Mothers with intrauterine growth restriction have shorter telomeres than those of uncomplicated pregnancies but not their offspring nor newborns conceived by in vitro fertilization
ConclusionsOur results support the safety of IVF and IUGR on the postnatal health of the newborns. The shorter telomeres of IUGR mothers may represent a higher cardiovascular risk that show clinical implications under the stress of pregnancy on otherwise healthy adults. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 21, 2018 Category: Reproduction Medicine Source Type: research

Pregnancy outcomes after recurrent pregnancy loss – a longitudinal cohort study on stress and depression
ConclusionsSelf-reported emotional distress did not impact future chance of live birth in this cohort. A live born child decreased emotional distress. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 20, 2018 Category: Reproduction Medicine Source Type: research

The impact of different temperature conditions on human embryo's in vitro: two sibling studies
CONCLUSIONCulture in an incubator with CTR does not improve fertilization rate or embryo quality. Embryo culture at 36.6°C or 37.1°C showed similar embryo development. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 20, 2018 Category: Reproduction Medicine Source Type: research

Soluble LH–HCG receptor and oestradiol as predictors of pregnancy and live birth in IVF
ConclusionssLHCGR levels are negatively related to AMH when oocyte yield is high. High early cycle sLHCGR is associated with elevated day-3 oestradiol. Low sLHCGR and SOR are indicators of increased clinical pregnancy and live birth rates. Patient age and SOR, combined with EOR, might improve prediction of IVF treatment outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 16, 2018 Category: Reproduction Medicine Source Type: research

Dydrogesterone: pharmacological profile and mechanism of action as luteal phase support in assisted reproduction
Publication date: Available online 15 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Georg Griesinger, Herman Tournaye, Nick Macklon, Felice Petraglia, Petra Arck, Christophe Blockeel, Peter van Amsterdam, Claire PexmanFieth, Bart CJM FauserThe pharmacological and physiological profiles of progestogens used for luteal phase support during assisted reproductive technology are likely to be important in guiding clinical choice towards the most appropriate treatment option. Various micronized progesterone formulations with differing pharmacological profiles have been investigated for several purposes. Dydrogest...
Source: Reproductive BioMedicine Online - December 16, 2018 Category: Reproduction Medicine Source Type: research

Low MFN2 expression related to ageing in granulosa cells is associated with assisted reproductive technology outcome
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lingjuan Wang, Su Song, Xuemei Liu, Mengdi Zhang, Wenpei XiangAbstractResearch questionIs low MFN2 expression associated with ageing in granulosa cells as well as assisted reproductive technology (ART) outcome, and what is the underlying mechanism of action of MFN2?DesignIn a prospective study, fresh granulosa cells were obtained from 161 women aged 20–40 years who underwent IVF with embryo transfer and who were divided into two groups: the diminished ovarian reserve (DOR) group (n = 51) and the control group (n...
Source: Reproductive BioMedicine Online - December 15, 2018 Category: Reproduction Medicine Source Type: research

Follitropin delta in repeated ovarian stimulation for IVF: a controlled, assessor-blind Phase 3 safety trial
ConclusionsThe trial demonstrated the low immunogenicity potential of follitropin delta in repeated ovarian stimulation, and confirmed the appropriateness of the follitropin delta dosing regimen in repeated cycles, with documented efficacy and safety. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 15, 2018 Category: Reproduction Medicine Source Type: research

Live births following human embryo gene editing: a call for clarity, self-control and regulation
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Helen O'Neill, Jacques Cohen (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 15, 2018 Category: Reproduction Medicine Source Type: research

The use of home remedies and complementary health approaches in endometriosis
ConclusionAs conventional therapies may not be sufficiently effective, women's needs should be closely examined, and individual treatment options should be discussed and initiated by clinicians to provide the best comprehensive treatment possible for endometriosis. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 15, 2018 Category: Reproduction Medicine Source Type: research

Choosing an expanded carrier screening panel: comparing two panels at a single fertility centre
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Sara L Bristow, Joshua M Morris, Alexandra Peyser, Amber Gamma, Tomer Singer, Christine Mullin, Kenan Onel, Avner HershlagAbstractResearch questionWhat are the factors contributing to similarities and differences in carrier rates between two expanded carrier screening (ECS) panels?DesignRetrospective cross-sectional study. A total of 7700 infertility patients who underwent ECS from one of two genetic testing laboratories (Panel A or Panel B) using a genotyping microarray were included in the study. Individuals presenting to...
Source: Reproductive BioMedicine Online - December 15, 2018 Category: Reproduction Medicine Source Type: research

