Fine-tuning blastocyst selection based on morphology: a multicentre analysis of 2461 single blastocyst transfers
Publication date: Available online 22 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ashleigh Storr, Esra Bilir, Simon Cooke, Don Garrett, Christos A VenetisAbstractResearch questionTo determine which blastocyst morphology parameter is associated with live birth (LB) after controlling for female age and endometrial receptivity.DesignThis retrospective study included fresh single blastocyst transfers (n=2461) where the value of serum progesterone on the day of human chorionic gonadotrophin trigger (P4dhCG) was available. Generalized estimating equation regression models evaluated the independent effects of devel...
Source: Reproductive BioMedicine Online - June 24, 2019 Category: Reproduction Medicine Source Type: research

A propensity-matched study of the association between prepregnancy maternal underweight and perinatal outcomes among singletons based on an ART cohort
ConclusionsAmong women undergoing ART, prepregnancy maternal underweight was associated with lower BW, increased LBW and SGA risks and decreased fetal macrosomia and LGA risks in singletons. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 24, 2019 Category: Reproduction Medicine Source Type: research

Pregnancy and perinatal outcomes of first-trimester crown−rump length discordant IVF dichorionic twin pregnancies – a retrospective cohort study
ConclusionsDiscordant twin pregnancies were at increased risk of one fetal loss prior to 12 weeks’ gestation. Except for birthweight discordance, there was no significant difference between CRL discordance and other adverse perinatal outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 22, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: July 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 21, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: July 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 21, 2019 Category: Reproduction Medicine Source Type: research

Association of gene polymorphisms in theanti-Müllerian hormone signalling pathway with ovarian function: a systematic review and meta-analysis
Publication date: Available online 26 April 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ran Cheng, Wei Xiong, Xiaoyan Luo, Yaxian Ma, Ying Nie, Xiaoyong Qiao, Hui Chen, Ying Hu, Liangzhi XuAbstractThis systematic review evaluated whether single nucleotide polymorphisms of AMH and AMHRII genes are associated with ovarian function. A literature search of PubMed and Embase was complemented by hand searches in the reference lists. Eight studies involving 3155 participants were included in a meta-analysis and 10 studies included for description. For AMH c.146T>G polymorphism, no significant difference in serum anti...
Source: Reproductive BioMedicine Online - June 20, 2019 Category: Reproduction Medicine Source Type: research

Association between disease extent and pain symptoms in patients with deep infiltrating endometriosis (DIE)
Publication date: Available online 19 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Eliana Montanari, Bernhard Dauser, Joerg Keckstein, Elisabeth Kirchner, Zoltan Nemeth, Gernot HudelistABSTRACTResearch QuestionTo assess associations between preoperative symptoms in patients with deep infiltrating endometriosis (DIE) and intraoperatively determined disease extent described by the revised ENZIAN score.DesignRetrospective data analysis of women who underwent surgery for DIE between 2014 and 2018 at the Department of Gynecology, Hospital St. John of God, Vienna (tertiary referral center for endometriosis).Results...
Source: Reproductive BioMedicine Online - June 20, 2019 Category: Reproduction Medicine Source Type: research

Supraphysiological serum oestradiol negatively affects birthweight in cryopreserved embryo transfers: a retrospective cohort study
ConclusionsPeak serum oestradiol during COH is negatively associated with birthweight. This model proposes a novel concept as well as new evidence that the effect on birthweight is due to the primary influence of a high oestradiol concentration on oocytes during COH. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 19, 2019 Category: Reproduction Medicine Source Type: research

The proportion of nuclear mature oocytes affects ooplasmic competence of metaphase-II in relation to implantation and live birth with ICSI
Publication date: Available online 18 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Alessandra Parrella, Mohamad Irani, Derek Keating, Stephen Chow, Zev Rosenwaks, Gianpiero D. PalermoAbstractResearch QuestionAlthough ooplasmic maturity has been studied for some time, it remains poorly defined. We aim to identify the competence of MII oocytes in terms of fertilization and embryo development while considering the proportional maturity of the retrieved cohort.DesignCouples treated by ICSI between 1993 and 2017 comprising female partners ≤35 years old were included. Cycles were divided into four groups accordi...
Source: Reproductive BioMedicine Online - June 19, 2019 Category: Reproduction Medicine Source Type: research

