Meet our new editor: Professor Nick Macklon
Publication date: Available online 3 December 2019Source: Reproductive BioMedicine OnlineAuthor(s): Nick Macklon (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 4, 2019 Category: Reproduction Medicine Source Type: research

Alternative patterns of partial embryo compaction: prevalence, morphokinetic history and possible implications
ConclusionsAlternative modalities of incomplete compaction were detected for the first time. Such patterns are characterized by different morphokinetic behaviours overarching the entire preimplantation development and by different developmental abilities. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 1, 2019 Category: Reproduction Medicine Source Type: research

In cases of familial primary ovarian insufficiency and disorders of gonadal development, consider NR5A1/SF-1 sequence variants
ConclusionSequence variation of the NR5A1 gene is a possibility that must be considered when a woman with POI or a diminished ovarian reserve has a family member or child with DGD. If a variant is identified, genetic counselling is essential for the patient and his/her family. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 30, 2019 Category: Reproduction Medicine Source Type: research

Cancer in IVF patients treated at age 40 and older: long term follow up
Conclusions: In this study, IVF treatment in older women was not found to be significantly associated with an excess risk of cancer at long term follow up. However, further studies are needed to confirm these findings. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 30, 2019 Category: Reproduction Medicine Source Type: research

Prevalence of thyroid autoimmunity and effect of levothyroxine treatment in a cohort of 1064 patients with recurrent pregnancy loss
ConclusionsTreatment of hypothyroidism in pregnancy should be initiated based on a TSH> 4 mIU/L. Treatment initiation based on thyroid autoimmunity or a TSH> 2.5 mIU/L may result in overtreatment. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 30, 2019 Category: Reproduction Medicine Source Type: research

Association between body mass index and oocyte maturation in patients triggered with GnRH agonist who are at high risk for severe ovarian hyperstimulation syndrome: an observational cohort study
ConclusionsAmong women at high risk for developing severe OHSS who are triggered with a standard dose (0.2 mg) of the GnRH agonist triptorelin, women with BMI 25 kg/m2 or greater had significantly fewer mature oocytes, required a higher total dose of recombinant FSH compared with women with BMI less than 25 kg/m2. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Polycystic ovarian syndrome novel proteins and significant pathways identified using graph clustering approach
ConclusionsThese results support that this approach can provide additional insight into the pathobiology of PCOS and these pathways have both biological and statistical support to its pathobiology. Thus, integrative analysis is able to unravel unknown mechanisms towards the development of accurate diagnosis and effective treatment in PCOS.Graphical abstract (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Drug- free in vitro activation of follicles and fresh tissue autotransplantation as a therapeutic option in primary ovarian insufficiency patients
ConclusionsDrug-Free IVA can be a useful therapeutic option in POI patients with hopeful IVF outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Analysis of 122 triplet and 1 quadruplet pregnancies after single embryo transfer in Japan
Publication date: Available online 29 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Satoko Yamashita, Yuko Ikemoto, Asako Ochiai, Satoshi Yamada, Keiichi Kato, Motoharu Ohno, Tomoya Segawa, Yoshiharu Nakaoka, Mayumi Toya, Satoshi Kawachiya, Yoshiaki Sato, Toshifumi Takahashi, Shigeto Takeuchi, Mari Nomiyama, Chisa Tabata, Toshihiro Fujiwara, Sumihide Okamoto, Toshihiro Kawamura, Jun Kawagoe, Mitsutoshi YamadaAbstractResearch questionTo estimate the prevalence of triplet and quadruplet pregnancies after single embryo transfer (SET) in Japan.DesignWe conducted a retrospective observational study on 274,605 p...
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Adenomyotic glands are highly related to endometrial glands
CONCLUSIONSTaken together, our results show that the protein expression pattern of adenomyosis is nearly identical to those of the endometrium with and without endometriosis externa thus suggesting endometrial glands as the main source for adenomyotic glands. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

The influence of stage and grade of breast cancer on fertility preservation outcome in reproductive aged women
ConclusionsHigh-grade breast cancer has a negative effect on the total number of mature oocytes and cryopreserved embryos. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

