Preimplantation genetic testing (PGT) for borderline indications – PGT for cancer
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Svetlana Rechistky, Anver Kuliev (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

PGD for HLA (ESHRE study)
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Georgia Kakourou (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

What about the maternal endometrium. The search for the personalized WOI and microbiota
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Carlos Simon (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

Review of the clinical evidence of mtDNA for embryo viability
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Luca Gianaroli, M. Cristina Magli, A. Pomante, S. De Fanti (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

When to transfer? Fresh vs. deferred transfer
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Semra Kahraman (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

Laboratory conditions/biopsy strategies
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Laura Rienzi (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

Mosaicism and segmentals in POCs and prenatal diagnosis
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): David Cram (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

It's a mosaic result- what do I say now?
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Don Leigh (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

Embryo culture conditions and more
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): María José De los Santos (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

Aneuploidy as both a cause and a cure for cancer
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Melvin Depamphilis (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

Common variants associated with mitotic-origin of aneuploidy in human embryos
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Supplement 1 Author(s): Rajiv McCoy, Zachary Demko, Allison Ryan, Milena Banjevic, Matthew Hill, Styrmir Sigurjonsson, Matthew Rabinowitz, Hunter Fraser, Dmitri Petrov (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 15, 2018 Category: Reproduction Medicine Source Type: research

In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies
Publication date: Available online 13 February 2018 Source:Reproductive BioMedicine Online Author(s): Michael J. Bertoldo, Kirsty A. Walters, William L. Ledger, Robert B. Gilchrist, Pascal Mermillod, Yann Locatelli Ovarian tissue is increasingly being collected from cancer patients and cryopreserved for fertility preservation. While the only available option to restore fertility is autologous transplantation, this treatment is not appropriate for all patients due to the risk of reintroducing cancer cells and causing disease recurrence. Harnessing the full reproductive potential of this tissue to restore fertility requires...
Source: Reproductive BioMedicine Online - February 14, 2018 Category: Reproduction Medicine Source Type: research

Investigation of anti-M üllerian hormone concentrations in relation to natural conception rate and time to pregnancy
In conclusion, high AMH, especially in ovulatory women, was associated with higher pregnancy rates. Nonetheless, TTP reflected a large variation in fecundity within similar AMH concentrations and natural conceptions occurred with AMH down to 1.2 pmol/l. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 10, 2018 Category: Reproduction Medicine Source Type: research

An evidence-based scoring system for prioritizing mosaic aneuploid embryos following preimplantation genetic screening
In conclusion, due to the paucity of prospective studies on the actual transfer of mosaic aneuploid embryos, we suggest using this evidence-based scoring system to provide a useful tool for clinicians, embryologists and patients. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 10, 2018 Category: Reproduction Medicine Source Type: research

Chief editor's 2017 annual report
Publication date: March 2018 Source:Reproductive BioMedicine Online, Volume 36, Issue 3 Author(s): Bart C.J.M. Fauser, Kamal K. Ahuja (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 9, 2018 Category: Reproduction Medicine Source Type: research