Preconception serum lipids and lipophilic micronutrient levels are associated with live birth rates after in vitro fertilization
ConclusionWhile components of a mixture of lipids and lipophilic micronutrients were associated with live birth outcomes following IVF, a larger investigation is necessary to fully evaluate the potential clinical implications. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 15, 2019 Category: Reproduction Medicine Source Type: research

Mechanical zona pellucida removal of vitrified-warmed human blastocysts does not affect the clinical outcome
ConclusionTotal mechanical removal of the zona pellucida did not affect the tested parameters of clinical outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 15, 2019 Category: Reproduction Medicine Source Type: research

Oxytocin antagonism reverses the effects of high estrogen levels and oxytocin on decidualization and cyclooxygenase activity in endometrial tissues
ConclusionsOT antagonist reversed the effects of high E2 and OT on parameters related to endometrial receptivity. This might point to an additional mechanism of support of embryo implantation in the application of oxytocin antagonists prior to embryo transfer. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 14, 2019 Category: Reproduction Medicine Source Type: research

Five-year study assessing the clinical utility of Anti-Müllerian Hormone (AMH) measurements in reproductive age women with cancer
Publication date: Available online 11 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): KE Palinska-Rudzka, T Ghobara, N Parsons, J Milner, G Lockwood, GM HartshorneAbstractResearch questionAn important discussion point prior to chemotherapy is ovarian toxicity, a side effect that profoundly affects young women with cancer. Their quality of life after successful treatment, including the ability to conceive, is a major concern. We asked whether serum Anti-Müllerian hormone (AMH) measurements before chemotherapy for two most common malignancies are predictive of long-term changes in ovarian reserve?DesignA pros...
Source: Reproductive BioMedicine Online - June 12, 2019 Category: Reproduction Medicine Source Type: research

Oocyte donation in donors with levonorgestrel intrauterine device: a good match?
ConclusionsThe LNG-IUD does not have a negative impact on CLBR. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 8, 2019 Category: Reproduction Medicine Source Type: research

Atherosclerotic cardiovascular disease in women with endometriosis: A critical review of risk factors and prospects for early surveillance
Publication date: Available online 8 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Justin Tan, Omur Taskin, Mahmoud Iews, Arthur J Lee, Arohumam Kan, Timothy Rowe, Mohamed A. BedaiwyABSTRACTEndometriosis and atherosclerotic cardiovascular disease (ASCVD) share similar pathogenic mechanisms. Hence, this systematic review evaluates the association between endometriosis and lifetime ASCVD risk including co-prevalence with dyslipidemia, atherosclerosis, and non-invasive markers of endothelial dysfunction. Among 12 studies (401 patients with surgically proven endometriosis and 557 controls), two prospective-cohort ...
Source: Reproductive BioMedicine Online - June 8, 2019 Category: Reproduction Medicine Source Type: research

Embryo morphokinetics is potentially associated with clinical outcomes of single embryo transfers in preimplantation genetic testing for aneuploidy cycles
Publication date: Available online 6 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Chun-I Lee, Chien-Hong Chen, Chun-Chia Huang, En-Hui Cheng, Hsiu-Hui Chen, Su-Ting Ho, Pin‐Yao Lin, Maw-Sheng Lee, Tsung-Hsien LeeAbstractResearch questionIs morphokinetics of euploid blastocysts evaluated by a generally applicable algorithm associated with clinical outcomes of single embryo transfers (SETs)?DesignTime-lapse microscopy was used to compare morphokinetic variables between expanded blastocysts derived from preimplantation genetic testing for aneuploidy cycles using high-resolution next-generation sequencing (hr-N...
Source: Reproductive BioMedicine Online - June 7, 2019 Category: Reproduction Medicine Source Type: research

