P-008 - Comparison of artificial shrinkage efficiency on D5 and D6 blastocysts
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Ricardo Azambuja, Lilian Okada, Virginia Reig, Alice Tagliani Ribeiro, Leticia Proença, Shana Flach, Marta Hentschke, Mariangela Badalotti, Alvaro Petracco (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-009 - Decision making processes of women who seek social oocyte cryopreservation
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Ran Kim, Lyu Sang Woo, Yoon Tae Ki, Shim Sung Han, Jayeon Kim (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-010 - Efficacy of preimplantation genetic screening in women with a history of spontaneous abortion(s) of eukaryotic or aneuploidy abortus
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Eun Jeong Yu, Sang Woo Lyu, Sung Han Shim, Tae Ki Yoon, Ja Yeon Kim (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-011 - Ionophore treatment for artificial oocyte activation does not alter morphokinetics of the associated embryos
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Thomas Ebner, Elisabeth Radler, Richard Bernhard Mayer, Lea Peter, Sabine Enengl, Peter Oppelt, Omar Shebl (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-012 - A time-lapse study of pronuclear fading in 39,241 human embryos, following IVF or ICSI. Is it time to fine-tune practice for standard fertilization assessment practice?
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Alison Campbell, Ioannis Gallos, Fatima Mirzazadeh, Best Louise, Rachel Smith, Samantha Duffy, Fiona Foad, Sarah Thirlby, Stacy Wheat, Sue Montgomery, Sarah O'boyle, Laina Davies (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-013 - Fresh transfer of day 5 slowly developing embryos versus postponed transfer of vitrified fully-developed day 6 blastocysts: what is the best approach?
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Lisbet Van Landuyt, Hilde Van De Velde, Christophe Blockeel, Anick De Vos, Greta Verheyen (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-014 - MiRNA expression pattern of spent human blastocyst culture medium correlates with pregnancy outcome
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Katalin Gombos, Miklos Oldal, Krisztina Kalacs, Krisztina Gödöny, Akos Varnagy, Jozsef Bodis, Gabor Laszlo Kovacs (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-015 - The impact of asynchronous syngamy on IVF outcome
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Trina Shah, Catarina Moreira, Nick Macklon, Ahuja Kamal, Wang Jinjun (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-016 - Is blastulation time frame (D5/6) and origin of the embryo (fresh/frozen) correlated with early embryo development assay (eeva) and reproductive outcome?
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Sonia Pérez Albalá, Belén Aparicio Ruiz, Laura Romany, Lucía Alegre, Fernanda Insua, Pilar Gámiz, Marcos Meseguer (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-017 - Sperm quality do not influence D5 embryo quality and number of euploid embryo
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Pitra Rahmawati, Arief Setiawan, Muhamad Rizal, Wahyu Indrasari, Nining Handayani, Ivan Sini, Arie Poliem, Arief Boediono (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-018 - Effects and pregnancy outcomes of L-carnitine supplementation in culture media for human embryo development from in vitro fertilization (IVF)
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Sang Woo Lyu, Min Kyoung Kim, Sung Han Shim, Tae Ki Yoon (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-019 - Vitrolife sequential media versus Irvine single step media systems for the culture and selection of human embryos for transfer and vitrification
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): David Orourke, Christian Ottolini, Jinjun Wang (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

P-020 - The effect of oocyte vitrification on subsequent embryo developmental morphokinetics and blastocyst formation: a prospective time-lapse sibling oocyte study
Publication date: May 2018Source: Reproductive BioMedicine Online, Volume 37, Supplement 1Author(s): Stefanie De Gheselle, Vanessa Muyshond, Kelly Tilleman, Petra De Sutter (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Ovarian reserve and response to stimulation in women undergoing fertility preservation according to malignancy type
ConclusionsAs the type of cancer does not seem to significantly affect ovarian reserve and ovarian response to ovarian stimulation, our results do not support the relevance of integrating this parameter when establishing ovarian stimulation protocol for oocyte vitrification cycle in women with cancer. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Maternal concentrations of human chorionic gonadotrophin in very early IVF pregnancies and duration of pregnancy: a follow-up study
ConclusionHigh maternal HCG concentration on a fixed day after embryo transfer is likely to indicate early embryo implantation. After embryo transfer, pregnancies with early implantation are shorter than pregnancies with late implantation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

The impact of music therapy on pain and stress reduction during oocyte retrieval – a randomized controlled trial
