Contents
Publication date: March 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 3Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 14, 2020 Category: Reproduction Medicine Source Type: research

Chief Editor's 2019 annual report
Publication date: March 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 3Author(s): Bart C.J.M. Fauser, Kamal K. Ahuja (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 14, 2020 Category: Reproduction Medicine Source Type: research

The effect of follicular phase length on cycle outcomes and endometrial development in gonadotrophin ovarian stimulation/intrauterine insemination cycles
Publication date: March 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 3Author(s): Jennifer B. Bakkensen, Georgios Christou, Irene Dimitriadis, Kaitlyn James, Irene Souter (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 14, 2020 Category: Reproduction Medicine Source Type: research

Analysis of 122 triplet and one quadruplet pregnancies after single embryo transfer in Japan
Publication date: March 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 3Author(s): Satoko Yamashita, Yuko Ikemoto, Asako Ochiai, Satoshi Yamada, Keiichi Kato, Motoharu Ohno, Tomoya Segawa, Yoshiharu Nakaoka, Mayumi Toya, Satoshi Kawachiya, Yoshiaki Sato, Toshifumi Takahashi, Shigeto Takeuchi, Mari Nomiyama, Chisa Tabata, Toshihiro Fujiwara, Sumihide Okamoto, Toshihiro Kawamura, Jun Kawagoe, Mitsutoshi Yamada (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 14, 2020 Category: Reproduction Medicine Source Type: research

Is early initiation of infertility treatment justified in women over the age of 35 years?
Publication date: March 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 3Author(s): Edgardo Somigliana, Andrea Busnelli, Paola Vigano, Walter Vegetti, Alice Goisis, Paolo Vercellini (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 14, 2020 Category: Reproduction Medicine Source Type: research

A technical note on the assessment of human sperm vitality using eosin-nigrosin staining
Publication date: Available online 10 March 2020Source: Reproductive BioMedicine OnlineAuthor(s): David Mortimer (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 11, 2020 Category: Reproduction Medicine Source Type: research

Cytoplasmic halo characteristics during fertilisation and their implications for human pre-implantation embryo development and pregnancy outcome
Publication date: Available online 9 March 2020Source: Reproductive BioMedicine OnlineAuthor(s): Kenji Ezoe, Cristina Hickman, Tetsuya Miki, Tadashi Okimura, Kazuo Uchiyama, Akiko Yabuuchi, Tamotsu Kobayashi, Giovanni Coticchio, Keiichi Kato (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 10, 2020 Category: Reproduction Medicine Source Type: research

Serum progesterone levels are associated with live birth rates in frozen-embryo transfer under artificial preparation. Are progesterone levels affected by other determinants?
Publication date: Available online 10 March 2020Source: Reproductive BioMedicine OnlineAuthor(s): I. González-Foruria, S. Gaggiotti-Marre, M. Álvarez, F. Martínez, S. García, I. Rodríguez, B. Coroleu, N.P. Polyzos (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 10, 2020 Category: Reproduction Medicine Source Type: research

A Primate Perspective on Oocytes and Transgenerational PCOS
Publication date: Available online 7 March 2020Source: Reproductive BioMedicine OnlineAuthor(s): Daniel A. Dumesic, Jennifer R. Wood, David H. Abbott, Jerome F. Strauss (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 8, 2020 Category: Reproduction Medicine Source Type: research

Adjustment for non-confounders could increase systematic error
Publication date: Available online 29 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Omar El Tokhy, Tarek El-Toukhy (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 1, 2020 Category: Reproduction Medicine Source Type: research

A prospective, randomized, controlled trial comparing two different treatments of intrauterine adhesions
Publication date: Available online 29 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Xiao-wan Huang, Meng-meng Lin, Hong-qin Zhao, Martin Powell, Yuan-qiu Wang, Ru-ru Zheng, Laura Burney Ellis, Wei-ting Xia, Feng Lin (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 29, 2020 Category: Reproduction Medicine Source Type: research