Advanced fibroid study: paying homage to John Sampson
Publication date: Available online 25 April 2019Source: Reproductive BioMedicine OnlineAuthor(s): John L Yovich, Philip K Rowlands, Sunthra Lingam, Mark Sillender, Shanthi SrinivasanAbstractA recent article supports our longstanding view that all intramural fibroids can cause disturbance of uterine function. This may be reflected in the symptom of menorrhagia or fertility-related issues, as well as pregnancy losses at all gestational stages. However, it was disappointing that there was no reference to either the mechanism by which fibroids disturb uterine function nor to the gynaecologist who described this more than 100 y...
Source: Reproductive BioMedicine Online - June 6, 2019 Category: Reproduction Medicine Source Type: research

GLP-1 receptor agonists versus metformin in PCOS: a systematic review and meta-analysis
Publication date: Available online 25 April 2019Source: Reproductive BioMedicine OnlineAuthor(s): Yi Han, Yingjie Li, Bing HeAbstractThis meta-analysis aimed to evaluate the efficacy and safety of glucagon-like peptide 1 (GLP-1) receptor agonists for women with polycystic ovary syndrome (PCOS) by comparing their effect with that of metformin. Electronic databases (PubMed, EMBASE, Cochrane Library, WanFang Database, CNKI) dating from their establishment to June 2018 were searched to find all randomized controlled trials (RCTs) reporting the efficacy of GLP-1 receptor agonists versus metformin for patients with PCOS. Therape...
Source: Reproductive BioMedicine Online - June 6, 2019 Category: Reproduction Medicine Source Type: research

Chemosensitivity and chemoresistance in endometriosis – differences for ectopic versus eutopic cells
CONCLUSIONSOverall, our results confirm the evidence of large-scale metabolic reprogramming in endometriotic cells, which underlies the observed differences in sensitivity towards toxins. The enhanced efficiency of doxorubicin interfering with redox equilibria and/or DNA repair mechanisms pinpoints key players that can be potentially used for selective targeting of ectopic lesions in endometriosis. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 1, 2019 Category: Reproduction Medicine Source Type: research

The relationship between FSH receptor polymorphism status and IVF cycle outcome: a retrospective observational study
ConclusionThis is the largest study to date regarding live birth and FSHR and found that the homozygous Ser/Ser genotype of FSHR polymorphism at position 680 is associated with a reduced ovarian response to ovarian stimulation in IVF/ICSI. We found no difference in cumulative live birth rate. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 1, 2019 Category: Reproduction Medicine Source Type: research

Intrauterine insemination: simultaneous with or 36 h after HCG? A randomized clinical trial
ConclusionsThis multicentre randomized controlled trial did not demonstrate that IUI carried out at the point of HCG triggering increases pregnancy rates compared with IUI carried out around the time of ovulation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 31, 2019 Category: Reproduction Medicine Source Type: research

Anti-Müllerian hormone as a diagnostic tool for PCOS under different diagnostic criteria in an unselected population
ConclusionAMH has poor to fair validity to diagnose PCOS among an unselected group of women, except for patients bearing all features of the syndrome (Phenotype A). This finding is valid using the NIH, Rotterdam-2003 and AE-PCOS criteria and even after revising the definition of PCOM as AFC ≥20. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 31, 2019 Category: Reproduction Medicine Source Type: research

The window is wide: flexible timing for vitrified–warmed embryo transfer in natural cycles
ConclusionsThe results suggest that the timing of blastocyst transfer in a natural cycle after LH surge is flexible within 24 h. Outcomes are equally good with day of embryo transfer 6 or 7 days after LH surge date. Oestradiol dynamics and progesterone concentration 6 days prior to NC-VET did not have a significant impact on OPR. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 30, 2019 Category: Reproduction Medicine Source Type: research

The female post-cancer fertility-counselling clinic: looking beyond the freezer. A much needed addition to oncofertility care
Publication date: Available online 29 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kirsten Tryde Macklon, Bart CJM Fauser (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 30, 2019 Category: Reproduction Medicine Source Type: research

The microRNA polymorphisms inmiR-150 andmiR-1179 are associated with risk of idiopathic recurrent pregnancy loss
ConclusionsThe miR-150G>A and miR-1179A>T polymorphisms were more frequently associated with RPL compared with controls. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 29, 2019 Category: Reproduction Medicine Source Type: research

