Metabolomics shows no impairment of the microenvironment of the cumulus–oocyte complex in women with isolated endometriosis
ConclusionsNo specific metabolomic signature of endometriosis was found in the follicular fluid of women undergoing IVF. These results suggest that there is no microenvironmental impairment of the COC in cases of isolated endometriosis among women with infertility. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 5, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: October 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 4Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 4, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: October 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 4Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 4, 2019 Category: Reproduction Medicine Source Type: research

High proportion of immature oocytes in a cohort reduces fertilization, embryo development, pregnancy and live birth rates following ICSI
This study aimed to evaluate metaphase II (MII) oocyte competence in terms of fertilization, embryo development and cycle outcomes, according to the oocyte maturity ratio.DesignCouples treated by intracytoplasmic sperm injection (ICSI) between 1993 and 2017 with female partners ≤35 years old were included. Cycles were divided into four groups according to proportion of MII oocytes at the time of retrieval: optimal (76–100%), adequate (51–75%), partial (26–50%) and minimal (1–25%).ResultsA total of 7672 ICSI cycles (optimal: 4838; adequate: 2252; partial: 518; minimal oocyte maturity: 64) were inc...
Source: Reproductive BioMedicine Online - October 4, 2019 Category: Reproduction Medicine Source Type: research

Atherosclerotic cardiovascular disease in women with endometriosis: a systematic review of risk factors and prospects for early surveillance
Publication date: Available online 8 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Justin Tan, Omur Taskin, Mahmoud Iews, Arthur J Lee, Arohumam Kan, Timothy Rowe, Mohamed A BedaiwyAbstractEndometriosis and atherosclerotic cardiovascular disease (ASCVD) share similar pathogenic mechanisms. Hence, this systematic review evaluates the association between endometriosis and lifetime ASCVD risk including co-prevalence with dyslipidaemia, atherosclerosis and non-invasive markers of endothelial dysfunction. The electronic databases Embase, PubMed, MEDLINE, Cochrane Register of Trials and ClinicalTrials.gov were syste...
Source: Reproductive BioMedicine Online - October 4, 2019 Category: Reproduction Medicine Source Type: research

Predictors of uterine fibroid volume reduction under ulipristal acetate: a prospective MRI study
ConclusionsThe location, initial volume and number of fibroids may allow prediction of the outcome of a single 3-month treatment course of daily 5 mg doses of UPA in terms of reduction in volume before surgery. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 1, 2019 Category: Reproduction Medicine Source Type: research

Could ethnicity have a different effect on fresh and frozen embryo transfer outcomes: a retrospective study
ConclusionSouth Asian and Black Afro-Caribbean women have a significantly lower live birth rate than White Caucasian women after fresh embryo transfer, but their frozen embryo transfer live birth rates are not significantly different.Graphical abstract (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 1, 2019 Category: Reproduction Medicine Source Type: research

Fertility preservation knowledge, attitudes and intentions among children by proxy and adolescents with cancer
ConclusionsFertility preservation care has advanced but there are still gender and age differences in counselling and treatment initiation in the paediatric and adolescent cancer population. Interventions to improve provider–patient–parent communication regarding fertility preservation and to help patients address the observed intention–behaviour gap in relation to fertility preservation options are needed.Graphical Abstract (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 1, 2019 Category: Reproduction Medicine Source Type: research

Oocyte vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes but is potentially useful for diagnostic purposes
ConclusionsVitrified-warmed mouse oocytes display reduced Ca2+-releasing potential upon oocyte activation, caused by cryoprotectant exposure. With adapted classification criteria, these oocytes can be used for diagnosing oocyte activation deficiencies in patients. Evaluating the Ca2+-signalling machinery in vitrified-warmed human oocytes is required. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 30, 2019 Category: Reproduction Medicine Source Type: research

Monitoring IVF children birth weight is still a current issue and still a history of maternal factors
ConclusionsOur results suggested that maternal background and obstetric parameters could strongly influence the SGA rate than fresh-ET conception. Similarly, our results FET conception could be associated with an increase of LGA rate in the fetus, especially in cases of female infertility. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 30, 2019 Category: Reproduction Medicine Source Type: research

Dysregulated immunological and metabolic functions discovered by a polygenic integrative analysis for polycystic ovary syndrome
ConclusionThis study provided a comprehensive view of the dysregulated functions and information of further management of PCOS. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 30, 2019 Category: Reproduction Medicine Source Type: research

