Revista do Instituto de Medicina Tropical de Sao Paulo This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Viable Leishmania parasites in the absence of an in vitro IFN- γ response in asymptomatic carriers
This study aimed to identify the in vitro expression of IFN-γ in asymptomatic carriers of viable Leishmania parasites. Asymptomatic infection was identified using the Montenegro skin test in an at-risk population from Yucatan, Mexico. Parasite viability was evinced in the blood by 7SL RNA transcripts amplification. The expression of mRNA IFN-γ was analyzed in peripheral blood mononuclear cells stimulated with soluble Leishmania antigen, using RT-qPCR. Parasite viability was observed in 33.3 % (5/15) of asymptomatic subjects. No differences were found in the expression of IFN-γ between asymptomatic and healthy subjects, ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 21, 2024 Category: Tropical Medicine Authors: Elsy Nalleli Lor ía-Cervera Erika Ivett Sosa-Bibiano Karina Beatriz L ópez-Ávila Ana Celia Montes de Oca-Aguilar Marisol Sarah í Moreno-Nava Jimmy Raymundo Torres-Castro Source Type: research

Cardiorespiratory optimal point in post-COVID-19 patients: a cross-sectional study
This study aimed to assess COP values among post-COVID-19 patients and categorized them based on the initial severity of their disease. In this cross-sectional study conducted in the Northeast Brazil, 80 patients (26 females and 54 males) previously infected with SARS-CoV-2 underwent CPET. We clinically stratified patients into mild, moderate, or severe COVID-19 categories and assessed COP values and other cardiorespiratory metrics. We found differences in the predicted COP between patients with mild and severe COVID-19 (p=0.042). Additionally, patients with moderate and severe COVID-19 record had an average COP value exce...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 21, 2024 Category: Tropical Medicine Authors: Karinne Sim ões da Cruz Santos Gabriela Menezes Gon çalves de Brito Enaldo Vieira de Melo Ant ônio Carlos Sobral Sousa Paulo Ricardo Martins-Filho Milena Dos Santos Barros Campos Source Type: research

In vitro susceptibility to fosfomycin in clinical and environmental extended-spectrum beta-lactamase producing and/or ciprofloxacin-non-susceptible Escherichia coli isolates
Rev Inst Med Trop Sao Paulo. 2024 Feb 5;66:e5. doi: 10.1590/S1678-9946202466005. eCollection 2024.ABSTRACTExtended-spectrum beta-lactamase producing and ciprofloxacin-non-susceptible Escherichia coli are clinical and environmental issues. We evaluated the susceptibility profile of fosfomycin in non-susceptible E. coli isolated from urine and the environment. We measured the activity of fosfomycin against 319 and 36 E. coli strains from urine and environmental isolates, respectively, collected from rivers. Fosfomycin resistance profiles were investigated using the minimal inhibitory concentration (MIC), according to the Cli...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Victoria Stadler Tasca Ribeiro Larissa Bail Carmen Antonia Sanches Ito Ana Paula de Andrade Lavinia Nery Villa Stangler Arend Paula Hansen Suss Keite da Silva Nogueira Haniel Siqueira Mortagua Walflor Helisson Faoro Lia Carolina Soares de Medeiros Kuczera Source Type: research

Secondary oral syphilis presenting as a tumor-like lesion on the lower lip
This study presents a case of atypical manifestation of secondary syphilis. Diagnosis was initiated prompted by the patient's complaint of a lower lip lesion, present for three months, resembling a malignant neoplasm. The lesion, a 3 cm (diameter) ulcerated nodule, arising from conjunctive tissue, raised concern. However, further physical examination revealed additional clinical features, including cervical micropolyadenopathy and erythematous skin lesions, prompting a reevaluation of the diagnosis, most likely secondary syphilis. These findings led to a serological investigation, which, ultimately, confirmed the diagnosis...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Norberto Sugaya Dante Migliari Source Type: research

Incomplete recovery of the CD4+/CD8+ ratio is associated with the late introduction of antiretroviral therapy among people living with HIV infection
In conclusion, the increase in the CD4+/CD8+ ratio occurred mostly for patients undergoing early strategy treatment and its extension did not seem to be related to previous HIV-related factors.PMID:38324873 | PMC:PMC10846540 | DOI:10.1590/S1678-9946202466007 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Gabriela da Silva Prates Mariana Amelia Monteiro Éricka Constantinov Oliveira Najara Ataide de Lima Nascimento Ana Paula Rocha Veiga Mauricio Domingues Ferreira Thales Jos é Bueno Polis Gabriela Prandi Caetano Beatriz Rodrigues Pellegrina Soares Marcell Source Type: research