A follow-up survey on the reproductive intentions and experiences of women undergoing planned oocyte cryopreservation
ConclusionsPlanned oocyte cryopreservation as a prophylactic intervention to reduce the risk of infertility at a later age appears to be generally well received by women who are mostly single and who wish to “buy time” while they seek a suitable partner to create a family. The majority of women who underwent OoC do not regret their experience and many have found a partner in subsequent years. The overall positive attitude of our respondents towards planned OoC contrasts with the paucity of published data pertaining to the efficacy of this approach in terms of live birth rates. Twenty-one percent of respondents ...
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

The Effect of Intra-Ovarian Androgen Priming on Ovarian Reserve Parameters in Bologna Poor Responders
ConclusionsLong-term intra-ovarian androgen priming in the current set-up had no significant effect on hormone levels, AFC and recruitable follicles after ovarian stimulation in Bologna POR patients undergoing IVF. Further studies are needed to explore other androgen priming protocols and the clinical value of priming regimens in IVF. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Ethnic discordance in serum müllerian hormone (AMH) in healthy women; population study from China and Europe
ConclusionsThere were independent effects of age and ethnicity on serum AMH concentrations, with Chinese women having a substantially lower AMH in adult life than their European counterparts from age 25 onwards. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 29, 2019 Category: Reproduction Medicine Source Type: research

Time-lapse imaging of cytoplasmic strings at the blastocyst stage indicates their association with spontaneous collapse
Publication date: Available online 28 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ebner T, Sesli O, Kresic S, Enengl S, Stoiber B, Reiter E, Oppelt P, Mayer RB, Shebl OAbstractResearch questionTo study the origin and temporal behaviour of cytoplasmic strings spanning the blastocoel (main objective) and their influence on treatment outcome (secondary objective).DesignThis retrospective analysis of prospectively collected data was set up in a university medical centre. Patients who either underwent fresh (n = 95) or vitrified/warmed (n = 55) single blastocyst transfer were included. Time-lapse sequ...
Source: Reproductive BioMedicine Online - November 28, 2019 Category: Reproduction Medicine Source Type: research

Ovarian reserve markers after discontinuing long-term use of combined oral contraceptives
Publication date: Available online 15 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): Selma Kloeve Landersoe, Kathrine Birch Petersen, Anne Lyngholm Sørensen, Elisabeth Clare Larsen, Torben Martinussen, Stine Aagaard Lunding, Mie Stougaard Kroman, Henriette Svarre Nielsen, Anders Nyboe AndersenAbstractResearch questionHow early do the ovarian reserve markers anti-Müllerian hormone (AMH) and antral follicle count (AFC) normalize after discontinuation of the long-term use of combined oral contraceptives (COC).DesignThis was a prospective cohort study of 68 women with a history of long-term COC use. ...
Source: Reproductive BioMedicine Online - November 28, 2019 Category: Reproduction Medicine Source Type: research

In-vitro development of embryos derived from vitrified–warmed oocytes is delayed compared with embryos derived from fresh oocytes: a time-lapse sibling oocyte study
ConclusionsTiming of development is altered and blastocyst formation is delayed in embryos derived from vitrified–warmed donor oocytes compared with their fresh sibling counterparts. Although preliminary results suggest that the clinical impact of this delay may be limited, this needs further investigation in larger randomized studies. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 23, 2019 Category: Reproduction Medicine Source Type: research

Endometrial thickness and IVF cycle outcomes: a meta-analysis
Publication date: Available online 18 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ge Gao, Xianfeng Cui, Shuang Li, Pan Ding, Shuai Zhang, Yunshan ZhangAbstractResearch questionIn this meta-analysis, the association between endometrial thickness (EMT) and cycle outcomes after IVF is explored. Associations between EMT and cycle outcomes according to study and individual characteristics were also assessed.DesignStudies evaluating associations between EMT and pregnancy, implantation, miscarriage, live birth or ongoing pregnancy and ectopic pregnancy rates in individuals after IVF were identified on PubMed, ...
Source: Reproductive BioMedicine Online - November 21, 2019 Category: Reproduction Medicine Source Type: research