Luteal phase progesterone and oestradiol after ovarian stimulation: relation to response and prediction of pregnancy
In this study, serial endocrine measurements were taken in 600 patients after a gonadotrophin-releasing hormone antagonist stimulation protocol. On the day of blastocyst transfer, serum progesterone and oestradiol were similar irrespective of a subsequent positive or negative pregnancy test (median 99 ng/ml versus 103 ng/ml for progesterone, respectively) or a subsequent live birth or pregnancy loss. Serum progesterone was significantly correlated to each ovarian response parameter (total number of follicles, number of oocytes retrieved and oestradiol concentration; r = 0.45, 0.57 and 0.54 respectively, all P...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Dienogest suppresses the activation of primordial follicles and preserves the primordial follicle stockpile for fertility in mice
Publication date: Available online 17 January 2018 Source:Reproductive BioMedicine Online Author(s): Luyi Zheng, Fuminori Kimura, Di Wu, Aina Morimune, Yoko Niwa, Shizuka Mita, Kentaro Takahashi, Takashi Murakami The aim of the present study was to characterize the effect of long-term usage of dienogest, a fourth-generation progestin that possesses progestogen and anti-androgen activities, on the stockpile of oocytes and fertility after administration. Female ICR mice (100 days old) were divided into a dienogest group and a control group. The mice received 16 consecutive subcutaneous injections of 5 mg dienogest di...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Leukaemia inhibitory factor in serum and follicular fluid of women with polycystic ovary syndrome and its correlation with IVF outcome
Publication date: Available online 20 January 2018 Source:Reproductive BioMedicine Online Author(s): Zewu Li, Yueting Zhu, Hongchang Li, Wenjie Jiang, Hongbin Liu, Junhao Yan, Zi-Jiang Chen, Weiping Li Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Leukaemia inhibitory factor (LIF) affects many reproductive activities, including follicular development, embryo implantation and growth. The aim of this study was to evaluate LIF concentrations in serum and follicular fluid of women with PCOS and controls who underwent IVF with embryo transfer (IVF&...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

In-vitro development of vitrified –warmed bovine oocytes after activation may be predicted based on mathematical modelling of cooling and warming rates during vitrification, storage and sample removal
In this study, we tested the validity of one such model by assessing in-vitro development of vitrified and warmed bovine oocytes after parthenogenetic activation and culture. The viability of oocytes vitrified in four different cryo-devices was assessed. Consistent with modelling predictions, oocytes vitrified using cryo-devices with the highest modelled cooling rates had significantly (P < 0.05) better cleavage and blastocyst formation rates. We then evaluated a two-step sample removal process, in which oocytes were held in nitrogen vapour for 15 s to simulate sample identification during clinical applicatio...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Multiple pregnancies achieved with IVF/ICSI and risk of specific congenital malformations: a meta-analysis of cohort studies
Publication date: Available online 31 January 2018 Source:Reproductive BioMedicine Online Author(s): Zan Zheng, Letao Chen, Tubao Yang, Hong Yu, Hua Wang, Jiabi Qin Studies comparing risk of specific congenital malformations (CM) between multiple pregnancies resulting from IVF/intracytoplasmic sperm injection (ICSI) and those conceived naturally report conflicting results; furthermore, there is a lack of a complete overview. This meta-analysis aimed to address which types of CM are increased in IVF/ICSI multiple pregnancies compared with those conceived naturally. All studies testing the association between IVF/ICSI multi...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Patients with a high proportion of immature and meiotically resistant oocytes experience defective nuclear oocyte maturation patterns and impaired pregnancy outcomes
In conclusion, appropriate treatment strategies, including clinical utilization of IVM oocytes from Study group patients, warrant further investigation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Are synechiae a complication of laparotomic myomectomy?
Publication date: Available online 2 February 2018 Source:Reproductive BioMedicine Online Author(s): Perrine Capmas, Anne-Gaelle Pourcelot, Hervé Fernandez Laparotomic myomectomy is often the only realistic solution for symptomatic women with multiple or large myomas who wish to retain their fertility. The aim of this study was to document the rate of uterine synechiae and their associated risk factors after laparotomic myomectomy. This prospective observational study took place in a teaching hospital from May 2009 to June 2014. It included all women aged 18–45 years who had laparotomic myomectomies (without ...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Effect of male body mass index on assisted reproduction treatment outcome: an updated systematic review and meta-analysis
Publication date: Available online 2 February 2018 Source:Reproductive BioMedicine Online Author(s): Rabia Mushtaq, Jyotsna Pundir, Chiara Achilli, Osama Naji, Yacoub Khalaf, Tarek El-Toukhy Men with a body mass index (BMI) of 30 or over are more likely to have reduced fertility and fecundity rates. This systematic review and meta-analysis evaluated the effect of male BMI on IVF and intracytoplasmic sperm injection (ICSI) outcome. An electronic search for published literature was conducted in MEDLINE and EMBASE between 1966 and November 2016. Outcome measures were clinical pregnancy rates (CPR) and live birth rates (LBR) ...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Can time-lapse parameters predict embryo ploidy? A systematic review
In conclusion, the available studies are too heterogeneous for firm conclusions to be drawn on the predictive value of time-lapse analysis for embryo aneuploidy screening. Hence, morphokinetic parameters should not be used yet as a surrogate for PGS to determine embryo ploidy in vitro. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A
Publication date: Available online 2 February 2018 Source:Reproductive BioMedicine Online Author(s): Miriam Cortés, Jose-Luis Royo, Arturo Reyes-Palomares, Ana M. Lendínez, Maximiliano Ruiz-Galdón, Armando Reyes-Engel Spermatozoa and neurones share similar membrane characteristics and features. Associations of multiple polymorphisms traditionally related to neurotransmission were investigated. Infertile men were grouped into controls with normospermia (n = 182) and idiopathic infertile men with asthenozoospermia (n = 103), and analysed as a case-control study and as a quantitative association of each ...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Poor ovarian response as a predictor for live birth in older women undergoing IVF
This study was designed to assess whether poor ovarian response (POR) according to the Bologna criteria is a significant predictor for live birth in women over 40. The outcomes of subsequent IVF cycles were also studied. The results of 1870 fresh IVF cycles in 1212 women were retrospectively analysed. The live birth per cycle was 3.3 times higher (11.61% versus 3.54%, P < 0.001) in good responders with more than three oocytes collected compared with women with less. Ovarian response defined by oocytes collected, but not by the number of follicles, was independently associated with live birth (odds ratio, 2.0; 95% co...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

