Evaluation of dietary dose administration as an alternative to oral gavage in the rodent uterotrophic and Hershberger assays
Publication date: Available online 9 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Lauren Markell, John C. O'Connor, Ruijuan Luo, Joseph Klems, Brian Sayers, Robert Mingoia (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 10, 2020 Category: Toxicology Source Type: research

The activity of methacrylate esters in skin sensitisation test methods II. A review of complementary and additional analyses
Publication date: Available online 10 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Ian Kimber (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 10, 2020 Category: Toxicology Source Type: research

The performance, reliability and potential application of in silico models for predicting the acute oral toxicity of pharmaceutical compounds
Publication date: Available online 6 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Jessica Graham, Maryann Rodas, Jedd Hillegass, Gene Schulze (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 7, 2020 Category: Toxicology Source Type: research

Assessment of the potential allergenicity and toxicity of Pichia proteins in a novel leghemoglobin preparation
Publication date: Available online 7 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Teresa F. Reyes, Yiming Chen, Rachel Z. Fraser, Teresa Chan, Xin Li (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 7, 2020 Category: Toxicology Source Type: research

Computational identification of preservatives with potential neuronal cytotoxicity
Publication date: Available online 4 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Hung-Lin Kan, Chia-Chi Wang, Ying-Chi Lin, Chun-Wei Tung (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 6, 2020 Category: Toxicology Source Type: research

Corrigendum to “28-day somatic gene mutation study of 1-Bromopropane in female big blue® B6C3F1 Mice via whole-Body inhalation: Support for a carcinogenic threshold” [Regul. Toxicol. Pharmacol., 104 (2019) 1–7]
Publication date: Available online 3 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Mark Stelljes, Robert Young, Jeff Weinberg (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 4, 2020 Category: Toxicology Source Type: research

Considerations for setting occupational exposure limits for novel pharmaceutical modalities
Publication date: Available online 2 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Jessica Graham, Jedd Hillegass, Gene Schulze (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 3, 2020 Category: Toxicology Source Type: research

A retrospective study on EU harmonised classifications for carcinogenicity to guide future research
Publication date: Available online 28 October 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Claire Terry, Zhongyu Yan, Marco Corvaro, Sean C. Gehen (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - October 29, 2020 Category: Toxicology Source Type: research

Statistical analysis of in vivo alkaline comet assay data - Comparison of median and geometric mean as centrality measures
Publication date: Available online 28 October 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Timur Tug, Katja Ickstadt, Michael Kunz, Andreas Sutter, Bernd-Wolfgang Igl (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - October 29, 2020 Category: Toxicology Source Type: research

Choosing the best for preventing the worst: A structured analysis of the selection of risk management options in REACH restriction dossiers
Publication date: Available online 26 October 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Isabel Hilber, Silke Gabbert (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - October 27, 2020 Category: Toxicology Source Type: research

Thirteen-week oral toxicity study of fermented ginseng, GBCK25, in Sprague-Dawley rats
Publication date: Available online 26 October 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Kyung-Tai Kim, Doo-Wan Cho, Mi-Jin Yang, Da-Hee Kim, Seung-Hyuk Shin, Jeong Ho Hwang, Dong Ho Woo, Dong Gyu Shin, Jeong Hun Seo, Young-Su Yang, Su-Cheol Han (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - October 27, 2020 Category: Toxicology Source Type: research

Safety evaluation of Eucommia ulmoides extract
Publication date: Available online 26 October 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Xiaomei Luo, Jiashuo Wu, Zhuangzhuang Li, Weiyi Jin, Fangqing Zhang, Hong Sun, Yue Shi (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - October 27, 2020 Category: Toxicology Source Type: research

The translational value of animal models in orphan medicines designations for rare paediatric neurological diseases
Publication date: Available online 26 October 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Dinah M. Duarte, Maria Beatriz da Silva Lima, Bruno Sepodes (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - October 26, 2020 Category: Toxicology Source Type: research

Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen
Publication date: Available online 22 October 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Gary Eichenbaum, Kyunghee Yang, Yeshitila Gebremichael, Brett A. Howell, Jay Murray, David Jacobson-Kram, Hartmut Jaeschke, Edwin Kuffner, Cathy Gelotte, John Lai, Daniele Wikoff, Evren Atillasoy (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - October 23, 2020 Category: Toxicology Source Type: research

Rebuttal to the letters to the editors by Terry et al. and Sewell et al. regarding Heringa et al. (2020)
Publication date: Available online 19 October 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Minne B. Heringa, Nicole H.P. Cnubben, Wout Slob, Marja E.J. Pronk, Andre Muller, Marjolijn Woutersen, Betty C. Hakkert (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - October 19, 2020 Category: Toxicology Source Type: research