ConclusionMusic is a simple, inexpensive and effective way to reduce pain score and increase satisfaction with pain control during TUGOR procedure, which may justify its routine use. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Gene expression changes in uterine myomas in response to ulipristal acetate treatment
Publication date: Available online 7 May 2018Source: Reproductive BioMedicine OnlineAuthor(s): Guillaume E. Courtoy, Jacques Donnez, Jérôme Ambroise, Pablo Arriagada, Mathieu Luyckx, Etienne Marbaix, Marie-Madeleine DolmansAbstractResearch questionDoes ulipristal acetate (UPA) modify the expression of genes related to apoptosis or the extracellular matrix in uterine myomas and are any modifications associated with a clinical response?DesignTargeted analysis of 176 apoptosis- or extracellular-matrix-related genes was conducted using polymerase chain reaction (PCR) arrays. Relevant results were validated by quan...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Cumulative live birth rates after IVF in patients with polycystic ovaries: phenotype matters
Publication date: Available online 7 May 2018Source: Reproductive BioMedicine OnlineAuthor(s): Michel De Vos, Stéphanie Pareyn, Panagiotis Drakopoulos, José M. Raimundo, Ellen Anckaert, Samuel Santos-Ribeiro, Nikolaos P. Polyzos, Herman Tournaye, Christophe BlockeelAbstractResearch questionDo cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment?DesignIn this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 ...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Light element distribution in fresh and frozen–thawed human ovarian tissues: a preliminary study
ConclusionsThe study demonstrates that elemental imaging techniques, particularly revealing the distribution of light elements, could be useful in establishing new cryopreservation protocols. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Clinical application of a protocol based on universal next-generation sequencing for the diagnosis of beta-thalassaemia and sickle cell anaemia in preimplantation embryos
ConclusionsIt is hoped that protocols that deliver almost universally applicable low-cost tests, without compromising diagnostic accuracy, will improve patient access to preimplantation genetic testing, especially in less affluent parts of the world. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Effect of the antioxidant idebenone on maternal diabetes-induced embryo alterations during early organogenesis
ConclusionMaternal idebenone treatment ameliorates altered parameters related to the prooxidant–proinflammatory environment found in embryos from mild diabetic rats, suggesting a putative treatment to prevent diabetes-induced embryo alterations. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism
Publication date: Available online 22 May 2018Source: Reproductive BioMedicine OnlineAuthor(s): Da Li, Hong-Xiang Liu, Yuan-Yuan Fang, Jia-Ning Huo, Qi-Jun Wu, Tian-Ren Wang, Yi-Ming Zhou, Xiu-Xia Wang, Xiao-Xin MaAbstractResearch questionWhat are the metabolic characteristics of homocysteine in polycystic ovary syndrome (PCOS)?DesignHomocysteine concentrations were determined in serum samples from non-obese and obese control subjects and PCOS patients. Homocysteine metabolism was studied in a rat model of PCOS established using dehydroepiandrosterone (DHEA) or DHEA in combination with a high-fat diet (HFD).ResultsIt was s...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

hsa-miRNA-154-5p expression in plasma of endometriosis patients is a potential diagnostic marker for the disease
ConclusionsmiRNA seem to be promising candidates for the non-invasive diagnosis of endometriosis. Further, other clinical parameters may help in distinguishing women suffering from endometriosis from healthy individuals. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Critical appraisal of the Vienna consensus: performance indicators for assisted reproductive technology laboratories
Publication date: Available online 24 May 2018Source: Reproductive BioMedicine OnlineAuthor(s): María Luisa Lopez-Regalado, Luis Martínez-Granados, Antonio González-Utor, Nereyda Ortiz, Miriam Iglesias, Manuel Ardoy, Jose A. Castilla, Special Interest Group in Quality of ASEBIR (Society for the Study of Reproductive Biology)AbstractThe Vienna consensus, based on the recommendations of an expert panel, has identified 19 performance indicators for assisted reproductive technology (ART) laboratories. Two levels of reference values are established for these performance indicators: competence and benchmark....
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Older women using their own eggs? Issue framed with two oldest reported IVF pregnancies and a live birth
ConclusionsFemale age above 42 is widely viewed as the ultimate barrier to conception with IVF. Data reported here, although small and preliminary, demonstrate that potential outcomes are better than widely perceived, while pregnancy and live birth rates remain significantly inferior to donor egg recipient cycles. However, for selected women at very advanced ages, especially with higher egg/embryo numbers, autologous oocyte IVF offers a better option than widely acknowledged, if they are given individualized age-specific care. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Is 45 years-of-age the cut-off for using autologous oocytes?