A demographic projection of the contribution of assisted reproductive technologies to world population growth
Publication date: Available online 3 February 2018 Source:Reproductive BioMedicine Online Author(s): Malcolm J. Faddy, Matthew D. Gosden, Roger G. Gosden Enormous unmet needs for infertility treatment exist because access to assisted reproductive technologies is demographically skewed. Since the first IVF baby in 1978, the number of people conceived by reproductive technology has grown much faster than expected, reaching several million today and rapidly approaching 0.1% of the total world population. As more patients build families, and their children in turn become parents, the number owing their existence to assisted r...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception
In conclusion, women with bilateral tubal occlusion or a combination of endometriosis and adhesions found on THL significantly reduced chances of natural conception. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Human oocyte maturation in vitro is improved by co-culture with cumulus cells from mature oocytes
In this study, the gene expression profiles of human oocytes were analysed according to their manner of maturation: in vivo (in the ovaries) or in vitro (matured either by the conventional method or by a new approach – co-cultured with cumulus cells of mature oocytes from the same patient). Our results show that the in-vitro maturation procedure strongly affects the gene expression profile of human oocytes, including several genes involved in transcriptional regulation, embryogenesis, epigenetics, development, and the cell cycle. The in-vitro maturation of oocytes co-cultured with cumulus cells from mature oocytes pr...
Source: Reproductive BioMedicine Online - February 6, 2018 Category: Reproduction Medicine Source Type: research

Response: time-lapse systems for ART
Publication date: Available online 5 January 2018 Source:Reproductive BioMedicine Online Author(s): Csaba Pribenszky, Anna-Maria Nilselid, Markus Montag (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 5, 2018 Category: Reproduction Medicine Source Type: research

Analysis of CDK2 mutations in chinese men with non-obstructive azoospermia who underwent testis biopsy
Publication date: Available online 4 January 2018 Source:Reproductive BioMedicine Online Author(s): Wen Liu, Xuan Gao, Lei Yan, Hongli Liu, Ruimei Yu, Shidou Zhao, Jinlong Ma To examine whether mutations of the CDK2 gene exist in Chinese men with non-obstructive azoospermia (NOA) with different histopathology, we recruited 175 Chinese men with idiopathic NOA who underwent testis biopsy, including hypospermatogenesis, germ cell maturation arrest and Sertoli cell only syndrome. Genomic DNA was extracted from peripheral blood samples. Subsequently, the seven exons of the CDK2 gene were amplified using polymerase chain reacti...
Source: Reproductive BioMedicine Online - January 4, 2018 Category: Reproduction Medicine Source Type: research