In Vitro Development of Embryos Derived from Vitrified-Warmed Oocytes is Delayed Compared to Embryos Derived from Fresh Oocytes: A Time-Lapse Sibling Oocyte Study
ConclusionsTiming of development is altered and blastocyst formation is delayed in embryos derived from vitrified-warmed donor oocytes compared to their fresh sibling counterparts. Although preliminary results suggest that the clinical impact of this delay may be limited, this needs further investigation in larger randomized studies. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 28, 2019 Category: Reproduction Medicine Source Type: research

Female age affects the utility of sperm DNA fragmentation in predicting the outcomes of in vitro fertilization and intracytoplasmic sperm injection
ConclusionFemale age has a negative effect and should be considered in predicting the effects of sperm DNA fragmentation on pregnancy outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 28, 2019 Category: Reproduction Medicine Source Type: research

Male fertility: a window on the health of this generation and the next
Publication date: Available online 24 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Chris Barratt, Richard Anderson, Chris De Jonge (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 25, 2019 Category: Reproduction Medicine Source Type: research

Risk of miscarriage in women conceiving after medically assisted reproduction with an ultrasound-verified viable pregnancy at 6–8 weeks’ gestation
ConclusionsAfter adjustment for maternal characteristics, none of the fertility treatment types were associated with an increased risk of miscarriage compared with naturally conceiving women. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 24, 2019 Category: Reproduction Medicine Source Type: research

Both high and low HCG day progesterone concentrations negatively affect live birth rates in IVF/ICSI cycles
Publication date: Available online 9 July 2019Source: Reproductive BioMedicine OnlineAuthor(s): P. Arvis, P. Lehert, A. Guivarc'h-LevêqueAbstractResearch questionCan previous reports of a decreased probability of success in stimulated IVF cycles with premature rise of progesterone, as determined by progesterone concentration on HCG day (PHCG), be confirmed?DesignRetrospective, observational, single-centre cohort study conducted on 5447 IVF and intracytoplasmic (ICSI) cycles carried out among 2192 patients between 2009 and 2015, with conventional ovarian stimulation. This large database was used to develop a non-linea...
Source: Reproductive BioMedicine Online - September 19, 2019 Category: Reproduction Medicine Source Type: research

Three-dimensional ultrasound diagnosis of T-shaped uterus is associated with adverse pregnancy outcomes after embryo transfer
Publication date: Available online 24 July 2019Source: Reproductive BioMedicine OnlineAuthor(s): S.A. Neal, S.J. Morin, M.D. Werner, N.A. Gueye, P. Pirtea, R.T. Scott, L.R. GoodmanAbstractResearch questionIs T-shaped uterine cavity morphology associated with adverse pregnancy outcomes after transfer of a single thawed euploid blastocyst?DesignIn this secondary analysis of a prospective cohort study, 648 patients with three-dimensional ultrasound (3D-US) data obtained on the day before embryo transfer were categorized into three groups according to uterine cavity morphology: normal (n = 472), intermediate (n = 166) ...
Source: Reproductive BioMedicine Online - September 19, 2019 Category: Reproduction Medicine Source Type: research

Endometrial thickness with in-vitro fertilization: a meta-analysis
Publication date: Available online 18 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Ge Gao, Xianfeng Cui, Shuang Li, Pan Ding, Shuai Zhang, Yunshan ZhangAbstractResearch QuestionThis meta-analysis aimed to explore whether endometrial thickness (EMT) could predict pregnancy outcomes after in-vitro fertilization (IVF). Moreover, the associations of EMT with the incidence of pregnancy outcomes according to study and individual characteristics were also assessed.DesignStudies evaluating the associations of EMT with the incidence of pregnancy rate, implantation rate, abortion rate, live birth or ongoing pregna...
Source: Reproductive BioMedicine Online - September 19, 2019 Category: Reproduction Medicine Source Type: research

Use of granulocyte colony-stimulating factor in assisted reproductive treatment does not increase the risk of adverse obstetrical outcomes and birth defects
ConclusionsWe can accept that G-CSF is a encouraging immunological treatment choice for recurrent miscarriage patients with KIR-HLA-C mismatch. Administration of G-CSF during the first phases of pregnancy does not convey a higher risk of perinatal complications (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 19, 2019 Category: Reproduction Medicine Source Type: research

Drug-free In Vitro Activation (IVA) of follicles for infertility treatment in poor ovarian response patients with decreased ovarian reserve
ConclusionsThe present drug-free IVA approach may be suitable for POR patients with DOR, as it increased the number of antral follicles. The procedure also eliminated the need for 2-day incubation with drugs and required only one surgery. This approach could allow the retrieval of more oocytes in middle-age women to achieve higher pregnancy rates and deserves proper evaluation in future randomized controlled trials. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 19, 2019 Category: Reproduction Medicine Source Type: research

Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction
ConclusionsHigher paternal preconception folate intake was associated with slightly longer gestation among live births achieved through assisted reproduction. The results suggest that preconception exposures of the father may have an impact on the health of his offspring, and therefore that preconception care should shift from a woman-centric to a couple-based approach. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 18, 2019 Category: Reproduction Medicine Source Type: research

Risk factors associated with preeclampsia in pregnancies after assisted reproductive technology
ConclusionsFrozen embryo transfer was an independent risk factor of preeclampsia in assisted reproductive technology. The high ovarian response may also increase the risk of preeclampsia. The embryo stage at transfer was not related to the risk of preeclampsia. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 18, 2019 Category: Reproduction Medicine Source Type: research

Gonadotrophins or clomiphene citrate in couples with unexplained infertility undergoing intrauterine insemination: a cost-effectiveness analysis
ConclusionsThe costs to achieve one additional ongoing pregnancy with gonadotrophins compared to CC were €21 804 (95%CI, €11 628 to €31 980).Trial registrationNTR 4057 (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 17, 2019 Category: Reproduction Medicine Source Type: research

Fully human glyco-optimized recombinant FSH (follitropin epsilon) - a randomized, comparator-controlled phase 2 clinical trial
Conclusions75 IU of daily follitropin epsilon results in similar ovarian response as compared to a standard dose of 150 IU follitropin alfa. This dose could be tested in phase III. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 16, 2019 Category: Reproduction Medicine Source Type: research

Influence of Caesarean section–pregnancy interval on uterine rupture risk and IVF pregnancy rates: systematic review and mathematical modelling
ConclusionThe risk of uterine rupture in relation to CSPI can be represented by means of a hyperbolic curve. After a 10-month CSPI, the expected uterine rupture rate is close to 0.7%. The impact of prolonging or reducing this interval on IVF pregnancy rates can be easily obtained from the table included in the article. This should be helpful in the decision-making process for both patients and physicians. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 13, 2019 Category: Reproduction Medicine Source Type: research

Oxytocin antagonism reverses the effects of high oestrogen levels and oxytocin on decidualization and cyclooxygenase activity in endometrial tissues
ConclusionsOxytocin antagonist reversed the effects of high oestradiol and oxytocin on parameters related to endometrial receptivity in conditions mimicking ovarian stimulation. This might point to a novel, endometrium-related mechanism to support embryo implantation achieved by the application of oxytocin antagonist prior to embryo transfer. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 13, 2019 Category: Reproduction Medicine Source Type: research

Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related infertility
ConclusionsInfertile women with stage I and II endometriosis present systemic oxidative stress during the early follicular phase of the menstrual cycle. Some oxidative stress markers were good predictors of clinical pregnancy and live births after ICSI. Serum TAC was predictive of clinical pregnancy and live births after ICSI in women with stage I or II endometriosis. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 13, 2019 Category: Reproduction Medicine Source Type: research

hMG versus recombinant FSH+ recombinant LH in controlled ovarian hyperstimulation for in vitro fertilization: Does the source of LH preparation matter?
ConclusionsConsidering the hitherto published studies, no firm conclusions can be drawn in favor of the different source of 'LH activity' containing preparation. Further large RCTs studies are needed to investigate the true impact of the source of LH supplementation on IVF outcome and to identify the selected groups of patients who are most likely to benefit from the addition of 'LH activity' supplementation to their COH protocol. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 13, 2019 Category: Reproduction Medicine Source Type: research

Conservative management of Caesarean scar pregnancies with systemic multidose methotrexate: predictors of treatment failure and reproductive outcomes
ConclusionsSystemic MTX therapy is a safe and effective strategy for the treatment of CSP, with favourable subsequent reproductive results and a low conversion rate to surgical management. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 11, 2019 Category: Reproduction Medicine Source Type: research

Depression and/or Anxiety Disorders during the First Trimester Not Preconception Increases the Risk of Low Birth Weight in Offspring: A Prospective Cohort Study
Publication date: Available online 11 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Jingwen Lang, Bingqian Zhang, Yueru Meng, Yanzhi Du, Linlin Cui, Weiping LiABSTRACTResearch QuestionAre maternal depression and anxiety disorders (MDAD) before and during pregnancy associated with in vitro fertilization (IVF) outcomes?DesignA total of 5556 women with their first IVF cycle started between August 15th, 2014, and December 31st, 2015 were pooled from a prospective cohort of assisted reproductive technology (ART) children. The self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to d...
Source: Reproductive BioMedicine Online - September 11, 2019 Category: Reproduction Medicine Source Type: research

