High prevalence of airway obstruction and pulmonary emphysema in urothelial (renal pelvis, ureter, and bladder) cancer patients
ConclusionsAirflow obstruction was identified in 38.6% of urothelial cancer patients. Age, smoking index (pack-years), and BMI were significant risk factors. A significantly higher emphysematous score was observed in subjects with urothelial cancer than in subjects with airway obstruction alone. (Source: Respiratory Investigation)
Source: Respiratory Investigation - February 20, 2020 Category: Respiratory Medicine Source Type: research
Lobar distribution of non-emphysematous gas trapping and lung hyperinflation in chronic obstructive pulmonary disease
ConclusionNon-emphysematous gas trapping in the upper and lower lobes has a distinct physiological effect, especially in COPD with minimal emphysema. This local evaluation might allow sensitive detection of changes in lung hyperinflation in COPD. (Source: Respiratory Investigation)
Source: Respiratory Investigation - February 19, 2020 Category: Respiratory Medicine Source Type: research
Clinical staging of idiopathic pulmonary fibrosis
Publication date: Available online 28 December 2019Source: Respiratory InvestigationAuthor(s): Tomoo Kishaba (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 30, 2019 Category: Respiratory Medicine Source Type: research
Characteristics of 68 patients with clinically proven sarcoidosis based on the Japan Society of Sarcoidosis and Other Granulomatous Disorders 2015 criteria
ConclusionsThe age-specific distribution of clinically diagnosed sarcoidosis was similar to histologically diagnosed sarcoidosis in women, as previously reported. Rates of elevated serum lysozyme and sIL-2R levels were lower in this study than previously reported in histologically diagnosed patients in Japan. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 27, 2019 Category: Respiratory Medicine Source Type: research
Quantitative computed tomography measures of skeletal muscle mass in patients with idiopathic pulmonary fibrosis according to a multidisciplinary discussion diagnosis: A retrospective nationwide study in Japan
ConclusionsLow ESMCSA on CT images may be a strong risk factor for all-cause mortality in IPF patients based on MDD diagnosis. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 25, 2019 Category: Respiratory Medicine Source Type: research
Editorial Board
Publication date: January 2020Source: Respiratory Investigation, Volume 58, Issue 1Author(s): (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 24, 2019 Category: Respiratory Medicine Source Type: research
The release of phosphorylated-HSP27 from activated platelets of obstructive sleep apnea syndrome (OSAS) patients
ConclusionThe results strongly suggest that phosphorylated-HSP27 is released from the activated platelets of OSAS patients. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 17, 2019 Category: Respiratory Medicine Source Type: research
Treatment of multidrug-resistant pulmonary tuberculosis with delamanid based on Japanese guideline recommendations
ConclusionsDelamanid is a relatively safe drug with few side effects. However, some patients could not continue it because of difficulty of use in combination, therefore delamanid should be prescribed considering the side effects of all therapies in the regimen. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 17, 2019 Category: Respiratory Medicine Source Type: research
Predictive factors for the recurrence of anti-aminoacyl-tRNA synthetase antibody-associated interstitial lung disease
ConclusionsRecurrence influenced long-term deterioration. KL-6 was a serum biomarker for disease behavior and recurrence prediction. The results suggest the importance of CNI continuation. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2019 Category: Respiratory Medicine Source Type: research
Immune reconstitution inflammatory syndrome in the lung in non-human immunodeficiency virus patients
ConclusionsThe diagnosis and management of IRIS in the lung in non-HIV patients should be investigated further, especially in the era of anti-TNF treatment. (Source: Respiratory Investigation)
Source: Respiratory Investigation - November 30, 2019 Category: Respiratory Medicine Source Type: research
Introducing the new anti-influenza drug, baloxavir marboxil
Publication date: Available online 29 November 2019Source: Respiratory InvestigationAuthor(s): Jiro Fujita (Source: Respiratory Investigation)
Source: Respiratory Investigation - November 30, 2019 Category: Respiratory Medicine Source Type: research
Characteristics of tobacco-related lung diseases in Fukuoka Prefecture, Japan: A prospective, multi-institutional, observational study
ConclusionThis study revealed the current status of lung diseases potentially related to tobacco smoking in Fukuoka Prefecture. Both COPD and CPFE were highly related to tobacco smoking, whereas 30% of patients with IIPs had never smoked. (Source: Respiratory Investigation)
Source: Respiratory Investigation - November 13, 2019 Category: Respiratory Medicine Source Type: research
Usefulness of new diagnostic criteria for chronic hypersensitivity pneumonitis established on the basis of a Delphi survey: A Japanese cohort study
ConclusionsHalf of the MDD-CHP patients were diagnosed with CHP using Morisset's CHP diagnostic criteria. Further investigation will be important for developing improved diagnostic criteria for CHP. (Source: Respiratory Investigation)
Source: Respiratory Investigation - November 10, 2019 Category: Respiratory Medicine Source Type: research
Serum amyloid A: A potential biomarker of lung disorders
Publication date: Available online 8 November 2019Source: Respiratory InvestigationAuthor(s): Lucia Vietri, Annalisa Fui, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, Piersante Sestini, Paola Rottoli, Elena BargagliAbstractSerum amyloid A is an acute-phase protein with multiple immunological functions. Serum amyloid A is involved in lipid metabolism, inflammatory reactions, granuloma formation, and cancerogenesis. Additionally, serum amyloid A is involved in the pathogenesis of different autoimmune lung diseases. The levels of serum amyloid A has been evaluated in biological fluids of patients with different lun...
Source: Respiratory Investigation - November 10, 2019 Category: Respiratory Medicine Source Type: research
Role of Nrf2 in the pathogenesis of respiratory diseases
Publication date: Available online 6 November 2019Source: Respiratory InvestigationAuthor(s): Kenji Mizumura, Shuichiro Maruoka, Tetsuo Shimizu, Yasuhiro GonAbstractNuclear factor erythroid 2-related factor (Nrf)2 is a transcription factor that integrates cellular stress signals by directing various transcriptional programs. As an evolutionarily conserved intracellular defense mechanism, Nrf2 and its endogenous inhibitor Kelch-like ECH-associated protein (Keap)1 inhibit oxidative stress in the lung, which is the internal organ that is continuously exposed to the environment. Oxidative stress is implicated in the pathogenes...
Source: Respiratory Investigation - November 6, 2019 Category: Respiratory Medicine Source Type: research