Influence of resveratrol supplementation on IVF–embryo transfer cycle outcomes
ConclusionsResveratrol supplementation during embryo transfer cycles appears to be detrimental for pregnancy outcomes. An analysis of the supplementation protocol and randomized controlled studies are needed. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 26, 2019 Category: Reproduction Medicine Source Type: research

Upper and lower genital tract Zika virus screening in a large cohort of reproductive-age women during the Americas epidemic
ConclusionThese findings represent evidence of the lack of vRNA persistence in the reproductive tract, in ZIKV exposed and/or recently infected reproductive age women and could help simplify current guidelines. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 24, 2019 Category: Reproduction Medicine Source Type: research

CCR5/CCR5 ligands induced myeloid-derived suppressor cells are related to the progression of endometriosis
ConclusionsOur study revealed that CCR5 and its ligands could drive the progression of endometriosis by enhancing the accumulation of MDSCs. These findings might bring a promising treatment which targets CCR5+MDSCs for EMS patients. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 24, 2019 Category: Reproduction Medicine Source Type: research

Conservative management of cesarean scar pregnancies with systemic multidose methotrexate: predictors of treatment failure and reproductive outcomes
ConclusionsSystemic MTX therapy is a safe and effective strategy for the treatment of CSP with favorable subsequent reproductive results and a low conversion rate for surgical management. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 24, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: June 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 6Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 23, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: June 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 6Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 23, 2019 Category: Reproduction Medicine Source Type: research

The microRNA polymorphisms in miR-150 and miR-1179 are associated with risk of idiopathic recurrent pregnancy loss
ConclusionsThe miR-150G>A and miR-1179A>T polymorphisms were more frequently associated with RPL compared with controls. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 22, 2019 Category: Reproduction Medicine Source Type: research

Miscarriage history association with euploid embryo transfer outcomes
CONCLUSIONSIn our cohort, there was no significant association between miscarriage history and euploid transfer outcomes (ongoing pregnancy, miscarriage) after adjustment for potential confounders. Further study in larger data sets is warranted. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 22, 2019 Category: Reproduction Medicine Source Type: research

The role of DEFB126 variation in male infertility and assisted reproductive technique outcome
ConclusionsThis sequence variation of DEFB126 may impair male reproductive function and can be related to male infertility. Consequently, the fertility rate is significantly less in del/del males than wt/wt males. Interestingly, males with the del/del genotype have normal spermogeram however, their sperm is functionally impaired, which can affect IUI treatment outcome. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 21, 2019 Category: Reproduction Medicine Source Type: research

Perinatal outcomes in 521 gestations after fresh and frozen cycles: a secondary outcome of a RCT comparing GnRH-antagonist versus GnRH-agonist protocols
Publication date: Available online 17 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): C. Tomas, M. Toftager, K. Løssl, J. Bogstad, L. Prætorius, A. Zedeler, T. Bryndorf, A. Nyboe Andersen, A. PinborgABSTRACTResearch QuestionAre perinatal outcomes different after treatment with the GnRH-antagonist versus the long GnRH-agonist protocol for IVF?DesignPerinatal outcomes were secondary outcomes in a large phase IV, dual-center, open-label, randomized controlled study, to compare GnRH-antagonist and long GnRH-agonist protocols in women 10 IU/L) were included (n=521). Data were analyzed to compare preterm birth (
Source: Reproductive BioMedicine Online - May 18, 2019 Category: Reproduction Medicine Source Type: research

Use of progestins to inhibit spontaneous ovulation during ovarian stimulation: the beginning of a new era?
Publication date: Available online 29 March 2019Source: Reproductive BioMedicine OnlineAuthor(s): Antonio La Marca, Martina CapuzzoAbstractAdvances in oocyte and embryo cryopreservation for assisted reproduction prompted new approaches to ovarian stimulation. Attention has been paid to progesterone and its derivatives to block the LH surge, as oocyte vitrification removes possible harmful effects of progestins on endometrial receptivity. This review summarizes the current status of progestin use to inhibit ovulation during ovarian stimulation compared with conventional ovarian stimulation. Progestin-primed ovarian stimulat...
Source: Reproductive BioMedicine Online - May 17, 2019 Category: Reproduction Medicine Source Type: research

