Retraction.
Authors: Abstract Since the following case report was found not to meet the ethical standards of Juntendo University, as previously stated by the authors, the article has been retracted from Regenerative Medicine: Kantake M, Hirano A, Sano M, Urushihata N, Tanemura H, Oki K, Suzaki E. Transplantation of allogeneic adipose-derived mesenchymal stem cells in a cerebral palsy patient. Regenerative Medicine doi:10.2217/rme-2017-0043 (2017) (Epub ahead of print). The authors and editors of Regenerative Medicine regret any negative consequences this publication might have caused in the scientific and medical communities...
Source: Regenerative Medicine - September 5, 2017 Category: Genetics & Stem Cells Tags: Regen Med Source Type: research

Opportunities and challenges for the cellular immunotherapy sector: a global landscape of clinical trials.
Abstract Global investments in cellular immunotherapies reflect their curative potential. Our landscape of clinical trials will aid developers, investors, adopters and payers in planning for adoption and implementation along realistic time horizons. Trend data enable stakeholders to adapt their business models and capacity to bring immunotherapies to the clinic. For cancer, trends suggest a shift from cancer vaccines to adoptive cellular transfer, alongside a focus on solid tumors. Academic centers, mainly in the USA, lead in early-phase clinical trials and target identification; but industry involvement has incre...
Source: Regenerative Medicine - August 29, 2017 Category: Genetics & Stem Cells Authors: Bonter K, Breckenridge Z, Lachance S, Delisle JS, Bubela T Tags: Regen Med Source Type: research

Host cell recruitment patterns by bone morphogenetic protein-2 releasing hyaluronic acid hydrogels in a mouse subcutaneous environment.
CONCLUSION: Hyaluronic acid+BMP-2 gels influenced the inflammatory response in the bone healing microenvironment. Host-derived putative mesenchymal stem cells were major contributors. Addition of hydroxyapatite nanoparticles modified the release pattern of rhBMP-2, resulting in enhanced bone formation. PMID: 28770657 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - August 3, 2017 Category: Genetics & Stem Cells Authors: Todeschi MR, El Backly RM, Varghese OP, Hilborn J, Cancedda R, Mastrogiacomo M Tags: Regen Med Source Type: research

Contributions for classification of platelet rich plasma - proposal of a new classification: MARSPILL.
i JM Abstract Platelet-rich plasma (PRP) has emerged as a significant therapy used in medical conditions with heterogeneous results. There are some important classifications to try to standardize the PRP procedure. The aim of this report is to describe PRP contents studying celular and molecular components, and also propose a new classification for PRP. The main focus is on mononuclear cells, which comprise progenitor cells and monocytes. In addition, there are important variables related to PRP application incorporated in this study, which are the harvest method, activation, red blood cells, number of spins, imag...
Source: Regenerative Medicine - July 31, 2017 Category: Genetics & Stem Cells Authors: Lana JFSD, Purita J, Paulus C, Huber SC, Rodrigues BL, Rodrigues AA, Santana MH, Madureira JL, Malheiros Luzo ÂC, Belangero WD, Annichino-Bizzacchi JM Tags: Regen Med Source Type: research

The patch assay reconstitutes mature hair follicles by culture-expanded human cells.
CONCLUSION: The patch assay has the potential for testing the trichogenicity of human cells. PMID: 28749726 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - July 27, 2017 Category: Genetics & Stem Cells Authors: Zhang Q, Zu T, Zhou Q, Wen J, Leng X, Wu X Tags: Regen Med Source Type: research

Preservation and stability of cell therapy products: recommendations from an expert workshop.
This report presents expert consensus on these and other issues which need to be addressed for more efficient delivery of cell therapies. PMID: 28721749 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - July 19, 2017 Category: Genetics & Stem Cells Authors: Stacey GN, Connon CJ, Coopman K, Dickson AJ, Fuller B, Hunt CJ, Kemp P, Kerby J, Man J, Matejtschuk P, Moore H, Morris J, Oreffo RO, Slater N, Ward S, Wiggins C, Zimmermann H Tags: Regen Med Source Type: research