Identification of SARS-CoV-2 in urban rodents from Southern Mexico City at the beginning of the COVID-19 pandemic
This study aimed to molecularly identify the presence of SARS-CoV-2 in urban wild rodents from Mexico City, trapped along a water channel of a public park as part of a pest control program, at the beginning of the COVID-19 pandemic, during the fall and winter of 2020. Up to 33 Mus musculus and 52 R. norvegicus were captured and euthanized, large intestine samples with feces from the animals were obtained. RNAs were obtained and subjected to qRT-PCR for SARS-CoV-2 identification and threshold cycle (Ct) values were obtained. Four mice (12.1%) and three rats (5.8%) were positive, three rodents exhibited Ct<30. Our results...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Fernando Mart ínez-Hernández Nelly Raquel Gonzalez-Arenas Jos é Antonio Ocampo Cervantes Guiehdani Villalobos Angelica Olivo-Diaz Emilio Rendon-Franco Pablo Maravilla Mirza Romero Valdovinos Claudia Irais Mu ñoz-Garcia Source Type: research

The influence of growth time on the identification of Bartonella henselae strains by MALDI-TOF mass spectrometry
Rev Inst Med Trop Sao Paulo. 2024 Feb 5;66:e9. doi: 10.1590/S1678-9946202466009. eCollection 2024.ABSTRACTBartonella spp. are bacteria responsible for neglected diseases worldwide. Bartonella henselae is the species most associated with human infections. It is associated with a large spectrum of clinical manifestations and is potentially fatal. The identification of Bartonella spp. is considered a challenge in clinical routine. These bacteria are fastidious, and the time required to isolate them varies from one to six weeks. MALDI-TOF mass spectrometry has emerged as an application for research on Bartonella spp. , and has...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Karina de Almeida Lins Cristiane Santos Cruz Piveta Carlos Emilio Levy Marina Rovani Drummond Luciene Silva Dos Santos Alessandra Sussulini Paulo Eduardo Neves Ferreira Velho Source Type: research

Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review
Rev Inst Med Trop Sao Paulo. 2024 Feb 5;66:e10. doi: 10.1590/S1678-9946202466010. eCollection 2024.ABSTRACTMultiple myeloma (MM) associated with Chagas disease is rarely described. This disease and its therapy suppress T cell and macrophage functions and increase regulatory T cell function, allowing the increase of parasitemia and the risk of Chagas Disease Reactivation (CDR). We aimed to analyze the role of conventional (cPCR) and quantitative Polymerase Chain Reaction (qPCR) for prospective monitoring of T. cruzi parasitemia, searching for markers of preemptive antiparasitic therapy in MM patients with Chagas disease. Mo...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Noemia Barbosa Carvalho Vera L úcia Teixeira de Freitas Fernanda Salles Seguro Rita Cristina Bezerra Giancarlo Fatobene Érika Yoshie Shimoda Nakanishi Helena Visnadi Gracia Martinez Marjorie Vieira Batista Vanderson Rocha Frederico Luis Dulley S ílvia Source Type: research

Prevalence and clinical consequences of Hepatitis C virus infection in patients undergoing hematopoietic stem cell transplantation
Rev Inst Med Trop Sao Paulo. 2024 Feb 5;66:e11. doi: 10.1590/S1678-9946202466011. eCollection 2024.ABSTRACTHepatitis C virus (HCV) infection is a significant cause of morbidity and mortality among hematopoietic stem cell transplant (HCT) recipients. In Brazil, its occurrence in HCT recipients remains undetermined. We now report on HCV prevalence in HCT recipients and its clinical consequences. The medical records of all HCT recipients seen at Hospital das Clinicas, Sao Paulo University Medical School, from January 2010 to January 2020 were reviewed to determine HCV serostatus. A retrospective analysis of medical charts was...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Ana Claudia Marques Barbosa Diaz Steven Sol Witkin Cesar de Almeida Neto Alfredo Mendrone Junior Vanderson Rocha Silvia Figueiredo Costa Jessica Fernandes Ramos Maria Cassia Mendes-Correa Source Type: research

In vitro susceptibility to fosfomycin in clinical and environmental extended-spectrum beta-lactamase producing and/or ciprofloxacin-non-susceptible Escherichia coli isolates
Rev Inst Med Trop Sao Paulo. 2024 Feb 5;66:e5. doi: 10.1590/S1678-9946202466005. eCollection 2024.ABSTRACTExtended-spectrum beta-lactamase producing and ciprofloxacin-non-susceptible Escherichia coli are clinical and environmental issues. We evaluated the susceptibility profile of fosfomycin in non-susceptible E. coli isolated from urine and the environment. We measured the activity of fosfomycin against 319 and 36 E. coli strains from urine and environmental isolates, respectively, collected from rivers. Fosfomycin resistance profiles were investigated using the minimal inhibitory concentration (MIC), according to the Cli...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Victoria Stadler Tasca Ribeiro Larissa Bail Carmen Antonia Sanches Ito Ana Paula de Andrade Lavinia Nery Villa Stangler Arend Paula Hansen Suss Keite da Silva Nogueira Haniel Siqueira Mortagua Walflor Helisson Faoro Lia Carolina Soares de Medeiros Kuczera Source Type: research