‘There is only one thing that is truly important in an IVF laboratory: everything’ Cairo Consensus Guidelines on IVF Culture Conditions
Publication date: Available online 10 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Cohen, Cairo 2018 Consensus GroupAbstractThis proceedings report presents the outcomes from an international expert meeting to establish consensus guidelines on IVF culture conditions. Topics reviewed and discussed were: embryo culture – basic principles and interactions; temperature in the IVF laboratory; humidity in culture; carbon dioxide control and medium pH; oxygen tension for embryo culture; workstations – design and engineering; incubators – maintaining the culture environment; micromanipula...
Source: Reproductive BioMedicine Online - November 20, 2019 Category: Reproduction Medicine Source Type: research

Cross-disorder analysis of endometriosis and its comorbid diseases reveals shared genes and molecular pathways and proposes putative biomarkers of endometriosis
Conclusionsour study results highlight the molecular processes underlying the etiopathogenesis of endometriosis and its comorbid conditions, and identify putative endometriosis biomarkers. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 20, 2019 Category: Reproduction Medicine Source Type: research

Transvaginal hydrolaparoscopy and laparoscopy
ConclusionTHL in an outpatient setting can detect anatomical abnormalities comparable to the, more invasive, reference standard diagnostic laparoscopy. If THL succeeds, there is no need to add a diagnostic laparoscopy in the work-up. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 17, 2019 Category: Reproduction Medicine Source Type: research

HPV infection and female Infertility: A systematic Review and meta-Analysis
Publication date: Available online 16 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Shuang Yuan, Yichao Qiu, Yuanyuan Xu, Hongjing WangAbstractIncreasing evidence shows that HPV infection affects reproductive health and fertility, although its impact on female fertility has not been thoroughly studied. We conducted a meta-analysis of 12 studies including 15450 female subjects that compared HPV prevalence between the infertile and general population, and evaluated the association between HPV positivity and female infertility. Seven case-controlled studies on 3581 participants reported indiscriminate genotyp...
Source: Reproductive BioMedicine Online - November 16, 2019 Category: Reproduction Medicine Source Type: research

Factors related to early spontaneous miscarriage during IVF/ICSI treatment: an analysis of 21,485 clinical pregnancies
Publication date: Available online 14 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Zhiqin Bu, Linli Hu, Yingchun Su, Yihong Guo, Jun Zhai, Yingpu SunAbstractResearch questionThe aim was to investigate factors related to early spontaneous miscarriage during in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) treatment.DesignA total of 21,485 clinical pregnancy cycles were included in the analysis. First, early spontaneous miscarriage rates were compared among different groups according to female age, body mass index (BMI), number of previous miscarriages, etc. Then, the spontaneous miscar...
Source: Reproductive BioMedicine Online - November 14, 2019 Category: Reproduction Medicine Source Type: research

Cannabis consumption might exert deleterious effects on sperm nuclear quality in infertile males
ConclusionsCannabis consumption might have deleterious effects on sperm nuclear quality in infertile males by increasing numerical chromosome abnormalities and DNA fragmentation. Cannabis consumption induces additional detrimental effects on the progression of spermatogenesis from meiotic stages to spermiogenesis and potentially on post-testicular sperm maturation in infertile males. However, any potential findings need to be validated with larger sample size and our data are only exploratory findings. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 14, 2019 Category: Reproduction Medicine Source Type: research

Birthweight of IVF children is still a current issue and still related to maternal factors
ConclusionsMaternal background and obstetric parameters are more likely to influence the SGA rate than fresh embryo transfer conception. FET conception could be associated with an increase in LGA rate. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 12, 2019 Category: Reproduction Medicine Source Type: research

Drug-free in-vitro activation of follicles for infertility treatment in poor ovarian response patients with decreased ovarian reserve
ConclusionsThe present drug-free IVA approach may be suitable for POR patients with DOR, as it increased the number of antral follicles. The procedure also eliminated the need for 2-day incubation with drugs and required only one surgery. This approach could allow the retrieval of more oocytes in middle-aged women to achieve higher pregnancy rates and deserves proper evaluation in future randomized controlled trials. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 10, 2019 Category: Reproduction Medicine Source Type: research

Female age affects the utility of sperm DNA fragmentation in predicting IVF and ICSI outcomes
ConclusionFemale age has a negative effect and should be considered in predicting the effects of sperm DNA fragmentation on pregnancy outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 10, 2019 Category: Reproduction Medicine Source Type: research

Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes
ConclusionsVitrified–warmed mouse oocytes display reduced Ca2+-releasing potential upon oocyte activation, caused by cryoprotectant exposure. With adapted classification criteria, these oocytes could be used for diagnosing oocyte activation deficiencies in patients. Evaluating the Ca2+-signalling machinery in vitrified–warmed human oocytes is required. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 10, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: November 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 5Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 9, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: November 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 5Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 9, 2019 Category: Reproduction Medicine Source Type: research

Cryopreserving testicular tissue is the preferred method to preserve SSCs prior to spermatogonial stem cell transplantation.
Conclusion(s)Cryopreservation of TT is the preferred method to cryopreserve spermatogonial stem cells (SSCs) prior to SSCT. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 7, 2019 Category: Reproduction Medicine Source Type: research

Impact of the mode of conception on gestational hypertensive disorders at very advanced maternal age
Publication date: Available online 7 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): R. Meyer, R. Orvieto, Y. Timerman, T. Gorodesky, S. Toussia-Cohen, A. Kedem, M.J. Simchen, R. MachtingerAbstractResearch questionTo study gestational hypertensive disorders in oocyte donation pregnancies compared with other modes of conception at very advanced maternal age.DesignA historical cohort study of all women aged 45-47 years who gave birth to singletons at a tertiary medical center between 3.2011-5.2018, at 24 weeks gestation or later. Pregnancy outcomes were compared between donor oocyte (IVF-OD), IVF using autolog...
Source: Reproductive BioMedicine Online - November 7, 2019 Category: Reproduction Medicine Source Type: research

Qualitative and quantitative aspects of sex life in the context of endometriosis: a multicentre case control study
Publication date: Available online 7 November 2019Source: Reproductive BioMedicine OnlineAuthor(s): Valerie Bernays, Alexandra Kohl Schwartz, Kirsten Geraedts, Martina Rauchfuss, Monika Maria Wölfler, Felix Haeberlin, Stephanie von Orelli, Markus Eberhard, Bruno Imthurn, Daniel Fink, Patrick Imesch, Brigitte LeenersAbstractResearch questionWhat are the specific characteristics of sexual activity in women with endometriosis compared to women without endometriosis?DesignMulticentre case control study. Participants were recruited in university hospitals, district hospitals, and doctor's offices in Germany, Switzerland an...
Source: Reproductive BioMedicine Online - November 7, 2019 Category: Reproduction Medicine Source Type: research

First trimester depression and/or anxiety disorders increase the risk of low birthweight in IVF offspring: a prospective cohort study
Publication date: Available online 11 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Jingwen Lang, Bingqian Zhang, Yueru Meng, Yanzhi Du, Linlin Cui, Weiping LiAbstractResearch questionAre maternal depression and/or anxiety disorders (MDAD) before and during pregnancy associated with IVF outcomes?DesignA total of 5661 women starting their first IVF cycle between 15 August 2014 and 31 December 2015 were pooled from a prospective cohort of IVF-conceived children. The self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to determine MDAD. IVF outcomes were compared between MDAD+ an...
Source: Reproductive BioMedicine Online - November 6, 2019 Category: Reproduction Medicine Source Type: research

Investigation of soluble anti-Müllerian hormone receptor type 2 as a biomarker for diagnosis of female fertility disorders
Publication date: Available online 27 August 2019Source: Reproductive BioMedicine OnlineAuthor(s): Lena Sophie Olivier, Osman Evliyaoglu, Ralf Weiskirchen, Josef van HeldenAbstractResearch questionThe ectodomain of the anti-Müllerian hormone (AMH) type 2 receptor is shed by proteases under certain conditions, which makes it measurable in the blood. The aim of this study was to identify correlations of soluble anti-Müllerian hormone receptor type 2 (sAMHR2) with other sex hormone concentrations and to assess whether sAMHR2 may serve as a new biomarker in fertility disorders.DesignIn a retrospective cross-sectional...
Source: Reproductive BioMedicine Online - November 3, 2019 Category: Reproduction Medicine Source Type: research

Identification of research priorities in infertility and assisted reproduction: an international, multicenter study
CONCLUSIONSResearchers and clinicians should keep in mind that, in addition to success rates and safety, patients greatly value research on causes, prevention and emotional aspects of infertility. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 1, 2019 Category: Reproduction Medicine Source Type: research