Association between early embryo morphokinetics plus cumulus cell gene expression and assisted reproduction outcomes in polycystic ovary syndrome women
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Nasim Tabibnejad, Mohammad Hasan Sheikhha, Nasrin Ghasemi, Fesahat, Mehrdad Soleimani, Abbas AflatoonianAbstractResearch questionCan a combination of time-lapse morphokinetic parameters and cumulus cell gene expression in polycystic ovary syndrome (PCOS) women be used to predict assisted reproductive treatment outcome?DesignA total of 547 embryos from 100 intracytoplasmic sperm injection (ICSI) cycles were evaluated. Fifty women with PCOS and 50 women who were categorized as tubal factor infertility were recruited. Time-lap...
Source: Reproductive BioMedicine Online - December 15, 2018 Category: Reproduction Medicine Source Type: research

Towards the global coverage of a unified registry of IVF outcomes
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Bart CJM Fauser (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 15, 2018 Category: Reproduction Medicine Source Type: research

The early life environment influences trajectory of post-partum weight loss
Publication date: Available online 12 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): C.E Aiken, J.L Tarry-Adkins, T.J Ashmore, S.E OzanneAbstractResearch questionThe physiological processes of pregnancy and lactation require profound changes in maternal metabolism and energy balance. The timescale of metabolic reversion after pregnancy, in particular postpartum weight loss, is highly variable between individuals. Currently, mechanisms influencing postpartum metabolic recovery are not well understood. We hypothesize that, in common with other metabolic and obesity-related outcomes, capacity for postpartum we...
Source: Reproductive BioMedicine Online - December 12, 2018 Category: Reproduction Medicine Source Type: research

Is There an Impact from the FMR1 Gene on In Vitro Fertilization Success?
Publication date: Available online 10 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lisa M Pastore, Mindy S Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y. Maher, William G KearnsABSTRACTWhile it is well known that FMR1 CCG trinucleotide repeat expansions are associated with Fragile X Syndrome (full mutations) and primary ovarian insufficiency (premutation range), the effect of FMR1 on fertility treatment success is less clear. This paper reviews the impact of FMR1 CGG repeat lengths on in vitro fertilization (IVF) outcomes after controlled ovarian hyperstimulation has commenced. PubM...
Source: Reproductive BioMedicine Online - December 11, 2018 Category: Reproduction Medicine Source Type: research

Reconceiving egg freezing: insights from an analysis of 5 years of data from a UK clinic
ConclusionsThe data require a reconceptualization of the phenomenon of egg freezing, and argue for the importance of clearly and accurately differentiating between different categories of egg-freezing practice in clinical and national data collection in order to adequately inform future practice, regulation and the decision-making processes of patients considering these procedures. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 11, 2018 Category: Reproduction Medicine Source Type: research

The IVF-LUBE trial – a randomized trial to assess lipiodol uterine bathing effect in women with endometriosis or repeat implantation failure undergoing in vitro fertilization
CONCLUSIONS: We found no evidence of benefit of lipiodol prior to fresh embryo transfer in women with endometriosis or RIF. We suggest this treatment should not be undertaken purely as an adjuvant in IVF other than in the context of a further well designed RCT. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 8, 2018 Category: Reproduction Medicine Source Type: research

Prognostic value of repeated serum Kisspeptin measurements in early first trimester pregnancy- A Preliminary Study
ConclusionSingle serum measurement of kisspeptin is significantly altered in women with and without pregnancy. However, it failed to discriminate between miscarriage and ongoing pregnancies in first trimester pregnancy. Neither single nor sequential kisspeptin have higher diagnostic performance for miscarriage than β-hCG in early stage. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 8, 2018 Category: Reproduction Medicine Source Type: research

Results of double freezing approach in the management of surplus embryos in IVF
Conclusions: Due to the low pregnancy rate of the re- freeze blastocyst embryos, the transfer of twice frozen-thawed embryos with slow freeze technique does not seem to be a beneficial plan ahead approach in managing the arsenal of frozen embryos. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 8, 2018 Category: Reproduction Medicine Source Type: research

Three-dimensional (3D) levitation culture improves the in vitro growth of secondary follicles in bovine model
Conclusion3D levitation culture system improves the in vitro development of bovine secondary follicles in terms of viability, antrum formation, and lower extrusion and degeneration rates as well as adequate growth rate leading to relevant oocyte viability and meiotic resumption after in vitro maturation. Moreover, this approach does not require specific medium and has potential to be applied as alternative method to in vitro follicle culture in several species as well as in humans. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 8, 2018 Category: Reproduction Medicine Source Type: research