Modified natural cycle IVF is a reasonable alternative in women of advanced maternal age
Publication date: Available online 29 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Panagiotis Drakopoulos, Alessia Romito, Herman Tournaye, Christophe Blockeel (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 29, 2020 Category: Reproduction Medicine Source Type: research

The prevalence of adenomyosis in an infertile population; A cross-sectional study
Publication date: Available online 26 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Hatem Abu Hashim, Solafa Elaraby, Ashraf A. Fouda, Mohamed E.l. Rakhawy (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 27, 2020 Category: Reproduction Medicine Source Type: research

Reconstructing Robert Edwards: biography and the history of reproduction
Publication date: Available online 25 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Nick Hopwood (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 25, 2020 Category: Reproduction Medicine Source Type: research

Fertility in female cancer survivors: a systematic review and meta-analysis
Publication date: Available online 22 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Andrea BUSNELLI, Amerigo VITAGLIANO, Laura MENSI, Stefano ACERBONI, Alessandro BULFONI, Francesca FILIPPI, Edgardo SOMIGLIANAAbstractSeveral epidemiological studies investigated the effects of cancer therapies on fertility. However, conflicting data have been reported.The present systematic review and meta-analysis aims to determine the chances of childbirth in women survived from different types of cancer.We systematically searched Pubmed, MEDLINE, Embase and Scopus, from database inception to July 17, 2019, for published ...
Source: Reproductive BioMedicine Online - February 23, 2020 Category: Reproduction Medicine Source Type: research

In vitro maturation is a safer and succesfull treatment option in infertile women with multiple sclerosis
We report the first two patients, who underwent in vitro maturation protocol in order to avoid the exacerbation risk due to controlled ovarian stimulation at a large tertiary university hospital. Both patients were referred to our infertility clinic with the concern of multiple sclerosis exacerbation after or during controlled ovarian stimulation treatment. The patients underwent in vitro maturation protocol in order to avoid ovarian stimulating agents. Both patients gave birth to healthy babies at term. They did not suffer any multiple sclerosis relapses during their treatment and during pregnancy. Controlled ovarian stim...
Source: Reproductive BioMedicine Online - February 21, 2020 Category: Reproduction Medicine Source Type: research

Physical resolution of tubal ectopic pregnancy on ultrasound imaging following successful expectant management
ConclusionsPhysical resolution of tubal ectopic pregnancy is often prolonged and is positively correlated with initial and maximum β-hCG levels. Our results indicate that β-hCG resolution cannot be used as the end-point of expectant management of tubal ectopic pregnancy, which should be considered when counselling women and planning for future pregnancies.Key MessageIn a significant proportion, physical resolution of tubal ectopic pregnancy takes several weeks following the return of serum β-hCG to non-pregnant levels. Women should be advised to delay trying for another pregnancy for three months, to avoid r...
Source: Reproductive BioMedicine Online - February 21, 2020 Category: Reproduction Medicine Source Type: research

The association between follicle size and oocyte development as a function of final follicular maturation triggering
Publication date: Available online 20 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Aya Mohr-Sasson, Raoul Orvieto, Shlomit Blumenfeld, Michal Axelrod, Danielle Mor-Hadar, Leonti Grin, Adva Aizer, Jigal HaasAbstractResearch QuestionTo study the association between follicle size and oocyte/embryo quality, as a function of different triggering mode for final follicular maturation.Study DesignA cohort study conducted in a single tertiary medical center between July 2018 and May 2019. All women undergoing controlled ovarian hyperstimulation with triggering using hCG, GnRH agonist, or Dual trigger (GnRH agonist...
Source: Reproductive BioMedicine Online - February 21, 2020 Category: Reproduction Medicine Source Type: research

