Editorial Board
Publication date: March 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 3Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 27, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: March 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 3Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 27, 2019 Category: Reproduction Medicine Source Type: research

Time-lapse imaging of inner cell mass splitting with monochorionic triamniotic triplets after elective single embryo transfer: a case report
ConclusionsAssisted reproductive techniques and in-vitro culture have been associated with an increased frequency of embryo splitting. This has been postulated to be linked to the in-vitro hatching method observed at the blastocyst stage of development. This case report highlights the need to objectively assess any splitting of the ICM, beyond standard grading of the quality of the ICM and the trophectoderm. Such assessments of ICM splitting should be routine practice in clinical embryology when selecting embryos for transfer. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 22, 2019 Category: Reproduction Medicine Source Type: research

Evaluation of sperm telomere length in infertile men with failed/low fertilization after intracytoplasmic sperm injection
This study therefore aimed to assess sperm telomere length in addition to DNA damage, lipid peroxidation and protamine deficiency in infertile men with previously failed/low fertilization post-ICSI.DesignSemen samples were obtained from infertile men with previous failed/low fertilization rates (n = 10). Chromatin integrity (chromomycin A3 staining and TUNEL assay), lipid peroxidation (BODIPY probe) and telomere length (real-time PCR) for semen samples from these men were compared with samples obtained from fertile individuals (n= 10).ResultsThe results showed significantly higher mean values for sperm DNA damage,...
Source: Reproductive BioMedicine Online - February 13, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: February 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 2Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 9, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: February 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 2Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 9, 2019 Category: Reproduction Medicine Source Type: research

Changes in visual function and ocular morphology in women who have undergone ART treatment and children born as a result of ART treatment: a systematic review
Publication date: Available online 7 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Mario D. Toro, Michele Reibaldi, Antonio Longo, Teresio Avitabile, Maria E. Lionetti, Sarah Tripodi, Chiara Posarelli, Stefano PalombaAbstractAs all the structures of the human eye are characterized by sex hormone receptors, this study tested the hypothesis that assisted reproductive technology (ART) treatment influences visual function and ocular morphology in women who have undergone ART treatment and children born as a result of ART treatment. A systematic literature search of all original articles published up to August ...
Source: Reproductive BioMedicine Online - February 8, 2019 Category: Reproduction Medicine Source Type: research

Prognostic value of repeated serum kisspeptin measurements in early first trimester pregnancy: a preliminary study
ConclusionSingle serum measurement of kisspeptin is significantly altered in pregnant and non-pregnant women. However, it failed to discriminate between miscarriage and ongoing pregnancies in first-trimester pregnancy. Neither single nor sequential kisspeptin have higher diagnostic performance for miscarriage than beta-HCG in early stage. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 8, 2019 Category: Reproduction Medicine Source Type: research

Effect of human embryonic morphological development on fetal growth parameters: the Rotterdam Periconceptional Cohort (Predict Study)
Publication date: Available online 21 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Francesca Parisi, Melek Rousian, Anton H.J. Koning, Sten P. Willemsen, Eric A.P. Steegers, Régine P.M. Steegers-TheunissenAbstractResearch questionIs embryonic morphological development according to the Carnegie stages associated with pregnancy outcome?DesignIn a tertiary hospital-based cohort, 182 singleton non-malformed pregnancies were selected. Serial transvaginal three-dimensional ultrasound (3D-US) scans were carried out between 6+0 and 10+2 gestational weeks. Embryonic development was annotated according to th...
Source: Reproductive BioMedicine Online - February 8, 2019 Category: Reproduction Medicine Source Type: research

A comparison of 2 months pretreatment with GnRH agonists with or without aromatase inhibitor in women with ultrasound-diagnosed ovarian endometriomas undergoing IVF
ConclusionsThe combination of depo-leuprolide acetate monthly for 60 days combined with daily letrozole has better clinical outcomes at IVF in women with endometriomas than depo-leuprolide acetate treatment alone. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 7, 2019 Category: Reproduction Medicine Source Type: research