ClinicalTrials.gov, stem cells and 'pay-to-participate' clinical studies.
Abstract Numerous US businesses that engage in direct-to-consumer advertising of stem cell interventions that are not US FDA-approved also recruit clients by listing 'pay-to-participate' studies listed on ClinicalTrials.gov . Individuals considering enrolling in such studies and NIH officials responsible for overseeing the database need to be aware that some businesses are using the registry to promote unapproved stem cell interventions that study subjects are charged to receive. Inclusion of such studies in ClinicalTrials.gov reveals that the database needs better screening tools. In particular, screening should ...
Source: Regenerative Medicine - July 19, 2017 Category: Genetics & Stem Cells Authors: Turner L Tags: Regen Med Source Type: research

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions 1-31 March 2017.
PMID: 28722542 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - July 19, 2017 Category: Genetics & Stem Cells Authors: Ilic D, Berengueras JM Tags: Regen Med Source Type: research

Enhanced bone repair induced by human adipose-derived stem cells on osteogenic extracellular matrix ornamented small intestinal submucosa.
CONCLUSION: This work suggested a biofabricated SIS scaffold coated with osteogenic ECM-facilitated bone regeneration with ADSCs synergistically. PMID: 28718708 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - July 18, 2017 Category: Genetics & Stem Cells Authors: Zhang C, Li M, Zhu J, Luo F, Zhao J Tags: Regen Med Source Type: research

Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells.
Abstract AIM: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. METHODS: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (
Source: Regenerative Medicine - July 18, 2017 Category: Genetics & Stem Cells Authors: Strong AL, Jones RB, Glowacki J, Boue SM, Burow ME, Bunnell BA Tags: Regen Med Source Type: research

WideCells Group PLC.
Abstract WideCells Group PLC (Manchester, UK) is a global stem cell services company with the aim of leading a transformation in cord blood banking and stem cell treatment. There are three key divisions: WideCells, WideAcademy and CellPlan. WideCells provides contract, collaborative and in-house research, and stem cell processing and storage facilities for a wide range of human tissues. WideAcademy, the education and training branch of the WideCells Group, aims to become the thought leader in stem cell technology, influencing and informing the next generation of healthcare professionals working in stem cell techno...
Source: Regenerative Medicine - July 13, 2017 Category: Genetics & Stem Cells Authors: Hollands P Tags: Regen Med Source Type: research

Our panel of experts highlight the most important research articles across the spectrum of topics relevant to the field of regenerative medicine.
PMID: 28703687 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - July 13, 2017 Category: Genetics & Stem Cells Authors: Kerstetter-Fogle A Tags: Regen Med Source Type: research

The decellularized extracellular matrix in regenerative medicine.
PMID: 28703695 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - July 13, 2017 Category: Genetics & Stem Cells Authors: Rijal G Tags: Regen Med Source Type: research

Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design.
CONCLUSION: This trial has been carefully designed so that valuable scientific and clinical information can be gathered throughout and in the final analysis. PMID: 28635368 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 21, 2017 Category: Genetics & Stem Cells Authors: Richardson JB, Wright KT, Wales J, Kuiper JH, McCarthy HS, Gallacher P, Harrison PE, Roberts S Tags: Regen Med Source Type: research

Interview with Darrell Kotton.
Abstract Dr Kotton is the David Seldin Professor of Medicine and the founding Director of the Center for Regenerative Medicine of Boston University and Boston Medical Center. He conducts basic stem cell research as an NIH-funded Principle Investigator in the Kotton Laboratory (focused on stem cell biology and gene therapy related to lung injury and repair). In addition, he attends in the Medical Intensive Care Unit, the Pulmonary Consultation Service, the Alpha-1 Center and the Pulmonary Outpatient Clinic, all at Boston Medical Center. PMID: 28621167 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Kotton D Tags: Regen Med Source Type: research

Therapeutic efficacy of multipotent adult progenitor cells versus mesenchymal stem cells in experimental autoimmune encephalomyelitis.
In this study, we have evaluated the therapeutic efficacy of mouse multipotent adult progenitor cells (mMAPCs) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, and compared it with mouse mesenchymal stem cells (mMSCs). MATERIALS & METHODS: We administered PKH26-labeled mMAPC and mMSC into EAE mice and evaluated their therapeutic efficacy. RESULTS: The mMAPC-treated mice in comparison with the mMSC group exhibited a higher suppression of EAE (p
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Singh SP, Jadhav SH, Chaturvedi CP, Nityanand S Tags: Regen Med Source Type: research