Should we continue to measure endometrial thickness in modern-day medicine? the effect on live birth rates and birth weight
In conclusion, these results reaffirm the use of EMT as a potential prognostic tool for live birth rates and neonatal birthweight in contemporary IVF, namely when considered together with other ovarian stimulation monitoring methods, such as the late-follicular endocrine profile. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 3, 2018 Category: Reproduction Medicine Source Type: research

Validation of a targeted next generation sequencing-based comprehensive chromosome screening platform for detection of triploidy in human blastocysts
This study aimed to validate triploidy detection in human blastocysts, its frequency and parental origin using genotyping data generated in parallel with chromosome copy number analysis by a targeted next generation sequencing (tNGS)-based comprehensive chromosome screening platform. Phase 1: diploid and triploid control samples were blinded, sequenced by tNGS and karyotype predictions compared for accuracy. Phase 2: tNGS was used to calculate the frequency of triploidy in 18,791 human blastocysts from trophectoderm (TE) biopsies. Phase 3: parental origin of the inherited extra alleles was evaluated by sequencing parental ...
Source: Reproductive BioMedicine Online - January 2, 2018 Category: Reproduction Medicine Source Type: research

Expression of sperm PLC ζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion
Publication date: Available online 29 December 2017 Source:Reproductive BioMedicine Online Author(s): Marziyeh Tavalaee, Michail Nomikos, F. Anthony Lai, Mohammad Hossein Nasr-Esfahani Globozoospermia is characterized by the presence of 100% acrosomeless round-headed spermatozoa in an ejaculate. Failed fertilization after intracytoplasmic sperm injection (ICSI) is commonly reported for globozoospermic couples and can be overcome by artificial oocyte activation (AOA). Phospholipase C zeta (PLCζ) is one of the main sperm factors involved in oocyte activation and its low expression levels mainly account for fertilizatio...
Source: Reproductive BioMedicine Online - December 29, 2017 Category: Reproduction Medicine Source Type: research

Artificial cryopreserved embryo transfer cycle success depends on blastocyst developmental rate and progesterone timing
Publication date: Available online 29 December 2017 Source:Reproductive BioMedicine Online Author(s): Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Peter Humaidan, Kevin Coetzee This retrospective cohort analysis compared the developmental competence of cryopreserved day-4 and 5 blastocysts, and investigated the effect of progesterone administration duration on the success of artificial frozen embryo transfers. Between October 2015 and March 2016, 868 intracytoplasmic sperm injection blastocyst cryo-all cycles were carried out, with 586 subsequently undergoing frozen embryo transfer. Of these, 243 were day-5 single blastoc...
Source: Reproductive BioMedicine Online - December 29, 2017 Category: Reproduction Medicine Source Type: research

Follicular flushing in patients with poor ovarian response: a systematic review and meta-analysis
Publication date: Available online 29 December 2017 Source:Reproductive BioMedicine Online Author(s): Kay Neumann, Georg Griesinger A systematic literature review and meta-analysis was conducted to evaluate the effect of follicular flushing on clinical outcomes (primary outcome: mean number of cumulus–oocyte–complexes [COC]) in poor-response IVF patients). The bibliographic databases OvidMedline (includes Pubmed), Cochrane Library and Web of Science were searched electronically for randomized controlled trials comparing follicular flushing with no flushing. Three randomized controlled trials with a total of 21...
Source: Reproductive BioMedicine Online - December 29, 2017 Category: Reproduction Medicine Source Type: research

