A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure.
Publication date: Available online 7 December 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): David J. Kirkland, Meredith L. Sheil, Michael A. Streicker, George E. Johnson (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 7, 2020 Category: Toxicology Source Type: research

A review to support the derivation of a worst-case dermal penetration value for nanoparticles
Publication date: February 2021Source: Regulatory Toxicology and Pharmacology, Volume 119Author(s): Irene Gimeno-Benito, Anna Giusti, Susan Dekkers, Andrea Haase, Gemma Janer (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - December 4, 2020 Category: Toxicology Source Type: research

Subchronic toxicity study in rats evaluating herbicide-tolerant soybean DAS-68416-4
Publication date: Available online 28 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Li Zhang, Shu-Fei Li, Qing-Hong Zhou, Ying-Hua Liu, Jing Zhang, Zhi-Yong Qian (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 28, 2020 Category: Toxicology Source Type: research

A call for action on the development and implementation of new methodologies for safety assessment of chemical-based products in the EU – A short communication
Publication date: Available online 26 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Derek J. Knight, Hubert Deluyker, Qasim Chaudhry, Jean-Marc Vidal, Alie de Boer (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 28, 2020 Category: Toxicology Source Type: research

A review to support the derivation of a worst-case dermal penetration value for nanoparticles.
Publication date: Available online 26 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Irene Gimeno-Benito, Anna Giusti, Susan Dekkers, Andrea Haase, Gemma Janer (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 28, 2020 Category: Toxicology Source Type: research

Evaluating chemical similarity as a measure to identify potential substances of very high concern
Publication date: Available online 20 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Pim N.H. Wassenaar, Emiel Rorije, Martina G. Vijver, Willie J.G.M. Peijnenburg (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 21, 2020 Category: Toxicology Source Type: research

Aloe gel-base food products: Chemical, toxicological, and regulatory aspects
Publication date: Available online 19 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Alessandra Baldi, Eduardo Sommella, Pietro Campiglia, Maria Daglia (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Antimony release from polyester textiles by artificial sweat solutions: A call for a standardized procedure
Publication date: Available online 19 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Marc Biver, Andrew Turner, Montserrat Filella (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Genotoxicity and subchronic toxicity studies of supercritical carbon dioxide and acetone extracts of rosemary
Publication date: Available online 19 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Kirt R. Phipps, Dayna Lozon, Nigel Baldwin (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Simple methodology for ensuring the precision of measuring radioactivity at low concentrations in very small tissues using quantitative whole-body autoradiography
Publication date: Available online 20 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Takanori Hironaka, Kazuhiro Inazawa, Yukari Tanaka, Hiroshi Hasegawa (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Editorial Board
Publication date: December 2020Source: Regulatory Toxicology and Pharmacology, Volume 118Author(s): (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 20, 2020 Category: Toxicology Source Type: research

Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies
Publication date: Available online 19 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Timothy K. MacLachlan, Sven Kronenberg, Nikki Marshall, Laura Andrews, Shawn Jay Berens, Frederic Brouta, Birgit Fogal, Wendy Freebern, Danuta Herzyk, Cris Kamperschroer, Andrea Kiessling, Marlowe Schneidkraut, Curtis Maier (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 19, 2020 Category: Toxicology Source Type: research

Safety assessment of ethanolic root extract of Zaleya decandra (EEZD) in Wistar rats
Publication date: Available online 17 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Malarvizhi Deivasigamani, Nagaraj Kannan, Nishu Sekar, Hariprasath Lakshmanan (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 18, 2020 Category: Toxicology Source Type: research

Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride Co-formulation against VX in a Guinea pig model
Publication date: Available online 16 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Jiska Kentrop, Vladimir Savransky, Steven D. Klaassen, Tomas van Groningen, Sara Bohnert, Alex S. Cornelissen, Laura Cochrane, John Barry, Marloes J.A. Joosen (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 17, 2020 Category: Toxicology Source Type: research

A 90-day drinking water study in mice to characterize early events in the cancer mode of action of 1,4-dioxane
Publication date: Available online 12 November 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Mark Lafranconi, Robert Budinsky, Lisa Corey, Joanna Klapacz, James Crissman, Matthew LeBaron, Rachel Golden, Richard Pleus (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - November 14, 2020 Category: Toxicology Source Type: research