Is cell-free DNA in spent embryo culture medium an alternative to embryo biopsy for preimplantation genetic testing? A systematic review.
Publication date: Available online 20 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Brouillet Sophie, Martinez Guillaume, Coutton Charles, Hamamah SamirABSTRACTPreimplantation genetic testing (PGT) is increasingly used worldwide. Currently, it entails the use of invasive techniques (i.e., polar body/blastomere/trophectoderm biopsy or blastocentesis) to obtain embryonic DNA, with major technical limitations and ethical issues. There is evidence to suggest that invasive PGT can lead to genetic misdiagnosis in the case of embryo mosaicism, and consequently to the selection of affected embryos for implantation...
Source: Reproductive BioMedicine Online - February 21, 2020 Category: Reproduction Medicine Source Type: research

Can combining vaginal and rectal progesterone achieve the optimum progesterone range required for implantation in the HRT-FET model?
Publication date: Available online 20 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Alsbjerg B, Thomsen L, Elbaek HO, Laursen R, Povlsen BB, Haahr T, Humaidan PAbstractResearch question: What is the ongoing pregnancy rate (OPR) in Frozen Embryo Transfer (FET) cycles, using combined rectal and vaginal progesterone in Hormonal Replacement Therapy (HRT)?Design: Prospective cohort study (n=277), including 239 HRT-FET cycles with serum progesterone (P4) measurements. Combined vaginal (90mg/12h) and rectal (90mg/12h) progesterone regimen and single blastocyst transfer on the 6th day of progesterone administratio...
Source: Reproductive BioMedicine Online - February 21, 2020 Category: Reproduction Medicine Source Type: research

Assisted reproductive techniques in latin america: the latin american registry, 2017
Conclusions: The number of initiated cycles slowly increases. Frozen embryo transfers, blastocyst transfers and SET are also increasing. Our data shows that especially in young women and oocyte recipients, when there is more than one blastocyst for transfer, elective SET should be the rule. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 21, 2020 Category: Reproduction Medicine Source Type: research

HPV in sperm is efficiently removed by washing: A suitable approach for assisted reproduction
Conclusions: Although sperm washing approaches failed so far, the procedure used herein was never tested for HPV. Indeed, such sperm washing technique can efficiently remove HPV from sperm. However, the present study was conducted on a small population and a larger follow-up study is recommended. HPV screening should be performed in sperm samples and, upon HPV-positivity, sperm-washing should be considered before assisted reproduction techniques. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2020 Category: Reproduction Medicine Source Type: research

Cytogenetic testing of pregnancy loss tissue, a meta-analysis
Publication date: Available online 15 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): M.A.J. Smits, M. van Maarle, G. Hamer, S. Mastenbroek, M. Goddijn, M. van WelyAbstractMany clinics offer routine genetic testing of pregnancy loss tissue. The present review presents a comprehensive literature search and meta-analysis on chromosomal abnormality rates of pregnancy loss tissue from women with a single or recurrent pregnancy loss. We included 55 studies, published since 2000, which we analyzed on the prevalence of test failure rates, abnormality detection rates and percentages of trisomy, monosomy X, structura...
Source: Reproductive BioMedicine Online - February 15, 2020 Category: Reproduction Medicine Source Type: research

Supplementation of intramuscular progesterone every third day to vaginal progesterone versus vaginal progesterone only in hormone replacement therapy cycles: Comparison of reproductive outcomes as analysed by percentiles of serum progesterone levels on the day of vitrified/thaw blastocyst transfer
Publication date: Available online 15 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Mehtap Polat, Sezcan Mumusoglu, Gurkan Bozdag, Irem Yarali Ozbek, Peter Humaidan, Hakan YaraliABSTRACTResearch QuestionDoes intramuscular progesterone supplementation (imP4-suppl), secures ongoing pregnancy rates (OPRs) compared to vaginal progesterone-only (VP4) in hormone replacement therapy (HRT) cycles for frozen/thaw embryo transfer (FET); and moreover, is there a possible window of serum progesterone concentration out of which reproductive outcomes may be negatively impacted?DesignRetrospective longitudinal cohort stu...
Source: Reproductive BioMedicine Online - February 15, 2020 Category: Reproduction Medicine Source Type: research

