Secondary spontaneous pneumothorax in idiopathic pulmonary fibrosis: Grim news
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Source: Respirology - January 9, 2018 Category: Respiratory Medicine Authors: Jos é M. Porcel Tags: Editorial Source Type: research

Pathophysiology of severe asthma: We ’ve only just started
ABSTRACT Severe asthma is defined by the high treatment requirements to partly or fully control the clinical manifestations of disease. It remains a problem worldwide with a large burden for individuals and health services. The key to improving targeted treatments, reducing disease burden and improving patient outcomes is a better understanding of the pathophysiology and mechanisms of severe disease. The heterogeneity, complexity and difficulties in undertaking clinical studies in severe asthma remain challenges to achieving better understanding and better outcomes. In this review, we focus on the structural, mechanical an...
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Authors: Gregory G. King, Alan James, Louise Harkness, Peter A.B. Wark Tags: Invited Review Series: Seeking Innovative solutions in Severe Asthma Source Type: research

E ‐cigarettes unlikely to raise significant health concerns in airways disease – Reply
See Letter (Source: Respirology)
Source: Respirology - January 9, 2018 Category: Respiratory Medicine Authors: Matthew J. Peters Tags: Correspondence Source Type: research

Comparison of respiratory system impedance in asthma and COPD: A prospective observational study
ConclusionΔX5 may be useful for long‐term assessment of airflow limitation in COPD. (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Takahiro Kamada, Masahiro Kaneko, Hiromi Tomioka Tags: Original Article Source Type: research

Management of venous thromboembolism: Time to measure our performance
(Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Michael W.Y. Tan, Sanjeev Chunilal, Darren Mansfield Tags: Commentary Source Type: research

Exercise desaturation and oxygen therapy in ILD and COPD: Similarities, differences and therapeutic relevance
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Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Christine F. McDonald Tags: Editorial Source Type: research

Pulmonary hypertension in interstitial lung disease: Limitations of echocardiography compared to cardiac catheterization
ConclusionIn patients with ILD and suspected PH, currently recommended ESC/ERS TR velocity screening thresholds were associated with a high positive predictive value (86%) for confirming PH, but were of limited value in excluding PH, with 40% of patients misclassified as low probability when PH was confirmed at subsequent RHC. (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Gregory J. Keir, S. John Wort, Maria Kokosi, Peter M. George, Simon L.F. Walsh, Joseph Jacob, Laura Price, Simon Bax, Elisabetta A. Renzoni, Toby M. Maher, Peter MacDonald, David M. Hansell, Athol U. Wells Tags: Original Article Source Type: research

Pneumonia as a cardiovascular disease
ABSTRACT Community‐acquired pneumonia (CAP) is an important cause of death around the globe. Up to 30% of patients admitted to hospital for CAP develop cardiovascular complications (i.e. new/worsening heart failure, new/worsening arrhythmias, myocardial infarctions and/or strokes), acutely and up to 10 years thereafter. Cardiac complications result from complex interactions between preexisting conditions, relative ischaemia, upregulation of the sympathetic system, systemic inflammation and direct pathogen‐mediated damage to the cardiovascular system. The exact mechanisms underlying the direct host–pathogen interact...
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Marcos I. Restrepo, Luis F. Reyes Tags: Invited Review Series: Respiratory Infections in the Asia ‐pacific Region Source Type: research

Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality
ConclusionCurrent IPAF criteria encompassed the majority of broadly defined UCTD‐ILD and included those with UIP findings. Survival compared with IPF in those with UIP was similar. Further studies are necessary to refine IPAF definitions for clinical use and guide directed management strategies. (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Bryan T. Kelly, Teng Moua Tags: Original Article Source Type: research

E ‐cigarettes unlikely to raise significant health concerns in airways disease
See Reply (Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Riccardo Polosa Tags: Correspondence Source Type: research

Respiratory symptoms and small airway dysfunction in current and former smokers without spirometric COPD
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Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Neil C Thomson Tags: Editorial Source Type: research

Severe asthma: We can fix it? We can try!
(Source: Respirology)
Source: Respirology - January 1, 2018 Category: Respiratory Medicine Authors: Vanessa M. McDonald, Steven Maltby, Peter G. Gibson Tags: Series Editorial ‐Epilogue: Seeking Innovative Solutions in Severe Asthma Source Type: research

Empiric antibiotics for community ‐acquired pneumonia: A macrolide and a beta‐lactam please!
See related Article (Source: Respirology)
Source: Respirology - December 26, 2017 Category: Respiratory Medicine Authors: Grant Waterer Tags: Editorial Source Type: research

Empiric antibiotics for community ‐acquired pneumonia: A macrolide and a beta‐lactam please!
Respirology, EarlyView. (Source: Respirology)
Source: Respirology - December 26, 2017 Category: Respiratory Medicine Source Type: research

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Respirology, Ahead of Print. (Source: Respirology)
Source: Respirology - December 26, 2017 Category: Respiratory Medicine Source Type: research