Revista Brasileira de Farmacognosia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Chemical characterization and toxicological assessment of hydroethanolic extract of Mandevilla velame xylopodium
Abstract The present study was aimed to characterize the chemical profile and evaluate the cytotoxicity and sub-chronic toxicity of the hydroethanolic extract of the xylopodium Mandevilla velame (A.St.-Hil.) Pichon, Apocynaceae. Chemical profile was analyzed by high performance liquid chromatography. Cytotoxic potential of hydroethanolic extract of the xylopodium M. velame was evaluated using Chinese hamster ovary cells. The sub-chronic assessment was done on rats with hydroethanolic extract of the xylopodium M. velame (50, 200 and 800 mg/kg) was orally administered daily for 30 consecutive days. High performance liquid ch...
Source: Revista Brasileira de Farmacognosia - December 9, 2019 Category: Drugs & Pharmacology Source Type: research
A newly validated HPLC–DAD-UV method to study the effects of medicinal plants extracts, fractions and isolate compounds on gastric emptying in rodents
In conclusion, the newly-validated analytical method is adequate for studying the effects of medicinal plants on gastric emptying. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - December 9, 2019 Category: Drugs & Pharmacology Source Type: research
Rhus coriaria (sumac) extract reduces migration capacity of uterus cervix cancer cells
In this study, we showed that non-cytotoxic concentrations of R. coriaria reduces uterus cervix cell migration capacity. We have also found that R. coriaria has a growth inhibitory effect on cervical cancer cells in a time- and a concentration-dependent manner. We have carried out a phytochemical compound analysis of R. coriaria extract using liquid chromatography – mass spectrometry method in order to identify bioactive compounds in R. coriaria extract that could potentially induce its anti-cancer effects. Our results are promising to involve R. coriaria as a therapeutic drug candidate for uterus cervix cancer. (Source:...
Source: Revista Brasileira de Farmacognosia - December 9, 2019 Category: Drugs & Pharmacology Source Type: research
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti
Abstract The species Waltheria viscosissima A.St. – Hil, Malvaceae, which is known as ‘ malva-branca', is traditionally used in the Brazilian northeast for the treatment of coughs. This research looks towards reporting the isolation of phytoconstituents of W. viscosissima, as well as the quantification of its phenolics, total flavonoid content, and free radical scavenging potential, along with an evaluation of its larvicidal activity against Aedes aegypti larvae. Chromatographic techniques were used to isolate the compounds and a structural elucidation was performed by 1D and 2D NMR. The quantification of total phenoli...
Source: Revista Brasileira de Farmacognosia - December 9, 2019 Category: Drugs & Pharmacology Source Type: research
Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity
Abstract Schisandra sphenanthera Rehder& E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS dat...
Source: Revista Brasileira de Farmacognosia - December 9, 2019 Category: Drugs & Pharmacology Source Type: research
RP-HPLC and LC–MS–MS determination of a bioactive artefact from Ipomoea pes-caprae extract
This study aimed to correlate the chromatographic profile with biological activity of Ipomoea pes-caprae (L.) R. Br., Convolvulaceae, extracts obtained with hydroethanolic extraction. Thus, aerial parts of I. pes-caprae were extracted with different concentration of ethanol (50, 70 and 90 °GL) and the obtained extracts were analysed by HPLC – UV. HPLC data were studied employing chemometrics to discriminate the samples. Moreover these samples were further characterized by using UPLC – QTOF/MS data. The extracts were also biomonitored through the paw-oedema and spontaneous nociception induced by trypsin in mice. Differ...
Source: Revista Brasileira de Farmacognosia - December 9, 2019 Category: Drugs & Pharmacology Source Type: research
Morphological, phytochemical and anti-hyperglycemic evaluation of Brachychiton populneus
Abstract Brachychiton populneus (Schott& Endl.) R.Br., Malvaceae, is one of five Brachychiton species cultivated in Egypt. Little information was found concerning the morphological, phytochemical and biological investigations of B. populneus. Morphological investigations of B. populneus were performed on fresh and dried leaves. Air-dried, ground leafy branches were extracted with 70% methanol/water yielding B. populneus extract. Seventeen flavonoids were isolated and identified using different chromatographic and spectroscopic techniques; eleven of them were reported for the first time from this plant. Potential activi...
Source: Revista Brasileira de Farmacognosia - December 9, 2019 Category: Drugs & Pharmacology Source Type: research
Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology
Abstract The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name as “ sai ão ” or “ coirama ” . Several studies have been published involving different parts and preparations of these species. Therefore, this review aims to provide an update overview about the traditional uses, chemical constitution, pharmacology and toxi...
Source: Revista Brasileira de Farmacognosia - October 18, 2019 Category: Drugs & Pharmacology Source Type: research
Chemical diversity and activity profiles of HIV-1 reverse transcriptase inhibitors from plants
Abstract Current challenges to antiretroviral therapy have opened new vistas in the search for novel drugs from natural products. This review focusses on plants as sources of inhibitors for human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Based on a systematic search of the literature, anti-HIV-1 reverse transcriptase activity was recorded for 132 plant species in 100 genera and 51 families. Seven families comprise 52.6% of plant species with anti-reverse transcriptase activity: Lamiaceae (13.7%), Fabaceae (10.7%), Euphorbiaceae (9.9%), Clusiaceae (6.1%), Asteraceae (4.6%), Combretaceae (4.6%), and Morace...