Evaluating the benefit of measuring serum progesterone prior to the administration of hCG: effect of the duration of late-follicular elevated progesterone following ovarian stimulation on fresh embryo transfer live birth rates
Conclusionthese results suggest a lack of benefit in measuring serum P in the days preceding hCG administration, since LBR in women with LFEP>1 day do not vary significantly from those with LFEP detected only on the day of hCG administration. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 8, 2018 Category: Reproduction Medicine Source Type: research

Birth characteristics in men with infertility
Publication date: Available online 8 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Susanne Liffner, Elizabeth Nedstrand, Marie Bladh, Heriberto Rodriguez-Martinez, Mats Hammar, Gunilla SydsjöAbstractResearch questionAre low birth weight, prematurity and/or being born small for gestational age associated with a higher risk of male factor infertility in adulthood?DesignA retrospective study on a clinical sample of men accepted for treatment of infertility between 2005 and 2010 at the Centre of Reproductive Medicine, University Hospital, Linköping, Sweden. The study sample consisted of 892 men, diag...
Source: Reproductive BioMedicine Online - December 8, 2018 Category: Reproduction Medicine Source Type: research

Novel inactivating mutations in the FSH receptor cause premature ovarian insufficiency with resistant ovary syndrome
ConclusionsThe three novel point mutations in FSHR were all functional inactivating mutations, and were the genetic aetiology of the three non-syndromic POI-with-ROS families. We report the first FSHR frameshift mutation, and the first missense mutation in the signal peptide-encoding region of FSHR to be associated with POI. Women affected by ROS should consider undergoing mutation screening for FSHR. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 8, 2018 Category: Reproduction Medicine Source Type: research

High responders are not exempt from detrimental effects of prematurely rising progesterone levels in fresh embryo transfer cycles
ConclusionHigh responders are not exempt from the detrimental effects of prematurely rising serum progesterone levels but the threshold interval where the detrimental effect begins is higher in the high responders compared with the low and normal responders. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 8, 2018 Category: Reproduction Medicine Source Type: research

Active compounds present inRosmarinus officinalis leaves andScutellaria baicalensis root evaluated as new therapeutic agents for endometriosis
Publication date: December 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 6Author(s): Luciana Ferella, Juan Ignacio Bastón, Mariela Andrea Bilotas, José Javier Singla, Alejandro Martín González, Carla Noemí Olivares, Gabriela Fabiana MeresmanAbstractResearch questionCan carnosic acid, (CA) rosmarinic acid (RA) and wogonin (WG) inhibit the growth of cultured human endometrial stromal cells and endometriotic-like lesions induced in a BALB/c model of endometriosis?DesignPrimary stromal cell cultures were established from endometrial biopsies from women with endometriosis and c...
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: December 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 6Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

Contents
Publication date: December 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 6Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

Omega-3 polyunsaturated fatty acids and in-vitro fertilization treatment
Publication date: Available online 6 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Amir Lass, Andrea BelluzziAbstractOmega-3 polyunsaturated fatty acids (PUFAs) are essential fatty acids, derived mostly from fish oil, that have a significant anti-inflammatory effect. Data from animal studies support their role in the reproductive mechanism, and recent human studies suggest a positive effect on sperm quality and natural conception. Their general role in human fertility, and specifically in IVF treatment, however, is not clear. A few small, prospective cohort studies have examined the relationship between se...
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

The correlation between morphology and implantation of euploid human blastocysts
Publication date: Available online 7 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Taraneh Gharib Nazem, Lucky Sekhon, Joseph A Lee, Jessica Overbey, Stephanie Pan, Marlena Duke, Christine Briton-Jones, Michael Whitehouse, Alan B Copperman, Daniel E SteinAbstractResearch questionDoes the composite morphology score or a particular developmental component (expansion stage, inner cell mass [ICM] or trophectoderm [TE]) of euploid blastocysts undergoing single frozen embryo transfer (FET) impact ongoing pregnancy/live birth (OP/LB) rates?DesignRetrospective cohort study including a total of 2236 embryos from 16...
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

Changes in visual function and ocular morphology in women who underwent assisted reproductive technologies (ARTs) and in their offspring: a systematic review
Publication date: Available online 7 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Mario D. Toro, Michele Reibaldi, Antonio Longo, Teresio Avitabile, Maria E. Lionetti, Sarah Tripodi, Chiara Posarelli, Stefano PalombaABSTRACTSince all the structures of the human eye are characterized by sex hormone receptors, we tested the hypothesis that assisted reproductive technologies (ARTs) influence visual function and ocular morphology both in women who underwent ARTs and in children born after ARTs. A systematic literature search of all original articles published until August 2018 was performed using the PubMed d...
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