Boundary cap neural crest stem cell transplants contribute Mts1/S100A4-expressing cells in the glial scar.
CONCLUSION: bNCSC transplants contribute nonpermissive Mts1/S100A4-expressing cells to the glial scar after dorsal root avulsion. PMID: 28621171 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Trolle C, Ivert P, Hoeber J, Rocamonde-Lago I, Vasylovska S, Lukanidin E, Kozlova EN Tags: Regen Med Source Type: research

Direct reprogramming into endothelial cells: a new source for vascular regeneration.
PMID: 28621172 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Lee S, Kim JE, Johnson BA, Andukuri A, Yoon YS Tags: Regen Med Source Type: research

In vivo investigation of tissue-engineered periosteum for the repair of allogeneic critical size bone defects in rabbits.
CONCLUSION: The TEP approach can effectively restore allogenic critical sized defects, and achieve maturity of long-bone structure in 12 weeks in rabbit models. PMID: 28621175 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Zhao L, Zhao J, Yu J, Sun R, Zhang X, Hu S Tags: Regen Med Source Type: research

Interview with Bernard Siegel.
Abstract Bernard Siegel is the Founder and full-time Executive Director of the nonprofit Regenerative Medicine Foundation (FL, USA). He is the Founder and the Co-chair of the World Stem Cell Summit series of global conferences and Editor-in-Chief of the World Stem Cell Report. He received his undergraduate and law degrees from the University of Miami (BA, 1972; JD, 1975) and has been a member of the Florida Bar since 1975. As a recognized policy expert relating to stem cell research, regenerative medicine and cloning, Bernard works with the world's leading stem cell researchers and advocates. He is also a frequent...
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Siegel B Tags: Regen Med Source Type: research

An integrated experimental and economic evaluation of cell therapy affinity purification technologies.
CONCLUSION: Technical and bioprocess benefits were noted with SpheriTech beads which, unlike FACS and MACS, require no cell labeling. This simplifies the bioprocess, reduces cell loss and leaves target cells label free. The economic tool predicted cost drivers and a critical dose (7 × 10(7) cells per dose) shifting the most cost-effective technology from FACS to MACS. Process optimization is required for SpheriTech to compete economically. PMID: 28621179 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Weil BD, Jenkins MJ, Uddin S, Bracewell DG, Wellings D, Farid SS, Veraitch F Tags: Regen Med Source Type: research

Sciatic nerve regeneration by transplantation of in vitro differentiated nucleus pulposus progenitor cells.
CONCLUSION: NP progenitor cells differentiated into Schwann-like cells. Transplantation of these cells promoted myelinated axon formation, morphology restoration and nerve function improvement. NP progenitor cells have the capacity to differentiate into neuronal cells and are candidates for peripheral nerve regeneration therapy. PMID: 28621199 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Ishii T, Sakai D, Schol J, Nakai T, Suyama K, Watanabe M Tags: Regen Med Source Type: research

Muscle-derived stem cells in peripheral nerve regeneration: reality or illusion?
Abstract Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential for multidifferentiation. MDSCs play an important role in trauma repair associated with neuromuscular and vascular injury by simultaneously promoting tissue regrowth via direct differentiation and systematic secretion under physiological conditions. However, the isolation, culture, induction and application of MDSCs require further...
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Zhou J, Cui H, Lu H, Xu Z, Feng W, Chen L, Jin X, Yang X, Qi Z Tags: Regen Med Source Type: research

Soluble TNF inhibition leads to remyelination.
PMID: 28621203 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Kerstetter-Fogle A Tags: Regen Med Source Type: research