Felt at distance of oocyte donation in France.
ConclusionsNone of the donors we interviewed regretted their donation. In France, the current principles governing this donation appear satisfactory to oocyte donors. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2020 Category: Reproduction Medicine Source Type: research

Endometrial expression of anti-müllerian hormone and its receptor type II in women with polycystic ovary syndrome
ConclusionsAlthough PCOS is associated with increased serum levels of AMH, protein expression of AMH and its receptor in the endometrium was not different to controls, and moreover not affected by lifestyle modification. Endometrial AMH-R immunostaining increased significantly during the menstrual cycle in both women with PCOS and controls. Our results imply that circulating AMH is not affecting expression of AMH and its receptor in the endometrium.The clinical trial registry numberID ISRCTN18400086. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2020 Category: Reproduction Medicine Source Type: research

Use of antioxidant could ameliorate the negative impact of etoposide on human sperm DNA during chemotherapy
ConclusionsNAC was able to protect sperm DNA integrity during etoposide treatment in vitro, suggesting that NAC may be useful as an adjuvant agent in preserving male fertility during chemotherapy treatments. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2020 Category: Reproduction Medicine Source Type: research

Role of gene polymorphisms related to progesterone elevation in women undergoing long GnRH agonist protocols
Publication date: Available online 30 December 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ping Cao, Benyu Miao, Yan Xu, Qi Fan, Qian Zhang, Guirong Zhang, Canquan Zhou, Yanwen XuABSTRACTResearch questionCan single-nucleotide polymorphisms (SNP) of genes related to progesterone synthesis predict the risk of premature serum progesterone elevation in women undergoing gonadotrophin-releasing hormone agonist protocols for ovarian stimulation?DesignA total of 765 women were divided into high progesterone and normal progesterone groups according to progesterone concentration on the day of human chorionic gonadotrophin ...
Source: Reproductive BioMedicine Online - February 14, 2020 Category: Reproduction Medicine Source Type: research

Cannabis consumption might exert deleterious effects on sperm nuclear quality in infertile men
ConclusionsCannabis consumption might have deleterious effects on sperm nuclear quality in infertile men by increasing numerical chromosome abnormalities and DNA fragmentation. Cannabis consumption induces these detrimental effects on the progression of spermatogenesis from meiotic stages to spermiogenesis and potentially on post-testicular sperm maturation in infertile men. Any potential findings, however, need to be validated with larger sample size, and our data are only exploratory findings. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Graph cluster approach in identifying novel proteins and significant pathways involved in polycystic ovary syndrome
ConclusionsThese results show that graph cluster analysis can provide additional insight into the pathobiology of PCOS, as the pathways identified as statistically significant correspond to earlier biological studies. Therefore, integrative analysis can reveal unknown mechanisms, which may enable the development of accurate diagnosis and effective treatment in PCOS.Graphical Abstract (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Fully human glyco-optimized recombinant FSH (follitropin epsilon) – a randomized, comparator-controlled phase II clinical trial
ConclusionsFollitropin epsilon 75 IU daily results in a similar ovarian response to a standard dose of 150 IU follitropin alfa. This dose could be tested in a phase III trial. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: February 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 2Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Contents
Publication date: February 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 2Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Drug-free in-vitro activation of ovarian cortex; can it really activate the ‘ovarian gold reserve’?
Publication date: February 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 2Author(s): Georg Griesinger, Bart C.J.M. Fauser (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Time-lapse imaging of cytoplasmic strings at the blastocyst stage suggests their association with spontaneous blastocoel collapse
Publication date: February 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 2Author(s): Thomas Ebner, Özcan Sesli, Sanja Kresic, Sabine Enengl, Barbara Stoiber, Elisabeth Reiter, Peter Oppelt, Richard Bernhard Mayer, Omar SheblAbstractResearch questionTo study the origin and temporal behaviour of cytoplasmic strings spanning the blastocoel (main objective) and their influence on treatment outcome (secondary objective).DesignThis retrospective analysis of prospectively collected data was set up in a university medical centre. Patients who either underwent fresh (n = 95) or vitrified–warmed (n&nbs...
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Human papillomavirus infection and female infertility: a systematic review and meta-analysis
Publication date: February 2020Source: Reproductive BioMedicine Online, Volume 40, Issue 2Author(s): Shuang Yuan, Yichao Qiu, Yuanyuan Xu, Hongjing WangAbstractThere is increasing evidence that human papillomavirus (HPV) infection affects reproductive health and fertility, although its impact on female fertility has not been thoroughly studied. MEDLINE, Embase, CENTRAL, Web of Science, CNKI, Wanfang, VIP and ClinicalTrials.gov databases were systematically searched for relevant articles. A meta-analysis was conducted of 11 studies including 15,450 female subjects that compared HPV prevalence between the infertile and gener...
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Testicular tissue cryopreservation is the preferred method to preserve spermatogonial stem cells prior to transplantation
ConclusionsCryopreservation of TET is the preferred method to cryopreserve SSCs prior to SSCT in a mouse model. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 11, 2020 Category: Reproduction Medicine Source Type: research