Mapping research in assisted reproduction worldwide
ConclusionsWe identify here the current hot topics on Human Assisted Reproduction worldwide and their temporal trends for 2005-2016. We provide an innovative picture of the current research that could help to explore the areas where further research is needed. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 1, 2019 Category: Reproduction Medicine Source Type: research

How common is real Repeated Implantation Failure? An indirect estimate of the prevalence
ConclusionsBased on our analyses, the estimated prevalence of RIF is 15%. The frequently used definition of RIF based on three failed attempts (but not two) in good prognosis couples seems justified. However, physicians should keep in mind that couples may be inappropriately labeled with this condition in one out of four cases. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 29, 2019 Category: Reproduction Medicine Source Type: research

Short Versus Extended Progesterone Supplementation for Luteal Phase Support in fresh IVF cycles: a systematic review and meta-analysis
Publication date: Available online 24 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): M Watters, M Noble, T Child, SM NelsonAbstractThis review and meta-analysis aims to assess the effect of prolonged progesterone support on pregnancy outcomes in women undergoing a fresh embryo transfer after IVF/ICSI.Two independent reviewers searched EMBASE, MEDLINE and grey literature from inception to January 2019 for RCTs of prolonged progesterone support vs early cessation. Risk of bias was assessed. Outcome measures were live birth, miscarriage and ongoing pregnancy rate. Study protocol CRD42018088605.Seven trials invo...
Source: Reproductive BioMedicine Online - October 25, 2019 Category: Reproduction Medicine Source Type: research

Large for gestational age is male gender dependent in artificial frozen embryo transfers cycles – a cohort study of 1295 singleton live births
Publication date: Available online 24 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Peter Humaidan, Kevin CoetzeeAbstractResearch QuestionTo investigate the effect of FET on infant birth weight outcomes and to identify the variables predicting large for gestational age (LGA) infants.DesignIn a large cohort study, the birth weight of 1295 singleton live births from blastocyst freeze-all-IVF treatments performed between February 2015 and February 2017 at a single IVF centre were analyzed. All embryo transfers were performed as vitrified-warmed blastocyst transfers ...
Source: Reproductive BioMedicine Online - October 25, 2019 Category: Reproduction Medicine Source Type: research

Replacing hMG/FSH by low dose hCG to complete corifollitropin alfa stimulation substantially reduces the cost per clinical pregnancy of IVF: a randomised pragmatic trial
ConclusionThis study provides evidence that using hCG instead of hMG/FSH for COS results in a significant reduction of the in cost of IVF with, at least, an equivalent pregnancy outcome. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 25, 2019 Category: Reproduction Medicine Source Type: research

Pathogenesis of Endometriosis: look no further than John Sampson
Publication date: Available online 24 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): John L Yovich, Philip K Rowlands, Sunthra Lingham, Mark Sillender, Shanthi SrinivasanAbstractRather than consider endometriosis as an enigmatic disease, reading John Sampson's two theories/ mechanisms explains virtually all cases affecting the female. It is true that Sampson's most recent, 1940 publication, that of retrograde menstruation via the fallopian tubes, clearly fails to explain many types of endometriosis, particularly that located in extra-pelvic sites. However, his earlier publications of 1911 and 1912 on radiogr...
Source: Reproductive BioMedicine Online - October 25, 2019 Category: Reproduction Medicine Source Type: research

Risk factors associated with pre-eclampsia in pregnancies conceived by ART
ConclusionsFrozen embryo transfer was an independent risk factor of pre-eclampsia in assisted reproductive technology. The high ovarian response may also increase the risk of pre-eclampsia. The embryo stage at transfer was not related to the risk of pre-eclampsia. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 23, 2019 Category: Reproduction Medicine Source Type: research

Use of granulocyte colony-stimulating factor in ART treatment does not increase the risk of adverse perinatal outcomes
Publication date: Available online 19 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): María Cruz, Diana Alecsandru, Juan Antonio García-Velasco, Antonio RequenaAbstractResearch questionGranulocyte colony-stimulating factor (G-CSF) acts on reproductive function at different stages, but its effects on the early stages of embryo development are unknown. The aim of this study was to assess the effect of G-CSF administration during treatment with assisted reproductive technologies (ART) and early pregnancy on newborns.DesignRetrospective study in women undergoing egg donation treatment, with a stud...
Source: Reproductive BioMedicine Online - October 23, 2019 Category: Reproduction Medicine Source Type: research