Time-lapse systems for ART
Publication date: Available online 29 December 2017 Source:Reproductive BioMedicine Online Author(s): Sarah Armstrong, Priya Bhide, Vanessa Jordan, Allan Pacey, Cynthia Farquhar (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 29, 2017 Category: Reproduction Medicine Source Type: research

Lower follicular fluid vitamin D concentration is related to a higher number of large ovarian follicles
In this study, lower follicular 25OHD3 concentrations predicted a better response to ovarian stimulation shown by a greater production of larger follicles and higher serum oestradiol concentrations. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 29, 2017 Category: Reproduction Medicine Source Type: research

Reliability and agreement on embryo assessment: 5 years of an external quality control programme
In conclusion, the ability of clinical embryologists to evaluate the presence of multinucleation and vacuoles in the early cleavage embryo, and to determine the category of the inner cell mass in blastocysts, needs to be improved. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 29, 2017 Category: Reproduction Medicine Source Type: research

The endometrial stem cell markers notch-1 and numb are associated with endometriosis
Publication date: Available online 28 December 2017 Source:Reproductive BioMedicine Online Author(s): Andreas N. Schüring, Beatrice Dahlhues, Anna Korte, Ludwig Kiesel, Ulf Titze, Birthe Heitkötter, Christian Ruckert, Martin Götte Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case–control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis. Fifty-one endometriosis patients and 76 controls were recruited in the IVF unit and tertiary endometriosis referral centre of a universi...
Source: Reproductive BioMedicine Online - December 28, 2017 Category: Reproduction Medicine Source Type: research

Optimal use of peri-operative human chorionic gonadotrophin concentrations to identify persistent ectopic pregnancy after laparoscopic salpingostomy: a retrospective cohort study
Publication date: Available online 28 December 2017 Source:Reproductive BioMedicine Online Author(s): Abraham N. MORSE, Wenyue SI, Shuang QIN, Huiying LIANG The aim of this study was to improve clinical decision-making for the identification of persistent ectopic pregnancy after linear salpingostomy. The study identified 854 laparoscopic salpingostomies performed between 2011 and 2016; 794 had a human chorionic gonadotrophin (HCG) concentration <10 mIU/ml documented in the electronic medical record within 1 month after surgery (‘successes’). Sixty (7%) received either methotrexate or repeat surgery for ...
Source: Reproductive BioMedicine Online - December 28, 2017 Category: Reproduction Medicine Source Type: research

A search for molecular mechanisms underlying male idiopathic infertility
In conclusion, male infertility is a complex, multi-factorial disorder and the underlying causes often remain unknown. Further research on the (epi)genetic and molecular defects in spermatogenesis and sperm function is necessary to improve the diagnosis and to develop more personalized treatments of men with idiopathic infertility. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 27, 2017 Category: Reproduction Medicine Source Type: research

Cost-effectiveness of ovarian stimulation with gonadotrophin and clomiphene citrate in an intrauterine insemination programme for subfertile couples
Publication date: Available online 27 December 2017 Source:Reproductive BioMedicine Online Author(s): Karen Peeraer, J. Luyten, C. Tomassetti, S. Verschueren, C. Spiessens, A. Tanghe, C. Meuleman, Sophie Debrock, Eline Dancet, T.M. D'Hooghe Ovarian stimulation with low-dose human menopausal gonadotrophin (HMG) is superior to clomiphene citrate in intrauterine insemination (IUI) cycles with respect to clinical pregnancy rate, but it is unclear whether HMG is also the more cost-effective option. The aim of this study was to compare the cost-effectiveness of ovarian stimulation with low-dose subcutaneously administred HMG (3...
Source: Reproductive BioMedicine Online - December 27, 2017 Category: Reproduction Medicine Source Type: research

Response from the Editors: Time-lapse systems for ART – meta-analyses and the issue of bias
Publication date: Available online 26 December 2017 Source:Reproductive BioMedicine Online Author(s): Mina Alikani, Bart C.J.M. Fauser, Richard Anderson, Juan Antonio García-Velasco, Martin Johnson (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 26, 2017 Category: Reproduction Medicine Source Type: research