Assessment of a double freezing approach in the management of surplus embryos in IVF
Publication date: Available online 8 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacob Farhi, Shai Elizur, Michal Yonish, Daniel S Seidman, Adrian Shulman, Eyal Schiff, Raoul OrvietoAbstractResearch questionWhat pregnancy rates are achieved after transfer of cryopreserved double slow-frozen embryos in IVF cycles? Patients in whom surplus thawed cleaved embryos (day 2 or 3) were grown to the blastocyst stage, re-frozen and then re-thawed for transfer (double freezing) were included.DesignData were collected on all patients who had undergone the above procedure at the IVF unit of Assuta Ramat Hachayal Hosp...
Source: Reproductive BioMedicine Online - February 6, 2019 Category: Reproduction Medicine Source Type: research

The effect of different temperature conditions on human embryosin vitro: two sibling studies
ConclusionCulture in an incubator with CTR does not improve fertilization rate or embryo quality. Embryo culture at 36.6°C or 37.1°C showed similar embryo development. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 1, 2019 Category: Reproduction Medicine Source Type: research

Does theFMR1 gene affect IVF success?
Publication date: Available online 10 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lisa M Pastore, Mindy S Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y Maher, William G KearnsAbstractFMR1 CGG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide rep...
Source: Reproductive BioMedicine Online - January 31, 2019 Category: Reproduction Medicine Source Type: research

Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cyst
Publication date: Available online 31 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Khaleque N Khan, Kazuo Yamamoto, Akira Fujishita, Akemi Koshiba, Haruo Kuroboshi, Satomi Sakabayashi, Satoshi Teramukai, Masahiro Nakashima, Jo KitawakiAbstractResearch questionIs there any relationship between the numbers of FOXP3+ regulatory T-cells (Treg) and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cyst?DesignThis is a retrospective cohort study and prospective case-controlled biological research. Peritoneal lesions and peritoneal fluid (PF) were collected from 27 women with ovarian...
Source: Reproductive BioMedicine Online - January 31, 2019 Category: Reproduction Medicine Source Type: research

Does Stress Affect IVF outcomes? A Prospective Study Assessing Cortisol Levels and Stress Questionnaires for Women Undergoing Through IVF Treatments
ConclusionIt can be cautiously concluded that physiological and psychological stress do not negatively affect IVF outcomes. Moreover, high follicular cortisol levels might have positive effects on pregnancy rates. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 31, 2019 Category: Reproduction Medicine Source Type: research

Live birth rates with a freeze-only strategy versus fresh embryo transfer: secondary analysis of a randomized clinical trial
ConclusionsSerum progesterone level on the day of trigger may have potential as a biomarker on which to base a prospective decision about whether to use a freeze-only or fresh embryo transfer strategy in women undergoing IVF. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 28, 2019 Category: Reproduction Medicine Source Type: research

Comparison of perinatal outcomes following blastocyst stage vs cleavage stage embryo transfer: 10 years data analysis from a single center
Publication date: Available online 25 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Wenhao Shi, Wei Zhang, Na Li, Xia Xue, Chen Liu, Pengfei Qu, Juanzi Shi, Chen HuangAbstractResearch QuestionIs there a risk of perinatal outcomes and congenital malformations after blastocyst transfer compared with cleavage stage embryo transfer in IVF?DesignThis was a retrospective cohort analysis form an ART center in a public hospital of China. All conceived women (15,254) and newborns (16,213) from IVF/ICSI cycles with cleavage embryo transfer or blastocyst transfer were included during 2006–2015. Outcome measureme...
Source: Reproductive BioMedicine Online - January 26, 2019 Category: Reproduction Medicine Source Type: research