The therapeutic effect of hysterosalpingography in couples with unexplained subfertility: a post-hoc analysis of a prospective multi-centre cohort study
ConclusionsHSG increases the ongoing pregnancy rate of couples with unexplained subfertility compared with no HSG, regardless of the contrast medium used. Results need to be validated in future, preferably randomized, studies. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

Morphokinetic parameters in chromosomal translocation carriers undergoing preimplantation genetic testing
Publication date: Available online 7 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jenna Lammers, Arnaud Reignier, Carole Splingart, Kamran Moradkhani, Paul Barrière, Thomas FréourAbstractResearch questionCan embryo morphokinetic parameters help identify unbalanced embryos in translocation carriers?DesignThis retrospective study was conducted in 67 translocation carriers undergoing 105 preimplantation genetic testing cycles for chromosomal structural rearrangements (PGT-SR) without aneuploidy screening (PGT-A). Using time-lapse imaging analysis, morphokinetic parameters of balanced and unbala...
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

Twin pregnancies and perinatal outcomes: a comparison between fresh and frozen embryo transfer: a two-centre study
ConclusionIn twin pregnancies, FET might have better perinatal outcomes compared with fresh embryo transfer in regards to birthweight and spontaneous second trimester miscarriages. Further research is needed to evaluate these results. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 7, 2018 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: November 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 5Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 5, 2018 Category: Reproduction Medicine Source Type: research

Contents
Publication date: November 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 5Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 5, 2018 Category: Reproduction Medicine Source Type: research

The expected cumulative incidence of live birth for patients starting IVF treatment at age 41 years or older
Publication date: November 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 5Author(s): Oshrit Lebovitz, Jigal Haas, Kaitlyn E. James, Daniel S. Seidman, Raoul Orvieto, Ariel HourvitzAbstractResearch questionWhat is the cumulative incidence of live birth (CILB) for high-order consecutive IVF cycles, and which factors are associated with live birth in women aged ≥41 years using autologous oocytes?DesignA retrospective cohort study including 146 patients aged 41 years to
Source: Reproductive BioMedicine Online - December 5, 2018 Category: Reproduction Medicine Source Type: research

Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF–ICSI: a pilot study
Publication date: Available online 23 November 2018Source: Reproductive BioMedicine OnlineAuthor(s): Meng Rao, Fang Zhou, Li Tang, Zhengyan Zeng, Shifu Hu, Yingying Wang, Dandan Ke, Guiping Cheng, Wei Xia, Ling Zhang, Changhong ZhuAbstractResearch questionIs humanin present in the human ovary and follicular fluid? What relationship exists between humanin concentration in the follicular fluid and ovarian reserve and clinical outcomes after IVF and intracytoplasmic sperm injection (ICSI)?DesignFollicular fluid samples were collected from 179 patients undergoing their first IVF or ICSI cycle during oocyte retrieval. Ovarian t...
Source: Reproductive BioMedicine Online - November 24, 2018 Category: Reproduction Medicine Source Type: research

Assisted reproductive technologies in Africa: first results from the African Network and Registry for Assisted Reproductive Technology, 2013
ConclusionThis marks the beginning of an ART registry in Africa, but because ART utilization could not be established, degree of access to ART remains speculative. Pregnancy rates were favourable but underpinned by a preponderance of young women and the transfer of multiple embryos. Efforts are needed to explore treatment barriers, improve pregnancy follow-up and reduce the high rate of multiples. This inaugural report from the African Network and Registry for Assisted Reproductive Technology (ANARA) indicates a willingness and ability of ART centres to voluntarily report and monitor utilization and outcomes of ART, which ...
Source: Reproductive BioMedicine Online - November 23, 2018 Category: Reproduction Medicine Source Type: research

Steroid profiles by liquid chromatography-mass spectrometry of matched serum and single dominant ovarian follicular fluid from women undergoing IVF
ConclusionsNone of the nine steroids measured in follicular fluid predicted pregnancy outcome in women undergoing IVF. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 23, 2018 Category: Reproduction Medicine Source Type: research

Comparison of DNA fragmentation levels in spermatozoa with different sex chromosome complements
Publication date: Available online 20 November 2018Source: Reproductive BioMedicine OnlineAuthor(s): Xiao Shi, David Yiu Leung Chan, Ming Peng Zhao, Carol Pui Shan Chan, Jin Huang, Tin-Chiu LiAbstractResearch questionDo spermatozoa with different sex chromosome complements (X and Y; aneuploidy and monosomy) have different degrees of DNA damage?DesignA prospective, observational study to measure the DNA fragmentation level and sex chromosome complement simultaneously using combined sperm chromosome dispersion (SCD) and fluorescence in-situ hybridization tests. Two methods were used to evaluate SCD images: a traditional semi...
Source: Reproductive BioMedicine Online - November 21, 2018 Category: Reproduction Medicine Source Type: research