Modified natural cycle IVF versus conventional stimulation in advanced-age Bologna poor responders
Conclusion(s)In advanced –age Bologna poor responders, MNC-IVF-IVF is a more patient-friendly approach and could be a reasonable alternative in this difficult group of women. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 17, 2019 Category: Reproduction Medicine Source Type: research

DNA methylation and histone post-translational modifications in the mouse germline following in vitro maturation of fresh or frozen/thawed prepubertal testicular tissue
ConclusionsDespite differences with the in vivo situation, DNA methylation and histone methylation and acetylation occur in the mouse germline in in vitro matured fresh or frozen/thawed mouse prepubertal testicular tissue, and the expression of the enzymes catalyzing these epigenetic modifications are maintained in vitro. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 17, 2019 Category: Reproduction Medicine Source Type: research

Parameters of the Mouse Embryo Assay that affect detection of peroxides in mineral oil
ConclusionsCurrent quality control protocols may not be sensitive enough to identify low presence of peroxides which, if undetected, can increase over time and become potentially harmful during gamete and embryo culture. The different parameters established in our study allow to optimize the sensitivity of the MEAs to specifically detect peroxides in mineral oil samples, prior to their release into the market and their broad use in human IVF. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 17, 2019 Category: Reproduction Medicine Source Type: research

Effect of pretreatment with a levonorgestrel-releasing intrauterine system on IVF and vitrified–warmed embryo transfer outcomes in women with adenomyosis
ConclusionsThe results of this study offer some support for evaluating the effect of pretreatment with LNG-IUS in women with adenomyosis in future randomized controlled trials. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 16, 2019 Category: Reproduction Medicine Source Type: research

Comparison of 36 assisted reproduction laboratories monitoring environmental conditions and instrument parameters using the same quality-control application
ConclusionsMajor differences exist in instrument monitoring practices among laboratories. Although incubator monitoring is the largest domain, many other sensitive instruments are diligently monitored by most laboratories. International standardization and guidelines are needed. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 16, 2019 Category: Reproduction Medicine Source Type: research

Women's health providers’ perspectives on preimplantation genetic testing
ConclusionsIn a sample of women's health providers across multiple different OB/GYN specialties, there was an overall supportive response towards PGT use for a variety of common indications. Infertility specialists were the most supportive of PGT use, which may reflect the familiarity these providers have with this procedure. There was an overwhelmingly non-supportive response to the use of PGT for non-disease related indications. The percentage of medical professionals working in women's health without prior knowledge of PGT (22.5%) is higher than expected, identifying the need for more education regarding the availabilit...
Source: Reproductive BioMedicine Online - May 12, 2019 Category: Reproduction Medicine Source Type: research

Modified natural cycle cryopreserved embryo transfer: is a washout period needed after a failed fresh cycle?
Publication date: Available online 11 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): Eran Horowitz, Yossi Mizrachi, Jacob Farhi, Amir Shalev, Arieh Raziel, Ariel WeissmanAbstractResearch questionAre the dynamics of the natural cycle (NC) or modified NC (mNC) or live birth rates (LBR) affected by delaying modified NC (mNC) frozen embryo transfer (FET) after a failed fresh IVF cycle?DesignIn a retrospective study, conducted at a university-affiliated tertiary center, 198 patients aged 18-45 years, undergoing their first FET cycle after a failed fresh ET attempt were evaluated. Only natural or modified-natural cycl...
Source: Reproductive BioMedicine Online - May 12, 2019 Category: Reproduction Medicine Source Type: research