Is there an association between artificial sweetener consumption and assisted reproduction outcomes?
This study is limited by the use of a non-validated food frequency questionnaire, lack of information on quantity of sweeteners consumed, and lack of data on glucose levels in blood serum or follicular fluid. Further investigation is warranted. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 24, 2017 Category: Reproduction Medicine Source Type: research

The impact of antenatal bisphenol a exposure on male reproductive function at 20 –22 years of age
Publication date: Available online 19 December 2017 Source:Reproductive BioMedicine Online Author(s): Roger J. Hart, Dorota A. Doherty, Jeffrey A. Keelan, Novia S. Minaee, Eric B. Thorstensen, Jan E. Dickinson, Craig E. Pennell, John P. Newnham, Robert McLachlan, Robert J. Norman, David J. Handelsman Bisphenol A (BPA) is a ubiquitous chemical suspected to possess oestrogenic hormonal activities. Male population studies suggest a negative impact on testicular function. As Sertoli cell proliferation occurs during fetal or early postnatal life, it is speculated that oestrogenic environmental exposures may influence mature te...
Source: Reproductive BioMedicine Online - December 20, 2017 Category: Reproduction Medicine Source Type: research

Interleukin 11 blockade during mid to late gestation does not affect maternal blood pressure, pregnancy viability or subsequent fertility in mice
Publication date: Available online 19 December 2017 Source:Reproductive BioMedicine Online Author(s): Amy Winship, Ellen Menkhorst, Michelle Van Sinderen, Evdokia Dimitriadis Interleukin (IL)11 is a crucial regulator during the initiation of pregnancy in humans and mice. Elevated levels are detected in serum, placenta and decidua of women with pre-eclampsia. Elevated IL11 during placentation recapitulates pre-eclampsia in mice, although withdrawal rescues pre-eclampsia features, suggesting that IL11 could provide a novel therapeutic target. The aim of this study was to determine the safety profile of an IL11 antagonist li...
Source: Reproductive BioMedicine Online - December 19, 2017 Category: Reproduction Medicine Source Type: research

Surging ahead
Publication date: Available online 13 December 2017 Source:Reproductive BioMedicine Online Author(s): Bart Fauser, Mina Alikani, Richard Anderson, Sarah Franklin, Martin H. Johnson, Juan Garcia Velasco (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 14, 2017 Category: Reproduction Medicine Source Type: research

Dignity again
Publication date: Available online 7 December 2017 Source:Reproductive BioMedicine Online Author(s): Alain Pottage Two recent contributions to this journal discuss a challenge to Stanford's time-lapse embryo monitoring patent, currently before the European Patent Office (EPO). Sterckx, Cockbain and Pennings (2017) would like to keep the morphokinetics of embryo division in the public domain; they argue that time-lapse monitoring (TLM) is a diagnostic method in the sense of European patent law and therefore unpatentable. In response, Pearce (2017) suggests that the jurisprudence of the EPO unambiguously says that TLM is no...
Source: Reproductive BioMedicine Online - December 8, 2017 Category: Reproduction Medicine Source Type: research

Role of Withania somnifera (Ashwagandha) in the management of male infertility
Publication date: Available online 7 December 2017 Source:Reproductive BioMedicine Online Author(s): Pallav Sengupta, Ashok Agarwal, Maria Pogrebetskaya, Shubhadeep Roychoudhury, Damayanthi Durairajanayagam, Ralf Henkel To manage male infertility caused by hormonal imbalance, infections and other predicaments, multifarious treatment strategies are emerging worldwide. Contemporary treatments, such as assisted reproductive techniques, are costly with low success rates of only 10–30%; however, herbal remedies are gaining more attention as an alternative or supplementary therapeutic modality for male infertility. The be...
Source: Reproductive BioMedicine Online - December 8, 2017 Category: Reproduction Medicine Source Type: research