Glycosaminoglycan-based resorbable polymer composites in tissue refurbishment.
Abstract Regeneration of tissue structure with the aid of bioactive polymer matrices/composites and scaffolds for respective applications is one of the emerging areas of biomedical engineering. Recent advances in conjugated glycosaminoglycan (GAG) hybrids using natural and synthetic polymers have opened new avenues for producing a wide variety of resorbable polymer matrices. These hybrid scaffolds are low-immunogenic, highly biocompatible and biodegradable with incredible mechanical and tensile properties. GAG-based resorbable polymeric matrices are being exploited in migration of stem cells, cartilage and bone re...
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Gulati K, Meher MK, Poluri KM Tags: Regen Med Source Type: research

Stem cells in court: historical trends in US legal cases related to stem cells.
Abstract Using two legal research platforms, we identified 193 stem-cell-related legal cases that were decided in US courts. Classifying the cases by category, we examined historical trends in the types of legal cases related to stem cells. Major types of cases involved plaintiffs seeking to overturn denial of health insurance coverage decisions, disputes related to intellectual property, false advertising, breaches of contract, exposure to hazardous agents, regulatory decisions, stem cell procedures and professional standard of care, use of stems cells in research, and public funding of embryonic stem cell resear...
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Martinho AM, Turner L Tags: Regen Med Source Type: research

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions, 1 January-28 February 2017.
PMID: 28621222 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - June 16, 2017 Category: Genetics & Stem Cells Authors: Ilic D, Yau S Tags: Regen Med Source Type: research

Transplantation of allogeneic adipose-derived mesenchymal stem cells in a cerebral palsy patient.
Abstract We studied the safety and efficacy of allogeneic human adipose-derived mesenchymal cell (hAMSC) transplantation in a patient with cerebral palsy (CP). The patient received six infusions of allogeneic hAMSCs intravenously, without or with intramuscular or local injections and was followed up for 12 months. Changes in quality of life were assessed using the Short Form 8 health survey questionnaire incorporating physical and mental component summary scores. Clinical manifestations improved remarkably, with significant improvements in the quality of life physical and mental scores. No serious adverse effect o...
Source: Regenerative Medicine - June 2, 2017 Category: Genetics & Stem Cells Authors: Kantake M, Hirano A, Sano M, Urushihata N, Tanemura H, Oki K, Suzaki E Tags: Regen Med Source Type: research

Cartilage engineering in reconstructive surgery: auricular, nasal and tracheal engineering from a surgical perspective.
Abstract This review provides an update on cartilage tissue engineering with particular focus on the head and neck. It is aimed at scientists and clinicians who are interested in tissue engineering and its clinical applicability. Principal tissue engineering strategies are summarized in the first part of this review. In the second part, current clinical approaches to auricular, nasal and tracheal reconstruction are discussed from a surgical perspective. By this approach, the requirements for clinical applicability are outlined and new insight into relevant aims of research is given to accelerate the transfer from ...
Source: Regenerative Medicine - May 19, 2017 Category: Genetics & Stem Cells Authors: Wiggenhauser PS, Schantz JT, Rotter N Tags: Regen Med Source Type: research

The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft.
CONCLUSION: Myeloid cell-derived PDGF contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition. PMID: 28524773 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - May 19, 2017 Category: Genetics & Stem Cells Authors: Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C Tags: Regen Med Source Type: research

Cardiac tissue engineering: from matrix design to the engineering of bionic hearts.
Abstract The field of cardiac tissue engineering aims at replacing the scar tissue created after a patient has suffered from a myocardial infarction. Various technologies have been developed toward fabricating a functional engineered tissue that closely resembles that of the native heart. While the field continues to grow and techniques for better tissue fabrication continue to emerge, several hurdles still remain to be overcome. In this review we will focus on several key advances and recent technologies developed in the field, including biomimicking the natural extracellular matrix structure and enhancing the tr...
Source: Regenerative Medicine - May 12, 2017 Category: Genetics & Stem Cells Authors: Fleischer S, Feiner R, Dvir T Tags: Regen Med Source Type: research

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions 1 December-31 December 2016.
PMID: 28353405 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 29, 2017 Category: Genetics & Stem Cells Authors: Dusko I, Sharon Y Tags: Regen Med Source Type: research