Source: Revista Brasileira de Farmacognosia - October 18, 2019 Category: Drugs & Pharmacology Source Type: research
GC–MS and LC–MS/MS workflows for the identification and quantitation of pyrrolizidine alkaloids in plant extracts, a case study: Echium plantagineum
Abstract Workflows based on gas and liquid chromatography coupled to mass spectrometry for the identification of toxic pyrrolizidine alkaloids present in plants were developed and applied to Echium plantagineum L., Boraginaceae, extracts. GC – MS based determinations need reduction and derivatization steps prior to MS analysis, which is performed using a Full Scan and Single Ion Monitoring sequence for screening, identification and quantification purposes. The LC – (ESI) – MS/MS determination was performed directly from the extract without derivatization. Acetyl lycopsamine, echimidine, echimidine N-oxide, echiumine,...
Source: Revista Brasileira de Farmacognosia - October 18, 2019 Category: Drugs & Pharmacology Source Type: research
Galanthamine and other Amaryllidaceae related alkaloids are inhibitors of α7, α4β2 and α3β4 nicotinic acetylcholine receptors
Abstract Galanthamine is an Amaryllidaceae-derived acetylcholinesterase inhibitor used to treat memory impairment in Alzheimer's disease and vascular dementia. There is evidence that galanthamine, in addition to its effects on acetylcholinesterase, may enhance or inhibit brain nicotinic acetylcholine receptors, which could increase or decrease the therapeutic efficacy of galanthamine, respectively. Here, we evaluated the effects of galanthamine and two others Amaryllidaceae acetylcholinesterase inhibitors (haemanthamine and tazettine) analyzed by gas chromatography – mass spectrometry and identified by comparing their ma...
Source: Revista Brasileira de Farmacognosia - October 18, 2019 Category: Drugs & Pharmacology Source Type: research
New cathepsin V inhibitor from stems of Bowdichia virgilioides
Abstract Bioassay-guided fractionation of Bowdichia virgilioides Kunth, Fabaceae, extracts has led to the isolation of cathepsin V inhibitors. The investigation of the hexane and ethyl acetate extracts allowed the characterization of eleven compounds: lupeol, lupenone, β -sitosterol and stigmasterol in mixture, trans p-coumaric acid ester derivative, syringaresinol, bowdenol, 8-methoxycoumestrol, 3,4-hydroxy-7-methoxyisoflavone, 7,3 ′ -dihydroxy-4 ′ -methoxyisoflavone, and 5,4 ′ -dihydroxy-7 ′ -methoxyisoflavone. Structures of compounds were stablished by 1D and 2D NMR, and MS experiments. Among the isolated compo...
Source: Revista Brasileira de Farmacognosia - October 18, 2019 Category: Drugs & Pharmacology Source Type: research
Isolation of erythrinan alkaloids from the leaves and flowers of Erythrina speciosa
Abstract In this paper, we describe the extraction of three alkaloids from the leaves and flowers of Erythrina speciosa, a plant documented in the literature to possess a range of potential medicinal applications. Two alkaloids were isolated from both leaves and flowers, with erythrartine being isolated from both plant parts. In agreement with the literature, we also isolated erysotrine from the flowers. The second alkaloid isolated from the leaves, and reported in this species for the first time, was (+)-11 β -hydroxyerysotramidine. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - October 18, 2019 Category: Drugs & Pharmacology Source Type: research
Identification of compounds from chufa (Eleocharis dulcis) peels with inhibitory acrylamide formation activity
Abstract Five compounds were isolated from the peels of chufa (Eleocharis dulcis (Burm.f.) Trin. ex Hensch., Cyperaceae). The chemical structures were determined by various spectroscopic analysis methods, including 1D and 2D NMR, and by comparison with literature data. All compounds were isolated for the first time from the peels of chufa. Compounds orcinol glucoside, leonuriside A, 2-hydroxymethyl-6-(5-hydroxy-2-methyl-phenoxy-methyl)-tetra-hydro-pyran-3,4,5-triol, and 1,4-dihydroxy-3-methoxy-phenyl-4-O- β -D-glucopyranoside showed good acrylamide formation activity, and acrylamide inhibition rates were 30.24, 32.81, 30....
Source: Revista Brasileira de Farmacognosia - October 18, 2019 Category: Drugs & Pharmacology Source Type: research
A valepotriate-enriched fraction from Valeriana glechomifolia Meyer inhibits leukocytes migration and nociception in formalin test in rodents
This study demonstrated for the first time that a valepotriate-enriched fraction obtained from V. glechomifolia display a peripheral anti-inflammatory like activity. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - October 18, 2019 Category: Drugs & Pharmacology Source Type: research