Prospective randomized multicentre comparison on sibling oocytes comparing G-Series media system with antioxidants versus standard G-Series media system
Publication date: Available online 5 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): D.K. Gardner, T. Kuramoto, M. Tanaka, S. Mitzumoto, M. Montag, A. YoshidaABSTRACTResearch questionDoes the inclusion of three antioxidants (A3), Acetyl-L-Carnitine (ALC), N-Acetyl-L-Cysteine (NAC) and α-Lipoic Acid (ALA) improve human embryo development and pregnancy potential?DesignProspective randomized multicentre comparison on sibling oocytes. A total of 1,563 MII oocytes from 133 patients in 2 IVF centres. Day 3 embryo and day 5/6 blastocyst quality were assessed. Good embryo quality on day 3 was defined as 8 to 1...
Source: Reproductive BioMedicine Online - February 6, 2020 Category: Reproduction Medicine Source Type: research

Does the prognosis of PGT-SR differ in female translocation carriers compare to male carriers? A lesson learned from 331 couples
ConclusionsFemale translocation carriers may respond poorly to COH and present a higher rate of unbalanced embryos, which means that a higher gonadotropins dose may be used safely in an attempt to increase the number of biopsied embryos. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 6, 2020 Category: Reproduction Medicine Source Type: research

PROGESTINS vs GONADOTROPIN RELEASING HORMONE ANALOGUES FOR PITUITARY SUPPRESSION DURING OVARIAN STIMULATION FOR ASSISTED REPRODUCTIVE TECHNOLOGY, A SYSTEMATIC REVIEW AND META-ANALYSIS
ConclusionsProgestins can effectively prevent premature ovulation in ART cycles. If larger and well-designed studies confirm these findings, progestins may be an effective and low-cost alternative to GnRH analogues when a fresh embryo transfer is not planned due to a medical indication. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 6, 2020 Category: Reproduction Medicine Source Type: research

A feasibility and acceptability study of the Positive Reappraisal Coping Intervention: a supportive intervention for women with recurrent pregnancy loss
ConclusionsThe study concluded that a definitive RCT of the PRCI is possible and that the model of care already has the potential to be made more widely available as a safe, low cost, convenient and easily deliverable intervention to provide much needed support to a vulnerable patient population. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 6, 2020 Category: Reproduction Medicine Source Type: research