Variation analysis of theTMEM150B gene in Chinese women with premature ovarian insufficiency
ConclusionThe results suggest that the perturbations in the TMEM150B gene are not a common explanation for POI in Chinese women. The role of autophagy in the pathogenic mechanism of POI needs further exploration. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 24, 2019 Category: Reproduction Medicine Source Type: research

Bureaucratic overheating is a parasite hampering modern clinical research – a viewpoint from the ‘belly of the beast’
Publication date: Available online 2 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Peter Humaidan, Thor HaahrAbstractClinical researchers in Europe are experiencing an increasing amount of bureaucracy, which in our eyes has now reached surrealistic heights, hampering the future of research, and thus, the development of new treatment regimens and advances in clinical research. In the long term, the current approval and control processes will negatively impact patient care, education, academia and the health economy of our countries. Thus, a debate is necessary including not only healthcare workers, but also ...
Source: Reproductive BioMedicine Online - January 24, 2019 Category: Reproduction Medicine Source Type: research

Early blastocyst expansion in euploid and aneuploid human embryos: evidence for a non-invasive and quantitative marker for embryo selection
Publication date: Available online 23 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): TTF Huang, DH Huang, HJ Ahn, C Arnette, CTF HuangAbstractResearch QuestionHow can the kinetics of human blastocyst expansion be used to evaluate an embryo's ploidy identified using PGT-A?DesignThis was a retrospective observational study of 188 autologous blastocysts from 34 sequential treatment cycles using PGT-A and blastocyst biopsy. Using time lapse imaging, blastocyst expansion was evaluated using a quantitative, standardized expansion assay (qSEA). Trophectoderm cell division was examined in selected, unbiopsied embryo...
Source: Reproductive BioMedicine Online - January 23, 2019 Category: Reproduction Medicine Source Type: research

Progesterone to number of mature oocyte index is a better predictor of live birth than blood progesterone level in GnRH antagonist protocols
Publication date: Available online 23 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Cynthia Simon, Lise Branet, Jessika Moreau, Nicolas Gatimel, Clementine Cohade, Florence Lesourd, Jean Parinaud, Roger LeandriABSTRACTResearch questionWhat is the part of blood progesterone (P) level and progesterone to mature oocytes index (PMOI) in in-vitro fertilization (IVF) outcomes.DesignClinical data from 960 couples undergoing their first fresh embryo transfer after an ICSI (intracytoplasmic sperm injection) attempt performed between September 2012 and July 2017 were analysed. All patients underwent ovarian stimulati...
Source: Reproductive BioMedicine Online - January 23, 2019 Category: Reproduction Medicine Source Type: research

Protective effect of estrogen receptor α-PvuII transition against idiopathic male infertility: A case-control study and meta-analysis
CONCLUSIONThe ERα-PvuII polymorphism could be considered as a possible protective factor against male infertility. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 23, 2019 Category: Reproduction Medicine Source Type: research

Meet our new editor: ProfessorFelice Petraglia
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 22, 2019 Category: Reproduction Medicine Source Type: research

Dual stimulation using corifollitropin alfa in 54 Bologna criteria poor ovarian responders – a case series
ConclusionsLuteal phase stimulation results in more oocytes in poor responders compared with follicular phase stimulation. DuoStim, using corifollitropin alfa followed by individualized FSH dosing, appears to be an alternative to conventional follicular phase stimulation, decreasing the risk of cycle cancellation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 22, 2019 Category: Reproduction Medicine Source Type: research