Sperm mitochondrial DNA measures and semen parameters among men undergoing fertility treatment
ConclusionsSperm mtDNAcn is a measure of consecutive abnormal semen parameters and has promise as a diagnostic test. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 16, 2018 Category: Reproduction Medicine Source Type: research

Construction and validation of a prediction model to minimize twin rates at preserved high live birth rates after IVF
ConclusionThe results provide the first successful construction, validation and impact analysis of a day 2 transfer PM to reduce multiple pregnancies. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 15, 2018 Category: Reproduction Medicine Source Type: research

Chromosomal translocations and semen quality: a study on 144 male translocation carriers
ConclusionsThe NPS-ASP appears to be a good parameter to assess sperm function and would be a useful tool to detect chromosomal translocations. Four redundant regions have been identified on four chromosomes, suggesting that they may contain genes of interest to study sperm functions. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 14, 2018 Category: Reproduction Medicine Source Type: research

Morphokinetic characteristics of embryos derived from in-vitro-matured oocytes and their in-vivo-matured siblings after ovarian stimulation
Publication date: Available online 10 November 2018Source: Reproductive BioMedicine OnlineAuthor(s): Tamar Margalit, Avi Ben-Haroush, Roni Garor, Naomi Kotler, Dania Shefer, Natalia Krasilnikov, Moran Tzabari, Galia Oron, Yoel Shufaro, Onit SapirAbstractResearch questionDoes delayed maturation of aspirated metaphase I (MI) oocytes, completed in vitro, adversely affect early embryo development?DesignTime-lapse microscopy was used to compare morphokinetic variables between embryos derived from oocytes with delayed maturation after ovarian stimulation and from in-vivo-matured metaphase II (MII) sibling oocytes from the same I...
Source: Reproductive BioMedicine Online - November 11, 2018 Category: Reproduction Medicine Source Type: research

How time to healthy singleton delivery could affect decision-making during infertility treatment: a Delphi consensus
ConclusionsTime to healthy singleton delivery should be taken into consideration when making decisions related to infertility treatment, and it is important that fertility treatment is provided in a timely manner, avoiding over- or under-treatment. In all subfertile women 35 years. However, more research is needed on the impact of treatment choices on time to healthy singleton delivery. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 8, 2018 Category: Reproduction Medicine Source Type: research

The dilemma of social oocyte freezing: usage rate is too low to make it cost-effective
Publication date: October 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 4Author(s): Zion Ben-RafaelAbstractDelayed childbearing in affluent countries and the financial crisis of the Y-generation have contributed to the dramatic decline in birth rate. Social oocyte freezing (SOF) has fuelled the imagination of patients and doctors to offer it as a solution to single, presumably fertile, women to preserve their fertility potential by egg banking at an early age. Some are calling on governments to support large-scale ‘fertility preservation’, but is it cost-effective? Social oocyte freezing is effe...
Source: Reproductive BioMedicine Online - November 3, 2018 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: October 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 4Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 3, 2018 Category: Reproduction Medicine Source Type: research

Contents
Publication date: October 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 4Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 3, 2018 Category: Reproduction Medicine Source Type: research

John D Biggers (1923 – 2018): A Eulogy
Publication date: October 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 4Author(s): Catherine Racowsky (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 3, 2018 Category: Reproduction Medicine Source Type: research

The UK´s anomalous 10-year limit on oocyte storage: time to change the law
Publication date: October 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 4Author(s): Peter Bowen-Simpkins, Jinjun J Wang, Kamal K AhujaAbstractThere has been a growing recognition in the UK that the statutory storage limit for frozen eggs, which currently stands at 10 years, requires a review. The UK regulator, the Human Fertilization and Embryology Authority (HFEA), has recognized the problem and the Equality and Human Rights Commission is also sympathetic with the demand to change the current legislation. There is also strong desire on the part of assisted reproductive technology (ART) professionals and pa...
Source: Reproductive BioMedicine Online - November 3, 2018 Category: Reproduction Medicine Source Type: research

Reproductive outcomes after oocyte banking for fertility preservation
Conclusion: Oocyte banking can be considered a form of risk management or preventive medicine because it is not certain that the women will experience sterility in the future. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - November 3, 2018 Category: Reproduction Medicine Source Type: research