HMG versus recombinant FSH plus recombinant LH in ovarian stimulation for IVF: does the source of LH preparation matter?
Publication date: Available online 11 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Raoul OrvietoAbstractStudies on the role of LH supplementation in patients undergoing assisted reproductive technique use different sources of LH bioactivity-containing preparations, daily doses and modes of administration. This review aims to critically present the available evidence comparing the effect of the two commercially available LH preparations (human menopausal gonadotrophin [HMG] and recombinant FSH + recombinant LH) with different sources of intrinsic LH bioactivity (HCG versus LH, respectively) on ovarian...
Source: Reproductive BioMedicine Online - October 19, 2019 Category: Reproduction Medicine Source Type: research

Evolution of Embryo Selection for IVF from Subjective Morphology Assessment to Objective Time-Lapse Algorithms Improves Chance of Live Birth.
ConclusionObjective TLIA is superior for the selection of embryos for their propensity to generate a live birth over a conventional, subjective blastocyst morphology scoring system (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 18, 2019 Category: Reproduction Medicine Source Type: research

When only one embryo is available, is it better to transfer on Day 3 or to grow on?
Publication date: Available online 21 August 2019Source: Reproductive BioMedicine OnlineAuthor(s): Joyce S Xiao, Martin Healey, Alon Talmor, Beverley VollenhovenAbstractResearch questionIn patients with only one embryo on Day 3 post-IVF treatment, does transferring the embryo into the uterine environment achieve a higher pregnancy rate than growing the embryo on with a plan to transfer at Day 4–6?DesignThis was a retrospective cohort study conducted in patients with only one viable embryo on Day 3 post-IVF treatment. Data were extracted from a standardized IVF database and included 1384 women who fulfilled this study...
Source: Reproductive BioMedicine Online - October 17, 2019 Category: Reproduction Medicine Source Type: research

Ovarian reserve markers after discontinuation of long-term use of combined oral contraceptives
Publication date: Available online 15 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): Selma Kloeve Landersoe, Kathrine Birch Petersen, Anne Lyngholm Sørensen, Elisabeth Clare Larsen, Torben Martinussen, Stine Aagaard Lunding, Mie Stougaard Kroman, Henriette Svarre Nielsen, Anders Nyboe AndersenAbstractResearch questionHow early does the ovarian reserve markers Anti-Müllerian hormone (AMH) and antral follicle count (AFC) normalize after discontinuation of long-term use of combined oral contraceptives (COC)DesignThis was a prospective cohort study of 68 women with a history of long-term COC use. Ser...
Source: Reproductive BioMedicine Online - October 16, 2019 Category: Reproduction Medicine Source Type: research

The association of BMI with oocyte maturation in high-risk for severe OHSS patients triggered with GnRH-agonist for final oocyte maturation: an observational cohort study
Publication date: Available online 15 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): G.T. Lainas, T.G. Lainas, I.A. Sfontouris, C.A. Venetis, K. Chatzimeletiou, G.F Grimbizis, B.C. Tarlatzis, E.M. KolibianakisAbstractResearch QuestionIs body-mass index (BMI) associated with oocyte maturation in women at high risk for developing severe ovarian hyperstimulation syndrome (OHSS) who are triggered with gonadotrophin releasing hormone (GnRH) agonist?DesignProspective observational cohort study.MethodsA total of 113 patients at high risk for severe OHSS (presence of at least 19 follicles≥11mm) pre-treated with G...
Source: Reproductive BioMedicine Online - October 16, 2019 Category: Reproduction Medicine Source Type: research

The impact of serum oestradiol concentration prior to progesterone administration on live birth rate in single vitrified–warmed blastocyst transfer cycles
ConclusionsSerum oestradiol concentration monitoring just prior to progesterone administration does not appear to be predictive for live birth rates in good prognosis patients undergoing single, autologous vitrified–warmed blastocyst transfer after artificial endometrial preparation. Therefore, the current practice of monitoring serum oestradiol concentration is not supported by this study. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 15, 2019 Category: Reproduction Medicine Source Type: research