Conference Scene: The 2015 Tissue Engineering Congress, London, UK, 8-10 September 2015.
Abstract The 2015 Tissue Engineering Congress, held in London, UK on 8-10 September 2015, brought together the principles of engineering and life sciences in tissue development and regenerative medicine to discuss scientific research and developments of clinical applications from leading experts in the field. The newest research and developing technology were presented in the field of stem cell biology, tissue regeneration, 3D culture and scaffolds and biomaterials. The focus was on interdisciplinary approaches based on the combination of new-generation biomaterials and cell-based therapies, which can lead to brea...
Source: Regenerative Medicine - March 29, 2017 Category: Genetics & Stem Cells Authors: Kalamarz-Kubiak H Tags: Regen Med Source Type: research

Human tooth-derived biomaterial as a graft substitute for hard tissue regeneration.
CONCLUSION: DDM grafts implanted in bone were better able to augment the bone compared with MDM grafts. However, both MDM and DDM failed to induce new bone in ectopic site, they could be considered as alternative autograft substitutes after protocol optimization. PMID: 28350271 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 28, 2017 Category: Genetics & Stem Cells Authors: Rijal G, Shin HI Tags: Regen Med Source Type: research

Advances in on-chip vascularization.
Abstract Microfluidics is invaluable for studying microvasculature, development of organ-on-chip models and engineering microtissues. Microfluidic design can cleverly control geometry, biochemical gradients and mechanical stimuli, such as shear and interstitial flow, to more closely mimic in vivo conditions. In vitro vascular networks are generated by two distinct approaches: via endothelial-lined patterned channels, or by self-assembled networks. Each system has its own benefits and is amenable to the study of angiogenesis, vasculogenesis and cancer metastasis. Various techniques are employed in order to generate...
Source: Regenerative Medicine - March 20, 2017 Category: Genetics & Stem Cells Authors: Haase K, Kamm RD Tags: Regen Med Source Type: research

Our panel of experts highlight the most important research articles across the spectrum of topics relevant to the field of regenerative medicine.
PMID: 28318389 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 20, 2017 Category: Genetics & Stem Cells Authors: Kerstetter-Fogle A Tags: Regen Med Source Type: research

Regulation of the microenvironment for cardiac tissue engineering.
Abstract The microenvironment of myocardium plays an important role in the fate and function of cardiomyocytes (CMs). Cardiovascular tissue engineering strategies commonly utilize stem cell sources in conjunction with microenvironmental cues that often include biochemical, electrical, spatial and biomechanical factors. Microenvironmental stimulation of CMs, in addition to the incorporation of intercellular interactions from non-CMs, results in the generation of engineered cardiac constructs. Current studies suggest that use of these factors when engineering cardiac constructs improve cardiac function when implante...
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Wanjare M, Huang NF Tags: Regen Med Source Type: research

IL4I1 decreases inflammation and promotes CNS repair in models of multiple sclerosis.
PMID: 28244822 [PubMed - in process] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Kerstetter-Fogle A Tags: Regen Med Source Type: research

The use of mesenchymal stromal cells in treatment of lung disorders.
Abstract The therapeutic use of mesenchymal stromal cells (MSCs) represents a promising alternative clinical strategy for treating acute and chronic lung disorders. Several preclinical reports demonstrated that MSCs can secrete multiple paracrine factors and that their immunomodulatory properties can support endothelial and epithelial regeneration, modulate the inflammatory cascade and protect lungs from damage. The effects of MSC transplantation into patients suffering from lung diseases should be fully evaluated through careful assessment of safety and associated risks, which is a prerequisite for translation of...
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Kardia E, Zakaria N, Sarmiza Abdul Halim NS, Widera D, Yahaya BH Tags: Regen Med Source Type: research

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions 1 October-30 November 2016.
PMID: 28244824 [PubMed - in process] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Ilic D, Trento C, Bisioti A Tags: Regen Med Source Type: research

Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair.
CONCLUSION: Combined MPs/ASCs cell therapy is a promising approach to restore muscle function and stimulate local angiogenesis in the ischemic limb. PMID: 28244825 [PubMed - in process] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Rybalko V, Hsieh PL, Ricles LM, Chung E, Farrar RP, Suggs LJ Tags: Regen Med Source Type: research