Predictive value of serum kisspeptin concentration at 14 and 21 days after frozen–thawed embryo transfer
Publication date: Available online 12 March 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kai-Lun Hu, Yongli Zhang, Zi Yang, Hongcui Zhao, Huiyu Xu, Yang Yu, Rong LiAbstractResearch questionCan serum kisspeptin levels 14 and 21 days after frozen–thawed embryo transfer predict the early pregnancy outcome of patients?DesignProspective study, with 133 patients undergoing frozen–thawed embryo transfer. Patients were divided into non-pregnant group and pregnant group (including biochemical pregnancy, singleton pregnancy, miscarriage and twin groups).ResultsSerum kisspeptin levels on day 21 were significantly...
Source: Reproductive BioMedicine Online - May 11, 2019 Category: Reproduction Medicine Source Type: research

MUC20 expression marks the receptive phase of the human endometrium
ConclusionOur results indicate to MUC20 as a novel marker of mid-secretory endometrial biology. Further investigations should reveal the precise function of MUC20 in human endometrium and the possible connection between MUC20 and HGF-activated MET receptor signalling. MUC20 could potentially be included in the list of endometrial receptivity markers after further clinical validation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 11, 2019 Category: Reproduction Medicine Source Type: research

Antimüllerian hormone in association with euploid embryo transfer outcomes
Publication date: Available online 11 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ange Wang, Ruth Lathi, Jonathan Kort, Lynn WestphalABSTRACTRESEARCH QUESTIONTo investigate the association between antimüllerian hormone (AMH) level and maternal age with single euploid frozen embryo transfer.DESIGNOur study was a retrospective cohort study from 2014-2018 at an academic medical center, including 389 cycles of in-vitro fertilization (IVF) with 24-chromosome day 5/6 preimplantation genetic testing for aneuploidies (PGT-A). We used multivariate logistic regression to study AMH and age in relation to IVF outcom...
Source: Reproductive BioMedicine Online - May 11, 2019 Category: Reproduction Medicine Source Type: research

Contemporary quality control in the IVF laboratory: heading to the cloud?
Publication date: Available online 10 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): David K. Gardner, Thomas B. Pool (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - May 10, 2019 Category: Reproduction Medicine Source Type: research

Inheritance of imbalances in recurrent chromosomal translocation t(11;22): clarification by PGT-SR and sperm-FISH analysis
ConclusionsThese findings highlight the divergence that may exist between meiotic segregation and post-zygotic selection. Post-zygotic selection would be responsible for the elimination of unbalanced embryos derived from the adjacent-1 segregation mode. The combined action of several factors occurs at the beginning of post-zygotic selection. Genetic counselling must consider the risk of a birth related to the adjacent-1 segregation mode, irrespective of the sex of the translocation carrier. These results will allow deeper understanding of the PGT results of t(11;22) carriers, which often include a high number of aneuploid ...
Source: Reproductive BioMedicine Online - May 9, 2019 Category: Reproduction Medicine Source Type: research

The effect of a GnRH antagonist on follicle maturation in normal women
Publication date: Available online 11 March 2019Source: Reproductive BioMedicine OnlineAuthor(s): Serafeim Pousias, Christina I. Messini, George Anifandis, George Sveronis, Panagiotis Georgoulias, Alexandros Daponte, Ioannis E. Messinis, Konstantinos DafopoulosAbstractResearch questionGanirelix is a gonadotrophin-releasing hormone (GnRH) antagonist used for the prevention of premature LH surge during ovarian stimulation. What is the impact of ganirelix on follicle maturation in normal women?DesignTen normally cycling women were investigated during two menstrual cycles, i.e. cycle 1 (control) and cycle 2 (ganirelix). During...
Source: Reproductive BioMedicine Online - May 8, 2019 Category: Reproduction Medicine Source Type: research

Fertility of women with cystic fibrosis: a French survey
Publication date: Available online 7 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): Anna Tournier, Marlène Murris, Anne Prevotat, Annlyse Fanton, Célia Bettiol, Jean ParinaudAbstractEven though the impact of cystic fibrosis (CF) on male fertility is well known, very few studies have investigated its effect on women fertility. In order to evaluate the fertility status of women with cystic fibrosis a questionnaire was sent to 220 women with cystic fibrosis. The questions concerned their desire to become a parent, achievement or not of a pregnancy, the time to became pregnant, the way to obtain pregna...
Source: Reproductive BioMedicine Online - May 8, 2019 Category: Reproduction Medicine Source Type: research