Publication date: Available online 19 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): John L Yovich, Michael J Chapman, Kevin N Keane, Julian Savulescu (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Time-lapse imaging algorithms rank human preimplantation embryos according to the probability of live birth
Publication date: Available online 22 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Simon Fishel, Alison Campbell, Sue Montgomery, Rachel Smith, Lynne Nice, Samantha Duffy, Lucy Jenner, Kathryn Berrisford, Louise Kellam, Rob Smith, Fiona Foad, Ashley BecclesAbstractResearch questionCan blastocysts leading to live births be ranked according to morphokinetic-based algorithms?DesignRetrospective analysis of 781 single blastocyst embryo transfers, including all patient clinical factors that might be potential confounders for the primary outcome measure of live birth, was weighed using separate multi-variable logis...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

The effect of blastocyst transfer on newborn sex ratio and monozygotic twinning rate: an updated systematic review and meta-analysis
ConclusionsThis meta-analysis provides an update and stronger evidence to support the observation that BT is associated with a higher proportion of males and an increased risk of MZT. In clinical practice, these BT-associated neonatal outcomes should be taken into account when counselling infertility patients. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?
Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Marie-Madeleine DolmansAbstractAt the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore ...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Biochemical pregnancy loss after frozen embryo transfer seems independent of embryo developmental stage and chromosomal status
ConclusionsBPL seems independent of the embryo's developmental stage, the use of trophectoderm biopsy and the chromosomal constitution at FET. Similar BPL rates after transferring euploid blastocysts compared with both untested cleavage and blastocyst stage embryos suggest investigating the role of endometrial and other embryonic factors putatively involved in the process of implantation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

The M2a macrophage subset may be critically involved in the fibrogenesis of endometriosis in mice
Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jie Duan, Xishi Liu, Honglin Wang, Sun-Wei GuoAbstractResearch questionRecent research has shown that endometriotic lesions are essentially wounds that undergo repeated tissue injury and repair, which results in epithelial–mesenchymal transition, fibroblast-to-myofibroblast transdifferentiation, smooth muscle metaplasia and ultimately fibrosis. Macrophages are a key regulator of tissue repair and fibrogenesis. But do macrophages also play a role in fibrogenesis of endometriosis, and, if yes, which subset of macrophages?De...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Very low anti-müllerian hormone concentrations are not an independent predictor of embryo quality and pregnancy rate
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Alberto Pacheco, María Cruz, Carlos Iglesias, Juan Antonio García-VelascoAbstractResearch questionIs anti-Müllerian hormone (AMH) serum concentration a useful tool to predict the outcome of assisted reproductive treatment?DesignRetrospective cohort study involving 2971 patients who underwent 5570 IVF cycles. Patients were classified into six groups according to their AMH levels and analysed for associations with reproductive outcome. Several parameters of ovarian response and clinical outcome were compared be...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Contents
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Cryostorage of human gametes and embryos: a reckoning
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Mina Alikani (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Remembering J Michael Bedford (1932 – 2018): a great thinker and scholar
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Ryuzo Yanagimachi, Mina Alikani (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

What is the best protocol to cryopreserve immature mouse testicular cell suspensions?