Mesenchymal stem cells in regenerative medicine: a new paradigm for degenerative bone diseases.
PMID: 28244826 [PubMed - in process] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Shyam H, Singh SK, Kant R, Saxena SK Tags: Regen Med Source Type: research

Deriving cells expressing markers of female germ cells from premature ovarian failure patient-specific induced pluripotent stem cells.
CONCLUSION: Our in vitro system was beneficial for POF-iPSCs differentiated cells to express STELLA, VASA and SCP3, which were the markers of meiosis initiation of FGCs. PMID: 28244827 [PubMed - in process] (Source: Regenerative Medicine)
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Wen Y, He W, Jiang M, Zeng M, Cai L Tags: Regen Med Source Type: research

Insurance systems and reimbursement concerning research and development of regenerative medicine in Japan.
Abstract In Japan, the Act on the Safety of Regenerative Medicine and the Pharmaceuticals, Medical Devices and Other Therapeutic Products Act were enacted in November 2014, creating a new framework for clinical research and products related to regenerative medicine. Together with these regulatory frameworks, new insurance procedures were created for handling regenerative medicine in Japan. For developing regenerative medicine in Japan, understanding medical insurance greatly influences funding and venture success, particularly in the stages between clinical research and market launch. The study aimed to identify t...
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Okada K, Miyata T, Sawa Y Tags: Regen Med Source Type: research

Regenerative capacity of autologous stem cell transplantation in elderly: a report of biomedical outcomes.
Abstract The occurrence of chronic diseases such as neurological, metabolic and cardiovascular degenerative disorders increases with age. Cell therapy is an emerging approach to the treatment of these conditions. Of particular interest is the application of autologous stem cells because it eliminates post-transplantation immune rejection and there are less ethical concerns associated with their use. The regenerative capacity of stem cells harvested from elderly people is however controversial. In this review, we analyze if self-renewal potential, differentiation capability and expression of stemness genes in stem ...
Source: Regenerative Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Gonzalez-Garza MT, Cruz-Vega DE Tags: Regen Med Source Type: research

Corrigendum.
Authors: PMID: 28142320 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 1, 2017 Category: Genetics & Stem Cells Tags: Regen Med Source Type: research

Erratum.
Authors: PMID: 28143381 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - February 1, 2017 Category: Genetics & Stem Cells Tags: Regen Med Source Type: research

The ethics of withdrawal: the case of follow-up from first-in-human clinical trials.
Abstract This paper aims to analyze whether patients should be allowed to veto research-related use of medical data collected during routine follow-ups after their withdrawal from first-in-human clinical trials. Forms of withdrawal are identified and it is argued that the right to withdraw might be limited to some of these. The paper concludes that if veto right is denied, then: the research participant should be informed about the potential use of his/her follow-up data in case of his/her withdrawal and consent to it; follow-up should not be initiated for research purposes; compulsory use of follow-up data should...
Source: Regenerative Medicine - December 15, 2016 Category: Genetics & Stem Cells Authors: Hug K, Johansson M Tags: Regen Med Source Type: research

Generation of endoderm lineages from pluripotent stem cells.
Abstract Definitive endoderm is the cellular precursor to respiratory- and digestive-related organs such as lungs, stomach, liver, pancreas and intestine. Endodermal lineage cells derived from pluripotent stem cells (PSCs) in vitro are a potentially unlimited resource for regenerative medicine. These cells are useful tools for studying the physiology, pathogenesis and medical therapies involving these tissues, and great progress has been achieved in PSCs differentiation protocols. In this review, we will focus on the most common and/or advanced differentiation strategies currently used in generating endodermal lin...
Source: Regenerative Medicine - December 15, 2016 Category: Genetics & Stem Cells Authors: Luo X, Wang H, Leighton J, O'Sullivan M, Wang P Tags: Regen Med Source Type: research

Patent eligibility of stem cells in Europe: where do we stand after 8 years of case law?
This article will give a short comprehensive overview of the case history, and discuss questions still unsolved. PMID: 27976982 [PubMed - as supplied by publisher] (Source: Regenerative Medicine)
Source: Regenerative Medicine - December 15, 2016 Category: Genetics & Stem Cells Authors: Storz U, Faltus T Tags: Regen Med Source Type: research