May the colleague who truly has no conflict of interest now please stand up!
Publication date: Available online 7 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): Bart CJM Fauser, NS Macklon (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 8, 2019 Category: Reproduction Medicine Source Type: research

Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis
Publication date: Available online 3 July 2019Source: Reproductive BioMedicine OnlineAuthor(s): Belinda G. Vermey, Su Jen Chua, Mohammad Hadi Zafarmand, Rui Wang, Salvatore Longobardi, Evelyn Cottell, Francois Beckers, Ben W. Mol, Christos A. Venetis, Thomas D'HoogheAbstractThe aim of this systematic review and meta-analysis was to determine the association between the number of oocytes aspirated after ovarian stimulation and the number of top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searche...
Source: Reproductive BioMedicine Online - September 7, 2019 Category: Reproduction Medicine Source Type: research

Circulatory metastin/kisspeptin-1 in polycystic ovary syndrome: a systematic review and meta-analysis with diagnostic test accuracy
Publication date: Available online 2 May 2019Source: Reproductive BioMedicine OnlineAuthor(s): Seshadri Reddy Varikasuvu, V Satya Prasad, VC Vamshika, MV Satyanarayana, Jaipal Reddy PangaAbstractResearch questionA close association between Kisspeptin-1 (KISS-1) and reproductive physiology has been reported, but the results on circulatory KISS-1 are ambiguous in patients with polycystic ovary syndrome (PCOS). A systematic review and meta-analysis were conducted to evaluate the association between KISS-1 and PCOS, and to test its diagnostic test accuracy (DTA) through DTA meta-analysis.DesignRelevant studies were identified ...
Source: Reproductive BioMedicine Online - September 5, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: September 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 3Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 5, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: September 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 3Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 5, 2019 Category: Reproduction Medicine Source Type: research

A mouse model for the effects of IVF procedures on the development of embryos
Publication date: September 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 3Author(s): Catherine Aiken, Martin Johnson (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 5, 2019 Category: Reproduction Medicine Source Type: research

Beneficial treatment effects of dietary nitrate supplementation on testicular injury in streptozotocin-induced diabetic male rats
Publication date: September 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 3Author(s): Rana Keyhanmanesh, Gholamreza Hamidian, Mohammad Reza Alipour, Hajar OghbaeiAbstractResearch questionDo low doses of dietary nitrate help to attenuate the progression of diabetic reproductive disorders in streptozotocin-induced diabetic male rats?DesignFifty male Wistar rats were divided into five groups: controls receiving distilled water; controls receiving 100 mg/l nitrate in distilled water; diabetic rats receiving distilled water; diabetic rats receiving insulin 2–4 U/day of neutral protamine hagedorn insulin; a...
Source: Reproductive BioMedicine Online - September 5, 2019 Category: Reproduction Medicine Source Type: research

Differential impacts of gonadotrophins, IVF and embryo culture on mouse blastocyst development
This study examined the developmental characteristics of mouse blastocysts derived from ART- compared with in-vivo-conceived embryos. To determine the effect of ovarian stimulation versus IVF versus in-vitro embryo culture on phenotype, six distinct groups of blastocysts were generated. Female mice were naturally cycling or treated with high or mild doses of gonadotrophin, followed by natural mating or IVF under clinical conditions. Embryo morphokinetics were assessed by continuous time-lapse monitoring. Cell lineage allocation to the inner cell mass (Oct4+) or trophectoderm (Cdx2+) was determined by immunohistochemistry, ...
Source: Reproductive BioMedicine Online - September 5, 2019 Category: Reproduction Medicine Source Type: research

Association of gene polymorphisms in the anti-Müllerian hormone signalling pathway with ovarian function: a systematic review and meta-analysis
Publication date: September 2019Source: Reproductive BioMedicine Online, Volume 39, Issue 3Author(s): Ran Cheng, Wei Xiong, Xiaoyan Luo, Yaxian Ma, Ying Nie, Xiaoyong Qiao, Hui Chen, Ying Hu, Liangzhi XuAbstractThis systematic review evaluated whether single nucleotide polymorphisms of AMH and AMHRII genes are associated with ovarian function. A literature search of PubMed and Embase was complemented by hand searches in the reference lists. Eight studies involving 3155 participants were included in a meta-analysis and 10 studies included for description. For AMH c.146T>G polymorphism, no significant difference in serum ...
Source: Reproductive BioMedicine Online - September 5, 2019 Category: Reproduction Medicine Source Type: research

