations are observed in 2 to 3 % of cases of non-small cell lung cancer (NSCLC). Several cases of NSCLC carrying such alterations and achieving objective response to MET tyrosine kinase inhibitorshave recently been published. This review summarizes the molecular mechanisms responsible for MET exon 14 skipping as well as the consequences of the loss of this exon on rece...
Source: Revue des Maladies Respiratoires - September 5, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[The usefulness of nasal provocation tests for respiratory physicians].
Authors: Doyen V, Braun JJ, Lutz C, Khayath N, de Blay F Abstract Rhinitis and asthma are common diseases that are strongly linked from both the epidemiological and patho-physiological point of view. A precise aetiological diagnosis is required in order to optimize treatment. Nasal provocation tests (NPT) determine precisely the role of the allergen in the initiation of the symptoms of rhinitis particularly when the history does not produce convincing evidence of the clinical relevance of an allergen. It may also have important consequences for the choice of an allergenic immunotherapy. NPT are not standardized but...
Source: Revue des Maladies Respiratoires - September 5, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[What do chemotherapy specialists expect of lung cancer?]
Authors: Pujol JL, Roch B, Coffy A, Mérel JP, Daurès JP Abstract OBJECTIVE: In an attempt to understand physicians' expectations of chemotherapy, a group of lung cancer specialists was involved in an online survey investigating their opinions by a self-questionnaire. The questionnaire described five different chemotherapy prescription situations for lung cancer patients (stages IIIB or IV). METHOD: A total of 30 expert specialists were invited; 22 responded (73%). For each of the clinical situations, the expert was asked for his opinion on 3 items: cure, prolongation of survival and alleviation of...
Source: Revue des Maladies Respiratoires - September 5, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Tumour assessment criteria for immune checkpoint inhibitors].
Authors: Wasielewski E, Cortot AB Abstract The development of immune checkpoint inhibitors in thoracic oncology has led to a reconsideration of the rules for radiological tumor assessment. The RECIST criteria are widely used for the assessment of conventional treatments but are not suitable for anti-tumoral immunotherapy. The mechanism of action of this new class of drugs may induce specific patterns of response, which are not fully assessed by the RECIST criteria. Several new criteria have been proposed to better detect these patterns of response. The changes usually include confirmation of progression, new ways o...
Source: Revue des Maladies Respiratoires - September 2, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Domestic exposure to moulds and mite allergens in Parisian patients].
CONCLUSIONS: This study describes the levels of contamination in the dwellings of Parisian patients. PMID: 30139719 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - August 26, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Search for the T790M mutation: The need to persevere].
We report 7 cases in which the identification of the T790M mutation required repeated analyses of cell free DNA and/or biopsies over a period of time. In some cases, a positive result was obtained a long time after progressive disease had been diagnosed during treatment with first or second generation EGFR-TKI. We discuss here the different modalities of screening for the T790M mutation and we encourage persevering in this search when no alternative mechanism of resistance has been identified. PMID: 30115389 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - August 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Coinfection with hydatid cyst and pulmonary tuberculosis].
We describe the case of a patient with pulmonary hydatid cyst associated with tuberculosis infection where the diagnosis was unknown prior to surgery because TB tests were negative. The surgical resection was very difficult because of inflammation in the surrounding tissue and its fragility. However, the postoperative course was uneventful. The goal of this case report is to keep in mind that such co-infection is possible especially in endemic countries. PMID: 30104049 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - August 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Exercise capacity in children with mild sleep-disordered breathing].
CONCLUSION: Mild SDB may be associated with impairment of both aerobic and anaerobic exercise capacity in children, related to poor physical activity. Exercise training could bring clinical benefit in this population. PMID: 30107963 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - August 16, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Guidelines for methacholine provocation testing].
Authors: Plantier L, Beydon N, Chambellan A, Degano B, Delclaux C, Dewitte JD, Dinh-Xuan AT, Garcia G, Kauffmann C, Paris C, Perez T, Poussel M, Wuyam B, Zerah-Lancner F, Chenuel B, pour le groupe Fonction de la SPLF Abstract Bronchial challenge with the direct bronchoconstrictor agent methacholine is commonly used for the diagnosis of asthma. The "Lung Function" thematic group of the French Pulmonology Society (SPLF) elaborated a series of guidelines for the performance and the interpretation of methacholine challenge testing, based on French clinical guideline methodology. Specifically, guidelines are p...
Source: Revue des Maladies Respiratoires - August 15, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research