Regulating ART: time for a re-think in the light of increasing efficacy, safety and efficiency
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): John L Yovich, Robert Casper, Michael Chapman, Jan Tesarek, Richard A Anderson (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Hormonal medication in medically assisted reproduction: a systematic review of assessments from patients
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kay Lankreijer, Thomas M D'Hooghe, Silke Apers, Walter Sermeus, Sjoerd Repping, Eline AF DancetAbstractSeveral hormonal fertility medications have comparable effectiveness. A literature review was conducted into patients’ assessments regarding seven medication characteristics including ‘side effects’ and ‘ease of use’. Medline, CINAHL and PsycINFO were searched for female fertility patients’ written assessments of a hormonal medication. The tools used were appraised and common (i.e. ≥10...
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Meet our new editor: Professor Felice Petraglia
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Felice Petraglia (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Meet our new editor: Professor Marinus JC Eijkemans
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): René Eijkemans (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Meet our new editor: Professor Christopher Barratt
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Christopher Barratt (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Overnight ovarian tissue transportation for centralized cryobanking: a feasible option
ConclusionsOvernight transportation for central cryobanking is a feasible concept that results in high reproducible success rates through standardized professional tissue freezing and storage. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Another new year
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): Bart Fauser, Mina Alikani, Richard Anderson, Sarah Franklin, Martin H. Johnson, Juan Garcia Velasco (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Thanks to our Referees
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Omega-3 polyunsaturated fatty acids and IVF treatment
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): Amir Lass, Andrea BelluzziAbstractOmega-3 polyunsaturated fatty acids (PUFAs) are essential fatty acids, derived mostly from fish oil, that have a significant anti-inflammatory effect. Data from animal studies support their role in the reproductive mechanism, and recent human studies suggest a positive effect on sperm quality and natural conception. Their general role in human fertility, and specifically in IVF treatment, however, is not clear. A few small, prospective cohort studies have examined the relationship between se...
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Follicular fluid progesterone level associated with fertilization outcome during in vitro fertilization: a systematic review and meta-analysis
Publication date: Available online 17 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Bernadett Nagy, Laszlo Poto, Nelli Farkas, Miklos Koppan, Akos Varnagy, Kalman Kovacs, Szilard Papp, Noemi Bohonyi, Jozsef BodisAbstractFollicular fluid (FF) is a key biochemical environment for oocyte development. The potential effect of follicular progesterone level on successful fertilization is a subject of debate, therefore our aim was to give a summary on the currently available evidence on the association between FF progesterone level and fertilization outcome.To do so, a systematic review and a meta-analysis were per...
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Hyperhomocysteinemia and metabolic syndrome show differences in ovulation, conception, pregnancy loss and live birth in women with PCOS: a secondary analysis of PCOSAct
ConclusionsIn PCOS patients, HHCY contributes to increased pregnancy loss and reduced ovulation, and MS was related to defects in ovulation, conception, pregnancy, pregnancy loss and live birth, indicating that the two conditions lead to defects at different reproductive stages. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Double stimulation in poor responders: a cause for concern?
Publication date: Available online 18 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Tarek El-Toukhy, Omar El Tokhy (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

The IVF-LUBE trial – a randomized trial to assess Lipiodol® uterine bathing effect in women with endometriosis or repeat implantation failure undergoing IVF
ConclusionsNo evidence was found of benefit of Lipiodol prior to fresh embryo transfer in women with endometriosis or RIF. It is suggested that this treatment should not be undertaken purely as an adjuvant in IVF other than in the context of a further well-designed RCT. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 16, 2019 Category: Reproduction Medicine Source Type: research

Does the FMR1 gene affect IVF success?
Publication date: Available online 10 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lisa M Pastore, Mindy S Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y Maher, William G KearnsAbstractFMR1 CCG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide rep...
Source: Reproductive BioMedicine Online - January 15, 2019 Category: Reproduction Medicine Source Type: research

Evaluating if ovulation suppression with progestins is cost effective compared to GnRH analogs in assisted reproduction cycles
ConclusionsOvulation inhibition in IVF using progestins requires a freeze only approach of embryos, and thus progestin use was not cost-effective compared to fresh embryo transfer cycles. However, progestins may be cost-effective compared to GnRH antagonist in planned freeze only cycles such as in PGT or fertility preservation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 12, 2019 Category: Reproduction Medicine Source Type: research

Knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in young BRCA-mutated breast cancer patients: results from the BCY3/BCC 2017 survey
Publication date: Available online 10 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Matteo Lambertini, Massimo Di Maio, Francesca Poggio, Olivia Pagani, Giuseppe Curigliano, Lucia Del Mastro, Shani Paluch-Shimon, Sibylle Loibl, Ann H. Partridge, Jr. Hatem A. Azim, Fedro A. Peccatori, Isabelle DemeestereABSTRACTResearch questionWe explored the knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in young BRCA-mutated breast cancer (BC) patients.DesignPhysicians attending two international BC conferences were asked to complete a 26-item questionnaire exploring fertili...
Source: Reproductive BioMedicine Online - January 11, 2019 Category: Reproduction Medicine Source Type: research

Germ cell arrest associated with aSETX mutation in ataxia oculomotor apraxia type 2
We describe the first case of human male infertility caused by germ cell arrest in a man with AOA2. Our patient has a homozygous mutation in the SETX gene (NC_000009.11:g.135158775dup), which results in a frameshift and premature protein termination (NM_015046.6:c.6422dup, p.[Ser2142Glufs*23]). In accordance with the murine phenotype, testis histology revealed disrupted seminiferous tubules with spermatogonia and primary spermatocytes, but absent spermatids. Collectively, these data support an essential role of senataxin in human spermatogenesis, and provide a compelling case that men with AOA2 should be cou...
Source: Reproductive BioMedicine Online - January 10, 2019 Category: Reproduction Medicine Source Type: research

Live births following genome editing in human embryos: a call for clarity, self-control and regulation
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Helen C O'Neill, Jacques Cohen (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 9, 2019 Category: Reproduction Medicine Source Type: research

Effect of oocyte morphology on post-warming survival and embryo development in vitrified autologous oocytes
ConclusionOocyte dysmorphisms did not seem to affect survival, fertilization and embryo development in vitrified autologous oocytes, and yielded comparable results to the morphologically normal oocytes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 9, 2019 Category: Reproduction Medicine Source Type: research

Consultation and Treatment Behavior of Infertile Couples in China: a population-based study
ConclusionWe conclude that the prevalence of infertility in China is high, but the uptake of treatment was relatively low. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 9, 2019 Category: Reproduction Medicine Source Type: research

Evaluation of next-generation sequencing–based preimplantation genetic diagnosis for balanced reciprocal translocation carriers
ConclusionsCNV-Seq-based NGS is an efficient and reliable PGD method for balanced reciprocal translocation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

Maternal β-hCG levels in early IVF pregnancy: association with the embryo development stage of blastocyst
Publication date: Available online 8 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Wenyue Zhu, Queenie Yeung, David Chan, Ling Chi, Jin Huang, Qiong Wang, Jacqueline Chung, TC LiAbstractResearch QuestionDoes the development stage of the blastocyst on embryo transfer (ET) day affect the serum β-human chorionic gonadotropin (β-hCG) level 9 days and 16 days after embryo transfer in women whose pregnancy progressed to beyond 13 weeks?DesignThe retrospective study involved 204 cases whose pregnancy progressed to beyond 13 weeks of single blastocyst transfer in fresh (n=66) or frozen (n=138) cycles in a...
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

The high-risk human Papillomavirus continuum along the female reproductive tract and its relationship to infertility and endometriosis
ConclusionsThis study demonstrate that there is an association between hrHPV infections in the UGT with infertility, particularly with endometriosis. It also show a possible continuum hrHPV infection, from LGT to UGT. It suggest future larger studies that could fully investigate the role of hrHPV as an eventual cause of endometriosis and infertility. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

A multicenter evaluation of the Elecsys® AMH immunoassay for prediction of antral follicle count
ConclusionThe Elecsys® AMH immunoassay provides a robust and fully automated method to measure serum AMH levels. Women with AMH values below the cut-off of 1.77 ng/mL are unlikely to have AFC>15. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research