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Jaime Onofre, Katrien Faes, Prashant Kadam, Elena Vicini, Ans M.M. van Pelt, Ellen GoossensAbstractResearch questionFrom a clinical perspective, which parameters grant optimal cryopreservation of mouse testicular cell suspensions?DesignWe studied the effect of different cryopreservation rates, the addition of sugars, different vessels and the addition of an apoptotic inhibitor on the efficiency of testicular cell suspension cryopreservation. After thawing and warming, testicular cell suspensions were transplanted to recipient m...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Early oocyte denudation does not compromise ICSI cycle outcome: a large retrospective cohort study
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Osama Naji, Natalie Moska, Yaser Dajani, Awatuf El-Shirif, Hassan El-Ashkar, Mohamed M. Hosni, Mohamed Khalil, Yacoub Khalaf, Virginia Bolton, Tarek El-ToukhyAbstractThis retrospective cohort study of 2051 consecutive fresh non-donor intracytoplasmic sperm injection (ICSI) cycles investigated whether time from oocyte retrieval to denudation, precisely measured and recorded by an operator-independent automated radiofrequency-based system, affected cycle outcome. ICSI cycles were divided into two groups: group I (denudation within
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Screening of miRNAs in human follicular fluid reveals an inverse relationship between microRNA-663b expression and blastocyst formation
ConclusionsMIR-663B expression levels in human follicular fluid samples were significantly negatively related to viable blastocyst formation and may become an objective evaluation criterion for embryo development potential after IVF. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Blastocyst vitrification, cryostorage and warming does not affect live birth rate, infant birth weight or timing of delivery
ConclusionsVitrification and cryostorage (up to 4 years) are safe and effective practices that do not significantly affect clinical outcome after embryo transfer. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Predicting live birth for poor ovarian responders: the PROsPeR concept
ConclusionsThis model, specific to PORs receiving r-hFSH, constitutes the best compromise between precision and simplicity, and is suitable for routine practice. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Prediction of Endometriosis Fertility Index in patients with endometriosis-associated infertility after laparoscopic treatment
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Xianghui Zhang, Dong Liu, Wei Huang, Qiushi Wang, Xue Feng, Jing TanAbstractThe effect of endometriosis on fecundity is unclear. Although surgery plays a vital role in the treatment of related infertility, pregnancy outcomes after laparoscopy are poorly correlated with the currently used staging system. To address this, the Endometriosis Fertility Index (EFI) was developed. This retrospective study was designed to assess the predictive value of the EFI for patients with endometriosis-associated infertility. A total of 1325 pati...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Clinical practice guidelines for fertility preservation in young women undergoing gonadotoxic treatment: an overview and critical appraisal of methodological quality and content
ConclusionCPGs on the subject of FP care are available, but there is room for improvement in quality and content. Although written for use in daily practice, the CPGs can also be used to develop quality indicators to monitor the quality of current FP care or to evaluate future improvement initiatives. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Survival of selected patients with ovarian cancer treated with fertility-sparing surgery
This study was a retrospective Danish nationwide study, evaluating the effect of FSS compared with RS in patients with EOC, age ≤45 years and International Federation of Gynecology and Obstetrics (FIGO) stage ≤IC3 from 2005 to 2016.ResultsA total of 106 patients were included. Of these, 13 were treated with FSS and 93 were treated with RS. Median age was 27 versus 42 years (P
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Oocyte retrieval difficulties in women with ovarian endometriomas
ConclusionsOocyte retrieval in women with ovarian endometriomas is more problematic but the magnitude of these increased difficulties is modest. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Genome-wide screening for smallest regions of overlaps in cryptorchidism
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Kristian Urh, Tanja KunejAbstractCryptorchidism is a urogenital abnormality associated with increased rates of testicular neoplasia and impaired spermatogenesis. The field is facing expansion of genomics data; however, it lacks protocols for biomarker prioritization. Identification of smallest regions of overlap (SRO) presents an approach for candidate gene identification but has not yet been systematically conducted in cryptorchidism. The aim of this study was to conduct a genome-wide screening for SRO (GW-SRO) associated with...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Sperm meiotic segregation of a balanced interchromosomal reciprocal insertion resulting in recurrent spontaneous miscarriage
ConclusionsThis study shows the value of sperm FISH analysis in improving genetic reproductive advice for IRI carriers. Disruption of critical genes through this rearrangement and their consequent functional impairment could result in recurrent miscarriages. In this case, several genes located in the 14q11.2 region, particularly RNase 3, would be good candidates to explain the lethality of the imbalances. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Duplication of SOX9 associated with 46,XX ovotesticular disorder of sex development
ConclusionThis study is thought to be the first report regarding a duplication of SOX9 that is associated with the presence of 46,XX ovotesticular DSD, encompassing at least −581 kb upstream, and the almost entire coding region of the gene. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Response: scoring of mosaic embryos after preimplantation genetic testing – the rollercoaster ride between fear, hope and embryo wastage
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Francesca Romana Grati, Gloria Gallazzi, Lara Branca, Federico Maggi, Giuseppe Simoni, Yuval Yaron (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Scoring of mosaic embryos after preimplantation genetic testing: a rollercoaster ride between fear, hope and embryo wastage
Publication date: July 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 1Author(s): Maximilian Murtinger, Barbara Wirleitner, Maximilian Schuff (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research