The impact of serum estradiol level prior to progesterone administration on live birth rate in single frozen-thawed blastocyst transfer cycles
ConclusionsSerum E2 level monitoring just prior to progesterone administration does not appear to be predictive for live birth rates in good prognosis patients undergoing single, autologous FBTs after artificial EP. Therefore, the current practice of monitoring serum E2 level is not supported by our study. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 4, 2019 Category: Reproduction Medicine Source Type: research

Male Infertility and antioxidants: one small step for man, no giant leap for andrology?
Publication date: Available online 3 September 2019Source: Reproductive BioMedicine OnlineAuthor(s): S J Martins da SilvaAbstractOxidative stress is detrimental to spermatozoa and is acknowledged to be a common pathology in infertile men. Antioxidant supplements therefore represent a logical therapeutic approach, although the recent Cochrane review recommends cautious interpretation of publications and findings to date. This commentary considers whether male fertility supplements have a place in current reproductive medicine practice. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 4, 2019 Category: Reproduction Medicine Source Type: research

The importance of soluble anti-Müllerian hormone receptor type 2 (sAMHR2) as a new serum marker in diagnosis of fertility disorders in women
ConclusionsThe sAMHR2/AMH ratio may serve as a useful biomarker for infertility diagnostics to identify women with ovarian insufficiency. The exact regulatory circuit of AMHR2 and the cleavage of its soluble form remain to be assessed. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 27, 2019 Category: Reproduction Medicine Source Type: research

Patient-tailored luteal phase support with progesterone may avoid unnecessary oocyte donation failures
Publication date: Available online 26 August 2019Source: Reproductive BioMedicine OnlineAuthor(s): Jan Tesarik, Raquel Mendoza-Tesarik (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 26, 2019 Category: Reproduction Medicine Source Type: research

Emeritus Professor Ian Logan Craft FRCS FRCOG: a 'Universal Genius' with scientific and artistic qualities
Publication date: Available online 19 August 2019Source: Reproductive BioMedicine OnlineAuthor(s): John L Yovich, Joyce C Harper (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 25, 2019 Category: Reproduction Medicine Source Type: research

A propensity-matched study of the association between pre-pregnancy maternal underweight and perinatal outcomes of singletons conceived through assisted reproductive technology
ConclusionsAmong women undergoing ART, pre-pregnancy maternal underweight was associated with lower birth weight, increased LBW and SGA risks, and decreased fetal macrosomia and LGA risks in singleton infants. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 24, 2019 Category: Reproduction Medicine Source Type: research

Improved detection of CFTR variants by targeted next-generation sequencing in male infertility: A case series
ConclusionTargeted NGS lead to the detection of 5 infertile males with CFTR variants, who otherwise would have remained undiagnosed after routine genetic screening during the fertility work-up for azoospermia or severe oligozoospermia. Given the wide availability of targeted NGS in an affordable manner, our data suggest that full gene analysis, and not mutation panels, should be considered to screen CFTR in azoospermic men. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 23, 2019 Category: Reproduction Medicine Source Type: research

Ovarian Stimulation (OS) Does Not Influence the Uterine Immune Environment in Healthy Infertile Women
ConclusionOS does not affect the uterine immune cell population or HLA-C binding in healthy women undergoing OS. Further studies are underway to find out if women with previous autoimmune disorders may provide different responses. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 22, 2019 Category: Reproduction Medicine Source Type: research

Fibrinogen alpha chain is upregulated and affects the pathogenesis of endometriosis
ConclusionsHigh expression of FGA in EM was closely related to disease severity and affected cell adhesion, migration, and invasion, which might play an important role in the pathogenesis of EM. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 21, 2019 Category: Reproduction Medicine Source Type: research

Only 1 embryo. Transfer on day 3 or grow on. What is best?
ConclusionsThese findings support day 3 cleavage stage embryo transfer instead of growing on to day 4-6 for blastocyst stage transfer when only a single embryo is available. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 21, 2019 Category: Reproduction Medicine Source Type: research

High proportion of immature oocytes in a cohort reduces fertilization, development, pregnancy and live birth rates following ICSI
This study aimed to evaluate metaphase II (MII) oocyte competence in terms of fertilization, embryo development and cycle outcomes, according to the oocyte maturity ratio.DesignCouples treated by intracytoplasmic sperm injection (ICSI) between 1993 and 2017 with female partners ≤35 years old were included. Cycles were divided into four groups according to proportion of MII oocytes at the time of retrieval: optimal (76–100%), adequate (51–75%), partial (26–50%) and minimal (1–25%).ResultsA total of 7672 ICSI cycles (optimal: 4838; adequate: 2252; partial: 518; minimal oocyte maturity: 64) were inc...
Source: Reproductive BioMedicine Online - August 20, 2019 Category: Reproduction Medicine Source Type: research