Secondary oral syphilis presenting as a tumor-like lesion on the lower lip
This study presents a case of atypical manifestation of secondary syphilis. Diagnosis was initiated prompted by the patient's complaint of a lower lip lesion, present for three months, resembling a malignant neoplasm. The lesion, a 3 cm (diameter) ulcerated nodule, arising from conjunctive tissue, raised concern. However, further physical examination revealed additional clinical features, including cervical micropolyadenopathy and erythematous skin lesions, prompting a reevaluation of the diagnosis, most likely secondary syphilis. These findings led to a serological investigation, which, ultimately, confirmed the diagnosis...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Norberto Sugaya Dante Migliari Source Type: research

Incomplete recovery of the CD4+/CD8+ ratio is associated with the late introduction of antiretroviral therapy among people living with HIV infection
In conclusion, the increase in the CD4+/CD8+ ratio occurred mostly for patients undergoing early strategy treatment and its extension did not seem to be related to previous HIV-related factors.PMID:38324873 | PMC:PMC10846540 | DOI:10.1590/S1678-9946202466007 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Gabriela da Silva Prates Mariana Amelia Monteiro Éricka Constantinov Oliveira Najara Ataide de Lima Nascimento Ana Paula Rocha Veiga Mauricio Domingues Ferreira Thales Jos é Bueno Polis Gabriela Prandi Caetano Beatriz Rodrigues Pellegrina Soares Marcell Source Type: research

Identification of SARS-CoV-2 in urban rodents from Southern Mexico City at the beginning of the COVID-19 pandemic
This study aimed to molecularly identify the presence of SARS-CoV-2 in urban wild rodents from Mexico City, trapped along a water channel of a public park as part of a pest control program, at the beginning of the COVID-19 pandemic, during the fall and winter of 2020. Up to 33 Mus musculus and 52 R. norvegicus were captured and euthanized, large intestine samples with feces from the animals were obtained. RNAs were obtained and subjected to qRT-PCR for SARS-CoV-2 identification and threshold cycle (Ct) values were obtained. Four mice (12.1%) and three rats (5.8%) were positive, three rodents exhibited Ct<30. Our results...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Fernando Mart ínez-Hernández Nelly Raquel Gonzalez-Arenas Jos é Antonio Ocampo Cervantes Guiehdani Villalobos Angelica Olivo-Diaz Emilio Rendon-Franco Pablo Maravilla Mirza Romero Valdovinos Claudia Irais Mu ñoz-Garcia Source Type: research

The influence of growth time on the identification of Bartonella henselae strains by MALDI-TOF mass spectrometry
Rev Inst Med Trop Sao Paulo. 2024 Feb 5;66:e9. doi: 10.1590/S1678-9946202466009. eCollection 2024.ABSTRACTBartonella spp. are bacteria responsible for neglected diseases worldwide. Bartonella henselae is the species most associated with human infections. It is associated with a large spectrum of clinical manifestations and is potentially fatal. The identification of Bartonella spp. is considered a challenge in clinical routine. These bacteria are fastidious, and the time required to isolate them varies from one to six weeks. MALDI-TOF mass spectrometry has emerged as an application for research on Bartonella spp. , and has...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Karina de Almeida Lins Cristiane Santos Cruz Piveta Carlos Emilio Levy Marina Rovani Drummond Luciene Silva Dos Santos Alessandra Sussulini Paulo Eduardo Neves Ferreira Velho Source Type: research

Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review
Rev Inst Med Trop Sao Paulo. 2024 Feb 5;66:e10. doi: 10.1590/S1678-9946202466010. eCollection 2024.ABSTRACTMultiple myeloma (MM) associated with Chagas disease is rarely described. This disease and its therapy suppress T cell and macrophage functions and increase regulatory T cell function, allowing the increase of parasitemia and the risk of Chagas Disease Reactivation (CDR). We aimed to analyze the role of conventional (cPCR) and quantitative Polymerase Chain Reaction (qPCR) for prospective monitoring of T. cruzi parasitemia, searching for markers of preemptive antiparasitic therapy in MM patients with Chagas disease. Mo...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - February 7, 2024 Category: Tropical Medicine Authors: Noemia Barbosa Carvalho Vera L úcia Teixeira de Freitas Fernanda Salles Seguro Rita Cristina Bezerra Giancarlo Fatobene Érika Yoshie Shimoda Nakanishi Helena Visnadi Gracia Martinez Marjorie Vieira Batista Vanderson Rocha Frederico Luis Dulley S ílvia Source Type: research