Role of serum anti-Müllerian hormone and other factors in delineating the cumulative live birth rate following in vitro fertilization
Publication date: Available online 5 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Kai-Lun Hu, Fen-Ting Liu, Huiyu Xu, Rong Li, Jie QiaoAbstractResearch questionWhat are the optimal values of maternal age and body mass index (BMI), paternal age and BMI, number of oocytes retrieved, and serum AMH levels for the cumulative live birth rate (CLBR) in in vitro fertilization and embryo transfer (IVF-ET)?DesignThis retrospective cohort study included 9,494 women who underwent their first IVF-ET cycle between January 2017 and July 2018. The primary outcome was the CLBR within one complete cycle.ResultsThe CLBR was...
Source: Reproductive BioMedicine Online - February 6, 2020 Category: Reproduction Medicine Source Type: research

Oocyte Cryopreservation for Fertility Preservation in Women with Ovarian Endometriosis
ConclusionsWomen with endometrioma should be counseled about oocyte cryopreservation for FP before surgery. The optimal number of oocytes for cryopreservation can be secured by repeated oocyte retrieval. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 6, 2020 Category: Reproduction Medicine Source Type: research

Endometrioma, the follicular fluid inflammatory network and its association with oocyte and embryo characteristics
ConclusionsThe results suggest that the inflammatory milieu of ovarian endometriosis is strongly localized and has a more modestly systemic effect. The effect of endometriomas on infertility, however, cannot be entirely explained by increased inflammation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 5, 2020 Category: Reproduction Medicine Source Type: research

Research and business – The Yin and Yang in modern medicine
Publication date: Available online 4 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Thor Haahr, Jørgen Skov Jensen, Peter Humaidan (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 5, 2020 Category: Reproduction Medicine Source Type: research

A randomized double-blinded non-inferiority trial comparing fentanyl/midazolam versus pethidine/diazepam for pain relief during oocyte retrieval performed under conscious sedation
Publication date: Available online 31 January 2020Source: Reproductive BioMedicine OnlineAuthor(s): Shui Fan Lai, Mei Ting Lam, Hang Wun Raymond Li, Ernest Hung Yu NgAbstractResearch question: Is fentanyl/midazolam non-inferior to pethidine/diazepam in pain relief during oocyte retrieval performed under conscious sedation?Design: A randomized double-blinded non-inferiority trial recruited 170 infertile women between March 2016 and February 2018. Infertile women undergoing oocyte retrieval under conscious sedation in an assisted reproduction centre were randomized to receive intravenously either (1) 0.1mg fentanyl and 5mg m...
Source: Reproductive BioMedicine Online - February 1, 2020 Category: Reproduction Medicine Source Type: research

Frequent and mild scrotal heat stress impairs embryo development, implantation, and offspring sex ratio in mice
ConclusionsfmSHS not only reduced the fertilization ability of spermatozoa but also influenced its function in deep levels after fertilization, even after changing the offspring sex ratio. These results may help to shed new light on the infertility treatment of males with scrotal heat risk and the health concerns of offspring propagated from these fathers. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 1, 2020 Category: Reproduction Medicine Source Type: research

Upregulation of miR-145 may contribute to repeated implantation failure in vitro fertilization by targeting PAI-1
ConclusionsThe study suggested that miR-145 may target and downregulate PAI-1 expression and influence embryo implantation in RIF patients undergoing IVF. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 31, 2020 Category: Reproduction Medicine Source Type: research

Characterization of early pregnancy placental progesterone production by utilization of dydrogesterone in programmed frozen-thawed embryo transfer cycles
ConclusionsDydrogesterone does not cross-react with placental P4 in ECLIA or LC-MS/MS assessment. The onset of substantial P4 production is the 7 th GW. P4 increase is nonlinear, depends on the chorionicity/zygosity and may have predictive potential on the outcome of pregnancies originating from FET cycles. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 31, 2020 Category: Reproduction Medicine Source Type: research

Live birth in women with multiple sclerosis receiving assisted reproduction
ConclusionThe chance of a live birth was not decreased, in women with MS undergoing ART, compared to women without MS. The use of corticosteroids had no impact on the result. These novel results on ART treatment are useful when counseling women with MS undergoing assisted reproduction. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 28, 2020 Category: Reproduction Medicine Source Type: research